Metabolism of N-substituted 7-methoxy-4-(aminomethyl)-coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points

Xenobiotica

Volumn 36, Issue 9, 2006, Pages 763-771

  Keizers, P H J ^a   Van Dijk, B R ^a   De Graaf, C ^a   Van Vugt Lussenburg, B M A ^a   Vermeulen, N P E ^a   Commandeur, J N M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

7 methoxy 4 (aminomethyl) coumarin (MAMC); Active site topology; Coumarine; Cytochrome P450 2D6; Mutagenesis

Indexed keywords

COUMARIN DERIVATIVE; CYTOCHROME P450; MUTANT PROTEIN;

AEROBIC METABOLISM; ARTICLE; BINDING SITE; CATALYSIS; DEALKYLATION; DEMETHYLATION; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; SEQUENCE HOMOLOGY; WILD TYPE;

ALKYLATION; BINDING SITES; CATALYSIS; COUMARINS; CYTOCHROME P-450 CYP2D6; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROPHOBICITY; METHYLATION; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; SUBSTRATE SPECIFICITY;

EID: 33748682723     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600765325     Document Type: Article

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