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Volumn 6, Issue 34, 2015, Pages 35344-35357

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: A mechanistic insight

Author keywords

AMPK; Autophagy; Gerotarget; MTOR; Neurodegeneration; Oleuropein aglycone

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; OLEUROPEIN AGLYCONE; POLYPHENOL; S6 KINASE; UNCLASSIFIED DRUG; IRIDOID; MTOR PROTEIN, HUMAN; OLEUROPEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84946866919     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6119     Document Type: Article
Times cited : (118)

References (40)
  • 1
    • 84875953344 scopus 로고    scopus 로고
    • Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases
    • Del Rio D, Rodriguez-Mateos A, Spencer J, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013; 18:1818-1892.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1818-1892
    • Del Rio, D.1    Rodriguez-Mateos, A.2    Spencer, J.3    Tognolini, M.4    Borges, G.5    Crozier, A.6
  • 3
    • 84907998488 scopus 로고    scopus 로고
    • Beneficial properties of natural phenols: highlight on protection against pathological conditions associated with amyloid aggregation
    • Stefani M, Rigacci S. Beneficial properties of natural phenols: highlight on protection against pathological conditions associated with amyloid aggregation. Biofactors. 2014; 40 482-493.
    • (2014) Biofactors , vol.40 , pp. 482-493
    • Stefani, M.1    Rigacci, S.2
  • 4
    • 84881233274 scopus 로고    scopus 로고
    • Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation
    • Kim H, Montana V, Jang H, Parpura V, Kim J. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem. 2013; 288:22693-22705.
    • (2013) J Biol Chem , vol.288 , pp. 22693-22705
    • Kim, H.1    Montana, V.2    Jang, H.3    Parpura, V.4    Kim, J.5
  • 6
    • 84900344034 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance
    • Zhou J, Farah B, Sinha R, Wu Y, Singh B, Bay B, Yang C, Yen P. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PLoS One. 2014; 29:e87161.
    • (2014) PLoS One , vol.29
    • Zhou, J.1    Farah, B.2    Sinha, R.3    Wu, Y.4    Singh, B.5    Bay, B.6    Yang, C.7    Yen, P.8
  • 7
    • 84888380983 scopus 로고    scopus 로고
    • The autophagosome: origins unknown, biogenesis complex
    • Lamb C, Yoshimori T, Tooze S. The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol. 2013; 14 759-774.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 759-774
    • Lamb, C.1    Yoshimori, T.2    Tooze, S.3
  • 8
    • 84867385981 scopus 로고    scopus 로고
    • The autophagosome: origins unknown, biogenesis complex
    • Pallauf K, Rimbach G. The autophagosome: origins unknown, biogenesis complex. Ageing Res Rev. 2013; 12:237-252.
    • (2013) Ageing Res Rev , vol.12 , pp. 237-252
    • Pallauf, K.1    Rimbach, G.2
  • 9
    • 56349168452 scopus 로고    scopus 로고
    • Autophagy and aging: keeping that old broom working
    • Cuervo A. Autophagy and aging: keeping that old broom working. Trends Genet. 2008; 24:604-612.
    • (2008) Trends Genet , vol.24 , pp. 604-612
    • Cuervo, A.1
  • 10
    • 79960635284 scopus 로고    scopus 로고
    • Fighting neurodegeration with rapamycin: mechanistic insight
    • Bovè J, Martinez-Vicente M, Mila V. Fighting neurodegeration with rapamycin: mechanistic insight. Nat Rev Neurosci. 2011; 12:437-452.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 437-452
    • Bovè, J.1    Martinez-Vicente, M.2    Mila, V.3
  • 13
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo A, Klionsky D. Autophagy fights disease through cellular self-digestion. Nature. 2008; 451:1069-75.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.3    Klionsky, D.4
  • 15
    • 79953208952 scopus 로고    scopus 로고
    • Naturally secreted amyloidbeta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism
    • Caccamo A, Maldonado M, Majumder S, Medina D, Holbein W, Magrí A, Oddo S. Naturally secreted amyloidbeta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. J Biol Chem. 2011; 286:8924-8932.
    • (2011) J Biol Chem , vol.286 , pp. 8924-8932
    • Caccamo, A.1    Maldonado, M.2    Majumder, S.3    Medina, D.4    Holbein, W.5    Magrí, A.6    Oddo, S.7
  • 17
    • 84922359207 scopus 로고    scopus 로고
    • Autophagy in Huntington disease and huntingtin in autophagy
    • Martin D, Ladha S, Ehrnhoefer D, Hayden M.: Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci. 2015; 38:26-35.
    • (2015) Trends Neurosci , vol.38 , pp. 26-35
    • Martin, D.1    Ladha, S.2    Ehrnhoefer, D.3    Hayden, M.4
  • 18
    • 33750089740 scopus 로고    scopus 로고
    • Degradation of amyotrophic lateral sclerosis-linked mutant Cu, Zn-superoxide dismutase proteins by macroautophagy and the proteasome
    • Kabuta T, Suzuki Y, Wada K. Degradation of amyotrophic lateral sclerosis-linked mutant Cu, Zn-superoxide dismutase proteins by macroautophagy and the proteasome. J Biol Chem. 2006; 281:30524-30533.
    • (2006) J Biol Chem , vol.281 , pp. 30524-30533
    • Kabuta, T.1    Suzuki, Y.2    Wada, K.3
  • 20
    • 82055197196 scopus 로고    scopus 로고
    • A β(1-42) aggregates into nontoxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon
    • Rigacci S, Guidotti V, Bucciantini M, Nichino D, Relini A, Berti A, Stefani M. A β(1-42) aggregates into nontoxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon. Curr Alzheimer Res. 2011; 8:841-852.
    • (2011) Curr Alzheimer Res , vol.8 , pp. 841-852
    • Rigacci, S.1    Guidotti, V.2    Bucciantini, M.3    Nichino, D.4    Relini, A.5    Berti, A.6    Stefani, M.7
  • 22
    • 84925705424 scopus 로고    scopus 로고
    • Oleuropein Aglycone. A Possible Drug against Degenerative Conditions. In Vivo Evidence of its Effectiveness against Alzheimer's Disease
    • Casamenti F, Grossi C, Rigacci S, Pantano D, Luccarini I, Stefani M: Oleuropein Aglycone. A Possible Drug against Degenerative Conditions. In Vivo Evidence of its Effectiveness against Alzheimer's Disease. J Alzheimers Dis. 2015; 45:679-88.
    • (2015) J Alzheimers Dis , vol.45 , pp. 679-688
    • Casamenti, F.1    Grossi, C.2    Rigacci, S.3    Pantano, D.4    Luccarini, I.5    Stefani, M.6
  • 24
    • 84879335548 scopus 로고    scopus 로고
    • Polyphenols: multipotent therapeutic agents in neurodegenerative diseases
    • Bhullar K, Rupasinghe H. Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev. 2013;2013:891748.
    • (2013) Oxid Med Cell Longev , vol.2013
    • Bhullar, K.1    Rupasinghe, H.2
  • 25
    • 84893196378 scopus 로고    scopus 로고
    • New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
    • Kim H, Quon M, Kim J. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox Biol. 2014; 2:187-195.
    • (2014) Redox Biol , vol.2 , pp. 187-195
    • Kim, H.1    Quon, M.2    Kim, J.3
  • 26
    • 84864667633 scopus 로고    scopus 로고
    • Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch
    • Marquez R, Xu L. Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res. 2012; 2:214-221.
    • (2012) Am J Cancer Res , vol.2 , pp. 214-221
    • Marquez, R.1    Xu, L.2
  • 28
    • 84896300923 scopus 로고    scopus 로고
    • The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent
    • Liu X, Chipa R, Nakano I, Dasgupta B. The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent. Mol Cancer Ther. 2014;13:596-605.
    • (2014) Mol Cancer Ther , vol.13 , pp. 596-605
    • Liu, X.1    Chipa, R.2    Nakano, I.3    Dasgupta, B.4
  • 29
    • 84920833547 scopus 로고    scopus 로고
    • Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols
    • Rigacci S, Stefani M.: Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols. Expert Rev Neurother 2015;15:41-52.
    • (2015) Expert Rev Neurother , vol.15 , pp. 41-52
    • Rigacci, S.1    Stefani, M.2
  • 30
    • 57649227693 scopus 로고    scopus 로고
    • Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
    • Sarkar S, Ravikumar B, Floto R, Rubinsztein D: Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 2009; 16:46-56.
    • (2009) Cell Death Differ , vol.16 , pp. 46-56
    • Sarkar, S.1    Ravikumar, B.2    Floto, R.3    Rubinsztein, D.4
  • 31
    • 84915751046 scopus 로고    scopus 로고
    • Phosphoproteomics reveals resveratrol-dependent inhibition of Akt/mTORC1/S6K1 signaling
    • Alayev A, Doubleday P, Berger S, Ballif B, Holz M. Phosphoproteomics reveals resveratrol-dependent inhibition of Akt/mTORC1/S6K1 signaling. J Proteome Res. 2014;13: 5734-5742.
    • (2014) J Proteome Res , vol.13 , pp. 5734-5742
    • Alayev, A.1    Doubleday, P.2    Berger, S.3    Ballif, B.4    Holz, M.5
  • 32
    • 84906934962 scopus 로고    scopus 로고
    • Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase
    • Choi Y, Suh H, Yoon Y, Lee K, Kim D, Kim S, Lee B. Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase. Arch Pharm Res. 2014; 37:1169-1176.
    • (2014) Arch Pharm Res , vol.37 , pp. 1169-1176
    • Choi, Y.1    Suh, H.2    Yoon, Y.3    Lee, K.4    Kim, D.5    Kim, S.6    Lee, B.7
  • 33
    • 84878014129 scopus 로고    scopus 로고
    • A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
    • Wang L, Wang Y, Cui M, Luo W, Wang X, Barber P, ZY C. A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia. Eur J Neurosci. 2013; 37:1669-1681.
    • (2013) Eur J Neurosci , vol.37 , pp. 1669-1681
    • Wang, L.1    Wang, Y.2    Cui, M.3    Luo, W.4    Wang, X.5    Barber, P.Z.Y.C.6
  • 35
    • 84889687344 scopus 로고    scopus 로고
    • Epigenetic effects of green tea polyphenols in cancer
    • Henning S, Wang P, Carpenter C, Heber D Epigenetic effects of green tea polyphenols in cancer. Epigenomics. 2013; 5(6):729-741.
    • (2013) Epigenomics , vol.5 , Issue.6 , pp. 729-741
    • Henning, S.1    Wang, P.2    Carpenter, C.3    Heber, D.4
  • 37
    • 77956834462 scopus 로고    scopus 로고
    • Autophagy: a potential link between obesity and insulin resistance
    • Codogno P MA. Autophagy: a potential link between obesity and insulin resistance. Cell Metab. 2010; 11:449-451.
    • (2010) Cell Metab , vol.11 , pp. 449-451
    • Codogno, P.M.A.1
  • 38
    • 77956400005 scopus 로고    scopus 로고
    • Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
    • Yang L, Li P, Fu S, Calay ES, GS H. Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance. Cell Metab. 2010; 11:467-478.
    • (2010) Cell Metab , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 39
    • 71449091240 scopus 로고    scopus 로고
    • autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin
    • Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi J, Liu Z, W C. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem. 2009; 284:31484-31492.
    • (2009) J Biol Chem , vol.284 , pp. 31484-31492
    • Liu, H.Y.1    Han, J.2    Cao, S.Y.3    Hong, T.4    Zhuo, D.5    Shi, J.6    Liu, Z.7    Hepatic, W.C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.