Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: Switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 10, 1996, Pages 4644-4648

  Vaz, Alfin D N ^a   Pernecky, Steven J ^a,b   Raner, Gregory M ^a   Coon, Minor J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b EASTERN MICHIGAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYTOCHROME P450; IRON BINDING PROTEIN; OXENOID IRON; OXIDIZING AGENT; PEROXO IRON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME PURIFICATION; IRON TRANSPORT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT; TRANSPORT KINETICS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BASE SEQUENCE; BINDING SITES; CATALYSIS; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ELECTRON TRANSPORT; ESCHERICHIA COLI; HYDROGEN PEROXIDE; IRON; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; POINT MUTATION; PROTONS; RABBITS; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

EID: 0030004087     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.10.4644     Document Type: Article

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