-
1
-
-
44649120132
-
Chemokine signaling via the CXCR2 receptor reinforces senescence
-
Acosta, J.C., O'Loghlen, A., Banito, A., Guijarro, M.V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., Takatsu, Y., Melamed, J., d'Adda di Fagagna, F., Bernard, D., Hernando, E., Gil, J., Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133 (2008), 1006–1018.
-
(2008)
Cell
, vol.133
, pp. 1006-1018
-
-
Acosta, J.C.1
O'Loghlen, A.2
Banito, A.3
Guijarro, M.V.4
Augert, A.5
Raguz, S.6
Fumagalli, M.7
Da Costa, M.8
Brown, C.9
Popov, N.10
Takatsu, Y.11
Melamed, J.12
d'Adda di Fagagna, F.13
Bernard, D.14
Hernando, E.15
Gil, J.16
-
2
-
-
12944289732
-
Ageing and plasma adiponectin concentration in apparently healthy males and females
-
Adamczak, M., Rzepka, E., Chudek, J., Wiecek, A., Ageing and plasma adiponectin concentration in apparently healthy males and females. Clin. Endocrinol. (Oxf.) 62 (2005), 114–118.
-
(2005)
Clin. Endocrinol. (Oxf.)
, vol.62
, pp. 114-118
-
-
Adamczak, M.1
Rzepka, E.2
Chudek, J.3
Wiecek, A.4
-
3
-
-
84878867338
-
Detection of senescence-associated heterochromatin foci (SAHF)
-
Aird, K.M., Zhang, R., Detection of senescence-associated heterochromatin foci (SAHF). Methods Mol. Biol. 965 (2013), 185–196.
-
(2013)
Methods Mol. Biol.
, vol.965
, pp. 185-196
-
-
Aird, K.M.1
Zhang, R.2
-
4
-
-
13844298645
-
Gene expression profile of long-lived ames dwarf mice and little mice
-
Amador-Noguez, D., Yagi, K., Venable, S., Darlington, G., Gene expression profile of long-lived ames dwarf mice and little mice. Aging Cell 3 (2004), 423–441.
-
(2004)
Aging Cell
, vol.3
, pp. 423-441
-
-
Amador-Noguez, D.1
Yagi, K.2
Venable, S.3
Darlington, G.4
-
5
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
-
Baker, D.J., Wijshake, T., Tchkonia, T., LeBrasseur, N.K., Childs, B.G., van de Sluis, B., Kirkland, J.L., van Deursen, J.M., Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479 (2011), 232–236.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
LeBrasseur, N.K.4
Childs, B.G.5
van de Sluis, B.6
Kirkland, J.L.7
van Deursen, J.M.8
-
6
-
-
84958093401
-
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
-
Baker, D.J., Childs, B.G., Durik, M., Wijers, M.E., Sieben, C.J., Zhong, J., Saltness, R.A., Jeganathan, K.B., Verzosa, G.C., Pezeshki, A., Khazaie, K., Miller, J.D., van Deursen, J.M., Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 530 (2016), 184–189.
-
(2016)
Nature
, vol.530
, pp. 184-189
-
-
Baker, D.J.1
Childs, B.G.2
Durik, M.3
Wijers, M.E.4
Sieben, C.J.5
Zhong, J.6
Saltness, R.A.7
Jeganathan, K.B.8
Verzosa, G.C.9
Pezeshki, A.10
Khazaie, K.11
Miller, J.D.12
van Deursen, J.M.13
-
7
-
-
77950462015
-
Lack of p21 expression links cell cycle control and appendage regeneration in mice
-
Bedelbaeva, K., Snyder, A., Gourevitch, D., Clark, L., Zhang, X.M., Leferovich, J., Cheverud, J.M., Lieberman, P., Heber-Katz, E., Lack of p21 expression links cell cycle control and appendage regeneration in mice. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 5845–5850.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 5845-5850
-
-
Bedelbaeva, K.1
Snyder, A.2
Gourevitch, D.3
Clark, L.4
Zhang, X.M.5
Leferovich, J.6
Cheverud, J.M.7
Lieberman, P.8
Heber-Katz, E.9
-
8
-
-
84896892826
-
In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells
-
Berkenkamp, B., Susnik, N., Baisantry, A., Kuznetsova, I., Jacobi, C., Sorensen-Zender, I., Broecker, V., Haller, H., Melk, A., Schmitt, R., In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS One, 9, 2014, e88071.
-
(2014)
PLoS One
, vol.9
, pp. e88071
-
-
Berkenkamp, B.1
Susnik, N.2
Baisantry, A.3
Kuznetsova, I.4
Jacobi, C.5
Sorensen-Zender, I.6
Broecker, V.7
Haller, H.8
Melk, A.9
Schmitt, R.10
-
9
-
-
34547924424
-
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
-
Brack, A.S., Conboy, M.J., Roy, S., Lee, M., Kuo, C.J., Keller, C., Rando, T.A., Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317 (2007), 807–810.
-
(2007)
Science
, vol.317
, pp. 807-810
-
-
Brack, A.S.1
Conboy, M.J.2
Roy, S.3
Lee, M.4
Kuo, C.J.5
Keller, C.6
Rando, T.A.7
-
10
-
-
84910020575
-
Both low and high serum IGF-1 levels associate with increased risk of cardiovascular events in elderly men
-
Carlzon, D., Svensson, J., Petzold, M., Karlsson, M.K., Ljunggren, O., Tivesten, A., Mellstrom, D., Ohlsson, C., Both low and high serum IGF-1 levels associate with increased risk of cardiovascular events in elderly men. J. Clin. Endocrinol. Metab. 99 (2014), E2308–16.
-
(2014)
J. Clin. Endocrinol. Metab.
, vol.99
, pp. E2308-16
-
-
Carlzon, D.1
Svensson, J.2
Petzold, M.3
Karlsson, M.K.4
Ljunggren, O.5
Tivesten, A.6
Mellstrom, D.7
Ohlsson, C.8
-
11
-
-
84941316442
-
Cellular senescence and the aging brain
-
Chinta, S.J., Woods, G., Rane, A., Demaria, M., Campisi, J., Andersen, J.K., Cellular senescence and the aging brain. Exp. Gerontol. 68 (2015), 3–7.
-
(2015)
Exp. Gerontol.
, vol.68
, pp. 3-7
-
-
Chinta, S.J.1
Woods, G.2
Rane, A.3
Demaria, M.4
Campisi, J.5
Andersen, J.K.6
-
12
-
-
84937955226
-
Sirtuin 1 and aging theory for chronic obstructive pulmonary disease
-
Conti, V., Corbi, G., Manzo, V., Pelaia, G., Filippelli, A., Vatrella, A., Sirtuin 1 and aging theory for chronic obstructive pulmonary disease. Anal. Cell. Pathol. (Amst)., 2015, 2015, 897327.
-
(2015)
Anal. Cell. Pathol. (Amst).
, vol.2015
, pp. 897327
-
-
Conti, V.1
Corbi, G.2
Manzo, V.3
Pelaia, G.4
Filippelli, A.5
Vatrella, A.6
-
13
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe, J.P., Patil, C.K., Rodier, F., Sun, Y., Munoz, D.P., Goldstein, J., Nelson, P.S., Desprez, P.Y., Campisi, J., Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6 (2008), 2853–2868.
-
(2008)
PLoS Biol.
, vol.6
, pp. 2853-2868
-
-
Coppe, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Munoz, D.P.5
Goldstein, J.6
Nelson, P.S.7
Desprez, P.Y.8
Campisi, J.9
-
14
-
-
84878619211
-
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
-
Davalos, A.R., Kawahara, M., Malhotra, G.K., Schaum, N., Huang, J., Ved, U., Beausejour, C.M., Coppe, J.P., Rodier, F., Campisi, J., p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J. Cell Biol. 201 (2013), 613–629.
-
(2013)
J. Cell Biol.
, vol.201
, pp. 613-629
-
-
Davalos, A.R.1
Kawahara, M.2
Malhotra, G.K.3
Schaum, N.4
Huang, J.5
Ved, U.6
Beausejour, C.M.7
Coppe, J.P.8
Rodier, F.9
Campisi, J.10
-
15
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri, G.P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E.E., Linskens, M., Rubelj, I., Pereira-Smith, O., et, al., A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 92 (1995), 9363–9367.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
-
16
-
-
84901267951
-
Life extension factor klotho enhances cognition
-
Dubal, D.B., Yokoyama, J.S., Zhu, L., Broestl, L., Worden, K., Wang, D., Sturm, V.E., Kim, D., Klein, E., Yu, G.Q., Ho, K., Eilertson, K.E., Yu, L., Kuro-o, M., De Jager, P.L., Coppola, G., Small, G.W., Bennett, D.A., Kramer, J.H., Abraham, C.R., Miller, B.L., Mucke, L., Life extension factor klotho enhances cognition. Cell Rep. 7 (2014), 1065–1076.
-
(2014)
Cell Rep.
, vol.7
, pp. 1065-1076
-
-
Dubal, D.B.1
Yokoyama, J.S.2
Zhu, L.3
Broestl, L.4
Worden, K.5
Wang, D.6
Sturm, V.E.7
Kim, D.8
Klein, E.9
Yu, G.Q.10
Ho, K.11
Eilertson, K.E.12
Yu, L.13
Kuro-o, M.14
De Jager, P.L.15
Coppola, G.16
Small, G.W.17
Bennett, D.A.18
Kramer, J.H.19
Abraham, C.R.20
Miller, B.L.21
Mucke, L.22
more..
-
17
-
-
0033816629
-
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
-
Dulic, V., Beney, G.E., Frebourg, G., Drullinger, L.F., Stein, G.H., Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol. Cell. Biol. 20 (2000), 6741–6754.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6741-6754
-
-
Dulic, V.1
Beney, G.E.2
Frebourg, G.3
Drullinger, L.F.4
Stein, G.H.5
-
18
-
-
84902317419
-
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
-
Elabd, C., Cousin, W., Upadhyayula, P., Chen, R.Y., Chooljian, M.S., Li, J., Kung, S., Jiang, K.P., Conboy, I.M., Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat. Commun., 5, 2014, 4082.
-
(2014)
Nat. Commun.
, vol.5
, pp. 4082
-
-
Elabd, C.1
Cousin, W.2
Upadhyayula, P.3
Chen, R.Y.4
Chooljian, M.S.5
Li, J.6
Kung, S.7
Jiang, K.P.8
Conboy, I.M.9
-
19
-
-
0034051068
-
Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
-
Ershler, W.B., Keller, E.T., Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51 (2000), 245–270.
-
(2000)
Annu. Rev. Med.
, vol.51
, pp. 245-270
-
-
Ershler, W.B.1
Keller, E.T.2
-
20
-
-
16344363800
-
Altered proteasome structure, function, and oxidation in aged muscle
-
Ferrington, D.A., Husom, A.D., Thompson, L.V., Altered proteasome structure, function, and oxidation in aged muscle. FASEB J. 19 (2005), 644–646.
-
(2005)
FASEB J.
, vol.19
, pp. 644-646
-
-
Ferrington, D.A.1
Husom, A.D.2
Thompson, L.V.3
-
21
-
-
79951938474
-
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
-
Guevara-Aguirre, J., Balasubramanian, P., Guevara-Aguirre, M., Wei, M., Madia, F., Cheng, C.W., Hwang, D., Martin-Montalvo, A., Saavedra, J., Ingles, S., de Cabo, R., Cohen, P., Longo, V.D., Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci. Transl. Med., 3, 2011, 70ra13.
-
(2011)
Sci. Transl. Med.
, vol.3
, pp. 70ra13
-
-
Guevara-Aguirre, J.1
Balasubramanian, P.2
Guevara-Aguirre, M.3
Wei, M.4
Madia, F.5
Cheng, C.W.6
Hwang, D.7
Martin-Montalvo, A.8
Saavedra, J.9
Ingles, S.10
de Cabo, R.11
Cohen, P.12
Longo, V.D.13
-
22
-
-
84899045860
-
Testosterone supplementation improves anemia in aging male mice
-
Guo, W., Li, M., Bhasin, S., Testosterone supplementation improves anemia in aging male mice. J. Gerontol. A Biol. Sci. Med. Sci. 69 (2014), 505–513.
-
(2014)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.69
, pp. 505-513
-
-
Guo, W.1
Li, M.2
Bhasin, S.3
-
23
-
-
84949805385
-
Early shifts of brain metabolism by caloric restriction preserve white matter integrity and long-Term memory in aging mice
-
Guo, J., Bakshi, V., Lin, A.L., Early shifts of brain metabolism by caloric restriction preserve white matter integrity and long-Term memory in aging mice. Front. Aging Neurosci., 7, 2015, 213.
-
(2015)
Front. Aging Neurosci.
, vol.7
, pp. 213
-
-
Guo, J.1
Bakshi, V.2
Lin, A.L.3
-
24
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
Harding, H.P., Zhang, Y., Zeng, H., Novoa, I., Lu, P.D., Calfon, M., Sadri, N., Yun, C., Popko, B., Paules, R., Stojdl, D.F., Bell, J.C., Hettmann, T., Leiden, J.M., Ron, D., An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 11 (2003), 619–633.
-
(2003)
Mol. Cell
, vol.11
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
Sadri, N.7
Yun, C.8
Popko, B.9
Paules, R.10
Stojdl, D.F.11
Bell, J.C.12
Hettmann, T.13
Leiden, J.M.14
Ron, D.15
-
25
-
-
79957519364
-
Fibroblasts from long-lived bird species are resistant to multiple forms of stress
-
Harper, J.M., Wang, M., Galecki, A.T., Ro, J., Williams, J.B., Miller, R.A., Fibroblasts from long-lived bird species are resistant to multiple forms of stress. J. Exp. Biol. 214 (2011), 1902–1910.
-
(2011)
J. Exp. Biol.
, vol.214
, pp. 1902-1910
-
-
Harper, J.M.1
Wang, M.2
Galecki, A.T.3
Ro, J.4
Williams, J.B.5
Miller, R.A.6
-
26
-
-
78650758398
-
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
-
Herranz, D., Munoz-Martin, M., Canamero, M., Mulero, F., Martinez-Pastor, B., Fernandez-Capetillo, O., Serrano, M., Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat. Commun., 1, 2010, 3.
-
(2010)
Nat. Commun.
, vol.1
, pp. 3
-
-
Herranz, D.1
Munoz-Martin, M.2
Canamero, M.3
Mulero, F.4
Martinez-Pastor, B.5
Fernandez-Capetillo, O.6
Serrano, M.7
-
27
-
-
84928568835
-
IL-6 as a keystone cytokine in health and disease
-
Hunter, C.A., Jones, S.A., IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16 (2015), 448–457.
-
(2015)
Nat. Immunol.
, vol.16
, pp. 448-457
-
-
Hunter, C.A.1
Jones, S.A.2
-
28
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan, J.C., Ferreira, M., Sedivy, J.M., Herbig, U., Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 128 (2007), 36–44.
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
29
-
-
84941746180
-
Regenerative medicine. ‘Rejuvenating' protein doubted
-
Kaiser, J., Regenerative medicine. ‘Rejuvenating' protein doubted. Science, 348, 2015, 849.
-
(2015)
Science
, vol.348
, pp. 849
-
-
Kaiser, J.1
-
30
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., Cohen, H.Y., The sirtuin SIRT6 regulates lifespan in male mice. Nature 483 (2012), 218–221.
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
Naiman, S.2
Amir, G.3
Peshti, V.4
Zinman, G.5
Nahum, L.6
Bar-Joseph, Z.7
Cohen, H.Y.8
-
31
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy, J., Torrice, C., Ramsey, M.R., Kovalev, G.I., Al-Regaiey, K., Su, L., Sharpless, N.E., Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114 (2004), 1299–1307.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
32
-
-
58849154235
-
Senescence-messaging secretome: SMS-ing cellular stress
-
Kuilman, T., Peeper, D.S., Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer 9 (2009), 81–94.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 81-94
-
-
Kuilman, T.1
Peeper, D.S.2
-
33
-
-
42449087698
-
The GH-IGF1 axis and longevity: the paradigm of IGF1 deficiency
-
Laron, Z., The GH-IGF1 axis and longevity: the paradigm of IGF1 deficiency. Hormones (Athens). 7 (2008), 24–27.
-
(2008)
Hormones (Athens).
, vol.7
, pp. 24-27
-
-
Laron, Z.1
-
34
-
-
84855854046
-
Chronic kidney disease
-
Levey, A.S., Coresh, J., Chronic kidney disease. Lancet 379 (2012), 165–180.
-
(2012)
Lancet
, vol.379
, pp. 165-180
-
-
Levey, A.S.1
Coresh, J.2
-
35
-
-
84924134974
-
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice
-
Li, W., Miller, R.A., Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. J. Gerontol. A Biol. Sci. Med. Sci. 70 (2015), 263–272.
-
(2015)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.70
, pp. 263-272
-
-
Li, W.1
Miller, R.A.2
-
36
-
-
0031037294
-
Long-term caloric restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo
-
Li, Y., Yan, Q., Wolf, N.S., Long-term caloric restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo. Invest. Ophthalmol. Vis. Sci. 38 (1997), 100–107.
-
(1997)
Invest. Ophthalmol. Vis. Sci.
, vol.38
, pp. 100-107
-
-
Li, Y.1
Yan, Q.2
Wolf, N.S.3
-
37
-
-
84911393921
-
ATF4 activity: a common feature shared by many kinds of slow-aging mice
-
Li, W., Li, X., Miller, R.A., ATF4 activity: a common feature shared by many kinds of slow-aging mice. Aging Cell 13 (2014), 1012–1018.
-
(2014)
Aging Cell
, vol.13
, pp. 1012-1018
-
-
Li, W.1
Li, X.2
Miller, R.A.3
-
38
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin, A.W., Barradas, M., Stone, J.C., van Aelst, L., Serrano, M., Lowe, S.W., Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12 (1998), 3008–3019.
-
(1998)
Genes Dev.
, vol.12
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
39
-
-
84930088691
-
Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
-
Lin, A.L., Zhang, W., Gao, X., Watts, L., Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain. Neurobiol. Aging 36 (2015), 2296–2303.
-
(2015)
Neurobiol. Aging
, vol.36
, pp. 2296-2303
-
-
Lin, A.L.1
Zhang, W.2
Gao, X.3
Watts, L.4
-
40
-
-
84903744473
-
Biological markers in older people at risk of mobility limitations
-
Lippi, G., Sanchis-Gomar, F., Montagnana, M., Biological markers in older people at risk of mobility limitations. Curr. Pharm. Des. 20 (2014), 3222–3244.
-
(2014)
Curr. Pharm. Des.
, vol.20
, pp. 3222-3244
-
-
Lippi, G.1
Sanchis-Gomar, F.2
Montagnana, M.3
-
41
-
-
67651180787
-
Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
-
Liu, Y., Sanoff, H.K., Cho, H., Burd, C.E., Torrice, C., Ibrahim, J.G., Thomas, N.E., Sharpless, N.E., Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 8 (2009), 439–448.
-
(2009)
Aging Cell
, vol.8
, pp. 439-448
-
-
Liu, Y.1
Sanoff, H.K.2
Cho, H.3
Burd, C.E.4
Torrice, C.5
Ibrahim, J.G.6
Thomas, N.E.7
Sharpless, N.E.8
-
42
-
-
84877687210
-
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
-
Loffredo, F.S., Steinhauser, M.L., Jay, S.M., Gannon, J., Pancoast, J.R., Yalamanchi, P., Sinha, M., Dall'Osso, C., Khong, D., Shadrach, J.L., Miller, C.M., Singer, B.S., Stewart, A., Psychogios, N., Gerszten, R.E., Hartigan, A.J., Kim, M.J., Serwold, T., Wagers, A.J., Lee, R.T., Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153 (2013), 828–839.
-
(2013)
Cell
, vol.153
, pp. 828-839
-
-
Loffredo, F.S.1
Steinhauser, M.L.2
Jay, S.M.3
Gannon, J.4
Pancoast, J.R.5
Yalamanchi, P.6
Sinha, M.7
Dall'Osso, C.8
Khong, D.9
Shadrach, J.L.10
Miller, C.M.11
Singer, B.S.12
Stewart, A.13
Psychogios, N.14
Gerszten, R.E.15
Hartigan, A.J.16
Kim, M.J.17
Serwold, T.18
Wagers, A.J.19
Lee, R.T.20
more..
-
43
-
-
84940450609
-
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities
-
Long, D.L., Ulici, V., Chubinskaya, S., Loeser, R.F., Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities. Osteoarthritis Cartilage 23 (2015), 1523–1531.
-
(2015)
Osteoarthritis Cartilage
, vol.23
, pp. 1523-1531
-
-
Long, D.L.1
Ulici, V.2
Chubinskaya, S.3
Loeser, R.F.4
-
44
-
-
33746228121
-
Sirtuins in aging and age-related disease
-
Longo, V.D., Kennedy, B.K., Sirtuins in aging and age-related disease. Cell 126 (2006), 257–268.
-
(2006)
Cell
, vol.126
, pp. 257-268
-
-
Longo, V.D.1
Kennedy, B.K.2
-
45
-
-
0032831782
-
Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats
-
Lynch, C.D., Cooney, P.T., Bennett, S.A., Thornton, P.L., Khan, A.S., Ingram, R.L., Sonntag, W.E., Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats. Neurobiol. Aging 20 (1999), 191–200.
-
(1999)
Neurobiol. Aging
, vol.20
, pp. 191-200
-
-
Lynch, C.D.1
Cooney, P.T.2
Bennett, S.A.3
Thornton, P.L.4
Khan, A.S.5
Ingram, R.L.6
Sonntag, W.E.7
-
46
-
-
84929009106
-
In vivo and in vitro evidences of dehydroepiandrosterone protective role on the cardiovascular system
-
Mannic, T., Viguie, J., Rossier, M.F., In vivo and in vitro evidences of dehydroepiandrosterone protective role on the cardiovascular system. Int. J. Endocrinol. Metab., 13, 2015, e24660.
-
(2015)
Int. J. Endocrinol. Metab.
, vol.13
, pp. e24660
-
-
Mannic, T.1
Viguie, J.2
Rossier, M.F.3
-
47
-
-
84866163081
-
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
-
Mattison, J.A., Roth, G.S., Beasley, T.M., Tilmont, E.M., Handy, A.M., Herbert, R.L., Longo, D.L., Allison, D.B., Young, J.E., Bryant, M., Barnard, D., Ward, W.F., Qi, W., Ingram, D.K., de Cabo, R., Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489 (2012), 318–321.
-
(2012)
Nature
, vol.489
, pp. 318-321
-
-
Mattison, J.A.1
Roth, G.S.2
Beasley, T.M.3
Tilmont, E.M.4
Handy, A.M.5
Herbert, R.L.6
Longo, D.L.7
Allison, D.B.8
Young, J.E.9
Bryant, M.10
Barnard, D.11
Ward, W.F.12
Qi, W.13
Ingram, D.K.14
de Cabo, R.15
-
48
-
-
33644796631
-
Fibroblasts from long-lived snell dwarf mice are resistant to oxygen-induced in vitro growth arrest
-
Maynard, S.P., Miller, R.A., Fibroblasts from long-lived snell dwarf mice are resistant to oxygen-induced in vitro growth arrest. Aging Cell 5 (2006), 89–96.
-
(2006)
Aging Cell
, vol.5
, pp. 89-96
-
-
Maynard, S.P.1
Miller, R.A.2
-
49
-
-
0037850928
-
Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening
-
Melk, A., Kittikowit, W., Sandhu, I., Halloran, K.M., Grimm, P., Schmidt, B.M., Halloran, P.F., Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int. 63 (2003), 2134–2143.
-
(2003)
Kidney Int.
, vol.63
, pp. 2134-2143
-
-
Melk, A.1
Kittikowit, W.2
Sandhu, I.3
Halloran, K.M.4
Grimm, P.5
Schmidt, B.M.6
Halloran, P.F.7
-
50
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita, M., Nunez, S., Heard, E., Narita, M., Lin, A.W., Hearn, S.A., Spector, D.L., Hannon, G.J., Lowe, S.W., Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113 (2003), 703–716.
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
Narita, M.4
Lin, A.W.5
Hearn, S.A.6
Spector, D.L.7
Hannon, G.J.8
Lowe, S.W.9
-
51
-
-
84949097466
-
mTOR activation is a biomarker and a central pathway to autoimmune disorders cancer, obesity, and aging
-
Perl, A., mTOR activation is a biomarker and a central pathway to autoimmune disorders cancer, obesity, and aging. Ann. N. Y. Acad. Sci. 1346 (2015), 33–44.
-
(2015)
Ann. N. Y. Acad. Sci.
, vol.1346
, pp. 33-44
-
-
Perl, A.1
-
52
-
-
84929011938
-
Lifespan of mice and primates correlates with immunoproteasome expression
-
Pickering, A.M., Lehr, M., Miller, R.A., Lifespan of mice and primates correlates with immunoproteasome expression. J. Clin. Invest. 125 (2015), 2059–2068.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 2059-2068
-
-
Pickering, A.M.1
Lehr, M.2
Miller, R.A.3
-
53
-
-
84878862873
-
Senescence regulation by the p53 protein family
-
Qian, Y., Chen, X., Senescence regulation by the p53 protein family. Methods Mol. Biol. 965 (2013), 37–61.
-
(2013)
Methods Mol. Biol.
, vol.965
, pp. 37-61
-
-
Qian, Y.1
Chen, X.2
-
54
-
-
77958449473
-
p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate
-
Romanov, V.S., Abramova, M.V., Svetlikova, S.B., Bykova, T.V., Zubova, S.G., Aksenov, N.D., Fornace, A.J. Jr., Pospelova, T.V., Pospelov, V.A., p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate. ABBV Cell Cycle 9 (2010), 3945–3955.
-
(2010)
ABBV Cell Cycle
, vol.9
, pp. 3945-3955
-
-
Romanov, V.S.1
Abramova, M.V.2
Svetlikova, S.B.3
Bykova, T.V.4
Zubova, S.G.5
Aksenov, N.D.6
Fornace, A.J.7
Pospelova, T.V.8
Pospelov, V.A.9
-
55
-
-
84986218395
-
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
-
973–7
-
Roos, C.M., Zhang, B., Palmer, A.K., Ogrodnik, M.B., Pirtskhalava, T., Thalji, N.M., Hagler, M., Jurk, D., Smith, L.A., Casaclang-Verzosa, G., Zhu, Y., Schafer, M.J., Tchkonia, T., Kirkland, J.L., Miller, J.D., Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice. Aging Cell, 15(5), 2016 973–7.
-
(2016)
Aging Cell
, vol.15
, Issue.5
-
-
Roos, C.M.1
Zhang, B.2
Palmer, A.K.3
Ogrodnik, M.B.4
Pirtskhalava, T.5
Thalji, N.M.6
Hagler, M.7
Jurk, D.8
Smith, L.A.9
Casaclang-Verzosa, G.10
Zhu, Y.11
Schafer, M.J.12
Tchkonia, T.13
Kirkland, J.L.14
Miller, J.D.15
-
56
-
-
0027484180
-
Aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin
-
Rutanen, E.M., Karkkainen, T., Stenman, U.H., Yki-Jarvinen, H., Aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin. J. Clin. Endocrinol. Metab. 77 (1993), 1152–1155.
-
(1993)
J. Clin. Endocrinol. Metab.
, vol.77
, pp. 1152-1155
-
-
Rutanen, E.M.1
Karkkainen, T.2
Stenman, U.H.3
Yki-Jarvinen, H.4
-
57
-
-
0033785401
-
Serum leptin levels and blood pressure in the overweight elderly
-
Sanchez-Rodriguez, M., Garcia-Sanchez, A., Retana-Ugalde, R., Mendoza-Nunez, V.M., Serum leptin levels and blood pressure in the overweight elderly. Arch. Med. Res. 31 (2000), 425–428.
-
(2000)
Arch. Med. Res.
, vol.31
, pp. 425-428
-
-
Sanchez-Rodriguez, M.1
Garcia-Sanchez, A.2
Retana-Ugalde, R.3
Mendoza-Nunez, V.M.4
-
58
-
-
84928635382
-
A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging
-
Sanchis-Gomar, F., Pareja-Galeano, H., Santos-Lozano, A., Garatachea, N., Fiuza-Luces, C., Venturini, L., Ricevuti, G., Lucia, A., Emanuele, E., A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging. Age (Dordr)., 37, 2015, 9776.
-
(2015)
Age (Dordr).
, vol.37
, pp. 9776
-
-
Sanchis-Gomar, F.1
Pareja-Galeano, H.2
Santos-Lozano, A.3
Garatachea, N.4
Fiuza-Luces, C.5
Venturini, L.6
Ricevuti, G.7
Lucia, A.8
Emanuele, E.9
-
59
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner, S.E., Linford, N.J., Martin, G.M., Treuting, P., Ogburn, C.E., Emond, M., Coskun, P.E., Ladiges, W., Wolf, N., Van Remmen, H., Wallace, D.C., Rabinovitch, P.S., Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308 (2005), 1909–1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.8
Wolf, N.9
Van Remmen, H.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
60
-
-
1642602686
-
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
-
Sedelnikova, O.A., Horikawa, I., Zimonjic, D.B., Popescu, N.C., Bonner, W.M., Barrett, J.C., Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6 (2004), 168–170.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 168-170
-
-
Sedelnikova, O.A.1
Horikawa, I.2
Zimonjic, D.B.3
Popescu, N.C.4
Bonner, W.M.5
Barrett, J.C.6
-
61
-
-
84958060584
-
Longevity and skeletal muscle mass: the role of IGF signalling the sirtuins, dietary restriction and protein intake
-
Sharples, A.P., Hughes, D.C., Deane, C.S., Saini, A., Selman, C., Stewart, C.E., Longevity and skeletal muscle mass: the role of IGF signalling the sirtuins, dietary restriction and protein intake. Aging Cell 14 (2015), 511–523.
-
(2015)
Aging Cell
, vol.14
, pp. 511-523
-
-
Sharples, A.P.1
Hughes, D.C.2
Deane, C.S.3
Saini, A.4
Selman, C.5
Stewart, C.E.6
-
62
-
-
0033450849
-
Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals
-
Sonntag, W.E., Lynch, C.D., Cefalu, W.T., Ingram, R.L., Bennett, S.A., Thornton, P.L., Khan, A.S., Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. J. Gerontol. A Biol. Sci. Med. Sci. 54 (1999), B521–38.
-
(1999)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.54
, pp. B521-38
-
-
Sonntag, W.E.1
Lynch, C.D.2
Cefalu, W.T.3
Ingram, R.L.4
Bennett, S.A.5
Thornton, P.L.6
Khan, A.S.7
-
63
-
-
0034523517
-
The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing
-
Sonntag, W.E., Lynch, C., Thornton, P., Khan, A., Bennett, S., Ingram, R., The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J. Anat. 197:Pt. 4 (2000), 575–585.
-
(2000)
J. Anat.
, vol.197
, pp. 575-585
-
-
Sonntag, W.E.1
Lynch, C.2
Thornton, P.3
Khan, A.4
Bennett, S.5
Ingram, R.6
-
64
-
-
0030929766
-
Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice
-
Spaulding, C.C., Walford, R.L., Effros, R.B., Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech. Ageing Dev. 93 (1997), 87–94.
-
(1997)
Mech. Ageing Dev.
, vol.93
, pp. 87-94
-
-
Spaulding, C.C.1
Walford, R.L.2
Effros, R.B.3
-
65
-
-
41949089130
-
Yeast life span extension by depletion of 60 s ribosomal subunits is mediated by Gcn4
-
Steffen, K.K., MacKay, V.L., Kerr, E.O., Tsuchiya, M., Hu, D., Fox, L.A., Dang, N., Johnston, E.D., Oakes, J.A., Tchao, B.N., Pak, D.N., Fields, S., Kennedy, B.K., Kaeberlein, M., Yeast life span extension by depletion of 60 s ribosomal subunits is mediated by Gcn4. Cell 133 (2008), 292–302.
-
(2008)
Cell
, vol.133
, pp. 292-302
-
-
Steffen, K.K.1
MacKay, V.L.2
Kerr, E.O.3
Tsuchiya, M.4
Hu, D.5
Fox, L.A.6
Dang, N.7
Johnston, E.D.8
Oakes, J.A.9
Tchao, B.N.10
Pak, D.N.11
Fields, S.12
Kennedy, B.K.13
Kaeberlein, M.14
-
66
-
-
84865108931
-
Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan
-
Steinbaugh, M.J., Sun, L.Y., Bartke, A., Miller, R.A., Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am. J. Physiol. Endocrinol. Metab. 303 (2012), E488–E495.
-
(2012)
Am. J. Physiol. Endocrinol. Metab.
, vol.303
, pp. E488-E495
-
-
Steinbaugh, M.J.1
Sun, L.Y.2
Bartke, A.3
Miller, R.A.4
-
67
-
-
84964579908
-
17alpha-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization
-
Stout, M.B., Steyn, F.J., Jurczak, M.J., Camporez, J.G., Zhu, Y., Hawse, J.R., Jurk, D., Palmer, A.K., Xu, M., Pirtskhalava, T., Evans, G.L., de Souza Santos, R., Frank, A.P., White, T.A., Monroe, D.G., Singh, R.J., Casaclang-Verzosa, G., Miller, J.D., Clegg, D.J., LeBrasseur, N.K., von Zglinicki, T., Shulman, G.I., Tchkonia, T., Kirkland, J.L., 17alpha-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization. J. Gerontol. A. Biol. Sci. Med. Sci. 00:00 (2016), 1–13.
-
(2016)
J. Gerontol. A. Biol. Sci. Med. Sci.
, pp. 1-13
-
-
Stout, M.B.1
Steyn, F.J.2
Jurczak, M.J.3
Camporez, J.G.4
Zhu, Y.5
Hawse, J.R.6
Jurk, D.7
Palmer, A.K.8
Xu, M.9
Pirtskhalava, T.10
Evans, G.L.11
de Souza Santos, R.12
Frank, A.P.13
White, T.A.14
Monroe, D.G.15
Singh, R.J.16
Casaclang-Verzosa, G.17
Miller, J.D.18
Clegg, D.J.19
LeBrasseur, N.K.20
von Zglinicki, T.21
Shulman, G.I.22
Tchkonia, T.23
Kirkland, J.L.24
more..
-
68
-
-
67651181100
-
Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway
-
Su, N., Thiaville, M.M., Awad, K., Gjymishka, A., Brant, J.O., Yang, T.P., Kilberg, M.S., Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway. Hepatology 50 (2009), 282–290.
-
(2009)
Hepatology
, vol.50
, pp. 282-290
-
-
Su, N.1
Thiaville, M.M.2
Awad, K.3
Gjymishka, A.4
Brant, J.O.5
Yang, T.P.6
Kilberg, M.S.7
-
69
-
-
36448984298
-
Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
-
Swindell, W.R., Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging. BMC Genomics, 8, 2007, 353.
-
(2007)
BMC Genomics
, vol.8
, pp. 353
-
-
Swindell, W.R.1
-
70
-
-
39149086075
-
Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
-
Swindell, W.R., Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues. Mech. Ageing Dev. 129 (2008), 138–153.
-
(2008)
Mech. Ageing Dev.
, vol.129
, pp. 138-153
-
-
Swindell, W.R.1
-
71
-
-
78349299099
-
Fat tissue, aging, and cellular senescence
-
Tchkonia, T., Morbeck, D.E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M.D., Kirkland, J.L., Fat tissue, aging, and cellular senescence. Aging Cell 9 (2010), 667–684.
-
(2010)
Aging Cell
, vol.9
, pp. 667-684
-
-
Tchkonia, T.1
Morbeck, D.E.2
Von Zglinicki, T.3
Van Deursen, J.4
Lustgarten, J.5
Scrable, H.6
Khosla, S.7
Jensen, M.D.8
Kirkland, J.L.9
-
72
-
-
84874603171
-
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
-
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., Kirkland, J.L., Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J. Clin. Invest. 123 (2013), 966–972.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 966-972
-
-
Tchkonia, T.1
Zhu, Y.2
van Deursen, J.3
Campisi, J.4
Kirkland, J.L.5
-
73
-
-
84863550186
-
NF-kappaB inhibition delays DNA damage-induced senescence and aging in mice
-
Tilstra, J.S., Robinson, A.R., Wang, J., Gregg, S.Q., Clauson, C.L., Reay, D.P., Nasto, L.A., St Croix, C.M., Usas, A., Vo, N., Huard, J., Clemens, P.R., Stolz, D.B., Guttridge, D.C., Watkins, S.C., Garinis, G.A., Wang, Y., Niedernhofer, L.J., Robbins, P.D., NF-kappaB inhibition delays DNA damage-induced senescence and aging in mice. J. Clin. Invest. 122 (2012), 2601–2612.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2601-2612
-
-
Tilstra, J.S.1
Robinson, A.R.2
Wang, J.3
Gregg, S.Q.4
Clauson, C.L.5
Reay, D.P.6
Nasto, L.A.7
St Croix, C.M.8
Usas, A.9
Vo, N.10
Huard, J.11
Clemens, P.R.12
Stolz, D.B.13
Guttridge, D.C.14
Watkins, S.C.15
Garinis, G.A.16
Wang, Y.17
Niedernhofer, L.J.18
Robbins, P.D.19
-
74
-
-
84904858835
-
Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence
-
Tran, D., Bergholz, J., Zhang, H., He, H., Wang, Y., Zhang, Y., Li, Q., Kirkland, J.L., Xiao, Z.X., Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell 13 (2014), 669–678.
-
(2014)
Aging Cell
, vol.13
, pp. 669-678
-
-
Tran, D.1
Bergholz, J.2
Zhang, H.3
He, H.4
Wang, Y.5
Zhang, Y.6
Li, Q.7
Kirkland, J.L.8
Xiao, Z.X.9
-
75
-
-
74449084536
-
Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan
-
Tsaih, S.W., Pezzolesi, M.G., Yuan, R., Warram, J.H., Krolewski, A.S., Korstanje, R., Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan. Kidney Int. 77 (2010), 201–210.
-
(2010)
Kidney Int.
, vol.77
, pp. 201-210
-
-
Tsaih, S.W.1
Pezzolesi, M.G.2
Yuan, R.3
Warram, J.H.4
Krolewski, A.S.5
Korstanje, R.6
-
76
-
-
84930952017
-
Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions
-
Turinetto, V., Giachino, C., Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions. Nucleic Acids Res. 43 (2015), 2489–2498.
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 2489-2498
-
-
Turinetto, V.1
Giachino, C.2
-
77
-
-
84901288438
-
The role of senescent cells in ageing
-
van Deursen, J.M., The role of senescent cells in ageing. Nature 509 (2014), 439–446.
-
(2014)
Nature
, vol.509
, pp. 439-446
-
-
van Deursen, J.M.1
-
78
-
-
80052410357
-
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
-
Villeda, S.A., Luo, J., Mosher, K.I., Zou, B., Britschgi, M., Bieri, G., Stan, T.M., Fainberg, N., Ding, Z., Eggel, A., Lucin, K.M., Czirr, E., Park, J.S., Couillard-Despres, S., Aigner, L., Li, G., Peskind, E.R., Kaye, J.A., Quinn, J.F., Galasko, D.R., Xie, X.S., Rando, T.A., Wyss-Coray, T., The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477 (2011), 90–94.
-
(2011)
Nature
, vol.477
, pp. 90-94
-
-
Villeda, S.A.1
Luo, J.2
Mosher, K.I.3
Zou, B.4
Britschgi, M.5
Bieri, G.6
Stan, T.M.7
Fainberg, N.8
Ding, Z.9
Eggel, A.10
Lucin, K.M.11
Czirr, E.12
Park, J.S.13
Couillard-Despres, S.14
Aigner, L.15
Li, G.16
Peskind, E.R.17
Kaye, J.A.18
Quinn, J.F.19
Galasko, D.R.20
Xie, X.S.21
Rando, T.A.22
Wyss-Coray, T.23
more..
-
79
-
-
84876282986
-
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints
-
Vo, N., Niedernhofer, L.J., Nasto, L.A., Jacobs, L., Robbins, P.D., Kang, J., Evans, C.H., An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. J. Orthop. Res. 31 (2013), 831–837.
-
(2013)
J. Orthop. Res.
, vol.31
, pp. 831-837
-
-
Vo, N.1
Niedernhofer, L.J.2
Nasto, L.A.3
Jacobs, L.4
Robbins, P.D.5
Kang, J.6
Evans, C.H.7
-
80
-
-
84907426794
-
Immunologic changes in frail older adults
-
Wang, G.C., Casolaro, V., Immunologic changes in frail older adults. Transl. Med. UniSa. 9 (2014), 1–6.
-
(2014)
Transl. Med. UniSa.
, vol.9
, pp. 1-6
-
-
Wang, G.C.1
Casolaro, V.2
-
81
-
-
66149167336
-
DNA damage response and cellular senescence in tissues of aging mice
-
Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin-Ruiz, C., von Zglinicki, T., DNA damage response and cellular senescence in tissues of aging mice. Aging Cell. 8 (2009), 311–323.
-
(2009)
Aging Cell.
, vol.8
, pp. 311-323
-
-
Wang, C.1
Jurk, D.2
Maddick, M.3
Nelson, G.4
Martin-Ruiz, C.5
von Zglinicki, T.6
-
82
-
-
0033377627
-
The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: a review
-
Wolf, N.S., Pendergrass, W.R., The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: a review. J. Gerontol. A Biol. Sci. Med. Sci. 54 (1999), B502–17.
-
(1999)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.54
, pp. B502-17
-
-
Wolf, N.S.1
Pendergrass, W.R.2
-
83
-
-
0028969497
-
Caloric restriction: conservation of in vivo cellular replicative capacity accompanies life-span extension in mice
-
Wolf, N.S., Penn, P.E., Jiang, D., Fei, R.G., Pendergrass, W.R., Caloric restriction: conservation of in vivo cellular replicative capacity accompanies life-span extension in mice. Exp. Cell Res. 217 (1995), 317–323.
-
(1995)
Exp. Cell Res.
, vol.217
, pp. 317-323
-
-
Wolf, N.S.1
Penn, P.E.2
Jiang, D.3
Fei, R.G.4
Pendergrass, W.R.5
-
84
-
-
84878326433
-
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice
-
Xu, C., Bai, B., Fan, P., Cai, Y., Huang, B., Law, I.K., Liu, L., Xu, A., Tung, C., Li, X., Siu, F.M., Che, C.M., Vanhoutte, P.M., Wang, Y., Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. Am. J. Transl. Res. 5 (2013), 412–426.
-
(2013)
Am. J. Transl. Res.
, vol.5
, pp. 412-426
-
-
Xu, C.1
Bai, B.2
Fan, P.3
Cai, Y.4
Huang, B.5
Law, I.K.6
Liu, L.7
Xu, A.8
Tung, C.9
Li, X.10
Siu, F.M.11
Che, C.M.12
Vanhoutte, P.M.13
Wang, Y.14
-
85
-
-
84988603034
-
Targeting senescent cells enhances adipogenesis and metabolic function in old age
-
Xu, M., Palmer, A.K., Ding, H., Weivoda, M.M., Pirtskhalava, T., White, T.A., Sepe, A., Johnson, K.O., Stout, M.B., Giorgadze, N., Jensen, M.D., LeBrasseur, N.K., Tchkonia, T., Kirkland, J.L., Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife, 4, 2015.
-
(2015)
Elife
, vol.4
-
-
Xu, M.1
Palmer, A.K.2
Ding, H.3
Weivoda, M.M.4
Pirtskhalava, T.5
White, T.A.6
Sepe, A.7
Johnson, K.O.8
Stout, M.B.9
Giorgadze, N.10
Jensen, M.D.11
LeBrasseur, N.K.12
Tchkonia, T.13
Kirkland, J.L.14
-
86
-
-
84904647648
-
Tempol intake improves inflammatory status in aged mice
-
Yamato, M., Ishimatsu, A., Yamanaka, Y., Mine, T., Yamada, K., Tempol intake improves inflammatory status in aged mice. J. Clin. Biochem. Nutr. 55 (2014), 11–14.
-
(2014)
J. Clin. Biochem. Nutr.
, vol.55
, pp. 11-14
-
-
Yamato, M.1
Ishimatsu, A.2
Yamanaka, Y.3
Mine, T.4
Yamada, K.5
-
87
-
-
84945283715
-
Changes in regenerative capacity through lifespan
-
Yun, M.H., Changes in regenerative capacity through lifespan. Int. J. Mol. Sci. 16 (2015), 25392–25432.
-
(2015)
Int. J. Mol. Sci.
, vol.16
, pp. 25392-25432
-
-
Yun, M.H.1
-
88
-
-
33947236204
-
Molecular dissection of formation of senescence-associated heterochromatin foci
-
Zhang, R., Chen, W., Adams, P.D., Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 27 (2007), 2343–2358.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 2343-2358
-
-
Zhang, R.1
Chen, W.2
Adams, P.D.3
-
89
-
-
84928243456
-
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
-
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A.C., Ding, H., Giorgadze, N., Palmer, A.K., Ikeno, Y., Hubbard, G.B., Lenburg, M., O'Hara, S.P., LaRusso, N.F., Miller, J.D., Roos, C.M., Verzosa, G.C., LeBrasseur, N.K., Wren, J.D., Farr, J.N., Khosla, S., Stout, M.B., McGowan, S.J., Fuhrmann-Stroissnigg, H., Gurkar, A.U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y.Y., Barghouthy, A.S., Navarro, D.C., Sano, T., Robbins, P.D., Niedernhofer, L.J., Kirkland, J.L., The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14 (2015), 644–658.
-
(2015)
Aging Cell
, vol.14
, pp. 644-658
-
-
Zhu, Y.1
Tchkonia, T.2
Pirtskhalava, T.3
Gower, A.C.4
Ding, H.5
Giorgadze, N.6
Palmer, A.K.7
Ikeno, Y.8
Hubbard, G.B.9
Lenburg, M.10
O'Hara, S.P.11
LaRusso, N.F.12
Miller, J.D.13
Roos, C.M.14
Verzosa, G.C.15
LeBrasseur, N.K.16
Wren, J.D.17
Farr, J.N.18
Khosla, S.19
Stout, M.B.20
McGowan, S.J.21
Fuhrmann-Stroissnigg, H.22
Gurkar, A.U.23
Zhao, J.24
Colangelo, D.25
Dorronsoro, A.26
Ling, Y.Y.27
Barghouthy, A.S.28
Navarro, D.C.29
Sano, T.30
Robbins, P.D.31
Niedernhofer, L.J.32
Kirkland, J.L.33
more..
-
90
-
-
84928586002
-
Inflammation and the depot-specific secretome of human preadipocytes
-
Zhu, Y., Tchkonia, T., Stout, M.B., Giorgadze, N., Wang, L., Li, P.W., Heppelmann, C.J., Bouloumie, A., Jensen, M.D., Bergen, H.R. 3rd, Kirkland, J.L., Inflammation and the depot-specific secretome of human preadipocytes. Obesity (Silver Spring) 23 (2015), 989–999.
-
(2015)
Obesity (Silver Spring)
, vol.23
, pp. 989-999
-
-
Zhu, Y.1
Tchkonia, T.2
Stout, M.B.3
Giorgadze, N.4
Wang, L.5
Li, P.W.6
Heppelmann, C.J.7
Bouloumie, A.8
Jensen, M.D.9
Bergen, H.R.10
Kirkland, J.L.11
-
91
-
-
84922627875
-
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging
-
Ziegler, D.V., Wiley, C.D., Velarde, M.C., Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell 14 (2015), 1–7.
-
(2015)
Aging Cell
, vol.14
, pp. 1-7
-
-
Ziegler, D.V.1
Wiley, C.D.2
Velarde, M.C.3
|