Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6

Journal of Biological Chemistry

Volumn 278, Issue 6, 2003, Pages 4021-4027

  Paine, Mark J I ^a   McLaughlin, Lesley A ^a   Flanagan, Jack U ^a   Kemp, Carol A ^b   Sutcliffe, Michael J ^b   Roberts, Gordon C K ^b   Wolf, C Roland ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSTS; COMPUTATIONAL METHODS; DRUG DOSAGE; ELECTROSTATICS; ESTERS;

REGIOSELECTIVITY;

BIOCHEMISTRY;

ASPARAGINE; ASPARTIC ACID; BUFURALOL; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DICLOFENAC; GLUTAMIC ACID; GLUTAMINE; LEUCINE; LYSINE; NIFEDIPINE; NITROGEN; PHENYLALANINE; TOLBUTAMIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DEMETHYLATION; DRUG METABOLISM; ELECTRIC POTENTIAL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; MATHEMATICAL MODEL; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS; ALKYLATION; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM;

ALKYLATION; ASPARTIC ACID; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; GLUTAMIC ACID; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; SUBSTRATE SPECIFICITY;

EID: 0037423276     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209519200     Document Type: Article

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