메뉴 건너뛰기




Volumn 46, Issue , 2018, Pages 14-31

Anti-senescence compounds: A potential nutraceutical approach to healthy aging

Author keywords

Aging; Anti senescence diet; Cellular senescence; Polyphenols; Senolytic

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOTRIENOL; APIGENIN; CATECHIN; CURCUMIN; DASATINIB; DEOXYGLUCOSE; EPIGALLOCATECHIN GALLATE; GENISTEIN; GINSENOSIDE; HEAT SHOCK PROTEIN 90 INHIBITOR; JANUS KINASE INHIBITOR; KAEMPFEROL; NARINGENIN; NATURAL PRODUCT; NAVITOCLAX; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUTRACEUTICAL; OLEUROPEIN; PANOBINOSTAT; PHLOROGLUCINOL; PIPERLONGUMINE; POLYPHENOL DERIVATIVE; PROTEIN P53; QUERCETIN; RAPAMYCIN; SPERMIDINE; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG; ANTIOXIDANT; POLYPHENOL;

EID: 85048714345     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2018.05.001     Document Type: Review
Times cited : (149)

References (306)
  • 1
    • 0037204953 scopus 로고    scopus 로고
    • A road map for those who know JAK-STAT
    • Aaronson, D.S., Horvath, C.M., A road map for those who know JAK-STAT. Science 296 (2002), 1653–1655.
    • (2002) Science , vol.296 , pp. 1653-1655
    • Aaronson, D.S.1    Horvath, C.M.2
  • 4
    • 84935026487 scopus 로고    scopus 로고
    • Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: a regression and CART approach in the BELFRAIL study
    • Adriaensen, W., Matheï, C., Vaes, B., van Pottelbergh, G., Wallemacq, P., Degryse, J.M., Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: a regression and CART approach in the BELFRAIL study. Exp. Gerontol. 69 (2015), 53–61, 10.1016/j.exger.2015.06.005.
    • (2015) Exp. Gerontol. , vol.69 , pp. 53-61
    • Adriaensen, W.1    Matheï, C.2    Vaes, B.3    van Pottelbergh, G.4    Wallemacq, P.5    Degryse, J.M.6
  • 6
  • 8
    • 85009168575 scopus 로고    scopus 로고
    • Pharmacologic approaches to glycemic treatment
    • American Diabetes Association, Pharmacologic approaches to glycemic treatment. Diabetes Care 40:Suppl. 1 (2017), S64–S74.
    • (2017) Diabetes Care , vol.40 , pp. S64-S74
    • American Diabetes Association1
  • 11
    • 84949724978 scopus 로고    scopus 로고
    • Inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians
    • Arai, Y., Martin-Ruiz, C.M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., von Zglinicki, T., Inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians. EBioMedicine 2 (2015), 1549–1558, 10.1016/j.ebiom.2015.07.029.
    • (2015) EBioMedicine , vol.2 , pp. 1549-1558
    • Arai, Y.1    Martin-Ruiz, C.M.2    Takayama, M.3    Abe, Y.4    Takebayashi, T.5    Koyasu, S.6    Suematsu, M.7    Hirose, N.8    von Zglinicki, T.9
  • 13
    • 67349228774 scopus 로고    scopus 로고
    • Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges
    • Atadja, P., Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges. Cancer Lett. 280 (2009), 233–241, 10.1016/j.canlet.2009.02.019.
    • (2009) Cancer Lett. , vol.280 , pp. 233-241
    • Atadja, P.1
  • 15
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: multiple constituents and multiple actions
    • Attele, A.S., Wu, J.A., Yuan, C.S., Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 58 (1999), 1685–1693.
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 20
    • 85021061927 scopus 로고    scopus 로고
    • Aging and caloric restriction research: a biological perspective with translational potential
    • Balasubramanian, P., Howell, P.R., Anderson, R.M., Aging and caloric restriction research: a biological perspective with translational potential. EBioMedicine 21 (2017), 37–44, 10.1016/j.ebiom.2017.06.015.
    • (2017) EBioMedicine , vol.21 , pp. 37-44
    • Balasubramanian, P.1    Howell, P.R.2    Anderson, R.M.3
  • 21
    • 84873725975 scopus 로고    scopus 로고
    • In vitro antioxidant properties of crude extracts and compounds from brown algae
    • Balboa, E.M., Conde, E., Moure, A., Falqué, E., Domínguez, H., In vitro antioxidant properties of crude extracts and compounds from brown algae. Food Chem. 138 (2013), 1764–1785, 10.1016/j.foodchem.2012.11.026.
    • (2013) Food Chem. , vol.138 , pp. 1764-1785
    • Balboa, E.M.1    Conde, E.2    Moure, A.3    Falqué, E.4    Domínguez, H.5
  • 22
    • 84861885929 scopus 로고    scopus 로고
    • The critical role of metabolic pathways in aging
    • Barzilai, N., Huffman, D.M., Muzumdar, R.H., Bartke, A., The critical role of metabolic pathways in aging. Diabetes 61 (2012), 1315–1322, 10.2337/db11-1300.
    • (2012) Diabetes , vol.61 , pp. 1315-1322
    • Barzilai, N.1    Huffman, D.M.2    Muzumdar, R.H.3    Bartke, A.4
  • 26
    • 85027142463 scopus 로고    scopus 로고
    • Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals
    • Bhat, M.I., Kapila, R., Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr. Rev. 75 (2017), 374–389, 10.1093/nutrit/nux001.
    • (2017) Nutr. Rev. , vol.75 , pp. 374-389
    • Bhat, M.I.1    Kapila, R.2
  • 28
    • 85018971231 scopus 로고    scopus 로고
    • Quantitative identification of senescent cells in aging and disease
    • Epub 2017 Apr 28
    • Biran, A., Zada, L., Abou Karam, P., Vadai, E., Roitman, L., Ovadya, Y., Porat, Z., Krizhanovsky, V., Quantitative identification of senescent cells in aging and disease. Aging Cell 16:Aug (4) (2017), 661–671, 10.1111/acel.12592 Epub 2017 Apr 28.
    • (2017) Aging Cell , vol.16 , Issue.Aug (4) , pp. 661-671
    • Biran, A.1    Zada, L.2    Abou Karam, P.3    Vadai, E.4    Roitman, L.5    Ovadya, Y.6    Porat, Z.7    Krizhanovsky, V.8
  • 29
    • 74549205329 scopus 로고    scopus 로고
    • Validation of anti-aging drugs by treating age-related diseases
    • Blagosklonny, M.V., Validation of anti-aging drugs by treating age-related diseases. Aging (Albany NY) 1 (2009), 281–288.
    • (2009) Aging (Albany NY) , vol.1 , pp. 281-288
    • Blagosklonny, M.V.1
  • 30
    • 84876979340 scopus 로고    scopus 로고
    • Mediterranean diet, telomere maintenance and health status among elderly
    • Boccardi, V., Esposito, A., Rizzo, M.R., Marfella, R., Barbieri, M., Paolisso, G., Mediterranean diet, telomere maintenance and health status among elderly. PLoS One, 8, 2013, e62781, 10.1371/journal.pone.0062781.
    • (2013) PLoS One , vol.8 , pp. e62781
    • Boccardi, V.1    Esposito, A.2    Rizzo, M.R.3    Marfella, R.4    Barbieri, M.5    Paolisso, G.6
  • 32
    • 4143049304 scopus 로고    scopus 로고
    • Comparative study on phenolic content and antioxidant activity during maturation of the olive cultivar Chemlali from Tunisia
    • Bouaziz, M., Chamkha, M., Sayadi, S., Comparative study on phenolic content and antioxidant activity during maturation of the olive cultivar Chemlali from Tunisia. J. Agric. Food Chem. 52 (2004), 5476–5481.
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 5476-5481
    • Bouaziz, M.1    Chamkha, M.2    Sayadi, S.3
  • 33
    • 85041748178 scopus 로고    scopus 로고
    • Cellular senescence: immunosurveillance and future immunotherapy
    • Burton, D.G.A., Stolzing, A., Cellular senescence: immunosurveillance and future immunotherapy. Ageing Res. Rev. 43 (2018), 17–25, 10.1016/j.arr.2018.02.001.
    • (2018) Ageing Res. Rev. , vol.43 , pp. 17-25
    • Burton, D.G.A.1    Stolzing, A.2
  • 34
    • 85027587777 scopus 로고    scopus 로고
    • Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis
    • Campbell, J.M., Bellman, S.M., Stephenson, M.D., Lisy, K., Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis. Ageing Res. Rev. 40 (2017), 31–44, 10.1016/j.arr.2017.08.003.
    • (2017) Ageing Res. Rev. , vol.40 , pp. 31-44
    • Campbell, J.M.1    Bellman, S.M.2    Stephenson, M.D.3    Lisy, K.4
  • 35
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: when bad things happen to good cells
    • Campisi, J., d'Adda di Fagagna, F., Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell. Biol. 8 (2007), 729–740.
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 36
    • 80855128461 scopus 로고    scopus 로고
    • Cellular senescence: a link between cancer and age-related degenerative disease?
    • Campisi, J., Andersen, J.K., Kapahi, P., Melov, S., Cellular senescence: a link between cancer and age-related degenerative disease?. Semin. Cancer Biol. 21 (2011), 354–359, 10.1016/j.semcancer.2011.09.001.
    • (2011) Semin. Cancer Biol. , vol.21 , pp. 354-359
    • Campisi, J.1    Andersen, J.K.2    Kapahi, P.3    Melov, S.4
  • 37
    • 85038885082 scopus 로고    scopus 로고
    • Application of kinase inhibitors for anti-aging intervention
    • Cano, M., Ayala, A., Marotta, F., Arguelles, S., Application of kinase inhibitors for anti-aging intervention. Curr. Pharm. Des. 23 (2017), 4351–4368, 10.2174/1381612823666170714143426.
    • (2017) Curr. Pharm. Des. , vol.23 , pp. 4351-4368
    • Cano, M.1    Ayala, A.2    Marotta, F.3    Arguelles, S.4
  • 38
    • 83455206803 scopus 로고    scopus 로고
    • Targeting sirtuin 1 to improve metabolism: all you need is NAD+?
    • Cantó, C., Auwerx, J., Targeting sirtuin 1 to improve metabolism: all you need is NAD+?. Pharmacol. Rev. 64 (2012), 166–187, 10.1124/pr.110.003905.
    • (2012) Pharmacol. Rev. , vol.64 , pp. 166-187
    • Cantó, C.1    Auwerx, J.2
  • 40
    • 85014918102 scopus 로고    scopus 로고
    • Olive polyphenols: new promising agents to combat aging-associated neurodegeneration
    • Casamenti, F., Stefani, M., Olive polyphenols: new promising agents to combat aging-associated neurodegeneration. Expert Rev. Neurother. 17 (2017), 345–358, 10.1080/14737175.2017.1245617.
    • (2017) Expert Rev. Neurother. , vol.17 , pp. 345-358
    • Casamenti, F.1    Stefani, M.2
  • 42
    • 40349087577 scopus 로고    scopus 로고
    • Phenols and polyphenols from argania spinosa
    • Charrouf, Z., Guillaume, D., Phenols and polyphenols from argania spinosa. Am. J. Food Technol. 2 (2007), 679–683.
    • (2007) Am. J. Food Technol. , vol.2 , pp. 679-683
    • Charrouf, Z.1    Guillaume, D.2
  • 44
    • 44349095712 scopus 로고    scopus 로고
    • Ginsenoside Rg1 delays tert-butyl hydroperoxide-induced premature senescence in human WI-38 diploid fibroblast cells
    • Chen, X., Zhang, J., Fang, Y., Zhao, C., Zhu, Y., Ginsenoside Rg1 delays tert-butyl hydroperoxide-induced premature senescence in human WI-38 diploid fibroblast cells. J. Gerontol. A. Biol. Sci. Med. Sci. 63 (2008), 253–264.
    • (2008) J. Gerontol. A. Biol. Sci. Med. Sci. , vol.63 , pp. 253-264
    • Chen, X.1    Zhang, J.2    Fang, Y.3    Zhao, C.4    Zhu, Y.5
  • 45
    • 85038438080 scopus 로고    scopus 로고
    • Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer
    • Chen, Y.J., Kuo, C.C., Ting, L.L., Lu, L.S., Lu, Y.C., Cheng, A.J., Lin, Y.T., Chen, C.H., Tsai, J.T., Chiou, J.F., Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer. Oncol. Lett. 15 (2018), 1789–1798, 10.3892/ol.2017.7486.
    • (2018) Oncol. Lett. , vol.15 , pp. 1789-1798
    • Chen, Y.J.1    Kuo, C.C.2    Ting, L.L.3    Lu, L.S.4    Lu, Y.C.5    Cheng, A.J.6    Lin, Y.T.7    Chen, C.H.8    Tsai, J.T.9    Chiou, J.F.10
  • 46
    • 84949555897 scopus 로고    scopus 로고
    • Cellular senescence in aging and age-related disease: from mechanisms to therapy
    • Childs, B.G., Durik, M., Baker, D.J., Van Deursen, J.M., Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat. Med. 21 (2015), 1424–1435, 10.1038/nm.4000.
    • (2015) Nat. Med. , vol.21 , pp. 1424-1435
    • Childs, B.G.1    Durik, M.2    Baker, D.J.3    Van Deursen, J.M.4
  • 50
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: evidence from mice and humans
    • Collado, M., Serrano, M., Senescence in tumours: evidence from mice and humans. Nat. Rev. Cancer 10 (2010), 51–57, 10.1038/nrc2772.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 51
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppé, J.P., Desprez, P.Y., Krtolica, A., Campisi, J., The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5 (2010), 99–118, 10.1146/annurev-pathol-121808-102144.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 99-118
    • Coppé, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 52
    • 84941730889 scopus 로고    scopus 로고
    • Mitochondria Are they causal players in cellular senescence?
    • Correia-Melo, C., Passos, J.F., Mitochondria Are they causal players in cellular senescence?. Biochim. Biophys. Acta 1847 (2015), 1373–1379, 10.1016/j.bbabio.2015.05.017.
    • (2015) Biochim. Biophys. Acta , vol.1847 , pp. 1373-1379
    • Correia-Melo, C.1    Passos, J.F.2
  • 54
    • 84964689366 scopus 로고    scopus 로고
    • Lifespan and healthspan: past, present, and promise
    • Crimmins, E.M., Lifespan and healthspan: past, present, and promise. Gerontologist 55 (2015), 901–911.
    • (2015) Gerontologist , vol.55 , pp. 901-911
    • Crimmins, E.M.1
  • 57
    • 0036176353 scopus 로고    scopus 로고
    • The effect of immunization with killed tumor cells, with/without feeding of Echinacea purpurea in an erythroleukemic mouse model
    • Currier, N.L., Miller, S.C., The effect of immunization with killed tumor cells, with/without feeding of Echinacea purpurea in an erythroleukemic mouse model. J. Altern. Complement. Med. 8 (2002), 49–58.
    • (2002) J. Altern. Complement. Med. , vol.8 , pp. 49-58
    • Currier, N.L.1    Miller, S.C.2
  • 59
    • 34249846128 scopus 로고    scopus 로고
    • Resveratrol stimulates AMP kinase activity in neurons
    • Dasgupta, B., Milbrandt, J., Resveratrol stimulates AMP kinase activity in neurons. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 7217–7222.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 7217-7222
    • Dasgupta, B.1    Milbrandt, J.2
  • 60
    • 84973300708 scopus 로고    scopus 로고
    • Cell senescence, and novel molecular mechanisms in aging and age-Related diseases
    • 356512
    • Davalli, P., Mitic, T., Caporali, A., Lauriola, A., D'Arca, D.R.O.S., Cell senescence, and novel molecular mechanisms in aging and age-Related diseases. Oxid. Med. Cell. Longev., 356512, 2016, 7, 10.1155/2016/3565127.
    • (2016) Oxid. Med. Cell. Longev. , pp. 7
    • Davalli, P.1    Mitic, T.2    Caporali, A.3    Lauriola, A.4    D'Arca, D.R.O.S.5
  • 65
    • 85020503420 scopus 로고    scopus 로고
    • The protective effect of Ginsenoside Rg1 on aging mouse pancreas damage induced by D-galactose
    • Dong, Z., Xu, M., Huang, J., Chen, L., Xia, J., Chen, X., Jiang, R., Wang, L., Wang, Y., The protective effect of Ginsenoside Rg1 on aging mouse pancreas damage induced by D-galactose. Exp. Ther. Med. 14 (2017), 616–622, 10.3892/etm.2017.4514.
    • (2017) Exp. Ther. Med. , vol.14 , pp. 616-622
    • Dong, Z.1    Xu, M.2    Huang, J.3    Chen, L.4    Xia, J.5    Chen, X.6    Jiang, R.7    Wang, L.8    Wang, Y.9
  • 68
    • 15844391440 scopus 로고    scopus 로고
    • Mechanism of action of the immunosuppressant rapamycin
    • Dumont, F.J., Su, Q., Mechanism of action of the immunosuppressant rapamycin. Life Sci. 58 (1996), 373–395.
    • (1996) Life Sci. , vol.58 , pp. 373-395
    • Dumont, F.J.1    Su, Q.2
  • 69
    • 84991694195 scopus 로고    scopus 로고
    • Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts
    • Durani, L.W., Jaafar, F., Tan, J.K., Tajul Arifin, K., Mohd Yusof, Y.A., Wan Ngah, W.Z., Makpol, S., Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. Clin. Ter. 166 (2015), e365–e373.
    • (2015) Clin. Ter. , vol.166 , pp. e365-e373
    • Durani, L.W.1    Jaafar, F.2    Tan, J.K.3    Tajul Arifin, K.4    Mohd Yusof, Y.A.5    Wan Ngah, W.Z.6    Makpol, S.7
  • 71
    • 85018884834 scopus 로고    scopus 로고
    • The gut microbiota: a key factor in the therapeutic effects of (poly)phenols
    • Espín, J.C., González-Sarrías, A., Tomás-Barberán, F.A., The gut microbiota: a key factor in the therapeutic effects of (poly)phenols. Biochem. Pharmacol. 139 (2017), 82–93, 10.1016/j.bcp.2017.04.033.
    • (2017) Biochem. Pharmacol. , vol.139 , pp. 82-93
    • Espín, J.C.1    González-Sarrías, A.2    Tomás-Barberán, F.A.3
  • 73
    • 84928925567 scopus 로고    scopus 로고
    • Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats
    • 651–660pmid:25762527
    • Etxeberria, U., Arias, N., Boqué, N., et al. Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. J. Nutr. Biochem., 26, 2015 651–660pmid:25762527.
    • (2015) J. Nutr. Biochem. , vol.26
    • Etxeberria, U.1    Arias, N.2    Boqué, N.3
  • 74
    • 9444239787 scopus 로고    scopus 로고
    • Effects of polyphenols from grape seeds on oxidative damage to cellular DNA. Mol
    • Fan, P., Lou, H., Effects of polyphenols from grape seeds on oxidative damage to cellular DNA. Mol. Cell. Biochem. 267 (2004), 67–74.
    • (2004) Cell. Biochem. , vol.267 , pp. 67-74
    • Fan, P.1    Lou, H.2
  • 75
    • 84953290851 scopus 로고    scopus 로고
    • Mechanism of ginsenoside Rg1 renal protection in a mouse model of d-galactose-induced subacute damage
    • Fan, Y., Xia, J., Jia, D., Zhang, M., Zhang, Y., Huang, G., Wang, Y., Mechanism of ginsenoside Rg1 renal protection in a mouse model of d-galactose-induced subacute damage. Pharm. Biol. 54 (2016), 1815–1821, 10.3109/13880209.2015.1129543.
    • (2016) Pharm. Biol. , vol.54 , pp. 1815-1821
    • Fan, Y.1    Xia, J.2    Jia, D.3    Zhang, M.4    Zhang, Y.5    Huang, G.6    Wang, Y.7
  • 76
    • 85015168500 scopus 로고    scopus 로고
    • Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway
    • Fan, J., Yang, X., Li, J., Shu, Z., Dai, J., Liu, X., Li, B., Jia, S., Kou, X., Yang, Y., Chen, N., Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway. Oncotarget 8 (2017), 17475–17490, 10.18632/oncotarget.15728.
    • (2017) Oncotarget , vol.8 , pp. 17475-17490
    • Fan, J.1    Yang, X.2    Li, J.3    Shu, Z.4    Dai, J.5    Liu, X.6    Li, B.7    Jia, S.8    Kou, X.9    Yang, Y.10    Chen, N.11
  • 78
    • 84991721067 scopus 로고    scopus 로고
    • Activation of PPARγ by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization
    • Feng, X., Weng, D., Zhou, F., Owen, Y.D., Qin, H., Zhao, J., WenYu, Huang Y, Chen, J., Fu, H., Yang, N., Chen, D., Li, J., Tan, R., Shen, P., Activation of PPARγ by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization. EBioMedicine 9 (2016), 61–76, 10.1016/j.ebiom.2016.06.017.
    • (2016) EBioMedicine , vol.9 , pp. 61-76
    • Feng, X.1    Weng, D.2    Zhou, F.3    Owen, Y.D.4    Qin, H.5    Zhao, J.6    WenYu, H.Y.7    Chen, J.8    Fu, H.9    Yang, N.10    Chen, D.11    Li, J.12    Tan, R.13    Shen, P.14
  • 79
    • 53649106036 scopus 로고    scopus 로고
    • Effects of different cooking methods on antioxidant profile, antioxidant capacity, and physical characteristics of artichoke
    • Ferracane, R., Pellegrini, N., Visconti, A., Graziani, G., Chiavaro, E., Miglio, C., Fogliano, V., Effects of different cooking methods on antioxidant profile, antioxidant capacity, and physical characteristics of artichoke. J. Agric. Food Chem. 56 (2008), 8601–8608, 10.1021/jf800408w.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 8601-8608
    • Ferracane, R.1    Pellegrini, N.2    Visconti, A.3    Graziani, G.4    Chiavaro, E.5    Miglio, C.6    Fogliano, V.7
  • 80
    • 84949936624 scopus 로고    scopus 로고
    • Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program
    • Ferrand, M., Kirsh, O., Griveau, A., Vindrieux, D., Martin, N., Defossez, P.A., Bernard, D., Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7 (2015), 986–1003.
    • (2015) Aging (Albany NY) , vol.7 , pp. 986-1003
    • Ferrand, M.1    Kirsh, O.2    Griveau, A.3    Vindrieux, D.4    Martin, N.5    Defossez, P.A.6    Bernard, D.7
  • 81
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span–from yeast to humans
    • Fontana, L., Partridge, L., Longo, V.D., Extending healthy life span–from yeast to humans. Science 328 (2010), 321–326, 10.1126/science.1172539.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 83
    • 84937768865 scopus 로고    scopus 로고
    • Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis
    • Forouzandeh, F., Salazar, G., Patrushev, N., Xiong, S., Hilenski, L., Fei, B., Alexander, R.W., Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis. J. Am. Heart Assoc., 3(6), 2014, e001202, 10.1161/JAHA.114.001202.
    • (2014) J. Am. Heart Assoc. , vol.3 , Issue.6 , pp. e001202
    • Forouzandeh, F.1    Salazar, G.2    Patrushev, N.3    Xiong, S.4    Hilenski, L.5    Fei, B.6    Alexander, R.W.7
  • 84
    • 0037396614 scopus 로고    scopus 로고
    • Centenarians as a model for healthy aging
    • Franceschi, C., Bonafe, M., Centenarians as a model for healthy aging. Biochem. Soc. Trans. 31 (2003), 457–461.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 457-461
    • Franceschi, C.1    Bonafe, M.2
  • 86
    • 85008331114 scopus 로고    scopus 로고
    • Healthy ageing in 2016: obesity in geroscience − is cellular senescence the culprit?
    • Franceschi, C., Healthy ageing in 2016: obesity in geroscience − is cellular senescence the culprit?. Nat. Rev. Endocrinol. 13 (2017), 76–78, 10.1038/nrendo.2016.213.
    • (2017) Nat. Rev. Endocrinol. , vol.13 , pp. 76-78
    • Franceschi, C.1
  • 87
    • 79959918489 scopus 로고    scopus 로고
    • Antioxidant capacities and total phenolic contents of 62 fruits
    • Fu, L., Xu, B.T., Xu, X.R., Gan, R.Y., Zhang, Y., Xia, E.Q., Li, H.B., Antioxidant capacities and total phenolic contents of 62 fruits. Food Chem. 2 (2011), 345–350, 10.1016/j.foodchem.2011.04.079.
    • (2011) Food Chem. , vol.2 , pp. 345-350
    • Fu, L.1    Xu, B.T.2    Xu, X.R.3    Gan, R.Y.4    Zhang, Y.5    Xia, E.Q.6    Li, H.B.7
  • 90
    • 84938943169 scopus 로고    scopus 로고
    • Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress
    • Gao, M., Zhao, Z., Lv, P., Li, Y., Gao, J., Zhang, M., Zhao, B., Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress. Redox Biol. 6 (2015), 206–217, 10.1016/j.redox.2015.06.013.
    • (2015) Redox Biol. , vol.6 , pp. 206-217
    • Gao, M.1    Zhao, Z.2    Lv, P.3    Li, Y.4    Gao, J.5    Zhang, M.6    Zhao, B.7
  • 92
    • 84940391650 scopus 로고    scopus 로고
    • Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α-dependent senescence-Associated secretory phenotype
    • Gardner, S.E., Humphry, M., Bennett, M.R., Clarke, M.C., Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α-dependent senescence-Associated secretory phenotype. Arterioscler. Thromb. Vasc. Biol. 35 (2015), 1963–1974, 10.1161/ATVBAHA.115.305896.
    • (2015) Arterioscler. Thromb. Vasc. Biol. , vol.35 , pp. 1963-1974
    • Gardner, S.E.1    Humphry, M.2    Bennett, M.R.3    Clarke, M.C.4
  • 94
    • 33749684671 scopus 로고    scopus 로고
    • Phenolic and volatile compounds of extra virgin olive oil (Olea europaea L. Cv. Cornicabra) with regard to fruit ripening and irrigation management
    • Gomez-Rico, A., Salvador, M.D., La Greca, M., Fregapane, G., Phenolic and volatile compounds of extra virgin olive oil (Olea europaea L. Cv. Cornicabra) with regard to fruit ripening and irrigation management. J. Agric. Food Chem. 54 (2006), 7130–7136.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 7130-7136
    • Gomez-Rico, A.1    Salvador, M.D.2    La Greca, M.3    Fregapane, G.4
  • 95
    • 85014295439 scopus 로고    scopus 로고
    • Sirtuins, a promising target in slowing down the ageing process
    • Grabowska, W., Sikora, E., Bielak-Zmijewska, A., Sirtuins, a promising target in slowing down the ageing process. Biogerontology 18 (2017), 447–476, 10.1007/s10522-017-9685-9.
    • (2017) Biogerontology , vol.18 , pp. 447-476
    • Grabowska, W.1    Sikora, E.2    Bielak-Zmijewska, A.3
  • 97
    • 85031330446 scopus 로고    scopus 로고
    • Beneficial effects of dietary restriction in aging brain
    • pii: S0891-0618(17)30082-0
    • Hadem, I.K.H., Majaw, T., Kharbuli, B., Sharma, R., Beneficial effects of dietary restriction in aging brain. J. Chem. Neuroanat., 2017, 10.1016/j.jchemneu.2017.10.001 pii: S0891-0618(17)30082-0.
    • (2017) J. Chem. Neuroanat.
    • Hadem, I.K.H.1    Majaw, T.2    Kharbuli, B.3    Sharma, R.4
  • 100
    • 84871367411 scopus 로고    scopus 로고
    • Preventive effects of epigallocatechin-3-O gallate against replicative senescence associated with p53 acetylation in human dermal fibroblasts
    • Han, D.W., Lee, M.H., Kim, B., Lee, J.J., Hyon, S.H., Park, J.C., Preventive effects of epigallocatechin-3-O gallate against replicative senescence associated with p53 acetylation in human dermal fibroblasts. Oxid. Med. Cell. Longev., 2012, 10.1155/2012/850684.
    • (2012) Oxid. Med. Cell. Longev.
    • Han, D.W.1    Lee, M.H.2    Kim, B.3    Lee, J.J.4    Hyon, S.H.5    Park, J.C.6
  • 102
    • 70350772288 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors – a review on pharmacology, metabolism and side effects
    • Hartmann, J.T., Haap, M., Kopp, H.G., Lipp, H.P., Tyrosine kinase inhibitors – a review on pharmacology, metabolism and side effects. Curr. Drug Metab. 10 (2009), 470–481.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 470-481
    • Hartmann, J.T.1    Haap, M.2    Kopp, H.G.3    Lipp, H.P.4
  • 103
    • 85034836296 scopus 로고    scopus 로고
    • Translating measures of biological aging to test effectiveness of geroprotective interventions: what can we learn from research on telomeres?
    • Hastings, W.J., Shalev, I., Belsky, D.W., Translating measures of biological aging to test effectiveness of geroprotective interventions: what can we learn from research on telomeres?. Front. Genet., 8, 2017, 164, 10.3389/fgene.2017.00164.eCollection2017.
    • (2017) Front. Genet. , vol.8 , pp. 164
    • Hastings, W.J.1    Shalev, I.2    Belsky, D.W.3
  • 105
    • 84922149440 scopus 로고    scopus 로고
    • SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
    • Hayakawa, T., Iwai, M., Aoki, S., Takimoto, K., Maruyama, M., Maruyama, W., Motoyama, N., SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation. PLoS One, 10(1), 2015, 10.1371/journal.pone.0116480.
    • (2015) PLoS One , vol.10 , Issue.1
    • Hayakawa, T.1    Iwai, M.2    Aoki, S.3    Takimoto, K.4    Maruyama, M.5    Maruyama, W.6    Motoyama, N.7
  • 106
    • 85020028464 scopus 로고    scopus 로고
    • Senescence in health and disease
    • He, S., Sharpless, N.E., Senescence in health and disease. Cell 169:6 (2017), 1000–1011, 10.1016/j.cell.2017.05.015.
    • (2017) Cell , vol.169 , Issue.6 , pp. 1000-1011
    • He, S.1    Sharpless, N.E.2
  • 107
    • 85030840779 scopus 로고    scopus 로고
    • Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
    • Hekmatimoghaddam, S., Dehghani Firoozabadi, A., Zare-Khormizi, M.R., Pourrajab, F., Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging. Ageing Res. Rev. 40 (2017), 120–141, 10.1016/j.arr.2017.10.001.
    • (2017) Ageing Res. Rev. , vol.40 , pp. 120-141
    • Hekmatimoghaddam, S.1    Dehghani Firoozabadi, A.2    Zare-Khormizi, M.R.3    Pourrajab, F.4
  • 108
    • 84964057589 scopus 로고    scopus 로고
    • TORn about SASP regulation
    • Herranz, N., Gallage, S., Gil, J., TORn about SASP regulation. Cell Cycle 14:24 (2015), 3771–3772, 10.1080/15384101.2015.1105694.
    • (2015) Cell Cycle , vol.14 , Issue.24 , pp. 3771-3772
    • Herranz, N.1    Gallage, S.2    Gil, J.3
  • 109
    • 85042223621 scopus 로고    scopus 로고
    • Hallmarks of cellular senescence
    • pii: S0962-8924(18)30020-5
    • Hernandez-Segura, A., Nehme, J., Demaria, M., Hallmarks of cellular senescence. Trends Cell Biol., 2018, 10.1016/j.tcb.2018.02.001 pii: S0962-8924(18)30020-5.
    • (2018) Trends Cell Biol.
    • Hernandez-Segura, A.1    Nehme, J.2    Demaria, M.3
  • 111
    • 44449110115 scopus 로고    scopus 로고
    • Low-dose aspirin promotes endothelial progenitor cell migration and adhesion and prevents senescence
    • Hu, Z., Zhang, F., Yang, Z., Zhang, J., Zhang, D., Yang, N., Zhang, Y., Cao, K., Low-dose aspirin promotes endothelial progenitor cell migration and adhesion and prevents senescence. Cell Biol. Int. 32 (2008), 761–768, 10.1016/j.cellbi.2008.03.004.
    • (2008) Cell Biol. Int. , vol.32 , pp. 761-768
    • Hu, Z.1    Zhang, F.2    Yang, Z.3    Zhang, J.4    Zhang, D.5    Yang, N.6    Zhang, Y.7    Cao, K.8
  • 112
    • 85027957030 scopus 로고    scopus 로고
    • Different flavonoids can shape unique gut microbiota profile in vitro
    • Huang, J., Chen, L., Xue, B., Liu, Q., Ou, S., Wang, Y., Peng, X., Different flavonoids can shape unique gut microbiota profile in vitro. J. Food Sci. 81:9 (2016), H2273–H2279, 10.1111/1750-3841.13411.
    • (2016) J. Food Sci. , vol.81 , Issue.9 , pp. H2273-H2279
    • Huang, J.1    Chen, L.2    Xue, B.3    Liu, Q.4    Ou, S.5    Wang, Y.6    Peng, X.7
  • 113
  • 114
    • 85040344727 scopus 로고    scopus 로고
    • Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells
    • Hwang, H.V., Tran, D.T., Rebuffatti, M.N., Li, C.S., Knowlton, A.A., Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLoS One, 13, 2018, e0190374, 10.1371/journal.pone.0190374.eCollection2018.
    • (2018) PLoS One , vol.13 , pp. e0190374
    • Hwang, H.V.1    Tran, D.T.2    Rebuffatti, M.N.3    Li, C.S.4    Knowlton, A.A.5
  • 115
    • 84904751060 scopus 로고    scopus 로고
    • NAD+ and sirtuins in aging and disease
    • Imai, S., Guarente, L., NAD+ and sirtuins in aging and disease. Trends Cell Biol. 24 (2014), 464–471, 10.1016/j.tcb.2014.04.002.
    • (2014) Trends Cell Biol. , vol.24 , pp. 464-471
    • Imai, S.1    Guarente, L.2
  • 116
    • 84928056582 scopus 로고    scopus 로고
    • Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages
    • Izumi, H., Tsuda, M., Sato, Y., Kosaka, N., Ochiya, T., Iwamoto, H., Namba, K., Takeda, Y., Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages. J. Dairy Sci. 98 (2015), 2920–2933, 10.3168/jds.2014-9076.
    • (2015) J. Dairy Sci. , vol.98 , pp. 2920-2933
    • Izumi, H.1    Tsuda, M.2    Sato, Y.3    Kosaka, N.4    Ochiya, T.5    Iwamoto, H.6    Namba, K.7    Takeda, Y.8
  • 117
    • 84991029260 scopus 로고    scopus 로고
    • Effects of long-term use of flavonoids on the absorption and tissue distribution of orally administered doses of trace elements in rats
    • Jaccob, A.A., Hussain, S.A., Effects of long-term use of flavonoids on the absorption and tissue distribution of orally administered doses of trace elements in rats. Pharmacol. Pharm. 3 (2012), 474–480, 10.4236/pp.2012.34065.
    • (2012) Pharmacol. Pharm. , vol.3 , pp. 474-480
    • Jaccob, A.A.1    Hussain, S.A.2
  • 118
    • 85025122945 scopus 로고    scopus 로고
    • Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro
    • Janubová, M., Žitňanová, I., Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro. Food Funct. 8:7 (2017), 2394–2418, 10.1039/c7fo00161d.
    • (2017) Food Funct. , vol.8 , Issue.7 , pp. 2394-2418
    • Janubová, M.1    Žitňanová, I.2
  • 120
    • 84872527628 scopus 로고    scopus 로고
    • mTOR is a key modulator of ageing and age-related disease
    • Johnson, S.C., Rabinovitch, P.S., Kaeberlein, M., mTOR is a key modulator of ageing and age-related disease. Nature 493 (2013), 338–345, 10.1038/nature11861.
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 124
    • 84960369368 scopus 로고    scopus 로고
    • The tocotrienol-rich fraction is superior to tocopherol in promoting myogenic differentiation in the prevention of replicative senescence of myoblasts
    • Khor, S.C., Razak, A.M., Wan Ngah, W.Z., et al. The tocotrienol-rich fraction is superior to tocopherol in promoting myogenic differentiation in the prevention of replicative senescence of myoblasts. PLoS One, 11(2), 2016, e0149265.
    • (2016) PLoS One , vol.11 , Issue.2 , pp. e0149265
    • Khor, S.C.1    Razak, A.M.2    Wan Ngah, W.Z.3
  • 125
    • 84961116833 scopus 로고    scopus 로고
    • Sirtuins, cell senescence, and vascular aging
    • Kida, Y., Goligorsky, M.S., Sirtuins, cell senescence, and vascular aging. Can. J. Cardiol. 32 (2016), 634–641, 10.1016/j.cjca.2015.11.022.
    • (2016) Can. J. Cardiol. , vol.32 , pp. 634-641
    • Kida, Y.1    Goligorsky, M.S.2
  • 126
    • 84920504512 scopus 로고    scopus 로고
    • mTOR: a pharmacologic target for autophagy regulation
    • Kim, Y.C., Guan, K.L., mTOR: a pharmacologic target for autophagy regulation. J. Clin. Invest. 125 (2015), 25–32, 10.1172/JCI73939.
    • (2015) J. Clin. Invest. , vol.125 , pp. 25-32
    • Kim, Y.C.1    Guan, K.L.2
  • 127
    • 10944235044 scopus 로고    scopus 로고
    • Anti-inflammatory plant flavonoids and cellular action mechanisms
    • Kim, H.P., Son, K.H., Chang, H.W., Kang, S.S., Anti-inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacol. Sci. 96 (2004), 229–245.
    • (2004) J. Pharmacol. Sci. , vol.96 , pp. 229-245
    • Kim, H.P.1    Son, K.H.2    Chang, H.W.3    Kang, S.S.4
  • 128
    • 84923229083 scopus 로고    scopus 로고
    • Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition
    • Kim, R.K., Suh, Y., Yoo, K.C., Cui, Y.H., Hwang, E., Kim, H.J., Kang, J.S., Kim, M.J., Lee, Y.Y., Lee, S.J., Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition. Cancer Sci. 106 (2015), 94–101, 10.1111/cas.12562.
    • (2015) Cancer Sci. , vol.106 , pp. 94-101
    • Kim, R.K.1    Suh, Y.2    Yoo, K.C.3    Cui, Y.H.4    Hwang, E.5    Kim, H.J.6    Kang, J.S.7    Kim, M.J.8    Lee, Y.Y.9    Lee, S.J.10
  • 129
    • 85017444050 scopus 로고    scopus 로고
    • Cellular senescence a translational perspective
    • Kirkland, J.L., Tchkonia, T., Cellular senescence a translational perspective. EBioMedicine 21 (2017), 21–28, 10.1016/j.ebiom.2017.04.013.
    • (2017) EBioMedicine , vol.21 , pp. 21-28
    • Kirkland, J.L.1    Tchkonia, T.2
  • 131
    • 84872047225 scopus 로고    scopus 로고
    • Translating advances from the basic biology of aging into clinical application
    • Kirkland, J.L., Translating advances from the basic biology of aging into clinical application. Exp. Gerontol. 48 (2013), 1–5, 10.1016/j.exger.2012.11.014.
    • (2013) Exp. Gerontol. , vol.48 , pp. 1-5
    • Kirkland, J.L.1
  • 132
    • 85026771737 scopus 로고    scopus 로고
    • Why and how are we living longer?
    • Kirkwood, T.B.L., Why and how are we living longer?. Exp. Physiol. 102 (2017), 1067–1074, 10.1113/EP086205.
    • (2017) Exp. Physiol. , vol.102 , pp. 1067-1074
    • Kirkwood, T.B.L.1
  • 133
    • 33744917232 scopus 로고    scopus 로고
    • Comparison of three different dietary scores in relation to 10-year mortality in elderly European subjects: the HALE project
    • Knoops, K.T., Groot de, L.C., Fidanza, F., Alberti-Fidanza, A., Kromhout, D., van Staveren, W.A., Comparison of three different dietary scores in relation to 10-year mortality in elderly European subjects: the HALE project. Eur. J. Clin. Nutr. 60 (2006), 746–755.
    • (2006) Eur. J. Clin. Nutr. , vol.60 , pp. 746-755
    • Knoops, K.T.1    Groot de, L.C.2    Fidanza, F.3    Alberti-Fidanza, A.4    Kromhout, D.5    van Staveren, W.A.6
  • 134
    • 11844271504 scopus 로고    scopus 로고
    • Natural product polyphenols of relevance to human health
    • Kondratyuk, T.P., Pezzuto, J.M., Natural product polyphenols of relevance to human health. Pharm. Biol. 42 (2004), 46–63.
    • (2004) Pharm. Biol. , vol.42 , pp. 46-63
    • Kondratyuk, T.P.1    Pezzuto, J.M.2
  • 139
    • 84883464257 scopus 로고    scopus 로고
    • Resveratrol vs. calorie restriction: data from rodents to humans
    • Lam, Y.Y., Peterson, C.M., Ravussin, E., Resveratrol vs. calorie restriction: data from rodents to humans. Exp. Gerontol. 48 (2013), 1018–1024, 10.1016/j.exger.2013.04.005.
    • (2013) Exp. Gerontol. , vol.48 , pp. 1018-1024
    • Lam, Y.Y.1    Peterson, C.M.2    Ravussin, E.3
  • 140
    • 85035144303 scopus 로고    scopus 로고
    • Resveratrol, pterostilbene, and dementia
    • Lange, K.W., Li, S., Resveratrol, pterostilbene, and dementia. Biofactors 44:1 (2017), 83–90, 10.1002/biof.1396.
    • (2017) Biofactors , vol.44 , Issue.1 , pp. 83-90
    • Lange, K.W.1    Li, S.2
  • 141
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante, M., Sabatini, D.M., mTOR signaling in growth control and disease. Cell 149 (2012), 274–293, 10.1016/j.cell.2012.03.017.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 142
    • 69149098186 scopus 로고    scopus 로고
    • Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models
    • Larrosa, M., Luceri, C., Vivoli, E., Pagliuca, C., Lodovici, M., Moneti, G., Dolara, P., Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models. Mol. Nutr. Food Res. 53 (2009), 1044–1054, 10.1002/mnfr.200800446.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 1044-1054
    • Larrosa, M.1    Luceri, C.2    Vivoli, E.3    Pagliuca, C.4    Lodovici, M.5    Moneti, G.6    Dolara, P.7
  • 143
    • 84965082024 scopus 로고    scopus 로고
    • Context-dependent effects of cellular senescence in cancer development
    • Lecot, P., Alimirah, F., Desprez, P.Y., Campisi, J., Wiley, C., Context-dependent effects of cellular senescence in cancer development. Br. J. Cancer 114 (2016), 1180–1184, 10.1038/bjc.2016.115.
    • (2016) Br. J. Cancer , vol.114 , pp. 1180-1184
    • Lecot, P.1    Alimirah, F.2    Desprez, P.Y.3    Campisi, J.4    Wiley, C.5
  • 144
    • 84892406525 scopus 로고    scopus 로고
    • Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation
    • Lee, J.H., Lim, H., Shehzad, O., Kim, Y.S., Kim, H.P., Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. Eur. J. Pharmacol. 724 (2014), 145–151, 10.1016/j.ejphar.2013.12.035.
    • (2014) Eur. J. Pharmacol. , vol.724 , pp. 145-151
    • Lee, J.H.1    Lim, H.2    Shehzad, O.3    Kim, Y.S.4    Kim, H.P.5
  • 145
    • 84959423171 scopus 로고    scopus 로고
    • Genistein-induced LKB1-AMPK activation inhibits senescence of VSMC through autophagy induction
    • Lee, K.Y., Kim, J.R., Choi, H.C., Genistein-induced LKB1-AMPK activation inhibits senescence of VSMC through autophagy induction. Vasc. Pharmacol. 81 (2016), 75–82, 10.1016/j.vph.2016.02.007.
    • (2016) Vasc. Pharmacol. , vol.81 , pp. 75-82
    • Lee, K.Y.1    Kim, J.R.2    Choi, H.C.3
  • 146
    • 85041443948 scopus 로고    scopus 로고
    • Chemoprevention by resveratrol and pterostilbene: targeting on epigenetic regulation
    • Lee, P.S., Chiou, Y.S., Ho, C.T., Pan, M.H., Chemoprevention by resveratrol and pterostilbene: targeting on epigenetic regulation. Biofactors, 2017, 8, 10.1002/biof.1401.
    • (2017) Biofactors , pp. 8
    • Lee, P.S.1    Chiou, Y.S.2    Ho, C.T.3    Pan, M.H.4
  • 147
    • 85010525625 scopus 로고    scopus 로고
    • Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human
    • Lettieri-Barbato, D., Giovannetti, E., Aquilano, K., Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human. Aging (Albany NY) 8 (2016), 3341–3355, 10.18632/aging.101122.
    • (2016) Aging (Albany NY) , vol.8 , pp. 3341-3355
    • Lettieri-Barbato, D.1    Giovannetti, E.2    Aquilano, K.3
  • 149
    • 84919825142 scopus 로고    scopus 로고
    • Resources and biological activities of natural polyphenols
    • Li, A.N., Li, S., Zhang, Y.J., Xu, X.R., Chen, Y.M., Li, H.B., Resources and biological activities of natural polyphenols. Nutrients 6 (2014), 6020–6047, 10.3390/nu6126020.
    • (2014) Nutrients , vol.6 , pp. 6020-6047
    • Li, A.N.1    Li, S.2    Zhang, Y.J.3    Xu, X.R.4    Chen, Y.M.5    Li, H.B.6
  • 150
    • 84896692038 scopus 로고    scopus 로고
    • Rapamycin: one drug, many effects
    • Li, J., Kim, S.G., Blenis, J., Rapamycin: one drug, many effects. Cell Metab. 19 (2014), 373–379, 10.1016/j.cmet.2014.01.001.
    • (2014) Cell Metab. , vol.19 , pp. 373-379
    • Li, J.1    Kim, S.G.2    Blenis, J.3
  • 151
    • 85037362271 scopus 로고    scopus 로고
    • Effect of resveratrol and pterostilbene on aging and longevity
    • Li, Y.R., Li, S., Lin, C.C., Effect of resveratrol and pterostilbene on aging and longevity. Biofactors 44:1 (2017), 69–82, 10.1002/biof.1400.
    • (2017) Biofactors , vol.44 , Issue.1 , pp. 69-82
    • Li, Y.R.1    Li, S.2    Lin, C.C.3
  • 152
    • 84938291358 scopus 로고    scopus 로고
    • Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts
    • Lim, H., Park, H., Kim, H.P., Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts. Biochem. Pharmacol. 96 (2015), 337–348, 10.1016/j.bcp.2015.06.013.
    • (2015) Biochem. Pharmacol. , vol.96 , pp. 337-348
    • Lim, H.1    Park, H.2    Kim, H.P.3
  • 153
    • 80051978747 scopus 로고    scopus 로고
    • Use of metformin in the setting of mild-to-moderate renal insufficiency
    • Lipska, K.J., Bailey, C.J., Inzucchi, S.E., Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 34 (2011), 1431–1437, 10.2337/dc10-2361.
    • (2011) Diabetes Care , vol.34 , pp. 1431-1437
    • Lipska, K.J.1    Bailey, C.J.2    Inzucchi, S.E.3
  • 154
    • 24644460629 scopus 로고    scopus 로고
    • Cellular senescence in the glaucomatous outflow pathway
    • Liton, P.B., et al. Cellular senescence in the glaucomatous outflow pathway. Exp. Gerontol. 40 (2005), 745–748, 10.1016/j.exger.2005.06.005.
    • (2005) Exp. Gerontol. , vol.40 , pp. 745-748
    • Liton, P.B.1
  • 155
    • 79960339381 scopus 로고    scopus 로고
    • Rb1 protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox status
    • Liu, D.H., Chen, Y.M., Liu, Y., Hao, B.S., Zhou, B., Wu, L., Wang, M., Chen, L., Wu, W.K., Qian, X.X., Rb1 protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox status. Biol. Pharm. Bull. 34 (2011), 1072–1077.
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1072-1077
    • Liu, D.H.1    Chen, Y.M.2    Liu, Y.3    Hao, B.S.4    Zhou, B.5    Wu, L.6    Wang, M.7    Chen, L.8    Wu, W.K.9    Qian, X.X.10
  • 156
    • 85034775164 scopus 로고    scopus 로고
    • Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics
    • Liu, C., Gao, H., Lv, P., Liu, J., Liu, G., Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics. Hum. Vaccin Immunother. 13 (2017), 2678–2687, 10.1080/21645515.2017.1363935.
    • (2017) Hum. Vaccin Immunother. , vol.13 , pp. 2678-2687
    • Liu, C.1    Gao, H.2    Lv, P.3    Liu, J.4    Liu, G.5
  • 157
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: systematic review and meta-analysis
    • Lord, J.M., Flight, I.H., Norman, R.J., Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327 (2003), 951–953.
    • (2003) BMJ , vol.327 , pp. 951-953
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 158
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • Lozupone, C.A., Stombaugh, J., Gordon, J., Jansson, J.K., Knight, R., Diversity, stability and resilience of the human gut microbiota. Nature 13:September (489) (2012), 220–230, 10.1038/nature11550.
    • (2012) Nature , vol.13 , Issue.September (489) , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.2    Gordon, J.3    Jansson, J.K.4    Knight, R.5
  • 159
    • 85039940872 scopus 로고    scopus 로고
    • Mesenchymal stem cells secretory responses: senescence messaging secretome and immunomodulation perspective
    • Lunyak, V.V., Amaro-Ortiz, A., Gaur, M., Mesenchymal stem cells secretory responses: senescence messaging secretome and immunomodulation perspective. Front. Genet., 8, 2017, 220, 10.3389/fgene.2017.00220.eCollection2017.
    • (2017) Front. Genet. , vol.8 , pp. 220
    • Lunyak, V.V.1    Amaro-Ortiz, A.2    Gaur, M.3
  • 164
    • 84896295961 scopus 로고    scopus 로고
    • mTOR inhibition: a promising strategy for stabilization of atherosclerotic plaques
    • Martinet, W., De Loof, H., De Meyer, G.R., mTOR inhibition: a promising strategy for stabilization of atherosclerotic plaques. Atherosclerosis 233:2 (2014), 601–607, 10.1016/j.atherosclerosis.2014.01.040.
    • (2014) Atherosclerosis , vol.233 , Issue.2 , pp. 601-607
    • Martinet, W.1    De Loof, H.2    De Meyer, G.R.3
  • 166
    • 84973129659 scopus 로고    scopus 로고
    • Biomarkers to identify and isolate senescent cells
    • Matjusaitis, M., Chin, G., Sarnoski, E.A., Stolzing, A., Biomarkers to identify and isolate senescent cells. Ageing Res. Rev. 29 (2016), 1–12, 10.1016/j.arr.2016.05.003.
    • (2016) Ageing Res. Rev. , vol.29 , pp. 1-12
    • Matjusaitis, M.1    Chin, G.2    Sarnoski, E.A.3    Stolzing, A.4
  • 167
    • 85032726333 scopus 로고    scopus 로고
    • Modulation of the senescence-associated inflammatory phenotype in human fibroblasts by olive phenols
    • (pii: E2275)
    • Menicacci, B., Cipriani, C., Margheri, F., Mocali, A., Giovannelli, L., Modulation of the senescence-associated inflammatory phenotype in human fibroblasts by olive phenols. Int. J. Mol. Sci., 18(11), 2017, 10.3390/ijms18112275 (pii: E2275).
    • (2017) Int. J. Mol. Sci. , vol.18 , Issue.11
    • Menicacci, B.1    Cipriani, C.2    Margheri, F.3    Mocali, A.4    Giovannelli, L.5
  • 168
    • 84898902594 scopus 로고    scopus 로고
    • Lifestyle habits and mortality from all and specific causes of death: 40-year follow-up in the Italian Rural Areas of the Seven Countries Study
    • Menotti, A., Puddu, P.E., Lanti, M., Maiani, G., Catasta, G., Fidanza, A.A., Lifestyle habits and mortality from all and specific causes of death: 40-year follow-up in the Italian Rural Areas of the Seven Countries Study. J. Nutr. Health Aging 18 (2014), 314–321, 10.1007/s12603-013-0392-1.
    • (2014) J. Nutr. Health Aging , vol.18 , pp. 314-321
    • Menotti, A.1    Puddu, P.E.2    Lanti, M.3    Maiani, G.4    Catasta, G.5    Fidanza, A.A.6
  • 169
    • 79952084858 scopus 로고    scopus 로고
    • Dietary polyphenols and obesity
    • Meydani, M., Hasan, S.T., Dietary polyphenols and obesity. Nutrients 2 (2010), 737–751, 10.3390/nu2070737.
    • (2010) Nutrients , vol.2 , pp. 737-751
    • Meydani, M.1    Hasan, S.T.2
  • 170
    • 38549089435 scopus 로고    scopus 로고
    • Effects of different cooking methods on nutritional and physicochemical characteristics of selected vegetables
    • Miglio, C., Chiavaro, E., Visconti, A., Fogliano, V., Pellegrini, N., Effects of different cooking methods on nutritional and physicochemical characteristics of selected vegetables. J. Agric. Food Chem. 56 (2008), 139–147.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 139-147
    • Miglio, C.1    Chiavaro, E.2    Visconti, A.3    Fogliano, V.4    Pellegrini, N.5
  • 174
    • 84944441861 scopus 로고    scopus 로고
    • Sirolimus and everolimus in kidney transplantation
    • Moes, D.J., Guchelaar, H.J., de Fijter, J.W., Sirolimus and everolimus in kidney transplantation. Drug Discov. Today 20 (2015), 1243–1249, 10.1016/j.drudis.2015.05.006.
    • (2015) Drug Discov. Today , vol.20 , pp. 1243-1249
    • Moes, D.J.1    Guchelaar, H.J.2    de Fijter, J.W.3
  • 176
    • 80052483131 scopus 로고    scopus 로고
    • Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors
    • Montero, J.C., Seoane, S., Ocaña, A., Pandiella, A., Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. Clin. Cancer Res. 17 (2011), 5546–5552, 10.1158/1078-0432.CCR-10-2616.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5546-5552
    • Montero, J.C.1    Seoane, S.2    Ocaña, A.3    Pandiella, A.4
  • 177
    • 85033222929 scopus 로고    scopus 로고
    • Connecting chaperone-mediated autophagy dysfunction to cellular senescence
    • Moreno-Blas, D., Gorostieta-Salas, E., Castro-Obregón, S., Connecting chaperone-mediated autophagy dysfunction to cellular senescence. Ageing Res. Rev. 41 (2018), 34–41, 10.1016/j.arr.2017.11.001.
    • (2018) Ageing Res. Rev. , vol.41 , pp. 34-41
    • Moreno-Blas, D.1    Gorostieta-Salas, E.2    Castro-Obregón, S.3
  • 178
    • 85028661005 scopus 로고    scopus 로고
    • Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women
    • Most, J., Penders, J., Lucchesi, M., Goossens, G.H., Blaak, E.E., Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women. Eur. J. Clin. Nutr. 71 (2017), 1040–1045, 10.1038/ejcn.2017.89.
    • (2017) Eur. J. Clin. Nutr. , vol.71 , pp. 1040-1045
    • Most, J.1    Penders, J.2    Lucchesi, M.3    Goossens, G.H.4    Blaak, E.E.5
  • 182
    • 84865039191 scopus 로고    scopus 로고
    • Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action
    • Nag, S.A., Qin, J.J., Wang, W., Wang, M.H., Wang, H., Zhang, R., Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action. Front. Pharmacol., 3, 2012, 25, 10.3389/fphar.2012.00025.
    • (2012) Front. Pharmacol. , vol.3 , pp. 25
    • Nag, S.A.1    Qin, J.J.2    Wang, W.3    Wang, M.H.4    Wang, H.5    Zhang, R.6
  • 183
    • 0037667702 scopus 로고    scopus 로고
    • SW Lowe Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita, M., Nũnez, S., Heard, E., Narita, M., Lin, A.W., Hearn, S.A., Spector, D.L., Hannon, G.J., SW Lowe Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 13:June (113) (2003), 703–716.
    • (2003) Cell , vol.13 , Issue.June (113) , pp. 703-716
    • Narita, M.1    Nũnez, S.2    Heard, E.3    Narita, M.4    Lin, A.W.5    Hearn, S.A.6    Spector, D.L.7    Hannon, G.J.8
  • 184
    • 84925840299 scopus 로고    scopus 로고
    • Oleacein: translation from Mediterranean diet to potential antiatherosclerotic drug
    • Naruszewicz, M., Czerwińska, M.E., Kiss, A.K., Oleacein: translation from Mediterranean diet to potential antiatherosclerotic drug. Curr. Pharm. Des. 21 (2015), 1205–1212.
    • (2015) Curr. Pharm. Des. , vol.21 , pp. 1205-1212
    • Naruszewicz, M.1    Czerwińska, M.E.2    Kiss, A.K.3
  • 185
    • 85028344773 scopus 로고    scopus 로고
    • The senescent bystander effect is caused by ROS-activated NF-κB signalling
    • pii: S0047-6374(17)30075-1
    • Nelson, G., Kucheryavenko, O., Wordsworth, J., von Zglinicki, T., The senescent bystander effect is caused by ROS-activated NF-κB signalling. Mech. Ageing Dev., 2017, 10.1016/j.mad.2017.08.005 pii: S0047-6374(17)30075-1.
    • (2017) Mech. Ageing Dev.
    • Nelson, G.1    Kucheryavenko, O.2    Wordsworth, J.3    von Zglinicki, T.4
  • 186
    • 53549131261 scopus 로고    scopus 로고
    • SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans
    • Neumann-Haefelin, E., Qi, W., Finkbeiner, E., Walz, G., Baumeister, R., Hertweck, M., SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. Genes Dev. 22 (2008), 2721–2735.
    • (2008) Genes Dev. , vol.22 , pp. 2721-2735
    • Neumann-Haefelin, E.1    Qi, W.2    Finkbeiner, E.3    Walz, G.4    Baumeister, R.5    Hertweck, M.6
  • 188
    • 85008712424 scopus 로고    scopus 로고
    • Molecular pathology endpoints useful for aging studies
    • Niedernhofer, L.J., Kirkland, J.L., Ladiges, W., Molecular pathology endpoints useful for aging studies. Ageing Res. Rev. 35 (2017), 241–249, 10.1016/j.arr.2016.09.012.
    • (2017) Ageing Res. Rev. , vol.35 , pp. 241-249
    • Niedernhofer, L.J.1    Kirkland, J.L.2    Ladiges, W.3
  • 189
    • 84987725262 scopus 로고    scopus 로고
    • Anticancer efficacy of polyphenols and their combinations
    • (pii: E552)
    • Niedzwiecki, A., Roomi, M.W., Kalinovsky, T., Rath, M., Anticancer efficacy of polyphenols and their combinations. Nutrients, 8(9), 2016, 10.3390/nu8090552 (pii: E552).
    • (2016) Nutrients , vol.8 , Issue.9
    • Niedzwiecki, A.1    Roomi, M.W.2    Kalinovsky, T.3    Rath, M.4
  • 190
    • 85018926606 scopus 로고    scopus 로고
    • Techniques to induce and quantify cellular senescence
    • Noren Hooten, N., Evans, M.K., Techniques to induce and quantify cellular senescence. J. Vis. Exp., 123, 2017, 10.3791/55533.
    • (2017) J. Vis. Exp. , vol.123
    • Noren Hooten, N.1    Evans, M.K.2
  • 194
    • 84861854715 scopus 로고    scopus 로고
    • Biol The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes mellitus
    • Okayasu, S., Kitaichi, K., Hori, A., Suwa, T., Horikawa, Y., Yamamoto, M., Takeda, J., Itoh, Y., Biol The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes mellitus. Pharm. Bull. 35 (2012), 933–937.
    • (2012) Pharm. Bull. , vol.35 , pp. 933-937
    • Okayasu, S.1    Kitaichi, K.2    Hori, A.3    Suwa, T.4    Horikawa, Y.5    Yamamoto, M.6    Takeda, J.7    Itoh, Y.8
  • 195
    • 84946829704 scopus 로고    scopus 로고
    • DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
    • Olivieri, F., Albertini, M.C., Orciani, M., Ceka, A., Cricca, M., Procopio, A.D., Bonafè, M., DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging. Oncotarget 6 (2015), 35509–35521, 10.18632/oncotarget.5899.
    • (2015) Oncotarget , vol.6 , pp. 35509-35521
    • Olivieri, F.1    Albertini, M.C.2    Orciani, M.3    Ceka, A.4    Cricca, M.5    Procopio, A.D.6    Bonafè, M.7
  • 196
    • 85008402763 scopus 로고    scopus 로고
    • Circulating miRNAs and miRNA shuttles as biomarkers: perspective trajectories of healthy and unhealthy aging
    • Olivieri, F., Capri, M., Bonafè, M., Morsiani, C., Jung, H.J., Spazzafumo, L., Viña, J., Suh, Y., Circulating miRNAs and miRNA shuttles as biomarkers: perspective trajectories of healthy and unhealthy aging. Mech. Ageing Dev. 165:Pt B (2017), 162–170, 10.1016/j.mad.2016.12.004.
    • (2017) Mech. Ageing Dev. , vol.165 , pp. 162-170
    • Olivieri, F.1    Capri, M.2    Bonafè, M.3    Morsiani, C.4    Jung, H.J.5    Spazzafumo, L.6    Viña, J.7    Suh, Y.8
  • 197
    • 85042759885 scopus 로고    scopus 로고
    • Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming
    • Ong, A.L.C., Ramasamy, T.S., Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. Ageing Res. Rev. 43 (2018), 64–80, 10.1016/j.arr.2018.02.004.
    • (2018) Ageing Res. Rev. , vol.43 , pp. 64-80
    • Ong, A.L.C.1    Ramasamy, T.S.2
  • 198
    • 85042194401 scopus 로고    scopus 로고
    • The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence
    • Ong, S.M., Hadadi, E., Dang, T.M., Yeap, W.H., Tan, C.T., Ng, T.P., Larbi, A., Wong, S.C., The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. Cell. Death. Dis., 9, 2018, 266, 10.1038/s41419-018-0327-1.
    • (2018) Cell. Death. Dis. , vol.9 , pp. 266
    • Ong, S.M.1    Hadadi, E.2    Dang, T.M.3    Yeap, W.H.4    Tan, C.T.5    Ng, T.P.6    Larbi, A.7    Wong, S.C.8
  • 199
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    • Onken, B., Driscoll, M., Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One, 5(1), 2010, e8758, 10.1371/journal.pone.0008758.
    • (2010) PLoS One , vol.5 , Issue.1 , pp. e8758
    • Onken, B.1    Driscoll, M.2
  • 201
    • 77953474824 scopus 로고    scopus 로고
    • Plant polyphenols as dietary antioxidants in human health and disease
    • Pandey, K.B., Rizvi, S.I., Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev. 2 (2009), 270–278, 10.4161/oxim.2.5.9498.
    • (2009) Oxid. Med. Cell. Longev. , vol.2 , pp. 270-278
    • Pandey, K.B.1    Rizvi, S.I.2
  • 202
    • 85040817970 scopus 로고    scopus 로고
    • mTOR pathways in cancer and autophagy
    • (pii: E18)
    • Paquette, M., El-Houjeiri, L., Pause, A., mTOR pathways in cancer and autophagy. Cancers (Basel), 10(1), 2018, 10.3390/cancers10010018 (pii: E18).
    • (2018) Cancers (Basel) , vol.10 , Issue.1
    • Paquette, M.1    El-Houjeiri, L.2    Pause, A.3
  • 203
    • 85022330404 scopus 로고    scopus 로고
    • Epigenetics linking nutrition to molecular mechanisms in aging
    • Park, J.H., Yoo, Y., Park, Y.J., Epigenetics linking nutrition to molecular mechanisms in aging. Prev. Nutr. Food Sci. 22 (2017), 81–89, 10.3746/pnf.2017.22.2.81.
    • (2017) Prev. Nutr. Food Sci. , vol.22 , pp. 81-89
    • Park, J.H.1    Yoo, Y.2    Park, Y.J.3
  • 204
  • 207
    • 84861210529 scopus 로고    scopus 로고
    • Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development
    • Peltz, L., Gomez, J., Marquez, M., Alencastro, F., Atashpanjeh, N., Quang, T., Bach, T., Zhao, Y., Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development. PLoS One, 7, 2012, e37162, 10.1371/journal.pone.0037162.
    • (2012) PLoS One , vol.7 , pp. e37162
    • Peltz, L.1    Gomez, J.2    Marquez, M.3    Alencastro, F.4    Atashpanjeh, N.5    Quang, T.6    Bach, T.7    Zhao, Y.8
  • 208
    • 11244328276 scopus 로고    scopus 로고
    • Lifelong aspirin supplementation as a means to extending life span
    • Phillips, T., Leeuwenburgh, C., Lifelong aspirin supplementation as a means to extending life span. Rejuvenation Res. 7 (2004), 243–251.
    • (2004) Rejuvenation Res. , vol.7 , pp. 243-251
    • Phillips, T.1    Leeuwenburgh, C.2
  • 209
    • 84857997980 scopus 로고    scopus 로고
    • Phloroglucinol attenuates ultraviolet B radiation-induced matrix metalloproteinase-1 production in human keratinocytes via inhibitory actions against mitogen-activated protein kinases and activator Protein-1
    • Piao, M.J., Zhang, R., Lee, N.H., Hyun, J.W., Phloroglucinol attenuates ultraviolet B radiation-induced matrix metalloproteinase-1 production in human keratinocytes via inhibitory actions against mitogen-activated protein kinases and activator Protein-1. Photochem. Photobiol. 88 (2012), 381–388, 10.1111/j.1751-1097.2012.01074.x.
    • (2012) Photochem. Photobiol. , vol.88 , pp. 381-388
    • Piao, M.J.1    Zhang, R.2    Lee, N.H.3    Hyun, J.W.4
  • 210
    • 85000643949 scopus 로고    scopus 로고
    • Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation
    • Porras, D., Nistal, E., Martínez-Flórez, S., Pisonero-Vaquero, S., Olcoz, J.L., Jover, R., González-Gallego, J., García-Mediavilla, M.V., Sánchez-Campos, S., Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. Free Radic. Biol. Med. 102 (2017), 188–202, 10.1016/j.freeradbiomed.2016.11.037.
    • (2017) Free Radic. Biol. Med. , vol.102 , pp. 188-202
    • Porras, D.1    Nistal, E.2    Martínez-Flórez, S.3    Pisonero-Vaquero, S.4    Olcoz, J.L.5    Jover, R.6    González-Gallego, J.7    García-Mediavilla, M.V.8    Sánchez-Campos, S.9
  • 211
    • 85034054536 scopus 로고    scopus 로고
    • Nutritional factors affecting adult neurogenesis and cognitive function
    • Poulose, S.M., Miller, M.G., Scott, T., Shukitt-Hale, B., Nutritional factors affecting adult neurogenesis and cognitive function. Adv. Nutr. 8 (2017), 804–811, 10.3945/an.117.016261.
    • (2017) Adv. Nutr. , vol.8 , pp. 804-811
    • Poulose, S.M.1    Miller, M.G.2    Scott, T.3    Shukitt-Hale, B.4
  • 212
    • 84975318302 scopus 로고    scopus 로고
    • Inflammaging as a druggable target: a senescence-associated secretory phenotype-centered view of type 2 diabetes
    • Prattichizzo, F., De Nigris, V., La Sala, L., Procopio, A.D., Olivieri, F., Ceriello, A., Inflammaging as a druggable target: a senescence-associated secretory phenotype-centered view of type 2 diabetes. Oxid. Med. Cell Longev., 2016, 2016, 1810327, 10.1155/2016/1810327.
    • (2016) Oxid. Med. Cell Longev. , vol.2016 , pp. 1810327
    • Prattichizzo, F.1    De Nigris, V.2    La Sala, L.3    Procopio, A.D.4    Olivieri, F.5    Ceriello, A.6
  • 217
    • 40549139151 scopus 로고    scopus 로고
    • Lipid peroxidation and cyclooxygenase enzyme inhibitory activities of acidic aqueous extracts of some dietary supplements
    • Raman, P., Dewitt, D.L., Nair, M.G., Lipid peroxidation and cyclooxygenase enzyme inhibitory activities of acidic aqueous extracts of some dietary supplements. Phytother. Res. 22 (2008), 204–212.
    • (2008) Phytother. Res. , vol.22 , pp. 204-212
    • Raman, P.1    Dewitt, D.L.2    Nair, M.G.3
  • 218
    • 85026840123 scopus 로고    scopus 로고
    • The mechanisms of action of metformin
    • Rena, G., Hardie, D.G., Pearson, E.R., The mechanisms of action of metformin. Diabetologia 60:9 (2017), 1577–1585, 10.1007/s00125-017-4342-z.
    • (2017) Diabetologia , vol.60 , Issue.9 , pp. 1577-1585
    • Rena, G.1    Hardie, D.G.2    Pearson, E.R.3
  • 220
    • 84890215172 scopus 로고    scopus 로고
    • What are the roles of calorie restriction and diet quality in promoting healthy longevity?
    • Rizza, W., Veronese, N., Fontana, L., What are the roles of calorie restriction and diet quality in promoting healthy longevity?. Ageing Res. Rev. 13 (2014), 38–45, 10.1016/j.arr.2013.11.002.
    • (2014) Ageing Res. Rev. , vol.13 , pp. 38-45
    • Rizza, W.1    Veronese, N.2    Fontana, L.3
  • 222
    • 84963812026 scopus 로고    scopus 로고
    • Protective effects of the mediterranean diet on type 2 diabetes and metabolic syndrome
    • Salas-Salvadó, J., Guasch-Ferré, M., Lee, C.H., Estruch, R., Clish, C.B., Ros, E., Protective effects of the mediterranean diet on type 2 diabetes and metabolic syndrome. J. Nutr. 146 (2016), 920S–927S, 10.3945/jn.115.218487.
    • (2016) J. Nutr. , vol.146 , pp. 920S-927S
    • Salas-Salvadó, J.1    Guasch-Ferré, M.2    Lee, C.H.3    Estruch, R.4    Clish, C.B.5    Ros, E.6
  • 224
    • 85019464334 scopus 로고    scopus 로고
    • A novel indication for panobinostat as a senolytic drug in NSCLC and HNSCC
    • Samaraweera, L., Adomako, A., Rodriguez-Gabin, A., McDaid, H.M., A novel indication for panobinostat as a senolytic drug in NSCLC and HNSCC. Sci. Rep., 7, 2017, 1900, 10.1038/s41598-017-01964-1.
    • (2017) Sci. Rep. , vol.7 , pp. 1900
    • Samaraweera, L.1    Adomako, A.2    Rodriguez-Gabin, A.3    McDaid, H.M.4
  • 226
    • 78651487582 scopus 로고    scopus 로고
    • Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow
    • Santiago-Mora, R., Casado-Díaz, A., De Castro, M.D., Quesada-Gómez, J.M., Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow. Osteoporos. Int. 22 (2011), 675–684, 10.1007/s00198-010-1270-x.
    • (2011) Osteoporos. Int. , vol.22 , pp. 675-684
    • Santiago-Mora, R.1    Casado-Díaz, A.2    De Castro, M.D.3    Quesada-Gómez, J.M.4
  • 227
    • 85031421714 scopus 로고    scopus 로고
    • Gut microbiota changes in the extreme decades of human life: a focus on centenarians
    • Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., Franceschi, C., Gut microbiota changes in the extreme decades of human life: a focus on centenarians. Cell. Mol. Life Sci. 75:January (2018), 129–148, 10.1007/s00018-017-2674-y.
    • (2018) Cell. Mol. Life Sci. , vol.75 , Issue.January , pp. 129-148
    • Santoro, A.1    Ostan, R.2    Candela, M.3    Biagi, E.4    Brigidi, P.5    Capri, M.6    Franceschi, C.7
  • 228
    • 67349259948 scopus 로고    scopus 로고
    • Sorescu D, et al. NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells
    • Schilder, Y.D., Heiss, E.H., Schachner, D., Ziegler, J., Reznicek, G., Sorescu D, et al. NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells. Free Radic. Biol. Med. 46 (2009), 1598–1606, 10.1016/j.freeradbiomed.2009.03.013.
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 1598-1606
    • Schilder, Y.D.1    Heiss, E.H.2    Schachner, D.3    Ziegler, J.4    Reznicek, G.5
  • 230
    • 85032583527 scopus 로고    scopus 로고
    • To stay young, kill zombie cells
    • Scudellari, M., To stay young, kill zombie cells. Nature 550 (2017), 448–450, 10.1038/550448a.
    • (2017) Nature , vol.550 , pp. 448-450
    • Scudellari, M.1
  • 231
    • 84907857762 scopus 로고    scopus 로고
    • Translational geroscience: emphasizing function to achieve optimal longevity
    • Seals, D.R., Melov, S., Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY) 6 (2014), 718–730.
    • (2014) Aging (Albany NY) , vol.6 , pp. 718-730
    • Seals, D.R.1    Melov, S.2
  • 232
    • 84937521269 scopus 로고    scopus 로고
    • The resolution code of acute inflammation: novel pro-resolving lipid mediators in resolution
    • Serhan, C.N., Chiang, N., Dalli, J., The resolution code of acute inflammation: novel pro-resolving lipid mediators in resolution. Semin. Immunol. 27 (2015), 200–215, 10.1016/j.smim.2015.03.004.
    • (2015) Semin. Immunol. , vol.27 , pp. 200-215
    • Serhan, C.N.1    Chiang, N.2    Dalli, J.3
  • 233
    • 84901921079 scopus 로고    scopus 로고
    • Pro-resolving lipid mediators are leads for resolution physiology
    • Serhan, C.N., Pro-resolving lipid mediators are leads for resolution physiology. Nature 510 (2014), 92–101, 10.1038/nature13479.
    • (2014) Nature , vol.510 , pp. 92-101
    • Serhan, C.N.1
  • 234
    • 0034713329 scopus 로고    scopus 로고
    • Is b-Galactosidase staining a marker of senescence in vitro and in vivo?
    • Severino, J., Allen, R.G., Balin, S., Balin, A., Cristofalo, V.J., Is b-Galactosidase staining a marker of senescence in vitro and in vivo?. Exp. Cell Res. 257 (2000), 162–171.
    • (2000) Exp. Cell Res. , vol.257 , pp. 162-171
    • Severino, J.1    Allen, R.G.2    Balin, S.3    Balin, A.4    Cristofalo, V.J.5
  • 235
    • 84916925703 scopus 로고    scopus 로고
    • mTOR signaling from cellular senescence to organismal aging
    • Shaohua, X., Ying, C., Yuehua, W., mTOR signaling from cellular senescence to organismal aging. Aging Dis. 5 (2014), 263–273, 10.14336/AD.2014.0500263.
    • (2014) Aging Dis. , vol.5 , pp. 263-273
    • Shaohua, X.1    Ying, C.2    Yuehua, W.3
  • 236
    • 84901257251 scopus 로고    scopus 로고
    • Recent HSP90 inhibitors: current development and potential in cancer therapy
    • Sidera, K., Patsavoudi, E., Recent HSP90 inhibitors: current development and potential in cancer therapy. Pat. Anticancer Drug Discov. 9 (2014), 1–20.
    • (2014) Pat. Anticancer Drug Discov. , vol.9 , pp. 1-20
    • Sidera, K.1    Patsavoudi, E.2
  • 237
    • 84924140282 scopus 로고    scopus 로고
    • Cellular senescence in ageing, age-related disease and longevity
    • Sikora, E., Bielak-Zmijewska, A., Mosieniak, G., Cellular senescence in ageing, age-related disease and longevity. Curr. Vasc. Pharmacol. 12 (2014), 698–706.
    • (2014) Curr. Vasc. Pharmacol. , vol.12 , pp. 698-706
    • Sikora, E.1    Bielak-Zmijewska, A.2    Mosieniak, G.3
  • 238
    • 0036931477 scopus 로고    scopus 로고
    • Omega-3 fatty acids in inflammation and autoimmune diseases
    • Simopoulos, A.P., Omega-3 fatty acids in inflammation and autoimmune diseases. J. Am. Coll. Nutr. 21 (2002), 495–505.
    • (2002) J. Am. Coll. Nutr. , vol.21 , pp. 495-505
    • Simopoulos, A.P.1
  • 240
    • 0033795879 scopus 로고    scopus 로고
    • Potential health impacts of excessive flavonoid intake
    • Skibola, C.F., Smith, M.T., Potential health impacts of excessive flavonoid intake. Free Radic. Biol. Med. 29 (2000), 375–383.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 375-383
    • Skibola, C.F.1    Smith, M.T.2
  • 241
    • 84907699239 scopus 로고    scopus 로고
    • Phloroglucinol attenuates free radical-induced oxidative stress
    • So, M.J., Cho, E.J., Phloroglucinol attenuates free radical-induced oxidative stress. Prev. Nutr. Food Sci. 19 (2014), 129–135, 10.3746/pnf.2014.19.3.129.
    • (2014) Prev. Nutr. Food Sci. , vol.19 , pp. 129-135
    • So, M.J.1    Cho, E.J.2
  • 243
    • 84874462054 scopus 로고    scopus 로고
    • Cancer metabolism: key players in metabolic reprogramming
    • Soga, T.1, Cancer metabolism: key players in metabolic reprogramming. Cancer Sci. 104 (2013), 275–281, 10.1111/cas.12085.
    • (2013) Cancer Sci. , vol.104 , pp. 275-281
    • Soga, T.1
  • 247
    • 33845564908 scopus 로고    scopus 로고
    • Molecular targets of tea polyphenols in the cardiovascular system
    • Stangl, V., Dreger, H., Stangl, K., Lorenz, M., Molecular targets of tea polyphenols in the cardiovascular system. Cardiovasc. Res. 73 (2007), 348–358.
    • (2007) Cardiovasc. Res. , vol.73 , pp. 348-358
    • Stangl, V.1    Dreger, H.2    Stangl, K.3    Lorenz, M.4
  • 248
    • 84959422719 scopus 로고    scopus 로고
    • Age-associated increase in cytokine production during systemic inflammation-II: the role of IL-1β in age-dependent IL-6 upregulation in adipose tissue
    • Starr, M.E., Saito, M., Evers, B.M., Saito, H., Age-associated increase in cytokine production during systemic inflammation-II: the role of IL-1β in age-dependent IL-6 upregulation in adipose tissue. J. Gerontol. A. Biol. Sci. Med. Sci. 70 (2014), 1508–1515, 10.1093/gerona/glu197.
    • (2014) J. Gerontol. A. Biol. Sci. Med. Sci. , vol.70 , pp. 1508-1515
    • Starr, M.E.1    Saito, M.2    Evers, B.M.3    Saito, H.4
  • 250
    • 85015187138 scopus 로고    scopus 로고
    • Oleuropein, unexpected benefits!
    • Sun, W., Frost, B., Liu, J., Oleuropein, unexpected benefits!. Oncotarget, 8, 2017, 17409, 10.18632/oncotarget.15538.
    • (2017) Oncotarget , vol.8 , pp. 17409
    • Sun, W.1    Frost, B.2    Liu, J.3
  • 251
    • 85006274936 scopus 로고    scopus 로고
    • Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats
    • Sun, W., Wang, X., Hou, C., Yang, L., Li, H., Guo, J., Huo, C., Wang, M., Miao, Y., Liu, J., Kang, Y., Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Neuropharmacology 113:Pt A (2017), 556–566, 10.1016/j.neuropharm.2016.11.010.
    • (2017) Neuropharmacology , vol.113 , pp. 556-566
    • Sun, W.1    Wang, X.2    Hou, C.3    Yang, L.4    Li, H.5    Guo, J.6    Huo, C.7    Wang, M.8    Miao, Y.9    Liu, J.10    Kang, Y.11
  • 253
    • 84999751828 scopus 로고    scopus 로고
    • Mediterranean diets supplemented with virgin olive oil and nuts enhance plasmatic antioxidant capabilities and decrease xanthine oxidase activity in people with metabolic syndrome: the PREDIMED study
    • Sureda, A., Bibiloni, M.D., Martorell, M., Buil-Cosiales, P., Marti, A., Pons, A., Tur, J.A., Martinez-Gonzalez, M.Á., PREDIMED Study Investigators, Mediterranean diets supplemented with virgin olive oil and nuts enhance plasmatic antioxidant capabilities and decrease xanthine oxidase activity in people with metabolic syndrome: the PREDIMED study. Mol. Nutr. Food Res. 60 (2016), 2654–2664, 10.1002/mnfr.201600450.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 2654-2664
    • Sureda, A.1    Bibiloni, M.D.2    Martorell, M.3    Buil-Cosiales, P.4    Marti, A.5    Pons, A.6    Tur, J.A.7    Martinez-Gonzalez, M.Á.8    PREDIMED Study Investigators9
  • 255
    • 84983059084 scopus 로고    scopus 로고
    • From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
    • Szarc vel Szic, K., Declerck, K., Vidaković, M., Vanden Berghe, W., From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?. Clin. Epigenet., 7, 2015, 33, 10.1186/s13148-015-0068-2.
    • (2015) Clin. Epigenet. , vol.7 , pp. 33
    • Szarc vel Szic, K.1    Declerck, K.2    Vidaković, M.3    Vanden Berghe, W.4
  • 256
    • 85035223745 scopus 로고    scopus 로고
    • Quercetin metabolism by fecal microbiota from healthy elderly human subjects
    • Tamura, M., Hoshi, C., Kobori, M., Takahashi, S., Tomita, J., Nishimura, M., Nishihira, J., Quercetin metabolism by fecal microbiota from healthy elderly human subjects. PLoS One, 12(11), 2017, e0188271, 10.1371/journal.pone.0188271.
    • (2017) PLoS One , vol.12 , Issue.11 , pp. e0188271
    • Tamura, M.1    Hoshi, C.2    Kobori, M.3    Takahashi, S.4    Tomita, J.5    Nishimura, M.6    Nishihira, J.7
  • 258
    • 84988978417 scopus 로고    scopus 로고
    • Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study
    • Tong, T.Y., Wareham, N.J., Khaw, K.T., Imamura, F., Forouhi, N.G., Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study. BMC Med., 14, 2016, 135.
    • (2016) BMC Med. , vol.14 , pp. 135
    • Tong, T.Y.1    Wareham, N.J.2    Khaw, K.T.3    Imamura, F.4    Forouhi, N.G.5
  • 259
    • 0033732110 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
    • Toussaint, O., Medrano, E.E., von Zglinicki, T., Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 35 (2000), 927–945.
    • (2000) Exp. Gerontol. , vol.35 , pp. 927-945
    • Toussaint, O.1    Medrano, E.E.2    von Zglinicki, T.3
  • 260
    • 33847080728 scopus 로고    scopus 로고
    • Hardie DGAMP-activated protein kinase in metabolic control and insulin signaling
    • Towler, M.C., Hardie DGAMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 100 (2007), 328–341.
    • (2007) Circ. Res. , vol.100 , pp. 328-341
    • Towler, M.C.1
  • 261
  • 262
    • 85027942550 scopus 로고    scopus 로고
    • Epigenetic inheritance and the missing heritability
    • Trerotola, M., Relli, V., Simeone, P., Alberti, S., Epigenetic inheritance and the missing heritability. Hum. Genomics, 9, 2015, 17, 10.1186/s40246-015-0041-3.
    • (2015) Hum. Genomics , vol.9 , pp. 17
    • Trerotola, M.1    Relli, V.2    Simeone, P.3    Alberti, S.4
  • 263
    • 84954287264 scopus 로고    scopus 로고
    • Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium
    • Triggle, C.R., Ding, H., Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium. Acta Physiol. (Oxf). 219 (2017), 138–151, 10.1111/apha.12644.
    • (2017) Acta Physiol. (Oxf). , vol.219 , pp. 138-151
    • Triggle, C.R.1    Ding, H.2
  • 265
    • 33748904916 scopus 로고    scopus 로고
    • Comparative study of the cytotoxicity induced by antioxidant epicatechin conjugates obtained from grape
    • Ugartondo, V., Mitjans, M., Lozano, C., Torres, J.L., Vinardell, M.P.M.U., Comparative study of the cytotoxicity induced by antioxidant epicatechin conjugates obtained from grape. J. Agric. Food Chem. 54 (2006), 6945–6950.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 6945-6950
    • Ugartondo, V.1    Mitjans, M.2    Lozano, C.3    Torres, J.L.4    Vinardell, M.P.M.U.5
  • 266
    • 84988345815 scopus 로고    scopus 로고
    • Anti-aging pharmacology: promises and pitfalls ageing
    • Vaiserman, A.M., Lushchakb, O.V., Koliada, A.K., Anti-aging pharmacology: promises and pitfalls ageing. Res Rev. 31 (2016), 9–35, 10.1016/j.arr.2016.08.004.
    • (2016) Res Rev. , vol.31 , pp. 9-35
    • Vaiserman, A.M.1    Lushchakb, O.V.2    Koliada, A.K.3
  • 267
    • 84908602934 scopus 로고    scopus 로고
    • Mediterranean diet and healthy ageing: a Sicilian perspective
    • Vasto, S., Buscemi, S., Barera, A., Di Carlo, M., Accardi, G., Caruso, C., Mediterranean diet and healthy ageing: a Sicilian perspective. Gerontology 60 (2014), 508–518, 10.1159/000363060.
    • (2014) Gerontology , vol.60 , pp. 508-518
    • Vasto, S.1    Buscemi, S.2    Barera, A.3    Di Carlo, M.4    Accardi, G.5    Caruso, C.6
  • 268
    • 84922758619 scopus 로고    scopus 로고
    • Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases
    • Verburgh, K., Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases. Aging Cell 14 (2015), 17–24, 10.1111/acel.12284.
    • (2015) Aging Cell , vol.14 , pp. 17-24
    • Verburgh, K.1
  • 269
    • 85013384788 scopus 로고    scopus 로고
    • A mediterranean diet to improve cardiovascular and cognitive health: protocol for a randomised controlled intervention study
    • (pii: E145)
    • Wade, A.T., Davis, C.R., Dyer, K.A., Hodgson, J.M., Woodman, R.J., Keage, H.A., Murphy, K.J., A mediterranean diet to improve cardiovascular and cognitive health: protocol for a randomised controlled intervention study. Nutrients, 2017, 9, 10.3390/nu9020145 (pii: E145).
    • (2017) Nutrients , pp. 9
    • Wade, A.T.1    Davis, C.R.2    Dyer, K.A.3    Hodgson, J.M.4    Woodman, R.J.5    Keage, H.A.6    Murphy, K.J.7
  • 270
    • 85002142056 scopus 로고    scopus 로고
    • Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
    • Wang, Y., Chang, J., Liu, X., Zhang, X., Zhang, S., Zhang, X., Zhou, D., Zheng, G., Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging (Albany NY) 8 (2016), 2915–2926, 10.18632/aging.101100.
    • (2016) Aging (Albany NY) , vol.8 , pp. 2915-2926
    • Wang, Y.1    Chang, J.2    Liu, X.3    Zhang, X.4    Zhang, S.5    Zhang, X.6    Zhou, D.7    Zheng, G.8
  • 271
    • 85037688736 scopus 로고    scopus 로고
    • Improving anti-melanoma effect of curcumin by biodegradable nanoparticles
    • Wang, B., Liu, X., Teng, Y., Yu, T., Chen, J., Hu, Y., Liu, N., Zhang, L., Shen, Y., Improving anti-melanoma effect of curcumin by biodegradable nanoparticles. Oncotarget 8 (2017), 108624–108642.
    • (2017) Oncotarget , vol.8 , pp. 108624-108642
    • Wang, B.1    Liu, X.2    Teng, Y.3    Yu, T.4    Chen, J.5    Hu, Y.6    Liu, N.7    Zhang, L.8    Shen, Y.9
  • 274
    • 84942585419 scopus 로고    scopus 로고
    • Regulation of innate immune cell function by mTOR
    • Weichhart, T., Hengstschläger, M., Linke, M., Regulation of innate immune cell function by mTOR. Nat. Rev. Immunol. 15 (2015), 599–614, 10.1038/nri3901.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 599-614
    • Weichhart, T.1    Hengstschläger, M.2    Linke, M.3
  • 275
    • 84975510266 scopus 로고    scopus 로고
    • From ancient pathways to aging cells-connecting metabolism and cellular senescence
    • Wiley, C.D., Campisi, J., From ancient pathways to aging cells-connecting metabolism and cellular senescence. Cell Metab. 23 (2016), 1013–1021, 10.1016/j.cmet.2016.05.010.
    • (2016) Cell Metab. , vol.23 , pp. 1013-1021
    • Wiley, C.D.1    Campisi, J.2
  • 276
    • 77951598531 scopus 로고    scopus 로고
    • The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load
    • Willcox, D.C., Willcox, B.J., Todoriki, H., Suzuki, M., The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J. Am. Coll. Nutr. 28:Suppl (2009), 500S–516S.
    • (2009) J. Am. Coll. Nutr. , vol.28 , pp. 500S-516S
    • Willcox, D.C.1    Willcox, B.J.2    Todoriki, H.3    Suzuki, M.4
  • 277
    • 84899988753 scopus 로고    scopus 로고
    • Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet
    • Willcox, D.C., Scapagnini, G., Willcox, B.J., Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet. Mech. Ageing Dev. 136–137 (2014), 148–162, 10.1016/j.mad.2014.01.002.
    • (2014) Mech. Ageing Dev. , vol.136-137 , pp. 148-162
    • Willcox, D.C.1    Scapagnini, G.2    Willcox, B.J.3
  • 278
    • 46649096835 scopus 로고    scopus 로고
    • Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
    • Williamson, G., Holst, B., Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?. Br. J. Nutr. 99:Suppl. 3 (2008), S55–S58, 10.1017/S0007114508006867.
    • (2008) Br. J. Nutr. , vol.99 , pp. S55-S58
    • Williamson, G.1    Holst, B.2
  • 279
    • 85027557262 scopus 로고    scopus 로고
    • The role of polyphenols in modern nutrition
    • Williamson, G., The role of polyphenols in modern nutrition. Nutr Bull. 42 (2017), 226–235, 10.1111/nbu.12278.
    • (2017) Nutr Bull. , vol.42 , pp. 226-235
    • Williamson, G.1
  • 280
    • 85019825856 scopus 로고    scopus 로고
    • The emerging safety profile of JAK inhibitors in rheumatic disease
    • Winthrop, K.L., The emerging safety profile of JAK inhibitors in rheumatic disease. Nat. Rev. Rheumatol., 13, 2017, 320, 10.1038/nrrheum.2017.51.
    • (2017) Nat. Rev. Rheumatol. , vol.13 , pp. 320
    • Winthrop, K.L.1
  • 282
    • 75549087339 scopus 로고    scopus 로고
    • Mediterranean diet, culture and heritage: challenges for a new conception
    • Xavier Medina, F., Mediterranean diet, culture and heritage: challenges for a new conception. Public Health Nutr. 12:9A (2009), 1618–1620, 10.1017/S1368980009990450.
    • (2009) Public Health Nutr. , vol.12 , Issue.9A , pp. 1618-1620
    • Xavier Medina, F.1
  • 283
    • 77649207183 scopus 로고    scopus 로고
    • Biological activities of polyphenols from grapes
    • Xia, E.Q., Deng, G.F., Guo, Y.J., Li, H.B., Biological activities of polyphenols from grapes. Int. J. Mol. Sci. 11 (2010), 622–646, 10.3390/ijms11020622.
    • (2010) Int. J. Mol. Sci. , vol.11 , pp. 622-646
    • Xia, E.Q.1    Deng, G.F.2    Guo, Y.J.3    Li, H.B.4
  • 284
    • 84906311349 scopus 로고    scopus 로고
    • Studying navitoclax, a targeted anticancer drug, in healthy volunteers–ethical considerations and risk/benefit assessments and management
    • Xiong, H., Pradhan, R.S., Nada, A., Krivoshik, A.P., Holen, K.D., Rhodes, J.W., Gordon, G.B., Humerickhouse, R., Awni, W.M., Studying navitoclax, a targeted anticancer drug, in healthy volunteers–ethical considerations and risk/benefit assessments and management. Anticancer Res. 34 (2014), 3739–3746.
    • (2014) Anticancer Res. , vol.34 , pp. 3739-3746
    • Xiong, H.1    Pradhan, R.S.2    Nada, A.3    Krivoshik, A.P.4    Holen, K.D.5    Rhodes, J.W.6    Gordon, G.B.7    Humerickhouse, R.8    Awni, W.M.9
  • 287
    • 84975840886 scopus 로고    scopus 로고
    • Perspective Targeting the JAK/STAT pathway to fight age-related dysfunction
    • Xu, M., Tchkonia, T., Kirkland, J.L., Perspective Targeting the JAK/STAT pathway to fight age-related dysfunction. Pharmacol. Res. 111 (2016), 152–154, 10.1016/j.phrs.2016.05.015.
    • (2016) Pharmacol. Res. , vol.111 , pp. 152-154
    • Xu, M.1    Tchkonia, T.2    Kirkland, J.L.3
  • 288
    • 85041106858 scopus 로고    scopus 로고
    • Urolithins attenuate LPS-induced neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB signaling pathways
    • Xu, J., Yuan, C., Wang, G., Luo, J., Ma, H., Xu, L., Mu, Y., Li, Y., Seeram, N.P., Huang, X., Li, L., Urolithins attenuate LPS-induced neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB signaling pathways. J. Agric. Food Chem. 66 (2018), 571–580, 10.1021/acs.jafc.7b03285.
    • (2018) J. Agric. Food Chem. , vol.66 , pp. 571-580
    • Xu, J.1    Yuan, C.2    Wang, G.3    Luo, J.4    Ma, H.5    Xu, L.6    Mu, Y.7    Li, Y.8    Seeram, N.P.9    Huang, X.10    Li, L.11
  • 289
    • 84855810517 scopus 로고    scopus 로고
    • SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene
    • Yamashita, S., Ogawa, K., Ikei, T., Udono, M., Fujiki, T., Katakura, Y., SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene. Biochem. Biophys. Res. Commun. 417 (2012), 630–634, 10.1016/j.bbrc.2011.12.021.
    • (2012) Biochem. Biophys. Res. Commun. , vol.417 , pp. 630-634
    • Yamashita, S.1    Ogawa, K.2    Ikei, T.3    Udono, M.4    Fujiki, T.5    Katakura, Y.6
  • 290
    • 85014060468 scopus 로고    scopus 로고
    • The impacts of cellular senescence in elderly pneumonia and in age-related lung diseases that increase the risk of respiratory infections
    • (pii: E503)
    • Yanagi, S., Tsubouchi, H., Miura, A., Matsuo, A., Matsumoto, N., Nakazato, M., The impacts of cellular senescence in elderly pneumonia and in age-related lung diseases that increase the risk of respiratory infections. Int. J. Mol. Sci., 18(3), 2017, 25, 10.3390/ijms18030503 (pii: E503).
    • (2017) Int. J. Mol. Sci. , vol.18 , Issue.3 , pp. 25
    • Yanagi, S.1    Tsubouchi, H.2    Miura, A.3    Matsuo, A.4    Matsumoto, N.5    Nakazato, M.6
  • 291
    • 84907525188 scopus 로고    scopus 로고
    • Microbial imbalance and intestinal pathologies: connections and contributions
    • Yang, Y., Jobin, C., Microbial imbalance and intestinal pathologies: connections and contributions. Dis. Model Mech. 7 (2014), 1131–1142, 10.1242/dmm.016428.
    • (2014) Dis. Model Mech. , vol.7 , pp. 1131-1142
    • Yang, Y.1    Jobin, C.2
  • 292
    • 85016057465 scopus 로고    scopus 로고
    • Influences of the gut microbiota on DNA methylation and histone modification
    • Ye, J., Wu, W., Li, Y., Li, L., Influences of the gut microbiota on DNA methylation and histone modification. Dig. Dis. Sci. 62 (2017), 1155–1164, 10.1007/s10620-017-4538-6.
    • (2017) Dig. Dis. Sci. , vol.62 , pp. 1155-1164
    • Ye, J.1    Wu, W.2    Li, Y.3    Li, L.4
  • 293
    • 84994225360 scopus 로고    scopus 로고
    • HDAC and HDAC inhibitor from cancer to cardiovascular diseases
    • Yoon, S., Eom, G.H., HDAC and HDAC inhibitor from cancer to cardiovascular diseases. Chonnam Med. J. 52 (2016), 1–11, 10.4068/cmj.2016.52.1.1.
    • (2016) Chonnam Med. J. , vol.52 , pp. 1-11
    • Yoon, S.1    Eom, G.H.2
  • 296
    • 84973596343 scopus 로고    scopus 로고
    • Isoflavones: anti-inflammatory benefit and possible caveats
    • (pii: E361)
    • Yu, J., Bi, X., Yu, B., Chen, D., Isoflavones: anti-inflammatory benefit and possible caveats. Nutrients, 8(6), 2016, 10.3390/nu8060361 (pii: E361).
    • (2016) Nutrients , vol.8 , Issue.6
    • Yu, J.1    Bi, X.2    Yu, B.3    Chen, D.4
  • 297
    • 85048730113 scopus 로고    scopus 로고
    • Resveratrol protects against high-fat diet induced renal pathological damage and cell senescence by activating SIRT1
    • Zhang, N., Li, Z., Xu, K., Wang, Y., Wang, Z., Resveratrol protects against high-fat diet induced renal pathological damage and cell senescence by activating SIRT1. Biol. Pharm. Bull., 7, 2016, e37162, 10.1371/journal.pone.0037162.
    • (2016) Biol. Pharm. Bull. , vol.7 , pp. e37162
    • Zhang, N.1    Li, Z.2    Xu, K.3    Wang, Y.4    Wang, Z.5
  • 299
    • 33748575324 scopus 로고    scopus 로고
    • Clonal senescence alters endothelial ICAM-1 function
    • Zhou, X., Perez, F., Han, K., Jurivich, D.A., Clonal senescence alters endothelial ICAM-1 function. Mech. Ageing Dev. 127 (2006), 779–785.
    • (2006) Mech. Ageing Dev. , vol.127 , pp. 779-785
    • Zhou, X.1    Perez, F.2    Han, K.3    Jurivich, D.A.4
  • 300
    • 84903555260 scopus 로고    scopus 로고
    • Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging
    • Zhu, J., Mu, X., Zeng, J., Xu, C., Liu, J., Zhang, M., Li, C., Chen, J., Li, T., Wang, Y., Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLoS One, 9, 2014, e101291, 10.1371/journal.pone.0101291.
    • (2014) PLoS One , vol.9 , pp. e101291
    • Zhu, J.1    Mu, X.2    Zeng, J.3    Xu, C.4    Liu, J.5    Zhang, M.6    Li, C.7    Chen, J.8    Li, T.9    Wang, Y.10
  • 301
    • 84942889461 scopus 로고    scopus 로고
    • Effect of curcumin on aging retinal pigment epithelial cells
    • Zhu, W., Wu, Y., Meng, Y.F., Wang, J.Y., Xu, M., Tao, J.J., Lu, J., Effect of curcumin on aging retinal pigment epithelial cells. Drug Des. Dev. Ther. 9 (2015), 5337–5344, 10.2147/DDDT.S84979.
    • (2015) Drug Des. Dev. Ther. , vol.9 , pp. 5337-5344
    • Zhu, W.1    Wu, Y.2    Meng, Y.F.3    Wang, J.Y.4    Xu, M.5    Tao, J.J.6    Lu, J.7
  • 304
    • 84922627875 scopus 로고    scopus 로고
    • Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging
    • Ziegler, D.V., Wiley, C.D., Velarde, M.C., Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell 14 (2015), 1–7, 10.1111/acel.12287.
    • (2015) Aging Cell , vol.14 , pp. 1-7
    • Ziegler, D.V.1    Wiley, C.D.2    Velarde, M.C.3
  • 306
    • 0346256784 scopus 로고    scopus 로고
    • Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
    • Zwerschke, W., Mazurek, S., Stöckl, P., Hütter, E., Eigenbrodt, E., Jansen-Dürr, P., Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem. J. 376:Pt 2 (2003), 403–411, 10.1042/BJ20030816.
    • (2003) Biochem. J. , vol.376 , pp. 403-411
    • Zwerschke, W.1    Mazurek, S.2    Stöckl, P.3    Hütter, E.4    Eigenbrodt, E.5    Jansen-Dürr, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.