Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6

Proteins: Structure, Function and Genetics

Volumn 49, Issue 2, 2002, Pages 216-231

  Kirton, Stewart B ^a   Kemp, Carol A ^a   Tomkinson, Nicholas P ^b   St Gallay, Steven ^b   Sutcliffe, Michael J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Binding determinants; Model validation; Molecular modeling; Principal component analysis; Substrate specificity

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ASPARTIC ACID; CODEINE; CYTOCHROME P450; CYTOCHROME P450 2D6; GLUTAMINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MAMMAL CELL; MATHEMATICAL MODEL; MOLECULAR RECOGNITION; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; BACTERIA; BINDING SITES; CODEINE; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP2D6; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; REPRODUCIBILITY OF RESULTS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 0036836542     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10192     Document Type: Article

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