The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6

Archives of Biochemistry and Biophysics

Volumn 380, Issue 2, 2000, Pages 303-308

  Fukuda, Tsuyoshi ^a   Nishida, Yuko ^a   Imaoka, Susumu ^b   Hiroi, Toyoko ^b   Naohara, Masakazu ^a   Funae, Yoshihiko ^b   Azuma, Junichi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CYP2D6; CYP2D6*10; Expression; Polymorphism; Venlafaxine

Indexed keywords

CYTOCHROME P450 2D6; CYTOCHROME P450 ISOENZYME; PROLINE; SERINE; THREONINE -DB VENLAFAXINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CASE REPORT; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

EID: 0034663081     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2000.1936     Document Type: Article

References (31)