Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: A regression and CART approach in the BELFRAIL study

Experimental Gerontology

Volumn 69, Issue , 2015, Pages 53-61

  Adriaensen, Wim ^a,b   Matheï, Catharina ^a   Vaes, Bert ^a,b   van Pottelbergh, Gijs ^a   Wallemacq, Pierre ^c   Degryse, Jean Marie ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Hospitalization; IL 6; Inflammaging; Mortality; Oldest old

Indexed keywords

C REACTIVE PROTEIN; EPIDERMAL GROWTH FACTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PREALBUMIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; BIOLOGICAL MARKER;

AGED; ARTICLE; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HOSPITALIZATION; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; POPULATION RESEARCH; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RISK ASSESSMENT; SMOKING; SURVIVAL RATE; VERY ELDERLY; AGING; BELGIUM; BLOOD; KAPLAN MEIER METHOD; PREDICTIVE VALUE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; STATISTICS AND NUMERICAL DATA;

AGED, 80 AND OVER; AGING; BELGIUM; BIOMARKERS; C-REACTIVE PROTEIN; COHORT STUDIES; FEMALE; HOSPITALIZATION; HUMANS; INFLAMMATION; INTERLEUKIN-6; KAPLAN-MEIER ESTIMATE; MALE; MORTALITY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS;

EID: 84935026487     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2015.06.005     Document Type: Article

References (54)

1. Adriaensen W., Mathei C., Vaes B., van Pottelbergh G., Wallemacq P., Degryse J.M. Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study. Age (Dordr.) 2014, 36:9723.
2. Adriaensen W., Mathei C., van Pottelbergh G., Vaes B., Legrand D., Wallemacq P., Degryse J.M. Significance of serum immune markers in identification of global functional impairment in the oldest old: cross-sectional results from the BELFRAIL study. Age (Dordr.) 2014, 36:457-467.
3. Akbaraly T., Hamer M., Ferrie J., Lowe G., Batty G., Hagger-Johnson G., Singh-Manoux A., Shipley M., Kivimäki M. Chronic inflammation as a determinant of future aging phenotypes. CMAJ 2013, 185:E763-770.
4. Alexandraki K., Piperi C., Kalofoutis C., Singh J., Alaveras A., Kalofoutis A. Inflammatory process in type 2 diabetes: the role of cytokines. Ann. N. Y. Acad. Sci. 2006, 1084:89-117.
5. Alley D., Crimmins E., Bandeen-Roche K., Guralnik J., Ferrucci L. Three-year change in inflammatory markers in elderly people and mortality: the Invecchiare in Chianti study. J. Am. Geriatr. Soc. 2007, 55:1801-1807.
6. Baune B.T., Rothermundt M., Ladwig K.H., Meisinger C., Berger K. Systemic inflammation (Interleukin 6) predicts all-cause mortality in men: results from a 9-year follow-up of the MEMO Study. Age (Dordr.) 2011, 33:209-217.
7. Beenakker K., Ling C., Meskers C., de Craen A., Stijnen T., Westendorp R., Maier A. Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state. Ageing Res. Rev. 2010, 9:431-436.
8. Beleigoli A.M., Boersma E., Diniz Mde F., Vidigal P.G., Lima-Costa M.F., Ribeiro A.L. C-reactive protein and B-type natriuretic peptide yield either a non-significant or a modest incremental value to traditional risk factors in predicting long-term overall mortality in older adults. PLoS One 2013, 8:e75809.
9. Boeckxstaens P., Vaes B., Legrand D., Dalleur O., De Sutter A., Degryse J. The relationship of multimorbidity with disability and frailty in the oldest patients: a cross-sectional analysis of three measures of multimorbidity in the BELFRAIL cohort. Eur. J. Gen. Pract. 2014, 1:1-6.
10. Boeckxstaens P., Vaes B., Legrand D., Dalleur O., De Sutter A., Degryse J. The relationship of multimorbidity with disability and frailty in the oldest patients: a cross-sectional analysis of three measures of multimorbidity in the BELFRAIL cohort. Eur. J. Gen. Pract. 2015, 21:39-44.
11. Boeckxstaens P., Vaes B., Van Pottelbergh G., De Sutter A., Legrand D., Adriaensen W., Mathei C., Dalleur O., Degryse J. Multimorbidity measures were poor predictors of adverse events in patients aged >/=80years: a prospective cohort study. J. Clin. Epidemiol. 2015, 68:220-227.
12. Cesari M., Penninx B.W., Newman A.B., Kritchevsky S.B., Nicklas B.J., Sutton-Tyrrell K., Rubin S.M., Ding J., Simonsick E.M., Harris T.B., Pahor M. Inflammatory markers and onset of cardiovascular events: results from the Health ABC Study. Circulation 2003, 108:2317-2322.
13. Cesari M., Penninx B.W.J.H., Newman A.B., Kritchevsky S.B., Nicklas B.J., Sutton-Tyrrell K., Tracy R.P., Rubin S.M., Harris T.B., Pahor M. Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). Am. J. Cardiol. 2003, 92:522-528.
14. Cesari M., Onder G., Zamboni V., Capoluongo E., Russo A., Bernabei R., Pahor M., Landi F. C-reactive protein and lipid parameters in older persons aged 80years and older. J. Nutr. Health Aging 2009, 13:587-593.
15. Charlson M., Pompei P., Ales K., MacKenzie C. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 1987, 40:373-383.
16. Conraads V., Bosmans J., Vrints C. Chronic heart failure: an example of a systemic chronic inflammatory disease resulting in cachexia. Int. J. Cardiol. 2002, 85:33-49.
17. Cushman M., Arnold A.M., Psaty B.M., Manolio T.A., Kuller L.H., Burke G.L., Polak J.F., Tracy R.P. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation 2005, 112:25-31.
18. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., Lanctot K.L. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67:446-457.
19. Erta M., Quintana A., Hidalgo J. Interleukin-6, a major cytokine in the central nervous system. Int. J. Biol. Sci. 2012, 8:1254-1266.
20. Fabbri E., An Y., Zoli M., Simonsick E.M., Guralnik J.M., Bandinelli S., Boyd C.M., Ferrucci L. Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers. J. Gerontol. A Biol. Sci. Med. Sci. 2015, 70:63-70.
21. Ferrucci L., Corsi A., Lauretani F., Bandinelli S., Bartali B., Taub D.D., Guralnik J.M., Longo D.L. The origins of age-related proinflammatory state. Blood 2005, 105:2294-2299.
22. Friedman E.M., Christ S.L., Mroczek D.K. Inflammation partially mediates the association of multimorbidity and functional limitations in a national sample of middle-aged and older adults: the MIDUS Study. J. Aging Health 2015, Feb 2. pii: 0898264315569453. [Epub ahead of print].
23. Giovannini S., Onder G., Liperoti R., Russo A., Carter C., Capoluongo E., Pahor M., Bernabei R., Landi F. Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals. J. Am. Geriatr. Soc. 2011, 59:1679-1685.
24. Harris T., Ferrucci L., Tracy R., Corti M., Wacholder S., Ettinger W.J., Heimovitz H., Cohen H., Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 1999, 106:506-512.
25. Jenny N.S., Yanez N.D., Psaty B.M., Kuller L.H., Hirsch C.H., Tracy R.P. Inflammation biomarkers and near-term death in older men. Am. J. Epidemiol. 2007, 165:684-695.
26. Joppa P., Petrasova D., Stancak B., Tkacova R. Systemic inflammation in patients with COPD and pulmonary hypertension. Chest 2006, 130:326-333.
27. Jylhä M., Paavilainen P., Lehtimäki T., Goebeler S., Karhunen P., Hervonen A., Hurme M. Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study. J. Gerontol. A: Biol. Med. Sci. 2007, 62:1016-1021.
28. Kalogeropoulos A., Georgiopoulou V., Psaty B.M., Rodondi N., Smith A.L., Harrison D.G., Liu Y., Hoffmann U., Bauer D.C., Newman A.B., Kritchevsky S.B., Harris T.B., Butler J. Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) Study. J. Am. Coll. Cardiol. 2010, 55:2129-2137.
29. Lauw F.N., Pajkrt D., Hack C.E., Kurimoto M., van Deventer S.J.H., van der Poll T. Proinflammatory effects of IL-10 during human endotoxemia. J. Immunol. 2000, 165:2783-2789.
30. Lee J.K., Bettencourt R., Brenner D., Le T.A., Barrett-Connor E., Loomba R. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo Study. PLoS One 2012, 7:e34218.
31. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
32. Lumley T., Diehr P., Emerson S., Chen L. The importance of the normality assumption in large public health data sets. Annu. Rev. Public Health 2002, 23:151-169.
33. Milman S., Atzmon G., Huffman D., Wan J., Crandall J., Cohen P., Barzilai N. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell 2014, 14(14):769-771. 10.1111/acel.12213.
34. Moreno Velásquez I., Arnlöv J., Leander K., Lind L., Gigante B., Carlsson A. Interleukin-8 is associated with increased total mortality in women but not in men-findings from a community-based cohort of elderly. Ann. Med. 2014, 10:1-6.
35. Munoz-Canoves P., Scheele C., Pedersen B.K., Serrano A.L. Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?. FEBS J. 2013, 280:4131-4148.
36. Newman A.B., Sachs M.C., Arnold A.M., Fried L.P., Kronmal R., Cushman M., Psaty B.M., Harris T.B., Robbins J.A., Burke G.L., Kuller L.H., Lumley T. Total and cause-specific mortality in the cardiovascular health study. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:1251-1261.
37. Oliver J., Bland L., Oettinger C., Arduino M., McAllister S., Aguero S., Favero M. Cytokine kinetics in an in vitro whole blood model following an endotoxin challenge. Lymphokine Cytokine Res. 1993, 12:115-120.
38. Pawelec G., Goldeck D., Derhovanessian E. Inflammation, ageing and chronic disease. Curr. Opin. Immunol. 2014, 29C:23-28.
39. Reuben D., Cheh A., Harris T., Ferrucci L., Rowe J., Tracy R., Seeman T. Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. J. Am. Geriatr. Soc. 2002, 50:638-644.
40. Ridker P., Rifai N., Stampfer M., Hennekens C. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000, 101:1767-1772.
41. Rodondi N., Marques-Vidal P., Butler J., Sutton-Tyrrell K., Cornuz J., Satterfield S., Harris T., Bauer D.C., Ferrucci L., Vittinghoff E., Newman A.B. Markers of atherosclerosis and inflammation for prediction of coronary heart disease in older adults. Am. J. Epidemiol. 2010, 171:540-549.
42. Roubenoff R., Parise H., Payette H., Abad L., D'Agostino R., Jacques P., Wilson P., Dinarello C., Harris T. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am. J. Med. 2003, 115:429-435.
43. Salanitro A.H., Ritchie C.S., Hovater M., Roth D.L., Sawyer P., Locher J.L., Bodner E., Brown C.J., Allman R.M. Inflammatory biomarkers as predictors of hospitalization and death in community-dwelling older adults. Arch. Gerontol. Geriatr. 2012, 54:e387-391.
44. Singh T., Newman A.B. Inflammatory markers in population studies of aging. Ageing Res. Rev. 2011, 10:319-329.
45. Slattery M.L., John E.M., Stern M.C., Herrick J., Lundgreen A., Giuliano A.R., Hines L., Baumgartner K.B., Torres-Mejia M., Wolff R.K. Associations with growth factor genes (FGF1, FGF2, PDGFB,FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: The Breast Cancer Health Disparities Study. Breast Cancer Res Treat 2013, 140(3). 10.1007/s10549-013-2644-5.
46. Speybroeck N. Classification and regression trees. Int. J. Public Health 2012, 57:243-246.
47. Stuart M., Baune B. Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: a systematic review of biomarker studies. Neurosci. Biobehav. Rev. 2014, 42C:93-115.
48. Sutherland E.R., Martin R.J. Airway inflammation in chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 2003, 112:819-827.
49. Tracy R., Lemaitre R., Psaty B., Ives D., Evans R., Cushman M., Meilahn E., Kuller L. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arterioscler. Thromb. Vasc. Biol. 1997, 17:1121-1127.
50. Vaes B., Pasquet A., Wallemacq P., Rezzoug N., Mekouar H., Olivier P.A., Legrand D., Mathei C., Van Pottelbergh G., Degryse J. The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium. BMC Geriatr. 2010, 10:39.
51. Varadhan R., Yao W., Matteini A., Beamer B., Xue Q., Yang H., Manwani B., Reiner A., Jenny N., Parekh N., Fallin M., Newman A., Bandeen-Roche K., Tracy R., Ferrucci L., Walston J. Simple biologically informed inflammatory index of two serum cytokines predicts 10year all-cause mortality in older adults. J. Gerontol. A: Biol. Med. Sci. 2014, 69:165-173.
52. Vasan R.S. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 2003, 107:1486-1491.
53. Walston J.D., Matteini A.M., Nievergelt C., Lange L.A., Fallin D.M., Barzilai N., Ziv E., Pawlikowska L., Kwok P., Cummings S.R., Kooperberg C., LaCroix A., Tracy R.P., Atzmon G., Lange E.M., Reiner A.P. Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Exp. Gerontol. 2009, 44:350-355.
54. Yang G., Rao L., Tian L., Cai X. An association between EGF and EGFR gene polymorphisms with gastric cancer in a Chinese Han population. Hepatogastroentrology. 2012, 59(120):2668-2671.