Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Nature Communications

Volumn 7, Issue , 2016, Pages

  Yosef, Reut ^a   Pilpel, Noam ^a   Tokarsky Amiel, Ronit ^b   Biran, Anat ^a   Ovadya, Yossi ^a   Cohen, Snir ^a   Vadai, Ezra ^a   Dassa, Liat ^b   Shahar, Elisheva ^b   Condiotti, Reba ^b   Ben Porath, Ittai ^b   Krizhanovsky, Valery ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL W; PROTEIN BCL XL; ABT-737; ANTINEOPLASTIC AGENT; BCL2L1 PROTEIN, MOUSE; BCL2L2 PROTEIN, MOUSE; BIPHENYL DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; NITROPHENOL; PIPERAZINE DERIVATIVE; PROTEIN; PROTEIN BCL X; PROTEIN P53; SMALL INTERFERING RNA; SULFONAMIDE;

AGE; APOPTOSIS; CELLS AND CELL COMPONENTS; DNA; INHIBITION; MOLECULAR ANALYSIS; PATHOLOGY; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECTS; EPIDERMIS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; LUNG; MALE; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; BIPHENYL COMPOUNDS; CELL AGING; CELL LINE; CELL PROLIFERATION; DNA DAMAGE; EPIDERMIS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITROPHENOLS; PIPERAZINES; PRIMARY CELL CULTURE; PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SULFONAMIDES; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84963650460     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11190     Document Type: Article

References (47)

1. Salama, R., Sadaie, M., Hoare, M. and Narita, M. Cellular senescence and its effector programs. Genes Dev. 28, 99-114 (2014).
2. Munoz-Espin, D. and Serrano, M. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15, 482-496 (2014).
3. Campisi, J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 75, 685-705 (2013).
4. Kuilman, T., Michaloglou, C., Mooi, W. J. and Peeper, D. S. The essence of senescence. Genes Dev. 24, 2463-2479 (2010).
5. Krizhanovsky, V. et al. Senescence of activated stellate cells limits liver fibrosis. Cell 134, 657-667 (2008).
6. Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005).
7. Collado, M. et al. Tumour biology: senescence in premalignant tumours. Nature 436, 642 (2005).
8. Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005).
9. Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005).
10. Schmitt, C. A. et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109, 335-346 (2002).
11. Sagiv, A. and Krizhanovsky, V. Immunosurveillance of senescent cells: the bright side of the senescence program. Biogerontology 14, 617-628 (2013).
12. Ovadya, Y. and Krizhanovsky, V. Senescent cells: SASPected drivers of age-related pathologies. Biogerontology 15, 627-642 (2014).
13. Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. Y. and Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl Acad. Sci. USA 98, 12072-12077 (2001).
14. Baker, D. J. et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232-236 (2011).
15. Sagiv, A. et al. Granule exocytosis mediates immune surveillance of senescent cells. Oncogene 32, 1971-1977 (2013).
16. Wang, E. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res. 55, 2284-2292 (1995).
17. Sasaki, M., Kumazaki, T., Takano, H., Nishiyama, M. and Mitsui, Y. Senescent cells are resistant to death despite low Bcl-2 level. Mech. Ageing Dev. 122, 1695-1706 (2001).
18. Yip, K. W. and Reed, J. C. Bcl-2 family proteins and cancer. Oncogene 27, 6398-6406 (2008).
19. Cory, S., Huang, D. C. and Adams, J. M. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22, 8590-8607 (2003).
20. Azmi, A. S., Wang, Z., Philip, P. A., Mohammad, R. M. and Sarkar, F. H. Emerging Bcl-2 inhibitors for the treatment of cancer. Expert Opin. Emerg. Drugs 16, 59-70 (2011).
21. Zeitlin, B. D., Zeitlin, I. J. and Nor, J. E. Expanding circle of inhibition: smallmolecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents. J. Clin. Oncol. 26, 4180-4188 (2008).
22. Narita, M. et al. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126, 503-514 (2006).
23. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. and Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (1997).
24. Oltersdorf, T. et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435, 677-681 (2005).
25. Merino, D. et al. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood 119, 5807-5816 (2012).
26. Nguyen, M. et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc. Natl Acad. Sci. USA 104, 19512-19517 (2007).
27. Souers, A. J. et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 19, 202-208 (2013).
28. Haupt, Y., Maya, R., Kazaz, A. and Oren, M. Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299 (1997).
29. Holcik, M. and Sonenberg, N. Translational control in stress and apoptosis. Nat. Rev. Mol. Cell Biol. 6, 318-327 (2005).
30. Spriggs, K. A., Bushell, M. and Willis, A. E. Translational regulation of gene expression during conditions of cell stress. Mol. Cell 40, 228-237 (2010).
31. Marash, L. et al. DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis. Mol. Cell 30, 447-459 (2008).
32. Laplante, M. and Sabatini, D. M. mTOR signaling in growth control and disease. Cell 149, 274-293 (2012).
33. Yoon, A. et al. Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science 312, 902-906 (2006).
34. Weingarten-Gabbay, S. et al. The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA. Oncogene 33, 611-618 (2014).
35. Le, O. N. et al. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell 9, 398-409 (2010).
36. Tokarsky-Amiel, R. et al. Dynamics of senescent cell formation and retention revealed by p14ARF induction in the epidermis. Cancer Res. 73, 2829-2839 (2013).
37. Storer, M. et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 155, 1119-1130 (2013).
38. Munoz-Espin, D. et al. Programmed cell senescence during mammalian embryonic development. Cell 155, 1104-1118 (2013).
39. Chuprin, A. et al. Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes Dev. 27, 2356-2366 (2013).
40. Laberge, R. M. et al. MTOR regulates the pro-tumorigenic senescenceassociated secretory phenotype by promoting IL1A translation. Nat. Cell Biol. 17, 1049-1061 (2015).
41. Herranz, N. et al. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat. Cell Biol. 17, 1205-1217 (2015).
42. Chang, J. et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat. Med. 22, 78-83 (2016).
43. Zhu, Y. et al. The Achilles heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14, 644-658 (2015).
44. McCurrach, M. E. and Lowe, S. W. Methods for studying pro- and antiapoptotic genes in nonimmortal cells. Methods Cell Biol. 66, 197-227 (2001).
45. Biran, A. et al. Senescent cells communicate via intercellular protein transfer. Genes Dev. 29, 791-802 (2015).
46. Jensen, K. B., Driskell, R. R. and Watt, F. M. Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat. Protoc. 5, 898-911 (2010).
47. Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. and Toussaint, O. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat. Protoc. 4, 1798-1806 (2009).