If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

Aging

Volumn 3, Issue 2, 2011, Pages 148-157

  Anisimov, Vladimir N ^a   Berstein, Lev M ^a   Popovich, Irina G ^a   Zabezhinski, Mark A ^a   Egormin, Peter A ^a   Piskunova, Tatiana S ^a   Semenchenko, Anna V ^a   Tyndyk, Margarita L ^a   Yurova, Maria N ^a   Kovalenko, Irina G ^a   Poroshina, Tatiana E ^a  

^a N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

Author keywords

Age of initiation; Biomarkers of aging; Life extension; Metformin; Mice; Spontaneous carcinogenesis

Indexed keywords

ANTIDIABETIC AGENT; METFORMIN;

AGE; ANIMAL; ARTICLE; BODY TEMPERATURE; BODY WEIGHT; DRINKING; DRUG EFFECT; EATING; ESTRUS CYCLE; FEMALE; HUMAN; LIFE EXPECTANCY; LONGEVITY; MOUSE; NEOPLASM; PATHOLOGY; PHYSIOLOGY;

AGE FACTORS; ANIMALS; BODY TEMPERATURE; BODY WEIGHT; DRINKING; EATING; ESTROUS CYCLE; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; LIFE EXPECTANCY; LONGEVITY; METFORMIN; MICE; NEOPLASMS;

EID: 79959564452     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100273     Document Type: Article

References (48)

1. Bartke A, Chandrashekar V, Dominici F, Turyn D, Kinney B, Steger R, Kopchick H. Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights. Biogerontology 2003; 4: 1-8.
2. Facchini FS, Hua NW, Reaven GM, Stoohs RA. Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? Free Radicals Biol Med 2000; 29: 1302-1306.
3. Dilman VM. Development, Aging and Disease. A New Rationale for an Intervention. Chur: Harwood Academic Publ 1994.
4. Gupta K, Krishnaswamy G, Karnad A, Peiris AN. Insulin: a novel factor in carcinogenesis. Am J Med Sci 2002; 323: 140-145.
5. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D. Diabetes and cancer: a consensus report. CA Cancer J Clin. 2010; 60:207-221.
6. Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Floyd RA, Halter JB, Ramsey JJ, Richardson A, Roth GS, Spindler SR. Caloric restriction mimetics: metabolic intervention. J Gerontol Biol Sci 2001; 56A, Special Issue 1: 20-33.
7. Ingram DK, Zhu M, Mamczarz J, Zou S, Lane MA, Roth GS, deCabo R. Calorie restriction mimetics: an emerging research field. Aging Cell 2006; 5: 97-108.
8. Dilman VM. Age-associated elevation of hypothalamic threshold to feedback control and its role in development, aging and disease. Lancet 1971; 1: 1211-9.
9. Dilman VM, Anisimov VN. Effect of treatment with phenformin, dyphenylhydantoin or L-DOPA on life span and tumor incidence in C3H/Sn mice. Gerontology 1980; 26: 241-245.
10. Anisimov VN, Semenchenko AV, Yashin AI. Insulin and longevity: antidiabetic biguanides as geroprotectors. Biogerontology 2003; 4: 297-307.
11. Anisimov VN. Metformin for aging and cancer prevention. Aging 2010; 2: 760-774.
12. Blagosklonny MV. Aging and immortality. Quasiprogrammed senescence and its phamacological inhibition. Cell Cycle 2006; 5:2087-2102.
13. Blagosklonny MV, An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Discovery Today 2007; 12: 218-224.
14. Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging 2009; 1:281-8.
15. Dilman VM, Berstein LM, Yevtushenko TP, Tsyrlina YV, Ostroumova MN, Bobrov YuF, Revskoy SYu, Kovalenko IG, Simonov NN. Preliminary evidence on metabolic rehabilitation of cancer patients. Arch Geschwulstforsch. 1988; 58: 175-183.
16. Berstein LM. Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer. Cancer Lett 2005; 224: 203-212.
17. Berstein LM. Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond. Future Oncol 2010; 6:1313-23.
18. Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Kovalenko IG, Poroshina TE, Semenchenko AV, Provinciali M, Re F, Franceschi C. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol 2005; 40:685-93.
19. Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Yurova MN, Kovalenko IG, Poroshina TE, Semenchenko AV. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle 2008; 7:2769-73.
20. Anisimov VN, Egormin PA, Piskunova TS, Popovich IG, Tyndyk ML, Yurova MV, Zabezhinski MA, Anikin IV, Karkach AS, Romanyukha AA. Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo. Cell Cycle 2010; 9: 188-197.
21. Anisimov VN, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Egormin PA, Yurova MN, Semenchenko AV, Kovalenko IG, Poroshina TE, Berstein LM. Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. Aging 2011; 2:945-958.
22. Flurkey R, Astle CA, Harrison DE. Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogenous mice. J Gerontol Biol Sci Med Sci 2010; 65A:1275-1284.
23. Weindruch R. Caloric restriction and aging. Sci Am 1996; 274: 46-52.
24. Anisimov VN. Effect of buformin and diphenylhydantoin on life span, estrus function and spontaneous tumor incidence in female rats. Vopr Onkol 1980; 26(6):42-48.
25. Dilman VM, and Anisimov VN. Hypothalamic mechanisms of ageing and of specific age pathology - I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system. Exp Gerontol 1979; 14: 161-174.
26. Awartani KA, Cheung AP. Metformin and polycystic ovary syndrome: a literature review. J Obstet Gynecol Can 2002; 24: 393-401.
27. Weindruch R., Kayo T, Lee C-K, Prolla TA. Microarray profiling of gene expression in aging and ist alteration by caloric restriction in mice. J Nutr 2001;131:918S-923S.
28. Weindruch R, Walford RL. The retardation of aging and disease by dietary restriction. Springfield, Ill.: Thomas, 1988.
29. Kirpichnikov D., McFarlane SI, Sowers JR. Metformin: an update. Ann Intern Med 2002; 137:25-33.
30. Lipman RD, Smith DE, Blumberg JB, Bronson RT. Effects of caloric restriction or augmentation in adult rats: longevity and lesion biomarkers of aging. Aging Clin Exp Res. 1998; 10: 463-470.
31. Lipman RD, Smith DE, Bronson RT, Blumberg JB. Is the latelife caloric restriction beneficial? Aging Clin Exp Res. 2005; 7; 126-129.
32. Dhahbi JM, Kim H-J, Mote PL, Beaver RJ, Spindler SR. Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci USA. 2004; 101:5524-5529.
33. Masoro EJ. Overview of caloric restriction and aging. Mech Ageing Dev 2005; 16: 913-922.
34. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009; 460: 392-396.
35. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2011; 66:191-201.
36. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005; 330:1304-1305.
37. Martin-Castillo B, Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Metformin and cancer. Doses, mechanisms and the dandelion and hermetic phenomena. Cell Cycle 2010; 9: 1057-1064.
38. Arkadieva AV, Mamonov AA, Popovich IG, Anisimov VN, Mikhelson VM, Spivak IM. Metformin slow down ageing processes at the cellular level in SHR mice. Tsitologia 2011; 53: 166-173.
39. Pospelova TV, Demidenko ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle 2009; 8: 4112-4118.
40. Wang C, Maddick M, Miwa S, Jurk D, Czapiewski R, Saretzki G, Langie SA, Godschalk RW, Cameron K, von Zglinicki T. Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging 2010; 2: 555-566.
41. Anisimov VN, Khavinson VKh. Effect of polypeptide pineal preparation on life span and spontaneous tumor incidence in the elderly female rats. Dokl Akad Nauk SSSR 1991; 319:250-253.
42. Anisimov VN, Loktionov AS, Khavinson VKh, Morozov VG. Effect of low-molecular-weight factors of thymus and pineal gland on lifespan and spontaneous tumour development in female mice of different age. Mech Ageing Dev 1989; 19: 245-258.
43. Anisimov VN, Popovich IG, Zabezhinski MA, Methods of evaluating the effect of pharmacological drugs on aging and life span in mice. Methods Mol Biol 2007; 371: 227-236.
44. Turusov VS, Mohr U. (Eds) Pathology of Tumours in Laboratory Animals. Volume I. Tumours of the Mouse, 2nd ed. IARC Sci. Publ. 111. Lyon: IARC. 1994.
45. Goubler EV. Computing Methods of Pathology Analysis and Recognition. Leningrad: Meditsina. 1978.
46. Fletcher R. Practical Methods of Optimization, 2nd ed. New York: John Wiley & Sohn, 1987.
47. Davison AC, Hinkley DV. Bootstrap Methods and Their Application. Cambridge, England: Cambridge University Press, 1997.
48. Cox D. Regression models and life-tables (with discussion). J Royal Statistical Soc Series B (Methodological). 1972; 34:187-220.