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European Journal of Pharmaceutical Sciences

Volumn 12, Issue 2, 2000, Pages 151-158

Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin

(5) Venhorst, Jennifer a Onderwater, Rob C A a Meerman, John H N a Vermeulen, Nico P E a Commandeur, Jan N M a

a VU UNIVERSITY AMSTERDAM (Netherlands)

Author keywords

Flow injection analysis; High throughput screening; Human CYP2D6; Inhibition; Microplate reader; Validation

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE DERIVATIVE; CODEINE; COUMARIN DERIVATIVE; CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; FLUORESCENT DYE; PROADIFEN; QUINIDINE; SPARTEINE; TRIPROLIDINE;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE; FLOW INJECTION ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; PRIORITY JOURNAL;

CALIBRATION; CELL LINE; COUMARINS; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; HUMANS; KINETICS; MICROSOMES; MICROSOMES, LIVER; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY;

EID: 0033692456 PISSN: 09280987 EISSN: None Source Type: Journal
DOI: 10.1016/S0928-0987(00)00150-0 Document Type: Article

Times cited : (27)

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