Inflamm-aging. An evolutionary perspective on immunosenescence

Annals of the New York Academy of Sciences

Volumn 908, Issue , 2000, Pages 244-254

  Franceschi, Claudio ^a,b   Bonafè, Massimiliano ^a   Valensin, Silvana ^a   Olivieri, Fabiola ^b   De Luca, Maria ^d   Ottaviani, Enzo ^c   De Benedictis, Giovanna ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b INRCA   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d UNIVERSITY OF CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; BLOOD CLOTTING FACTOR; CYTOKINE;

AGING; ALZHEIMER DISEASE; ATHEROSCLEROSIS; CONFERENCE PAPER; DIABETES MELLITUS; EVOLUTION; IMMUNITY; INFLAMMATION; MACROPHAGE; OSTEOPOROSIS;

EID: 0033911488     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06651.x     Document Type: Conference Paper

References (34)

1. 1. FRANCESCHI, C. 1989. Cell proliferation, cell death and aging. Aging. Clin. Exp. Res. 1: 3-15.
2. 2. KIRKWOOD, T.B.L. & C. FRANCESCHI. 1992. Is ageing as complex as it would appear? New perspectives in gerontological research. Ann. N.Y. Acad. Sci. 663: 412-417.
3. 3. JAZWINSKI, S.M. 1999. Molecular mechanisms of yeast longevity. Trends Microbiol. 7: 247-252.
4. 4. MURAKAMI, S. & T.E. JOHNSON. 1998. Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. Curr. Biol. 8: 1091-1094.
5. 5. SOHAL, R.S. & R. WEINDRUCH. 1996. Oxidative stress, caloric restriction, and aging. Science 273: 59-63.
6. 6. BURKLE, A. 1998. Poly(ADP-ribose) polymerase and aging. Exp. Gerontol. 33: 519-523.
7. 7. OTTAVIANI, E., E. CASELGRANDI, M. BONDI et al. 1991. The "immuno-mobile" brain: evolutionary evidence. Adv. Neuroimmunol. 1: 27-39.
8. 8. OTTAVIANI, E., A. COSSARIZZA, C. ORTOLANI et al. 1991. ACTH-like molecules in gastropod molluscs: a possible role in ancestral immune response and stress. Proc. Roy. Soc. Ser. B 245: 215-218.
9. 9. OTTAVIANI, E., S. VALENSIN & C. FRANCESCHI. 1998. The neuro-immunological interface in an evolutionary perspective: the dynamic relationship between effector and recognition systems. Front. Biosci. 15: D431-D438.
10. 10. OTTAVIANI, E. & C. FRANCESCHI. 1996. The neuroimmunology of stress from invertebrates to man. Progr. Neurobiol. 48: 421-440.
11. 11. OTTAVIANI, E. & C. FRANCESCHI. 1997. The invertebrate phagocytic immunocyte: clues to a common evolution of the immune and the endocrine systems. Immunol. Today. 18: 169-174.
12. 12. OTTAVIANI, E. & C. FRANCESCHI. 1998. A new theory on the common evolutionary origin of natural immunity, inflammation and stress response: the invertebrate phagocytic immunocyte as an eye-witness. Domest. Animal Endocrinol. 15: 291-296.
13. 13. OTTAVIANI, E., A. FRANCHINI & C. FRANCESCHI. 1997. Pro-opiomelanocortin-derived peptides, cytokines and nitric oxide in immune responses and stress: an evolutionary approach. Int. Rev. Cytol. 170: 79-142.
14. 14. FRANCESCHI, C., S. VALENSIN, F. FAGNONI et al. 1999. Biomarkers of immunosenescence: the challenge of heterogeneity and the role of antigenic load. Exp Gerontol. 34: 911-921.
15. 15. FRANCESCHI, C., M. BONAFÈ & S. VALENSIN. 2000. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18: 1717-1720.
16. 16. FRANCESCHI, C., D. MONTI, P. SANSONI & A. COSSARIZZA. 1995. The immunology of exceptional individuals: the lesson of centenarians. Immunol. Today 16: 12-16.
17. 17. JOHNSON, T.E. & H. BRUUNSGAARD. 1998. Implications of hormesis for biomedical aging research. Hum. Exp. Toxicol. 17: 263-265.
18. 18. CALABRESE, E.J. & L.A. BALDWIN. 1999. The marginalization of hormesis. Toxicol. Pathol. 27: 187-194.
19. 19. BAGGIO, G., S. DONAZZAN, D. MONTI et al. 1998. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. FASEB J. 12: 433-437.
20. 20. CHIRICOLO, M., G. BARTOLINI, M. ORLANDI et al. 1986. Prostaglandin and tromboxane biosynthesis in resting and activated platelet-free monocytes from aged subjects. Gerontology 32: 69-73.
21. 21. MARI, D., P.M. MANNUCCI, R. COPPOLA et al. 1995. Hypercoagulability in centenarians: the paradox of successful aging. Blood 85: 3144-3149.
22. 22. MARI, D., P.M. MANNUCCI, F. DUCA et al. 1996. Mutant factor V (Arg506Gln) in healthy centenarians. Lancet 347: 1044.
23. 23. MANNUCCI, P.M., D. MARI, G. MERATI et al. 1997. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Arterioscler. Thromb. Vasc. Biol. 17: 755-759.
24. 24. HITT, R., Y. YOUNG-XU, M. SILVER & T. PERLS. 1999. Centenarians: the older you get, the healthier you have been. Lancet 354: 652.
25. 25. BRUUNSGAARD, H., K. ANDERSEN-RANBERG, B. JEUNE et al. 1999. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J. Gerontol. A. Biol. Sci. Med. Sci. 54: M357-M364.
26. 26. YASHIN, A., J.W. VAUPEL, K.F. ANDREEV et al. 1998. Combining genetic and demographic information in population studies of aging and longevity. J. Epidemiol. Biostatist. 3: 289-294.
27. 27. YASHIN, A.I., G. DE BENEDICTIS, J.W. VAUPEL et al. 1999. Genes, demography and life span: the contribution of demographic data in genetic studies on aging and longevity. Am. J. Human Genet. 65: 1178-1193.
28. 28. WEISSBERG, P.L. & M.R. BENNETT. 1999. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340: 1928-1929.
29. 29. EIKELENBOOM, P. & R. VEERHUIS. 1999. The importance of inflammatory mechanisms for the development of Alzheimer's disease. Exp. Gerontol. 34: 453-461.
30. 30. ERSHLER, W.B. 1993. Interleukin-6: a cytokine for gerontologists. J. Am. Geriatr. Soc. 41: 176-181.
31. 31. FAGIOLO, U., A. COSSARIZZA, E. SCALA et al. 1993. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23: 2375-2378.
32. 32. HARRIS, T.B., L. FERRUCCI, R.P. TRACY et al. 1999. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106: 506-512.
33. 33. FERRUCCI, L., T.B. HARRIS, J.M. GURALNIK et al. 1999. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47: 639-646.
34. 34. FISHMAN, D., G. FAULDS, R. JEFFERY et al. 1998. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 102: 1369-1376.