-
1
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
L. Hayflick The limited in vitro lifetime of human diploid cell strains Exp. Cell Res. 37 1965 614 636
-
(1965)
Exp. Cell Res.
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
2
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
J. Campisi Aging, cellular senescence, and cancer Annu. Rev. Physiol. 75 2013 685 705
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
3
-
-
79951912532
-
Four faces of cellular senescence
-
F. Rodier, and J. Campisi Four faces of cellular senescence J. Cell Biol. 192 2011 547 556
-
(2011)
J. Cell Biol.
, vol.192
, pp. 547-556
-
-
Rodier, F.1
Campisi, J.2
-
4
-
-
84906847476
-
Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease
-
M. Kumar, W. Seeger, and R. Voswinckel Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease Am. J. Respir. Cell Mol. Biol. 51 2014 323 333
-
(2014)
Am. J. Respir. Cell Mol. Biol.
, vol.51
, pp. 323-333
-
-
Kumar, M.1
Seeger, W.2
Voswinckel, R.3
-
6
-
-
80855128461
-
Cellular senescence: a link between cancer and age-related degenerative disease?
-
J. Campisi, J.K. Andersen, P. Kapahi, and S. Melov Cellular senescence: a link between cancer and age-related degenerative disease? Semin. Cancer Biol. 21 2011 354 359
-
(2011)
Semin. Cancer Biol.
, vol.21
, pp. 354-359
-
-
Campisi, J.1
Andersen, J.K.2
Kapahi, P.3
Melov, S.4
-
7
-
-
84894102511
-
Enhanced proinflammatory state and autoimmune activation: a breakthrough to understanding chronic diseases
-
A. Onat, and G. Can Enhanced proinflammatory state and autoimmune activation: a breakthrough to understanding chronic diseases Curr. Pharm. Des. 20 2014 575 584
-
(2014)
Curr. Pharm. Des.
, vol.20
, pp. 575-584
-
-
Onat, A.1
Can, G.2
-
8
-
-
79955017452
-
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
-
A. Freund, C. Patil, K. Age, and J. Campisi p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype EMBO J. 30 2011 1536 1548
-
(2011)
EMBO J.
, vol.30
, pp. 1536-1548
-
-
Freund, A.1
Patil, C.2
Age, K.3
Campisi, J.4
-
9
-
-
84856209016
-
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
-
A. Salminen, A. Kauppinen, and K. Kaarniranta Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP) Cell. Signal. 24 2012 835 845
-
(2012)
Cell. Signal.
, vol.24
, pp. 835-845
-
-
Salminen, A.1
Kauppinen, A.2
Kaarniranta, K.3
-
10
-
-
84901649819
-
Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation
-
P. Wang, L. Han, H. Shen, P. Wang, C. Lv, G. Zhao, and et al. Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation Proc. Natl. Acad. Sci. U. S. A. 111 2014 7683 7688
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 7683-7688
-
-
Wang, P.1
Han, L.2
Shen, H.3
Wang, P.4
Lv, C.5
Zhao, G.6
-
11
-
-
80054789761
-
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
-
Y. Chien, C. Scuoppo, X. Wang, X. Fang, B. Balgley, J.E. Bolden, and et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity Genes Dev. 25 2011 2125 2136
-
(2011)
Genes Dev.
, vol.25
, pp. 2125-2136
-
-
Chien, Y.1
Scuoppo, C.2
Wang, X.3
Fang, X.4
Balgley, B.5
Bolden, J.E.6
-
12
-
-
70350125106
-
Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
-
A.V. Orjalo, D. Bhaumik, B.K. Gengler, G.K. Scott, and J. Campisi Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network Proc. Natl. Acad. Sci. U. S. A. 106 2009 17031 17036
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 17031-17036
-
-
Orjalo, A.V.1
Bhaumik, D.2
Gengler, B.K.3
Scott, G.K.4
Campisi, J.5
-
13
-
-
84881278255
-
C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ
-
C.J. Huggins, R. Malik, S. Lee, J. Salotti, S. Thomas, N. Martin, and et al. C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ Mol. Cell. Biol. 33 2013 3242 3258
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 3242-3258
-
-
Huggins, C.J.1
Malik, R.2
Lee, S.3
Salotti, J.4
Thomas, S.5
Martin, N.6
-
14
-
-
84883444868
-
IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence
-
E. Alexander, D.G. Hildebrand, A. Kriebs, K. Obermayer, M. Manz, O. Rothfuss, and et al. IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence J. Cell Sci. 126 2013 3738 3745
-
(2013)
J. Cell Sci.
, vol.126
, pp. 3738-3745
-
-
Alexander, E.1
Hildebrand, D.G.2
Kriebs, A.3
Obermayer, K.4
Manz, M.5
Rothfuss, O.6
-
15
-
-
14844293877
-
Positive and negative regulation of nuclear factor-κB-mediated transcription by IκB-ζ, an inducible nuclear protein
-
M. Motoyama, S. Yamazaki, A. Eto-Kimura, K. Takeshige, and T. Muta Positive and negative regulation of nuclear factor-κB-mediated transcription by IκB-ζ, an inducible nuclear protein J. Biol. Chem. 280 2005 7444 7451
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7444-7451
-
-
Motoyama, M.1
Yamazaki, S.2
Eto-Kimura, A.3
Takeshige, K.4
Muta, T.5
-
16
-
-
84876786104
-
IκBζ is a transcriptional key regulator of CCL2/MCP-1
-
D.G. Hildebrand, E. Alexander, S. Hörber, S. Lehle, K. Obermayer, N.A. Münck, and et al. IκBζ is a transcriptional key regulator of CCL2/MCP-1 J. Immunol. 190 2013 4812 4820
-
(2013)
J. Immunol.
, vol.190
, pp. 4812-4820
-
-
Hildebrand, D.G.1
Alexander, E.2
Hörber, S.3
Lehle, S.4
Obermayer, K.5
Münck, N.A.6
-
17
-
-
34547467781
-
Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation
-
S. Matsuo, S. Yamazaki, K. Takeshige, and T. Muta Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation Biochem. J. 405 2007 605 615
-
(2007)
Biochem. J.
, vol.405
, pp. 605-615
-
-
Matsuo, S.1
Yamazaki, S.2
Takeshige, K.3
Muta, T.4
-
18
-
-
0033637140
-
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer
-
E. Middleton Jr., C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol. Rev. 52 2000 673 751
-
(2000)
Pharmacol. Rev.
, vol.52
, pp. 673-751
-
-
Middleton, E.1
Kandaswami, C.2
Theoharides, T.C.3
-
19
-
-
77956650041
-
Luteolin enhances insulin sensitivity via activation of PPARγ transcriptional activity in adipocytes
-
L. Ding, D. Jin, and X. Chen Luteolin enhances insulin sensitivity via activation of PPARγ transcriptional activity in adipocytes J. Nutr. Biochem. 21 2010 941 947
-
(2010)
J. Nutr. Biochem.
, vol.21
, pp. 941-947
-
-
Ding, L.1
Jin, D.2
Chen, X.3
-
20
-
-
84861865625
-
Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment
-
A. Csiszar, D. Sosnowska, M. Wang, E.G. Lakatta, W.E. Sonntag, and Z. Ungvari Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment J. Gerontol. A: Biol. Sci. Med. Sci. 67 2012 811 820
-
(2012)
J. Gerontol. A: Biol. Sci. Med. Sci.
, vol.67
, pp. 811-820
-
-
Csiszar, A.1
Sosnowska, D.2
Wang, M.3
Lakatta, E.G.4
Sonntag, W.E.5
Ungvari, Z.6
-
21
-
-
10944235044
-
Anti-inflammatory plant flavonoids and cellular action mechanisms
-
H.P. Kim, K.H. Son, H.W. Chang, and S.S. Kang Anti-inflammatory plant flavonoids and cellular action mechanisms J. Pharmacol. Sci. 96 2004 229 245
-
(2004)
J. Pharmacol. Sci.
, vol.96
, pp. 229-245
-
-
Kim, H.P.1
Son, K.H.2
Chang, H.W.3
Kang, S.S.4
-
22
-
-
84875145418
-
Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts
-
V. Pitozzi, A. Mocali, A. Laurenzana, E. Giannoni, I. Cifola, C. Battaglia, and et al. Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts J. Gerontol. A: Biol. Sci. Med. Sci. 68 2013 371 381
-
(2013)
J. Gerontol. A: Biol. Sci. Med. Sci.
, vol.68
, pp. 371-381
-
-
Pitozzi, V.1
Mocali, A.2
Laurenzana, A.3
Giannoni, E.4
Cifola, I.5
Battaglia, C.6
-
23
-
-
77953019948
-
Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase
-
J.M. Kim, E.K. Lee, D.H. Kim, B.P. Yu, and H.Y. Chung Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase Age (Dordr.) 32 2010 197 208
-
(2010)
Age (Dordr.)
, vol.32
, pp. 197-208
-
-
Kim, J.M.1
Lee, E.K.2
Kim, D.H.3
Yu, B.P.4
Chung, H.Y.5
-
24
-
-
84861455323
-
PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney
-
H.A. Lim, E.K. Lee, J.M. Kim, M.H. Park, D.H. Kim, Y.J. Choi, and et al. PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney Biogerontology 13 2012 133 145
-
(2012)
Biogerontology
, vol.13
, pp. 133-145
-
-
Lim, H.A.1
Lee, E.K.2
Kim, J.M.3
Park, M.H.4
Kim, D.H.5
Choi, Y.J.6
-
25
-
-
0033071142
-
Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants
-
K.M. You, H.G. Jong, and H.P. Kim Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants Arch. Pharm. Res. 22 1999 18 24
-
(1999)
Arch. Pharm. Res.
, vol.22
, pp. 18-24
-
-
You, K.M.1
Jong, H.G.2
Kim, H.P.3
-
26
-
-
30444451470
-
Synthesis and PGE2 inhibitory activity of 5,7-dihydroxyflavones and their O-methylated flavone analogs
-
T.T. Dao, Y.S. Chi, J. Kim, H.P. Kim, S. Kim, and H. Park Synthesis and PGE2 inhibitory activity of 5,7-dihydroxyflavones and their O-methylated flavone analogs Arch. Pharm. Res. 26 2003 345 350
-
(2003)
Arch. Pharm. Res.
, vol.26
, pp. 345-350
-
-
Dao, T.T.1
Chi, Y.S.2
Kim, J.3
Kim, H.P.4
Kim, S.5
Park, H.6
-
27
-
-
80052918619
-
A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production
-
H. Che, H. Lim, H.P. Kim, and H. Park A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production Eur. J. Med. Chem. 46 2011 4657 4660
-
(2011)
Eur. J. Med. Chem.
, vol.46
, pp. 4657-4660
-
-
Che, H.1
Lim, H.2
Kim, H.P.3
Park, H.4
-
28
-
-
84864010194
-
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
-
R.M. Laberge, L. Zhou, M.R. Sarantos, F. Rodier, A. Freund, P.L. de Keizer, and et al. Glucocorticoids suppress selected components of the senescence-associated secretory phenotype Aging Cell 11 2012 569 578
-
(2012)
Aging Cell
, vol.11
, pp. 569-578
-
-
Laberge, R.M.1
Zhou, L.2
Sarantos, M.R.3
Rodier, F.4
Freund, A.5
De Keizer, P.L.6
-
29
-
-
84892406525
-
Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation
-
J.H. Lee, H. Lim, O. Shehzad, Y.S. Kim, and H.P. Kim Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation Eur. J. Pharmacol. 724 2014 145 151
-
(2014)
Eur. J. Pharmacol.
, vol.724
, pp. 145-151
-
-
Lee, J.H.1
Lim, H.2
Shehzad, O.3
Kim, Y.S.4
Kim, H.P.5
-
30
-
-
84863208596
-
SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
-
C. Canino, F. Mori, A. Cambria, A. Diamantini, S. Germoni, G. Alessandrini, and et al. SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells Oncogene 31 2012 3148 3163
-
(2012)
Oncogene
, vol.31
, pp. 3148-3163
-
-
Canino, C.1
Mori, F.2
Cambria, A.3
Diamantini, A.4
Germoni, S.5
Alessandrini, G.6
-
31
-
-
25644444396
-
Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2′,4′,7-trimethoxyflavone and cellular action mechanism
-
C.K. Han, M.J. Son, H.W. Chang, Y.S. Chi, H. Park, and H.P. Kim Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2′,4′,7-trimethoxyflavone and cellular action mechanism Biol. Pharm. Bull. 28 2005 1366 1370
-
(2005)
Biol. Pharm. Bull.
, vol.28
, pp. 1366-1370
-
-
Han, C.K.1
Son, M.J.2
Chang, H.W.3
Chi, Y.S.4
Park, H.5
Kim, H.P.6
-
32
-
-
80755189987
-
New synthetic anti-inflammatory chrysin analog, 5,7-dihydroxy-8-(pyridine-4yl)flavone
-
H. Lim, J.H. Jin, H. Park, and H.P. Kim New synthetic anti-inflammatory chrysin analog, 5,7-dihydroxy-8-(pyridine-4yl)flavone Eur. J. Pharmacol. 670 2011 617 622
-
(2011)
Eur. J. Pharmacol.
, vol.670
, pp. 617-622
-
-
Lim, H.1
Jin, J.H.2
Park, H.3
Kim, H.P.4
-
33
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
F. Rodier, J.P. Coppé, C.K. Patil, W.A. Hoeijmakers, D.P. Muñoz, S.R. Raza, and et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion Nat. Cell Biol. 11 2009 973 979
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppé, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Muñoz, D.P.5
Raza, S.R.6
-
34
-
-
84877822086
-
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
-
O. Moiseeva, X. Deschênes-Simard, E. St-Germain, S. Igelmann, G. Huot, A.E. Cadar, and et al. Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation Aging Cell 12 2013 489 498
-
(2013)
Aging Cell
, vol.12
, pp. 489-498
-
-
Moiseeva, O.1
Deschênes-Simard, X.2
St-Germain, E.3
Igelmann, S.4
Huot, G.5
Cadar, A.E.6
-
35
-
-
67949110955
-
Nuclear protein IκB-ζ inhibits the activity of STAT3
-
Z. Wu, X. Zhang, J. Yang, G. Wu, Y. Zhang, Y. Yuan, and et al. Nuclear protein IκB-ζ inhibits the activity of STAT3 Biochem. Biophys. Res. Commun. 387 2009 348 352
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.387
, pp. 348-352
-
-
Wu, Z.1
Zhang, X.2
Yang, J.3
Wu, G.4
Zhang, Y.5
Yuan, Y.6
-
36
-
-
84855470274
-
Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ
-
T. Ohba, Y. Ariga, T. Maruyama, N.K. Truong, J. Inoue, and T. Muta Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ FEBS J. 279 2012 211 222
-
(2012)
FEBS J.
, vol.279
, pp. 211-222
-
-
Ohba, T.1
Ariga, Y.2
Maruyama, T.3
Truong, N.K.4
Inoue, J.5
Muta, T.6
-
37
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, and et al. Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 2006 337 342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
-
38
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
J.G. Wood, B. Rogina, S. Lavu, K. Howitz, S.L. Helfand, M. Tatar, and et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 2004 686 689
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
Helfand, S.L.5
Tatar, M.6
-
39
-
-
67649518873
-
The anti-inflammatory effect of kaempferol in aged kidney tissues: the involvement of nuclear factor-κB via nuclear factor-inducing kinase/IκB kinase and mitogen-activated protein kinase pathways
-
M.J. Park, E.K. Lee, H.S. Heo, M.S. Kim, B. Sung, M.K. Kim, and et al. The anti-inflammatory effect of kaempferol in aged kidney tissues: the involvement of nuclear factor-κB via nuclear factor-inducing kinase/IκB kinase and mitogen-activated protein kinase pathways J. Med. Food 12 2009 351 358
-
(2009)
J. Med. Food
, vol.12
, pp. 351-358
-
-
Park, M.J.1
Lee, E.K.2
Heo, H.S.3
Kim, M.S.4
Sung, B.5
Kim, M.K.6
-
40
-
-
9744242794
-
Dietary flavonoids and cancer risk: evidence from human population studies
-
M.L. Neuhouser Dietary flavonoids and cancer risk: evidence from human population studies Nutr. Cancer 50 2004 1 7
-
(2004)
Nutr. Cancer
, vol.50
, pp. 1-7
-
-
Neuhouser, M.L.1
-
41
-
-
84856370253
-
Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults
-
M.L. McCullough, J.J. Peterson, R. Patel, P.F. Jacques, R. Shah, and J.T. Dwyer Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults Am. J. Clin. Nutr. 95 2012 454 464
-
(2012)
Am. J. Clin. Nutr.
, vol.95
, pp. 454-464
-
-
McCullough, M.L.1
Peterson, J.J.2
Patel, R.3
Jacques, P.F.4
Shah, R.5
Dwyer, J.T.6
-
42
-
-
1842290326
-
Dietary flavonoids and the risk of lung cancer and other malignant neoplasms
-
P. Knekt, R. Järvinen, R. Seppänen, M. Hellövaara, L. Teppo, E. Pukkala, and et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms Am. J. Epidemiol. 146 1997 223 230
-
(1997)
Am. J. Epidemiol.
, vol.146
, pp. 223-230
-
-
Knekt, P.1
Järvinen, R.2
Seppänen, R.3
Hellövaara, M.4
Teppo, L.5
Pukkala, E.6
-
43
-
-
0027983625
-
Dietary flavonoids and cancer risk in the Zutphen Elderly Study
-
M.G. Hertog, E.J. Feskens, P.C. Hollman, M.B. Katan, and D. Kromhout Dietary flavonoids and cancer risk in the Zutphen Elderly Study Nutr. Cancer 22 1994 175 184
-
(1994)
Nutr. Cancer
, vol.22
, pp. 175-184
-
-
Hertog, M.G.1
Feskens, E.J.2
Hollman, P.C.3
Katan, M.B.4
Kromhout, D.5
-
44
-
-
84883287472
-
Higher dietary flavonol intake is associated with lower incidence of type 2 diabetes
-
P.F. Jacques, A. Cassidy, G. Rogers, J.J. Peterson, J.B. Meigs, and J.T. Dwyer Higher dietary flavonol intake is associated with lower incidence of type 2 diabetes J. Nutr. 143 2013 1474 1480
-
(2013)
J. Nutr.
, vol.143
, pp. 1474-1480
-
-
Jacques, P.F.1
Cassidy, A.2
Rogers, G.3
Peterson, J.J.4
Meigs, J.B.5
Dwyer, J.T.6
|