Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 2, 2005, Pages 328-334

  Goto, Akihisa ^a   Ueda, Koji ^b   Inaba, Atsuhiro ^b   Nakajima, Hiroshi ^a   Kobayashi, Hiroyuki ^a   Sakai, Kenichi ^c  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

^c KYORIN UNIVERSITY   (Japan)

Author keywords

Antiallergic drug; CYP3A4; Cytochrome P450 2D6 (CYP2D6); Metabolism; Oxatomide

Indexed keywords

ALPHA NAPHTHOFLAVONE; ANTIALLERGIC AGENT; CYTOCHROME P450; ISOPROTEIN; KETOCONAZOLE; OXATOMIDE; QUINIDINE; SULFAPHENAZOLE; TRANYLCYPROMINE; ENZYME INHIBITOR; ISOENZYME; PIPERAZINE DERIVATIVE;

ALLERGY; ARTICLE; BINDING KINETICS; CARDIOTOXICITY; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENCY; ENZYME DEGRADATION; ENZYME METABOLISM; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IC 50; IMMEDIATE TYPE HYPERSENSITIVITY; INHIBITION KINETICS; PROTEIN ANALYSIS; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LIVER MICROSOME; METABOLISM;

ANTI-ALLERGIC AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MICROSOMES, LIVER; PIPERAZINES;

EID: 19444366142     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.28.328     Document Type: Article

References (36)

1. Shinoda M., Watanabe N., Suko T., Mogi G., Takeyama M., Am. J. Rhinol., 11, 237-241 (1997).
2. Giorgi P. L., Oggiano N., Kantar A., Coppa G. V., Nicora V., Minerva Pediatr., 50, 339-346 (1998).
3. Manabe H., Ohmori K., Tomioka H., Yoshida S., Int. Arch. Allergy Appl. Immunol., 87, 91-97 (1988).
4. Ohmori K., Ishii H., Hirayama T., Shuto K., Nakamizo N., Folia Pharmacol. Jpn., 80, 251-260 (1982).
5. Kosaka Y., Kawabe H., Ishii A., Agents Actions, 21, 32-37 (1982).
6. Rosa M. L., Leonardi S., Marchese G., Corrias A., Barberio G., Oggiano N., Grimaldi I., Ann. Allergy Asthma Immunol., 87, 48-53 (2001).
7. Locci F., Del Giacco G. S., Drugs Exptl. Clin. Res., 17, 399-403 (1991).
8. Duse M., Merlini R., Gardenghi R., Porteri V., Minerva Pediatr., 50, 359-365 (1998).
9. Goto A., Nakajima H., Adachi Y., Inaba A., Kobayashi H., Sakai K., Biol. Pharm. Bull., 27, 684-690 (2004).
10. Jones B. C., Hyland R., Ackland M., Tyman C. A., Smith D. A., Drug Metab. Dispos., 26, 875-882 (1998).
11. Ling K.-H. J., Leeson G. A., Burmaste S. D., Hook R. H., Reith M. K., Cheng L. K., Drug Metab. Dispos., 23, 631-636 (1995).
12. Nicolas J. M., Whomsley R., Collart P., Roba J., Chem. Biol. Interact., 123, 63-79 (1999).
13. Davies A. J., Harindra V., McEwan A., Ghose R. R., Br. Med. J., 298, 325 (1989).
14. MacConnell T. J., Stanners A. J., Br. Med. J., 302, 1469 (1991).
15. Monahan B. P., Ferguson C. L., Killeavey E. S., Lloyd B. K., Troy J., Cantilena L. R., JAMA, 264, 2788-2790 (1990).
16. Snook J., Coothman-Burrell D., Watkins J., Colin-Jones D., Br. J. Clin. Pract., 42, 275-259 (1988).
17. Wiley J. F., Gelber M. L., Henretig F. M., Wiley C. C., Sandhu S., Loiselle J., J. Pediatr., 120, 799-802 (1992).
18. Hoppu K., Tikanoja T., Tapanainen P., Remes M., Saarenpaa-Heikkila O., Kouvalainen K., Lancet, 338, 538-540 (1991).
19. Zechnich A. D., Hedges J. R., West J. Med., 160, 321-325 (1994).
20. Ament P. W., Pharm D., Am. Fam. Physician, 56, 223-230 (1997).
21. Desager J. P., Horsmans Y., Clin. Pharmacokinet., 28, 419-432 (1995).
22. Woosley R. L., Annu. Rev. Pharmacol. Toxicol., 36, 233-252 (1996).
23. Haraguchi K., Ito K., Kotaki H., Sawada Y., Iga T., Drug Metab. Dispos., 25, 675-684 (1997).
24. Imiya M., Neurol. Mod., 37, 635-636 (1992).
25. Sharer J. E., Shipley L. A., Vandenbranden M. R., Binkley S. N., Wrighton S. A., Drug Metab. Dispos., 23, 1231-1241 (1995).
26. Chauret N., Gauthier A., Martin J., Nicoll-Griffith D. A., Drug Metab. Dispos., 25, 1130-1136 (1997).
27. Kishimoto W., Hiroi T., Sakai K., Funae Y., Igarashi T., Res. Com. Mol. Pathol. Pharmacol., 98, 273-288 (1997).
28. Honig P. K., Wortham D. C., Zamani K., Conner D. P., Mullin J. C., Cantilena L. R., JAMA, 269, 1513-1518 (1998).
29. Von Moltke L. L., Greenblatt D. J., Duan S. X., Harmatz J. S., Shader R. I., J. Clin. Pharmacol., 34, 1222-1227 (1994).
30. Ikeda S., Oka H., Matunaga K., Kubo S., Asai S., Miyahara Y., Osaka A., Kohno S., Jpn. Circ. J., 62, 225-227 (1998).
31. Davies B. H., Rocchiccioli K., Pharmatherapeutica, 3, 365-369 (1983).
32. Iwamoto K., Ikeda J., Nito M., Kosaka N., Ichikawa S., Ohmori K., Sakai K., Arzneim.-Forsch./Drug Res., 51, 971-976 (2001).
33. Haraguchi K., Ito K., Kotaki H., Sawada Y., Iga T., Drug Metab. Dispos., 25, 675-684 (1997).
34. Matsunaga K., Sato T., Shuto H., Tsuruta Y., Suemaru K., Gomita Y., Oishi R., Eur. J. Pharmacol., 350, 165-169 (1998).
35. Meuldermans W., Hendrickx J., Knaeps F., Lauwers W., Heykants J., Xenobiotica, 14, 445-462 (1984).
36. Kikuchi K., Ohishi T., Masuike T., Ohmori K., Sakai K., Arzneim.-Forsch./Drug Res., 52, 754-763 (2002).