Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway

Oncotarget

Volumn 8, Issue 11, 2017, Pages 17475-17490

  Fan, Jingjing ^a   Yang, Xiaoqi ^a   Li, Jie ^a   Shu, Ziyang ^a   Dai, Jun ^a   Liu, Xingran ^a   Li, Biao ^b   Jia, Shaohui ^a   Kou, Xianjuan ^a   Yang, Yi ^a   Chen, Ning ^a  

^a WUHAN SPORTS UNIVERSITY   (China)

^b Jilin Sport University   (China)

Author keywords

AMPK FOXO3a signal pathway; Autophagy; D galactose; Exercise; Gerotarget; Spermindine

Indexed keywords

BECLIN 1; CASPASE 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MALONALDEHYDE; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; PROTEIN BAX; PROTEIN BCL 2; SPERMIDINE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; FOXO3 PROTEIN, MOUSE; GALACTOSE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXERCISE; GASTROCNEMIUS MUSCLE; MALE; MITOPHAGY; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; DISEASE MODEL; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY; TUNEL ASSAY; WESTERN BLOTTING;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD BOX PROTEIN O3; GALACTOSE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPERMIDINE;

EID: 85015168500     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.15728     Document Type: Article

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