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Volumn 257, Issue 1, 2000, Pages 162-171

Is β-galactosidase staining a marker of senescence in vitro and in vivo?

Author keywords

Aging; Aging marker; Donor age; Immortalization; Senescence; gal

Indexed keywords

BETA GALACTOSIDASE; HYDROGEN PEROXIDE;

EID: 0034713329     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4875     Document Type: Article
Times cited : (322)

References (46)
  • 1
    • 0021846474 scopus 로고
    • Relationship between γ-irradiation, life span, metabolic rate and accumulation of fluorescent age pigment in the adult male housefly Musca domestica
    • Allen R. G. Relationship between γ-irradiation, life span, metabolic rate and accumulation of fluorescent age pigment in the adult male housefly Musca domestica. Arch. Gerontol. Geriatr. 4:1985;169-178.
    • (1985) Arch. Gerontol. Geriatr. , vol.4 , pp. 169-178
    • Allen, R.G.1
  • 2
    • 0025655449 scopus 로고
    • Role of free radicals in senescence
    • V. J. Cristofalo, & M. P. Lawton. New York: Springer-Verlag
    • Allen R. G. Role of free radicals in senescence. Cristofalo V. J., Lawton M. P. Annual Review of Gerontology and Geriatrics. 1990;198-213 Springer-Verlag, New York.
    • (1990) Annual Review of Gerontology and Geriatrics , pp. 198-213
    • Allen, R.G.1
  • 3
    • 0021278276 scopus 로고
    • Effects of paraquat administration on longevity, oxygen consumption, lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, inorganic peroxides and glutathione in the adult housefly
    • Allen R. G., Farmer K. J., Newton R. K., Sohal R. S. Effects of paraquat administration on longevity, oxygen consumption, lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, inorganic peroxides and glutathione in the adult housefly. Comp. Biochem. Physiol. 78C:1984;283-288.
    • (1984) Comp. Biochem. Physiol. , vol.78 , pp. 283-288
    • Allen, R.G.1    Farmer, K.J.2    Newton, R.K.3    Sohal, R.S.4
  • 4
    • 0029582857 scopus 로고
    • Expression and regulation of SOD activity in human skin fibroblasts from donors of different ages
    • Allen R. G., Keogh B. P., Gerhard G., Pignolo R., Horton J., Cristofalo V. J. Expression and regulation of SOD activity in human skin fibroblasts from donors of different ages. J. Cell. Physiol. 165:1995;576-587.
    • (1995) J. Cell. Physiol. , vol.165 , pp. 576-587
    • Allen, R.G.1    Keogh, B.P.2    Gerhard, G.3    Pignolo, R.4    Horton, J.5    Cristofalo, V.J.6
  • 6
    • 0033004248 scopus 로고    scopus 로고
    • Differences in electron transport potential antioxidant defenses and oxidant generation in young and senescent fetal lung fibroblasts (WI-38)
    • Allen R. G., Tresini M., Keogh B. P., Doggett D. L., Cristofalo V. J. Differences in electron transport potential antioxidant defenses and oxidant generation in young and senescent fetal lung fibroblasts (WI-38). J. Cell. Physiol. 180:1999;114-122.
    • (1999) J. Cell. Physiol. , vol.180 , pp. 114-122
    • Allen, R.G.1    Tresini, M.2    Keogh, B.P.3    Doggett, D.L.4    Cristofalo, V.J.5
  • 8
    • 85029461628 scopus 로고
    • Molecular mechanisms of biologic aging
    • A. Kligman, & Y. Takase. New York: Univ. of Tokyo Press
    • Balin A. K., Allen R. G. Molecular mechanisms of biologic aging. Kligman A., Takase Y. Cutaneous Aging. 1989;7-32 Univ. of Tokyo Press, New York.
    • (1989) Cutaneous Aging , pp. 7-32
    • Balin, A.K.1    Allen, R.G.2
  • 9
    • 0032531126 scopus 로고    scopus 로고
    • 2-treated young MRC5 fibroblasts correlates with increased glutathione peroxidase levels and resistance to DNA breakage
    • 2-treated young MRC5 fibroblasts correlates with increased glutathione peroxidase levels and resistance to DNA breakage. Mech. Ageing Dev. 105:1998;137-150.
    • (1998) Mech. Ageing Dev. , vol.105 , pp. 137-150
    • Caldini, R.1    Chevanne, M.2    Mocali, A.3    Tombaccini, D.4    Paoletti, F.5
  • 11
    • 0019952463 scopus 로고
    • Mohs' surgery, fresh-tissue technique. Our technique with a review
    • Cottel W. I., Proper S. Mohs' surgery, fresh-tissue technique. Our technique with a review. J. Dermatol. Surg. Oncol. 8:1982;576-587.
    • (1982) J. Dermatol. Surg. Oncol. , vol.8 , pp. 576-587
    • Cottel, W.I.1    Proper, S.2
  • 12
    • 0032168373 scopus 로고    scopus 로고
    • Relationship between donor age and the replicative life spans of human cells in culture: A re-evaluation
    • Cristofalo V. J., Allen R. G., Pignolo R. P., Martin B. M., Beck J. C. Relationship between donor age and the replicative life spans of human cells in culture: A re-evaluation. Proc. Natl. Acad. Sci. USA. 95:1998;10614-10619.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10614-10619
    • Cristofalo, V.J.1    Allen, R.G.2    Pignolo, R.P.3    Martin, B.M.4    Beck, J.C.5
  • 13
    • 0000936455 scopus 로고
    • A standard procedure for cultivating human diploid fibroblastlike cells to study cellular aging
    • Cristofalo V. J., Charpentier R. A standard procedure for cultivating human diploid fibroblastlike cells to study cellular aging. J. Tissue Culture Methods. 6:1980;117-121.
    • (1980) J. Tissue Culture Methods , vol.6 , pp. 117-121
    • Cristofalo, V.J.1    Charpentier, R.2
  • 14
    • 0016772118 scopus 로고
    • Lysosomal enzymes and aging in vitro: Subcellular enzyme distribution and effect of hydrocortisone on cell life-span
    • Cristofalo V. J., Kabakjian J. Lysosomal enzymes and aging in vitro: subcellular enzyme distribution and effect of hydrocortisone on cell life-span. Mech. Ageing Dev. 4:1975;19-28.
    • (1975) Mech. Ageing Dev. , vol.4 , pp. 19-28
    • Cristofalo, V.J.1    Kabakjian, J.2
  • 17
    • 0014101264 scopus 로고
    • Enzyme activity during the growth and aging of human cells in vitro
    • Cristofalo V. J., Parris N., Kritchevsky D. Enzyme activity during the growth and aging of human cells in vitro. J. Cell. Physiol. 69:1967;263-271.
    • (1967) J. Cell. Physiol. , vol.69 , pp. 263-271
    • Cristofalo, V.J.1    Parris, N.2    Kritchevsky, D.3
  • 18
    • 0027163464 scopus 로고
    • Replicative senesence of human fibroblast-like cells in culture
    • Cristofalo V. J., Pignolo R. J. Replicative senesence of human fibroblast-like cells in culture. Physiol. Rev. 73:1993;617-638.
    • (1993) Physiol. Rev. , vol.73 , pp. 617-638
    • Cristofalo, V.J.1    Pignolo, R.J.2
  • 19
    • 0015580671 scopus 로고
    • Cellular senescence and DNA synthesis:thymidine incorporation as a measure of population age in human diploid cells
    • Cristofalo V. J., Sharf B. B. Cellular senescence and DNA synthesis:thymidine incorporation as a measure of population age in human diploid cells. Exp. Cell Res. 76:1973;419-427.
    • (1973) Exp. Cell Res. , vol.76 , pp. 419-427
    • Cristofalo, V.J.1    Sharf, B.B.2
  • 20
    • 0003043421 scopus 로고    scopus 로고
    • Use of the fibroblast model in the study of cellular senescence
    • Y. Barnett, & C. R. Barnett. Totowa: Humana Press
    • Cristofalo V. J., Volker C., Allen R. G. Use of the fibroblast model in the study of cellular senescence. Barnett Y., Barnett C. R. Aging Methods and Protocols. 2000;Humana Press, Totowa.
    • (2000) Aging Methods and Protocols
    • Cristofalo, V.J.1    Volker, C.2    Allen, R.G.3
  • 22
    • 0002639740 scopus 로고
    • Lipid peroxidation, cross-linking reactions, and aging
    • (R. S. Sohal, Ed.), Elsevier/North-Holland, New York
    • Donato, H.1981. Lipid peroxidation, cross-linking reactions, and aging. InAge Pigments (R. S. Sohal, Ed.), pp. 63-81, Elsevier/North-Holland, New York.
    • (1981) In Age Pigments , pp. 63-81
    • Donato, H.1
  • 23
    • 0030744226 scopus 로고    scopus 로고
    • Abundance of α1(I) and α1(III) procollagen and p21 mRNAs in fibroblasts cultured from fetal and postnatal donors
    • Furth J. J., Allen R. G., Tresini M., Keogh B., Cristofalo V. J. Abundance of α1(I) and α1(III) procollagen and p21 mRNAs in fibroblasts cultured from fetal and postnatal donors. Mech. Ageing Dev. 97:1997;131-142.
    • (1997) Mech. Ageing Dev. , vol.97 , pp. 131-142
    • Furth, J.J.1    Allen, R.G.2    Tresini, M.3    Keogh, B.4    Cristofalo, V.J.5
  • 24
    • 0031935827 scopus 로고    scopus 로고
    • Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
    • Gire V., Wynford-Thomas D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell. Biol. 18:1998;1611-1621.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1611-1621
    • Gire, V.1    Wynford-Thomas, D.2
  • 25
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid strains
    • Hayflick L. The limited in vitro lifetime of human diploid strains. Exp. Cell Res. 37:1965;614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 28
    • 0030005458 scopus 로고    scopus 로고
    • Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages
    • Keogh B. P., Allen R. G., Pignolo R., Horton J., Tresini M., Cristofalo V. J. Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages. J. Cell. Physiol. 167:1996;512-522.
    • (1996) J. Cell. Physiol. , vol.167 , pp. 512-522
    • Keogh, B.P.1    Allen, R.G.2    Pignolo, R.3    Horton, J.4    Tresini, M.5    Cristofalo, V.J.6
  • 29
    • 0029913860 scopus 로고
    • Effects of cellular aging on the induction of c-fos by antioxidant treatments
    • Keogh B. P., Tresini M., Cristofalo V. J., Allen R. G. Effects of cellular aging on the induction of c-fos by antioxidant treatments. Mech. Ageing Dev. 86:1995;151-160.
    • (1995) Mech. Ageing Dev. , vol.86 , pp. 151-160
    • Keogh, B.P.1    Tresini, M.2    Cristofalo, V.J.3    Allen, R.G.4
  • 33
    • 0015611577 scopus 로고
    • Aging in vitro: Incorporation of RNA and protein precursors and acid phosphatase activity during the lifespan of chick embryo fibroblasts
    • Macieira-Coelho A., Lima L. Aging in vitro: Incorporation of RNA and protein precursors and acid phosphatase activity during the lifespan of chick embryo fibroblasts. Mech. Ageing Dev. 2:1973;13-18.
    • (1973) Mech. Ageing Dev. , vol.2 , pp. 13-18
    • Macieira-Coelho, A.1    Lima, L.2
  • 34
    • 0015156520 scopus 로고
    • Changes in lysosomal associated structures in human fibroblasts kept in resting phase
    • Maciera-Coelho A., Garcia-Giralt E., Adrian M. Changes in lysosomal associated structures in human fibroblasts kept in resting phase. Proc. Soc. Exp. Biol. Med. 138:1971;712-718.
    • (1971) Proc. Soc. Exp. Biol. Med. , vol.138 , pp. 712-718
    • Maciera-Coelho, A.1    Garcia-Giralt, E.2    Adrian, M.3
  • 36
    • 0028568245 scopus 로고
    • The effects of aging on area 46 of the frontal cortex of the rhesus monkey
    • Peters A., Leahu D., Moss M. B., McNally K. J. The effects of aging on area 46 of the frontal cortex of the rhesus monkey. Cereb. Cortex. 4:1994;621-635.
    • (1994) Cereb. Cortex , vol.4 , pp. 621-635
    • Peters, A.1    Leahu, D.2    Moss, M.B.3    Mcnally, K.J.4
  • 37
    • 0014800006 scopus 로고
    • Morphologic changes accompanying senescence of cultured human diploid cells
    • Robbins E., Levine E. M., Eagle H. Morphologic changes accompanying senescence of cultured human diploid cells. J. Exp. Med. 131:1970;1211-1222.
    • (1970) J. Exp. Med. , vol.131 , pp. 1211-1222
    • Robbins, E.1    Levine, E.M.2    Eagle, H.3
  • 39
    • 0001914255 scopus 로고
    • Metabolic rate, aging, and lipofuscin accumulation
    • R. S. Sohal. Elsevier/North-Holland
    • Sohal R. S. Metabolic rate, aging, and lipofuscin accumulation. Sohal R. S. Age Pigments. 1981;303-316 Elsevier/North-Holland.
    • (1981) Age Pigments , pp. 303-316
    • Sohal, R.S.1
  • 40
    • 0025614206 scopus 로고
    • Oxidative stress as a causal factor in differentiation and aging: A unifying hypothesis
    • Sohal R. S., Allen R. G. Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis. Exp. Gerontol. 25:1990;499-522.
    • (1990) Exp. Gerontol. , vol.25 , pp. 499-522
    • Sohal, R.S.1    Allen, R.G.2
  • 41
    • 0022387693 scopus 로고
    • Effects of exogenous antioxidants on the levels of endogenous antioxidants, lipid-soluble fluorescent material and life span in the housefly, Musca domestica
    • Sohal R. S., Allen R. G., Farmer K. J., Newton R. K., Toy P. L. Effects of exogenous antioxidants on the levels of endogenous antioxidants, lipid-soluble fluorescent material and life span in the housefly, Musca domestica. Mech. Ageing Dev. 31:1985;329-336.
    • (1985) Mech. Ageing Dev. , vol.31 , pp. 329-336
    • Sohal, R.S.1    Allen, R.G.2    Farmer, K.J.3    Newton, R.K.4    Toy, P.L.5
  • 42
    • 76549152982 scopus 로고
    • On the histochemistry and ultrastructure of age pigment
    • B. H. Strehler. New York: Academic Press
    • Strehler B. L. On the histochemistry and ultrastructure of age pigment. Strehler B. H. Advances in Gerontological Research. 1964;343-383 Academic Press, New York.
    • (1964) Advances in Gerontological Research , pp. 343-383
    • Strehler, B.L.1
  • 43
    • 0033016225 scopus 로고    scopus 로고
    • Expression of EPC-1 in human skin fibroblasts derived from donors of different ages
    • Tresini M., Pignolo R., Allen R. G., Cristofalo V. J. Expression of EPC-1 in human skin fibroblasts derived from donors of different ages. J. Cell. Physiol. 179:1999;11-17.
    • (1999) J. Cell. Physiol. , vol.179 , pp. 11-17
    • Tresini, M.1    Pignolo, R.2    Allen, R.G.3    Cristofalo, V.J.4
  • 44
    • 0033572894 scopus 로고    scopus 로고
    • Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures
    • Wei W., Sedivy J. M. Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures. Exp. Cell Res. 253:1999;519-522.
    • (1999) Exp. Cell Res. , vol.253 , pp. 519-522
    • Wei, W.1    Sedivy, J.M.2
  • 45
    • 0000999798 scopus 로고
    • Factors affecting lipid pigment formation
    • R. S. Sohal. Elsevier/North-Holland
    • Wolman M. Factors affecting lipid pigment formation. Sohal R. S. Age Pigments. 1981;265-281 Elsevier/North-Holland.
    • (1981) Age Pigments , pp. 265-281
    • Wolman, M.1
  • 46
    • 0032566278 scopus 로고    scopus 로고
    • Endogenous β-galactosidase activity in continuously nonproliferating cells
    • Yegorov Y. E., Akimov S. S., Hass R., Zelenin A. V., Prudovsky I. A. Endogenous β-galactosidase activity in continuously nonproliferating cells. Exp. Cell Res. 243:1998;207-211.
    • (1998) Exp. Cell Res. , vol.243 , pp. 207-211
    • Yegorov, Y.E.1    Akimov, S.S.2    Hass, R.3    Zelenin, A.V.4    Prudovsky, I.A.5


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