Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

Ageing Research Reviews

Volumn 43, Issue , 2018, Pages 64-80

  Ong, Agnes L C ^a   Ramasamy, Thamil Selvee ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Cellular energy metabolism; Inflammation; Localisation of sirtuins; Pluripotency; Senescence; Sirtuins; Tumour promoter; Tumour suppressor

Indexed keywords

DNA; HISTONE DEACETYLASE INHIBITOR; METFORMIN; N [2 [3 (1 PIPERAZINYLMETHYL)IMIDAZO[2,1 B]THIAZOL 6 YL]PHENYL] 2 QUINOXALINECARBOXAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RESVERATROL; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTINOL; SIRTUIN 1; TRANSCRIPTION FACTOR E2F1; SIRT1 PROTEIN, HUMAN;

AGING; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CALORIC RESTRICTION; CARCINOGENESIS; CELL AGING; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOPLASM; DEACETYLATION; DEGENERATIVE DISEASE; DNA DAMAGE; DNA REPAIR; ENERGY METABOLISM; HUMAN; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; INFLAMMATION; MALIGNANT NEOPLASM; MAMMAL; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATIVE STRESS; POSITIVE FEEDBACK; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; CELL DIFFERENTIATION; GENE REGULATORY NETWORK; GENETICS; IMMUNOLOGY; METABOLISM; NEOPLASM; PHYSIOLOGY; TRANSCRIPTION INITIATION;

AGING; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELLULAR REPROGRAMMING; CELLULAR SENESCENCE; DNA DAMAGE; GENE REGULATORY NETWORKS; HUMANS; NEOPLASMS; SIRTUIN 1; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85042759885     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2018.02.004     Document Type: Review

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