Structural basis for ligand promiscuity in cytochrome P450 3A4

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 37, 2006, Pages 13682-13687

  Ekroos, Marika ^a   Sjögren, Tove ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Drug metabolism; Inhibitor; Structural flexibility; Substrate; X ray crystallography

Indexed keywords

CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; ERYTHROMYCIN; KETOCONAZOLE;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY; CYTOCHROME P-450 ENZYME SYSTEM; ERYTHROMYCIN; HUMANS; KETOCONAZOLE; LIGANDS; PROTEIN CONFORMATION;

EID: 33748802003     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603236103     Document Type: Article

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