Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: Design and construction of a mutant with testosterone hydroxylase activity

Biochemical Journal

Volumn 331, Issue 3, 1998, Pages 783-792

  Smith, Gillian ^a   Modi, Sandeep ^b   Pillai, Ilona ^b   Lian, Lu Yun ^b   Sutcliffe, Michael J ^b   Pritchard, Michael P ^a   Friedberg, Thomas ^a   Roberts, Gordon C K ^b   Wolf, C Roland ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BUFURALOL; CYTOCHROME P450 2D6; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE 4 HYDROXYLASE; HEME; IRON; ISOLEUCINE; MUTANT PROTEIN; NITROGEN; OXYGENASE; PHENYLALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; TESTOSTERONE; TRYPTOPHAN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ESCHERICHIA COLI;

EID: 0032080291     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3310783     Document Type: Article

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