-
1
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
R.T. Abraham Cell cycle checkpoint signaling through the ATM and ATR kinases Genes Dev. 15 2001 2177 2196
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
2
-
-
70349773104
-
Healing and hurting: Molecular mechanisms, functions, and pathologies of cellular senescence
-
P.D. Adams Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence Mol. Cell 36 2009 2 14
-
(2009)
Mol. Cell
, vol.36
, pp. 2-14
-
-
Adams, P.D.1
-
3
-
-
84877001084
-
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence
-
K.M. Aird, G. Zhang, H. Li, Z. Tu, B.G. Bitler, A. Garipov, H. Wu, Z. Wei, S.N. Wagner, M. Herlyn, and R. Zhang Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence Cell Rep. 3 2013 1252 1265
-
(2013)
Cell Rep.
, vol.3
, pp. 1252-1265
-
-
Aird, K.M.1
Zhang, G.2
Li, H.3
Tu, Z.4
Bitler, B.G.5
Garipov, A.6
Wu, H.7
Wei, Z.8
Wagner, S.N.9
Herlyn, M.10
Zhang, R.11
-
4
-
-
84929287721
-
ATM couples replication stress and metabolic reprogramming during cellular senescence
-
K.M. Aird, A.J. Worth, N.W. Snyder, J.V. Lee, S. Sivanand, Q. Liu, I.A. Blair, K.E. Wellen, and R. Zhang ATM couples replication stress and metabolic reprogramming during cellular senescence Cell Rep. 11 2015 893 901
-
(2015)
Cell Rep.
, vol.11
, pp. 893-901
-
-
Aird, K.M.1
Worth, A.J.2
Snyder, N.W.3
Lee, J.V.4
Sivanand, S.5
Liu, Q.6
Blair, I.A.7
Wellen, K.E.8
Zhang, R.9
-
5
-
-
3042761646
-
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
-
D.J. Baker, K.B. Jeganathan, J.D. Cameron, M. Thompson, S. Juneja, A. Kopecka, R. Kumar, R.B. Jenkins, P.C. de Groen, P. Roche, and J.M. van Deursen BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice Nat. Genet. 36 2004 744 749
-
(2004)
Nat. Genet.
, vol.36
, pp. 744-749
-
-
Baker, D.J.1
Jeganathan, K.B.2
Cameron, J.D.3
Thompson, M.4
Juneja, S.5
Kopecka, A.6
Kumar, R.7
Jenkins, R.B.8
De Groen, P.C.9
Roche, P.10
Van Deursen, J.M.11
-
6
-
-
84943811969
-
Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts
-
F. Bengsch, Z. Tu, H.Y. Tang, H. Zhu, D.W. Speicher, and R. Zhang Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts Cell Cycle 14 2015 1540 1547
-
(2015)
Cell Cycle
, vol.14
, pp. 1540-1547
-
-
Bengsch, F.1
Tu, Z.2
Tang, H.Y.3
Zhu, H.4
Speicher, D.W.5
Zhang, R.6
-
7
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
K. Bensaad, A. Tsuruta, M.A. Selak, M.N. Vidal, K. Nakano, R. Bartrons, E. Gottlieb, and K.H. Vousden TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 2006 107 120
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
8
-
-
84938232611
-
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
-
K. Birsoy, T. Wang, W.W. Chen, E. Freinkman, M. Abu-Remaileh, and D.M. Sabatini An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis Cell 162 2015 540 551
-
(2015)
Cell
, vol.162
, pp. 540-551
-
-
Birsoy, K.1
Wang, T.2
Chen, W.W.3
Freinkman, E.4
Abu-Remaileh, M.5
Sabatini, D.M.6
-
9
-
-
0021673561
-
Increased glycolysis in ageing cultured human diploid fibroblasts
-
A.H. Bittles, and N. Harper Increased glycolysis in ageing cultured human diploid fibroblasts Biosci. Rep. 4 1984 751 756
-
(1984)
Biosci. Rep.
, vol.4
, pp. 751-756
-
-
Bittles, A.H.1
Harper, N.2
-
10
-
-
79960635284
-
Fighting neurodegeneration with rapamycin: Mechanistic insights
-
J. Bové, M. Martínez-Vicente, and M. Vila Fighting neurodegeneration with rapamycin: mechanistic insights Nat. Rev. Neurosci. 12 2011 437 452
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 437-452
-
-
Bové, J.1
Martínez-Vicente, M.2
Vila, M.3
-
11
-
-
58849158388
-
How does SIRT1 affect metabolism, senescence and cancer?
-
C.L. Brooks, and W. Gu How does SIRT1 affect metabolism, senescence and cancer? Nat. Rev. Cancer 9 2009 123 128
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 123-128
-
-
Brooks, C.L.1
Gu, W.2
-
12
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
J. Campisi Aging, cellular senescence, and cancer Annu. Rev. Physiol. 75 2013 685 705
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
13
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
J. Campisi, and F. d'Adda di Fagagna Cellular senescence: when bad things happen to good cells Nat. Rev. Mol. Cell Biol. 8 2007 729 740
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
D'Adda Di Fagagna, F.2
-
14
-
-
84867271418
-
CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis
-
C. Capparelli, B. Chiavarina, D. Whitaker-Menezes, T.G. Pestell, R.G. Pestell, J. Hulit, S. Andò, A. Howell, U.E. Martinez-Outschoorn, F. Sotgia, and M.P. Lisanti CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis Cell Cycle 11 2012 3599 3610
-
(2012)
Cell Cycle
, vol.11
, pp. 3599-3610
-
-
Capparelli, C.1
Chiavarina, B.2
Whitaker-Menezes, D.3
Pestell, T.G.4
Pestell, R.G.5
Hulit, J.6
Andò, S.7
Howell, A.8
Martinez-Outschoorn, U.E.9
Sotgia, F.10
Lisanti, M.P.11
-
15
-
-
84874244599
-
SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence
-
A. Cardus, A.K. Uryga, G. Walters, and J.D. Erusalimsky SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence Cardiovasc. Res. 97 2013 571 579
-
(2013)
Cardiovasc. Res.
, vol.97
, pp. 571-579
-
-
Cardus, A.1
Uryga, A.K.2
Walters, G.3
Erusalimsky, J.D.4
-
16
-
-
13244258369
-
5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation
-
A. Catalano, S. Rodilossi, P. Caprari, V. Coppola, and A. Procopio 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation EMBO J. 24 2005 170 179
-
(2005)
EMBO J.
, vol.24
, pp. 170-179
-
-
Catalano, A.1
Rodilossi, S.2
Caprari, P.3
Coppola, V.4
Procopio, A.5
-
17
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
J.P. Coppé, C.K. Patil, F. Rodier, Y. Sun, D.P. Muñoz, J. Goldstein, P.S. Nelson, P.Y. Desprez, and J. Campisi Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol. 6 2008 2853 2868
-
(2008)
PLoS Biol.
, vol.6
, pp. 2853-2868
-
-
Coppé, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Muñoz, D.P.5
Goldstein, J.6
Nelson, P.S.7
Desprez, P.Y.8
Campisi, J.9
-
18
-
-
80054682555
-
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
-
J.P. Coppé, F. Rodier, C.K. Patil, A. Freund, P.Y. Desprez, and J. Campisi Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype J. Biol. Chem. 286 2011 36396 36403
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 36396-36403
-
-
Coppé, J.P.1
Rodier, F.2
Patil, C.K.3
Freund, A.4
Desprez, P.Y.5
Campisi, J.6
-
19
-
-
84959065037
-
Mitochondria are required for pro-ageing features of the senescent phenotype
-
C. Correia-Melo, F.D. Marques, R. Anderson, G. Hewitt, R. Hewitt, J. Cole, B.M. Carroll, S. Miwa, J. Birch, A. Merz, and et al. Mitochondria are required for pro-ageing features of the senescent phenotype EMBO J. 35 2016 724 742
-
(2016)
EMBO J.
, vol.35
, pp. 724-742
-
-
Correia-Melo, C.1
Marques, F.D.2
Anderson, R.3
Hewitt, G.4
Hewitt, R.5
Cole, J.6
Carroll, B.M.7
Miwa, S.8
Birch, J.9
Merz, A.10
-
20
-
-
42949129074
-
Many roads lead to oncogene-induced senescence
-
S. Courtois-Cox, S.L. Jones, and K. Cichowski Many roads lead to oncogene-induced senescence Oncogene 27 2008 2801 2809
-
(2008)
Oncogene
, vol.27
, pp. 2801-2809
-
-
Courtois-Cox, S.1
Jones, S.L.2
Cichowski, K.3
-
21
-
-
84926469999
-
Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions
-
P. Dalle Pezze, G. Nelson, E.G. Otten, V.I. Korolchuk, T.B. Kirkwood, T. von Zglinicki, and D.P. Shanley Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions PLoS Comput. Biol. 10 2014 e1003728
-
(2014)
PLoS Comput. Biol.
, vol.10
, pp. e1003728
-
-
Dalle Pezze, P.1
Nelson, G.2
Otten, E.G.3
Korolchuk, V.I.4
Kirkwood, T.B.5
Von Zglinicki, T.6
Shanley, D.P.7
-
22
-
-
0030703154
-
Pyruvate protects neurons against hydrogen peroxide-induced toxicity
-
S. Desagher, J. Glowinski, and J. Prémont Pyruvate protects neurons against hydrogen peroxide-induced toxicity J. Neurosci. 17 1997 9060 9067
-
(1997)
J. Neurosci.
, vol.17
, pp. 9060-9067
-
-
Desagher, S.1
Glowinski, J.2
Prémont, J.3
-
23
-
-
84876945664
-
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
-
X. Deschênes-Simard, M.F. Gaumont-Leclerc, V. Bourdeau, F. Lessard, O. Moiseeva, V. Forest, S. Igelmann, F.A. Mallette, M.K. Saba-El-Leil, S. Meloche, and et al. Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation Genes Dev. 27 2013 900 915
-
(2013)
Genes Dev.
, vol.27
, pp. 900-915
-
-
Deschênes-Simard, X.1
Gaumont-Leclerc, M.F.2
Bourdeau, V.3
Lessard, F.4
Moiseeva, O.5
Forest, V.6
Igelmann, S.7
Mallette, F.A.8
Saba-El-Leil, M.K.9
Meloche, S.10
-
24
-
-
84884417141
-
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
-
J.R. Dörr, Y. Yu, M. Milanovic, G. Beuster, C. Zasada, J.H. Däbritz, J. Lisec, D. Lenze, A. Gerhardt, K. Schleicher, and et al. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy Nature 501 2013 421 425
-
(2013)
Nature
, vol.501
, pp. 421-425
-
-
Dörr, J.R.1
Yu, Y.2
Milanovic, M.3
Beuster, G.4
Zasada, C.5
Däbritz, J.H.6
Lisec, J.7
Lenze, D.8
Gerhardt, A.9
Schleicher, K.10
-
25
-
-
34547625742
-
Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin
-
A. Efeyan, A. Ortega-Molina, S. Velasco-Miguel, D. Herranz, L.T. Vassilev, and M. Serrano Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin Cancer Res. 67 2007 7350 7357
-
(2007)
Cancer Res.
, vol.67
, pp. 7350-7357
-
-
Efeyan, A.1
Ortega-Molina, A.2
Velasco-Miguel, S.3
Herranz, D.4
Vassilev, L.T.5
Serrano, M.6
-
26
-
-
77955374484
-
Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors
-
E.V. Efimova, H.J. Mauceri, D.W. Golden, E. Labay, V.P. Bindokas, T.E. Darga, C. Chakraborty, J.C. Barreto-Andrade, C. Crawley, H.G. Sutton, and et al. Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors Cancer Res. 70 2010 6277 6282
-
(2010)
Cancer Res.
, vol.70
, pp. 6277-6282
-
-
Efimova, E.V.1
Mauceri, H.J.2
Golden, D.W.3
Labay, E.4
Bindokas, V.P.5
Darga, T.E.6
Chakraborty, C.7
Barreto-Andrade, J.C.8
Crawley, C.9
Sutton, H.G.10
-
27
-
-
84870507227
-
Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells
-
E. Favaro, K. Bensaad, M.G. Chong, D.A. Tennant, D.J. Ferguson, C. Snell, G. Steers, H. Turley, J.L. Li, U.L. Günther, and et al. Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells Cell Metab. 16 2012 751 764
-
(2012)
Cell Metab.
, vol.16
, pp. 751-764
-
-
Favaro, E.1
Bensaad, K.2
Chong, M.G.3
Tennant, D.A.4
Ferguson, D.J.5
Snell, C.6
Steers, G.7
Turley, H.8
Li, J.L.9
Günther, U.L.10
-
28
-
-
79955017452
-
P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
-
A. Freund, C.K. Patil, and J. Campisi p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype EMBO J. 30 2011 1536 1548
-
(2011)
EMBO J.
, vol.30
, pp. 1536-1548
-
-
Freund, A.1
Patil, C.K.2
Campisi, J.3
-
29
-
-
65449117176
-
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
-
M. Gamerdinger, P. Hajieva, A.M. Kaya, U. Wolfrum, F.U. Hartl, and C. Behl Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 EMBO J. 28 2009 889 901
-
(2009)
EMBO J.
, vol.28
, pp. 889-901
-
-
Gamerdinger, M.1
Hajieva, P.2
Kaya, A.M.3
Wolfrum, U.4
Hartl, F.U.5
Behl, C.6
-
30
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
R.A. Gatenby, and R.J. Gillies Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4 2004 891 899
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
31
-
-
84893442805
-
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
A.P. Gomes, N.L. Price, A.J. Ling, J.J. Moslehi, M.K. Montgomery, L. Rajman, J.P. White, J.S. Teodoro, C.D. Wrann, B.P. Hubbard, and et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging Cell 155 2013 1624 1638
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
Price, N.L.2
Ling, A.J.3
Moslehi, J.J.4
Montgomery, M.K.5
Rajman, L.6
White, J.P.7
Teodoro, J.S.8
Wrann, C.D.9
Hubbard, B.P.10
-
32
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
M.C. Haigis, and D.A. Sinclair Mammalian sirtuins: biological insights and disease relevance Annu. Rev. Pathol. 5 2010 253 295
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
33
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
D.G. Hardie, F.A. Ross, and S.A. Hawley AMPK: a nutrient and energy sensor that maintains energy homeostasis Nat. Rev. Mol. Cell Biol. 13 2012 251 262
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
34
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, K. Flurkey, N.L. Nadon, J.E. Wilkinson, K. Frenkel, C.S. Carter, and et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature 460 2009 392 395
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
35
-
-
0141720388
-
Calorie restriction and aging: Review of the literature and implications for studies in humans
-
L.K. Heilbronn, and E. Ravussin Calorie restriction and aging: review of the literature and implications for studies in humans Am. J. Clin. Nutr. 78 2003 361 369
-
(2003)
Am. J. Clin. Nutr.
, vol.78
, pp. 361-369
-
-
Heilbronn, L.K.1
Ravussin, E.2
-
36
-
-
84940587703
-
MTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
-
N. Herranz, S. Gallage, M. Mellone, T. Wuestefeld, S. Klotz, C.J. Hanley, S. Raguz, J.C. Acosta, A.J. Innes, A. Banito, and et al. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype Nat. Cell Biol. 17 2015 1205 1217
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 1205-1217
-
-
Herranz, N.1
Gallage, S.2
Mellone, M.3
Wuestefeld, T.4
Klotz, S.5
Hanley, C.J.6
Raguz, S.7
Acosta, J.C.8
Innes, A.J.9
Banito, A.10
-
37
-
-
84880585547
-
Lysosome-mediated processing of chromatin in senescence
-
A. Ivanov, J. Pawlikowski, I. Manoharan, J. van Tuyn, D.M. Nelson, T.S. Rai, P.P. Shah, G. Hewitt, V.I. Korolchuk, J.F. Passos, and et al. Lysosome-mediated processing of chromatin in senescence J. Cell Biol. 202 2013 129 143
-
(2013)
J. Cell Biol.
, vol.202
, pp. 129-143
-
-
Ivanov, A.1
Pawlikowski, J.2
Manoharan, I.3
Van Tuyn, J.4
Nelson, D.M.5
Rai, T.S.6
Shah, P.P.7
Hewitt, G.8
Korolchuk, V.I.9
Passos, J.F.10
-
38
-
-
84961290321
-
Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease
-
E.L. James, R.D. Michalek, G.N. Pitiyage, A.M. de Castro, K.S. Vignola, J. Jones, R.P. Mohney, E.D. Karoly, S.S. Prime, and E.K. Parkinson Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease J. Proteome Res. 14 2015 1854 1871
-
(2015)
J. Proteome Res.
, vol.14
, pp. 1854-1871
-
-
James, E.L.1
Michalek, R.D.2
Pitiyage, G.N.3
De Castro, A.M.4
Vignola, K.S.5
Jones, J.6
Mohney, R.P.7
Karoly, E.D.8
Prime, S.S.9
Parkinson, E.K.10
-
39
-
-
79952280229
-
P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
-
P. Jiang, W. Du, X. Wang, A. Mancuso, X. Gao, M. Wu, and X. Yang p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase Nat. Cell Biol. 13 2011 310 316
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 310-316
-
-
Jiang, P.1
Du, W.2
Wang, X.3
Mancuso, A.4
Gao, X.5
Wu, M.6
Yang, X.7
-
40
-
-
84873678601
-
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
-
P. Jiang, W. Du, A. Mancuso, K.E. Wellen, and X. Yang Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence Nature 493 2013 689 693
-
(2013)
Nature
, vol.493
, pp. 689-693
-
-
Jiang, P.1
Du, W.2
Mancuso, A.3
Wellen, K.E.4
Yang, X.5
-
41
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
R.G. Jones, D.R. Plas, S. Kubek, M. Buzzai, J. Mu, Y. Xu, M.J. Birnbaum, and C.B. Thompson AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Mol. Cell 18 2005 283 293
-
(2005)
Mol. Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
42
-
-
79961194820
-
Autophagy impairment induces premature senescence in primary human fibroblasts
-
H.T. Kang, K.B. Lee, S.Y. Kim, H.R. Choi, and S.C. Park Autophagy impairment induces premature senescence in primary human fibroblasts PLoS ONE 6 2011 e23367
-
(2011)
PLoS ONE
, vol.6
, pp. e23367
-
-
Kang, H.T.1
Lee, K.B.2
Kim, S.Y.3
Choi, H.R.4
Park, S.C.5
-
43
-
-
84872355087
-
Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
-
S. Kang, J.P. Louboutin, P. Datta, C.P. Landel, D. Martinez, A.S. Zervos, D.S. Strayer, T. Fernandes-Alnemri, and E.S. Alnemri Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging Cell Death Differ. 20 2013 259 269
-
(2013)
Cell Death Differ.
, vol.20
, pp. 259-269
-
-
Kang, S.1
Louboutin, J.P.2
Datta, P.3
Landel, C.P.4
Martinez, D.5
Zervos, A.S.6
Strayer, D.S.7
Fernandes-Alnemri, T.8
Alnemri, E.S.9
-
44
-
-
84942456107
-
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
-
C. Kang, Q. Xu, T.D. Martin, M.Z. Li, M. Demaria, L. Aron, T. Lu, B.A. Yankner, J. Campisi, and S.J. Elledge The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 Science 349 2015 aaa5612
-
(2015)
Science
, vol.349
, pp. aaa5612
-
-
Kang, C.1
Xu, Q.2
Martin, T.D.3
Li, M.Z.4
Demaria, M.5
Aron, L.6
Lu, T.7
Yankner, B.A.8
Campisi, J.9
Elledge, S.J.10
-
45
-
-
84878679199
-
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
-
J. Kaplon, L. Zheng, K. Meissl, B. Chaneton, V.A. Selivanov, G. Mackay, S.H. van der Burg, E.M. Verdegaal, M. Cascante, T. Shlomi, and et al. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence Nature 498 2013 109 112
-
(2013)
Nature
, vol.498
, pp. 109-112
-
-
Kaplon, J.1
Zheng, L.2
Meissl, K.3
Chaneton, B.4
Selivanov, V.A.5
MacKay, G.6
Van Der Burg, S.H.7
Verdegaal, E.M.8
Cascante, M.9
Shlomi, T.10
-
46
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
J.W. Kim, and C.V. Dang Cancer's molecular sweet tooth and the Warburg effect Cancer Res. 66 2006 8927 8930
-
(2006)
Cancer Res.
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
47
-
-
24344454692
-
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal
-
M.Y. Kim, T. Zhang, and W.L. Kraus Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal Genes Dev. 19 2005 1951 1967
-
(2005)
Genes Dev.
, vol.19
, pp. 1951-1967
-
-
Kim, M.Y.1
Zhang, T.2
Kraus, W.L.3
-
48
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
H. Kondoh, M.E. Lleonart, J. Gil, J. Wang, P. Degan, G. Peters, D. Martinez, A. Carnero, and D. Beach Glycolytic enzymes can modulate cellular life span Cancer Res. 65 2005 177 185
-
(2005)
Cancer Res.
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
50
-
-
84934281252
-
P53 in survival, death and metabolic health: A lifeguard with a licence to kill
-
F. Kruiswijk, C.F. Labuschagne, and K.H. Vousden p53 in survival, death and metabolic health: a lifeguard with a licence to kill Nat. Rev. Mol. Cell Biol. 16 2015 393 405
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 393-405
-
-
Kruiswijk, F.1
Labuschagne, C.F.2
Vousden, K.H.3
-
51
-
-
84938751873
-
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
-
R.M. Laberge, Y. Sun, A.V. Orjalo, C.K. Patil, A. Freund, L. Zhou, S.C. Curran, A.R. Davalos, K.A. Wilson-Edell, S. Liu, and et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation Nat. Cell Biol. 17 2015 1049 1061
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 1049-1061
-
-
Laberge, R.M.1
Sun, Y.2
Orjalo, A.V.3
Patil, C.K.4
Freund, A.5
Zhou, L.6
Curran, S.C.7
Davalos, A.R.8
Wilson-Edell, K.A.9
Liu, S.10
-
52
-
-
33646946746
-
Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
-
B.Y. Lee, J.A. Han, J.S. Im, A. Morrone, K. Johung, E.C. Goodwin, W.J. Kleijer, D. DiMaio, and E.S. Hwang Senescence-associated beta-galactosidase is lysosomal beta-galactosidase Aging Cell 5 2006 187 195
-
(2006)
Aging Cell
, vol.5
, pp. 187-195
-
-
Lee, B.Y.1
Han, J.A.2
Im, J.S.3
Morrone, A.4
Johung, K.5
Goodwin, E.C.6
Kleijer, W.J.7
DiMaio, D.8
Hwang, E.S.9
-
53
-
-
84870292564
-
Cytosolic malate dehydrogenase regulates senescence in human fibroblasts
-
S.M. Lee, S.H. Dho, S.K. Ju, J.S. Maeng, J.Y. Kim, and K.S. Kwon Cytosolic malate dehydrogenase regulates senescence in human fibroblasts Biogerontology 13 2012 525 536
-
(2012)
Biogerontology
, vol.13
, pp. 525-536
-
-
Lee, S.M.1
Dho, S.H.2
Ju, S.K.3
Maeng, J.S.4
Kim, J.Y.5
Kwon, K.S.6
-
55
-
-
84868450290
-
ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis
-
L. Luo, W. Huang, R. Tao, N. Hu, Z.X. Xiao, and Z. Luo ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis Cancer Lett. 328 2013 114 119
-
(2013)
Cancer Lett.
, vol.328
, pp. 114-119
-
-
Luo, L.1
Huang, W.2
Tao, R.3
Hu, N.4
Xiao, Z.X.5
Luo, Z.6
-
56
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
S. Matoba, J.G. Kang, W.D. Patino, A. Wragg, M. Boehm, O. Gavrilova, P.J. Hurley, F. Bunz, and P.M. Hwang p53 regulates mitochondrial respiration Science 312 2006 1650 1653
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
57
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
E. Michishita, R.A. McCord, E. Berber, M. Kioi, H. Padilla-Nash, M. Damian, P. Cheung, R. Kusumoto, T.L. Kawahara, J.C. Barrett, and et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin Nature 452 2008 492 496
-
(2008)
Nature
, vol.452
, pp. 492-496
-
-
Michishita, E.1
McCord, R.A.2
Berber, E.3
Kioi, M.4
Padilla-Nash, H.5
Damian, M.6
Cheung, P.7
Kusumoto, R.8
Kawahara, T.L.9
Barrett, J.C.10
-
58
-
-
84895763135
-
Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
-
T. Mikawa, T. Maruyama, K. Okamoto, H. Nakagama, M.E. Lleonart, T. Tsusaka, K. Hori, I. Murakami, T. Izumi, A. Takaori-Kondo, and et al. Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2 J. Cell Biol. 204 2014 729 745
-
(2014)
J. Cell Biol.
, vol.204
, pp. 729-745
-
-
Mikawa, T.1
Maruyama, T.2
Okamoto, K.3
Nakagama, H.4
Lleonart, M.E.5
Tsusaka, T.6
Hori, K.7
Murakami, I.8
Izumi, T.9
Takaori-Kondo, A.10
-
59
-
-
84904702784
-
Cellular senescence: From physiology to pathology
-
D. Muñoz-Espín, and M. Serrano Cellular senescence: from physiology to pathology Nat. Rev. Mol. Cell Biol. 15 2014 482 496
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 482-496
-
-
Muñoz-Espín, D.1
Serrano, M.2
-
60
-
-
79956325949
-
Spatial coupling of mTOR and autophagy augments secretory phenotypes
-
M. Narita, A.R. Young, S. Arakawa, S.A. Samarajiwa, T. Nakashima, S. Yoshida, S. Hong, L.S. Berry, S. Reichelt, M. Ferreira, and et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes Science 332 2011 966 970
-
(2011)
Science
, vol.332
, pp. 966-970
-
-
Narita, M.1
Young, A.R.2
Arakawa, S.3
Samarajiwa, S.A.4
Nakashima, T.5
Yoshida, S.6
Hong, S.7
Berry, L.S.8
Reichelt, S.9
Ferreira, M.10
-
61
-
-
84903744004
-
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
-
B.J. North, M.A. Rosenberg, K.B. Jeganathan, A.V. Hafner, S. Michan, J. Dai, D.J. Baker, Y. Cen, L.E. Wu, A.A. Sauve, and et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan EMBO J. 33 2014 1438 1453
-
(2014)
EMBO J.
, vol.33
, pp. 1438-1453
-
-
North, B.J.1
Rosenberg, M.A.2
Jeganathan, K.B.3
Hafner, A.V.4
Michan, S.5
Dai, J.6
Baker, D.J.7
Cen, Y.8
Wu, L.E.9
Sauve, A.A.10
-
62
-
-
79959635610
-
Senescent cells develop a PARP-1 and nuclear factor-kappaB-associated secretome (PNAS)
-
M. Ohanna, S. Giuliano, C. Bonet, V. Imbert, V. Hofman, J. Zangari, K. Bille, C. Robert, B. Bressac-de Paillerets, P. Hofman, and et al. Senescent cells develop a PARP-1 and nuclear factor-kappaB-associated secretome (PNAS) Genes Dev. 25 2011 1245 1261
-
(2011)
Genes Dev.
, vol.25
, pp. 1245-1261
-
-
Ohanna, M.1
Giuliano, S.2
Bonet, C.3
Imbert, V.4
Hofman, V.5
Zangari, J.6
Bille, K.7
Robert, C.8
Bressac-De Paillerets, B.9
Hofman, P.10
-
63
-
-
70350125106
-
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
-
A.V. Orjalo, D. Bhaumik, B.K. Gengler, G.K. Scott, and J. Campisi Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network Proc. Natl. Acad. Sci. USA 106 2009 17031 17036
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 17031-17036
-
-
Orjalo, A.V.1
Bhaumik, D.2
Gengler, B.K.3
Scott, G.K.4
Campisi, J.5
-
64
-
-
76649142385
-
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1
-
Y.Y. Park, S. Lee, M. Karbowski, A. Neutzner, R.J. Youle, and H. Cho Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1 J. Cell Sci. 123 2010 619 626
-
(2010)
J. Cell Sci.
, vol.123
, pp. 619-626
-
-
Park, Y.Y.1
Lee, S.2
Karbowski, M.3
Neutzner, A.4
Youle, R.J.5
Cho, H.6
-
65
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
S. Parrinello, E. Samper, A. Krtolica, J. Goldstein, S. Melov, and J. Campisi Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts Nat. Cell Biol. 5 2003 741 747
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
Samper, E.2
Krtolica, A.3
Goldstein, J.4
Melov, S.5
Campisi, J.6
-
66
-
-
41549086994
-
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells
-
S. Patschan, J. Chen, A. Polotskaia, N. Mendelev, J. Cheng, D. Patschan, and M.S. Goligorsky Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells Am. J. Physiol. Heart Circ. Physiol. 294 2008 H1119 H1129
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.294
, pp. H1119-H1129
-
-
Patschan, S.1
Chen, J.2
Polotskaia, A.3
Mendelev, N.4
Cheng, J.5
Patschan, D.6
Goligorsky, M.S.7
-
67
-
-
80053036165
-
The Role of p53 in Metabolic Regulation
-
A.M. Puzio-Kuter The Role of p53 in Metabolic Regulation Genes Cancer 2 2011 385 391
-
(2011)
Genes Cancer
, vol.2
, pp. 385-391
-
-
Puzio-Kuter, A.M.1
-
68
-
-
84860319965
-
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
-
C. Quijano, L. Cao, M.M. Fergusson, H. Romero, J. Liu, S. Gutkind, I.I. Rovira, R.P. Mohney, E.D. Karoly, and T. Finkel Oncogene-induced senescence results in marked metabolic and bioenergetic alterations Cell Cycle 11 2012 1383 1392
-
(2012)
Cell Cycle
, vol.11
, pp. 1383-1392
-
-
Quijano, C.1
Cao, L.2
Fergusson, M.M.3
Romero, H.4
Liu, J.5
Gutkind, S.6
Rovira, I.I.7
Mohney, R.P.8
Karoly, E.D.9
Finkel, T.10
-
69
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
F. Rodier, J.P. Coppé, C.K. Patil, W.A. Hoeijmakers, D.P. Muñoz, S.R. Raza, A. Freund, E. Campeau, A.R. Davalos, and J. Campisi Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion Nat. Cell Biol. 11 2009 973 979
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppé, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Muñoz, D.P.5
Raza, S.R.6
Freund, A.7
Campeau, E.8
Davalos, A.R.9
Campisi, J.10
-
71
-
-
34547875773
-
Sirtuins: Critical regulators at the crossroads between cancer and aging
-
L.R. Saunders, and E. Verdin Sirtuins: critical regulators at the crossroads between cancer and aging Oncogene 26 2007 5489 5504
-
(2007)
Oncogene
, vol.26
, pp. 5489-5504
-
-
Saunders, L.R.1
Verdin, E.2
-
72
-
-
1942506067
-
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
-
F. Schwartzenberg-Bar-Yoseph, M. Armoni, and E. Karnieli The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression Cancer Res. 64 2004 2627 2633
-
(2004)
Cancer Res.
, vol.64
, pp. 2627-2633
-
-
Schwartzenberg-Bar-Yoseph, F.1
Armoni, M.2
Karnieli, E.3
-
73
-
-
84857289515
-
Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
-
K. Singh, S. Matsuyama, J.A. Drazba, and A. Almasan Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress Autophagy 8 2012 236 251
-
(2012)
Autophagy
, vol.8
, pp. 236-251
-
-
Singh, K.1
Matsuyama, S.2
Drazba, J.A.3
Almasan, A.4
-
74
-
-
84903276373
-
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging
-
L.R. Stein, and S. Imai Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging EMBO J. 33 2014 1321 1340
-
(2014)
EMBO J.
, vol.33
, pp. 1321-1340
-
-
Stein, L.R.1
Imai, S.2
-
75
-
-
33847199335
-
EIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
-
P. Syntichaki, K. Troulinaki, and N. Tavernarakis eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans Nature 445 2007 922 926
-
(2007)
Nature
, vol.445
, pp. 922-926
-
-
Syntichaki, P.1
Troulinaki, K.2
Tavernarakis, N.3
-
76
-
-
84930323338
-
Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells
-
S. Takebayashi, H. Tanaka, S. Hino, Y. Nakatsu, T. Igata, A. Sakamoto, M. Narita, and M. Nakao Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells Aging Cell 14 2015 689 697
-
(2015)
Aging Cell
, vol.14
, pp. 689-697
-
-
Takebayashi, S.1
Tanaka, H.2
Hino, S.3
Nakatsu, Y.4
Igata, T.5
Sakamoto, A.6
Narita, M.7
Nakao, M.8
-
77
-
-
34249696938
-
Extension of human cell lifespan by nicotinamide phosphoribosyltransferase
-
E. van der Veer, C. Ho, C. O'Neil, N. Barbosa, R. Scott, S.P. Cregan, and J.G. Pickering Extension of human cell lifespan by nicotinamide phosphoribosyltransferase J. Biol. Chem. 282 2007 10841 10845
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10841-10845
-
-
Van Der Veer, E.1
Ho, C.2
O'Neil, C.3
Barbosa, N.4
Scott, R.5
Cregan, S.P.6
Pickering, J.G.7
-
78
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
79
-
-
84859483420
-
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
-
M.C. Velarde, J.M. Flynn, N.U. Day, S. Melov, and J. Campisi Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin Aging (Albany, N.Y.) 4 2012 3 12
-
(2012)
Aging (Albany, N.Y.)
, vol.4
, pp. 3-12
-
-
Velarde, M.C.1
Flynn, J.M.2
Day, N.U.3
Melov, S.4
Campisi, J.5
-
80
-
-
0038035142
-
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function
-
W. Wang, X. Yang, I. López de Silanes, D. Carling, and M. Gorospe Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function J. Biol. Chem. 278 2003 27016 27023
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27016-27023
-
-
Wang, W.1
Yang, X.2
López De Silanes, I.3
Carling, D.4
Gorospe, M.5
-
81
-
-
84865191462
-
Autophagic activity dictates the cellular response to oncogenic RAS
-
Y. Wang, X.D. Wang, E. Lapi, A. Sullivan, W. Jia, Y.W. He, I. Ratnayaka, S. Zhong, R.D. Goldin, C.G. Goemans, and et al. Autophagic activity dictates the cellular response to oncogenic RAS Proc. Natl. Acad. Sci. USA 109 2012 13325 13330
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 13325-13330
-
-
Wang, Y.1
Wang, X.D.2
Lapi, E.3
Sullivan, A.4
Jia, W.5
He, Y.W.6
Ratnayaka, I.7
Zhong, S.8
Goldin, R.D.9
Goemans, C.G.10
-
82
-
-
12444279265
-
On the origin of cancer cells
-
O. Warburg On the origin of cancer cells Science 123 1956 309 314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
83
-
-
84957952429
-
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
-
C.D. Wiley, M.C. Velarde, P. Lecot, S. Liu, E.A. Sarnoski, A. Freund, K. Shirakawa, H.W. Lim, S.S. Davis, A. Ramanathan, and et al. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype Cell Metab. 23 2016 303 314
-
(2016)
Cell Metab.
, vol.23
, pp. 303-314
-
-
Wiley, C.D.1
Velarde, M.C.2
Lecot, P.3
Liu, S.4
Sarnoski, E.A.5
Freund, A.6
Shirakawa, K.7
Lim, H.W.8
Davis, S.S.9
Ramanathan, A.10
-
84
-
-
0036294999
-
A role for mitochondria as potential regulators of cellular life span
-
D. Xu, and T. Finkel A role for mitochondria as potential regulators of cellular life span Biochem. Biophys. Res. Commun. 294 2002 245 248
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.294
, pp. 245-248
-
-
Xu, D.1
Finkel, T.2
-
85
-
-
77953292238
-
SIRT1 and p53, effect on cancer, senescence and beyond
-
J. Yi, and J. Luo SIRT1 and p53, effect on cancer, senescence and beyond Biochim. Biophys. Acta 1804 2010 1684 1689
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1684-1689
-
-
Yi, J.1
Luo, J.2
-
86
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
-
J. Yoshino, K.F. Mills, M.J. Yoon, and S. Imai Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice Cell Metab. 14 2011 528 536
-
(2011)
Cell Metab.
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
87
-
-
80053635472
-
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
-
C. Zhang, M. Lin, R. Wu, X. Wang, B. Yang, A.J. Levine, W. Hu, and Z. Feng Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect Proc. Natl. Acad. Sci. USA 108 2011 16259 16264
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 16259-16264
-
-
Zhang, C.1
Lin, M.2
Wu, R.3
Wang, X.4
Yang, B.5
Levine, A.J.6
Hu, W.7
Feng, Z.8
-
88
-
-
84946836377
-
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase
-
H. Zhu, S. Ren, B.G. Bitler, K.M. Aird, Z. Tu, E. Skordalakes, Y. Zhu, J. Yan, Y. Sun, and R. Zhang SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase Cell Rep. 13 2015 1183 1193
-
(2015)
Cell Rep.
, vol.13
, pp. 1183-1193
-
-
Zhu, H.1
Ren, S.2
Bitler, B.G.3
Aird, K.M.4
Tu, Z.5
Skordalakes, E.6
Zhu, Y.7
Yan, J.8
Sun, Y.9
Zhang, R.10
-
89
-
-
70349438679
-
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
-
B.M. Zid, A.N. Rogers, S.D. Katewa, M.A. Vargas, M.C. Kolipinski, T.A. Lu, S. Benzer, and P. Kapahi 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila Cell 139 2009 149 160
-
(2009)
Cell
, vol.139
, pp. 149-160
-
-
Zid, B.M.1
Rogers, A.N.2
Katewa, S.D.3
Vargas, M.A.4
Kolipinski, M.C.5
Lu, T.A.6
Benzer, S.7
Kapahi, P.8
-
90
-
-
84922627875
-
Mitochondrial effectors of cellular senescence: Beyond the free radical theory of aging
-
D.V. Ziegler, C.D. Wiley, and M.C. Velarde Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging Aging Cell 14 2015 1 7
-
(2015)
Aging Cell
, vol.14
, pp. 1-7
-
-
Ziegler, D.V.1
Wiley, C.D.2
Velarde, M.C.3
-
91
-
-
0346256784
-
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
-
W. Zwerschke, S. Mazurek, P. Stöckl, E. Hütter, E. Eigenbrodt, and P. Jansen-Dürr Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence Biochem. J. 376 2003 403 411
-
(2003)
Biochem. J.
, vol.376
, pp. 403-411
-
-
Zwerschke, W.1
Mazurek, S.2
Stöckl, P.3
Hütter, E.4
Eigenbrodt, E.5
Jansen-Dürr, P.6
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