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Volumn 23, Issue 6, 2016, Pages 1060-1065

Metformin as a Tool to Target Aging

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Indexed keywords

METFORMIN;

EID: 84975491642     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.05.011     Document Type: Note
Times cited : (748)

References (80)
  • 1
    • 84890839540 scopus 로고    scopus 로고
    • Antidiabetic drugs and their potential role in treating mild cognitive impairment and Alzheimer's disease
    • K. Alagiakrishnan, S. Sankaralingam, M. Ghosh, L. Mereu, and P. Senior Antidiabetic drugs and their potential role in treating mild cognitive impairment and Alzheimer's disease Discov. Med. 16 2013 277 286
    • (2013) Discov. Med. , vol.16 , pp. 277-286
    • Alagiakrishnan, K.1    Sankaralingam, S.2    Ghosh, M.3    Mereu, L.4    Senior, P.5
  • 3
    • 84951266035 scopus 로고    scopus 로고
    • Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
    • J.S. Allard, E.J. Perez, K. Fukui, P. Carpenter, D.K. Ingram, and R. de Cabo Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice Behav. Brain Res. 301 2016 1 9
    • (2016) Behav. Brain Res. , vol.301 , pp. 1-9
    • Allard, J.S.1    Perez, E.J.2    Fukui, K.3    Carpenter, P.4    Ingram, D.K.5    De Cabo, R.6
  • 4
    • 77952941576 scopus 로고    scopus 로고
    • The cardiovascular effects of metformin: Further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus
    • G. Anfossi, I. Russo, K. Bonomo, and M. Trovati The cardiovascular effects of metformin: further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus Curr. Vasc. Pharmacol. 8 2010 327 337
    • (2010) Curr. Vasc. Pharmacol. , vol.8 , pp. 327-337
    • Anfossi, G.1    Russo, I.2    Bonomo, K.3    Trovati, M.4
  • 5
    • 84881661464 scopus 로고    scopus 로고
    • The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer
    • V.N. Anisimov, and A. Bartke The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer Crit. Rev. Oncol. Hematol. 87 2013 201 223
    • (2013) Crit. Rev. Oncol. Hematol. , vol.87 , pp. 201-223
    • Anisimov, V.N.1    Bartke, A.2
  • 10
    • 84914165449 scopus 로고    scopus 로고
    • Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
    • C.A. Bannister, S.E. Holden, S. Jenkins-Jones, C.L. Morgan, J.P. Halcox, G. Schernthaner, J. Mukherjee, and C.J. Currie Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls Diabetes Obes. Metab. 16 2014 1165 1173
    • (2014) Diabetes Obes. Metab. , vol.16 , pp. 1165-1173
    • Bannister, C.A.1    Holden, S.E.2    Jenkins-Jones, S.3    Morgan, C.L.4    Halcox, J.P.5    Schernthaner, G.6    Mukherjee, J.7    Currie, C.J.8
  • 12
  • 14
    • 84907370814 scopus 로고    scopus 로고
    • Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
    • H.R. Bridges, A.J. Jones, M.N. Pollak, and J. Hirst Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria Biochem. J. 462 2014 475 487
    • (2014) Biochem. J. , vol.462 , pp. 475-487
    • Bridges, H.R.1    Jones, A.J.2    Pollak, M.N.3    Hirst, J.4
  • 18
    • 84903158901 scopus 로고    scopus 로고
    • The search for antiaging interventions: From elixirs to fasting regimens
    • R. de Cabo, D. Carmona-Gutierrez, M. Bernier, M.N. Hall, and F. Madeo The search for antiaging interventions: from elixirs to fasting regimens Cell 157 2014 1515 1526
    • (2014) Cell , vol.157 , pp. 1515-1526
    • De Cabo, R.1    Carmona-Gutierrez, D.2    Bernier, M.3    Hall, M.N.4    Madeo, F.5
  • 21
    • 84859372038 scopus 로고    scopus 로고
    • Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study
    • Diabetes Prevention Program Research Group Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study Diabetes Care 35 2012 731 737
    • (2012) Diabetes Care , vol.35 , pp. 731-737
  • 23
    • 84925852614 scopus 로고    scopus 로고
    • Promoting health and longevity through diet: From model organisms to humans
    • L. Fontana, and L. Partridge Promoting health and longevity through diet: from model organisms to humans Cell 161 2015 106 118
    • (2015) Cell , vol.161 , pp. 106-118
    • Fontana, L.1    Partridge, L.2
  • 24
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span - From yeast to humans
    • L. Fontana, L. Partridge, and V.D. Longo Extending healthy life span - from yeast to humans Science 328 2010 321 326
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 30
    • 84911209192 scopus 로고    scopus 로고
    • Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus
    • M. Guo, J. Mi, Q.M. Jiang, J.M. Xu, Y.Y. Tang, G. Tian, and B. Wang Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus Clin. Exp. Pharmacol. Physiol. 41 2014 650 656
    • (2014) Clin. Exp. Pharmacol. Physiol. , vol.41 , pp. 650-656
    • Guo, M.1    Mi, J.2    Jiang, Q.M.3    Xu, J.M.4    Tang, Y.Y.5    Tian, G.6    Wang, B.7
  • 34
    • 84891560192 scopus 로고    scopus 로고
    • Metformin limits ceramide-induced senescence in C2C12 myoblasts
    • K.S. Jadhav, C.M. Dungan, and D.L. Williamson Metformin limits ceramide-induced senescence in C2C12 myoblasts Mech. Ageing Dev. 134 2013 548 559
    • (2013) Mech. Ageing Dev. , vol.134 , pp. 548-559
    • Jadhav, K.S.1    Dungan, C.M.2    Williamson, D.L.3
  • 35
    • 84872527628 scopus 로고    scopus 로고
    • MTOR is a key modulator of ageing and age-related disease
    • S.C. Johnson, P.S. Rabinovitch, and M. Kaeberlein mTOR is a key modulator of ageing and age-related disease Nature 493 2013 338 345
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 36
    • 84877251996 scopus 로고    scopus 로고
    • Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
    • E. Karnevi, K. Said, R. Andersson, and A.H. Rosendahl Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells BMC Cancer 13 2013 235
    • (2013) BMC Cancer , vol.13 , pp. 235
    • Karnevi, E.1    Said, K.2    Andersson, R.3    Rosendahl, A.H.4
  • 40
    • 63849328978 scopus 로고    scopus 로고
    • Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus
    • A. Kooy, J. de Jager, P. Lehert, D. Bets, M.G. Wulffelé, A.J. Donker, and C.D. Stehouwer Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus Arch. Intern. Med. 169 2009 616 625
    • (2009) Arch. Intern. Med. , vol.169 , pp. 616-625
    • Kooy, A.1    De Jager, J.2    Lehert, P.3    Bets, D.4    Wulffelé, M.G.5    Donker, A.J.6    Stehouwer, C.D.7
  • 44
    • 78651451726 scopus 로고    scopus 로고
    • Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
    • M.S. Lee, C.C. Hsu, M.L. Wahlqvist, H.N. Tsai, Y.H. Chang, and Y.C. Huang Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals BMC Cancer 11 2011 20
    • (2011) BMC Cancer , vol.11 , pp. 20
    • Lee, M.S.1    Hsu, C.C.2    Wahlqvist, M.L.3    Tsai, H.N.4    Chang, Y.H.5    Huang, Y.C.6
  • 46
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • G. Libby, L.A. Donnelly, P.T. Donnan, D.R. Alessi, A.D. Morris, and J.M. Evans New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes Diabetes Care 32 2009 1620 1625
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3    Alessi, D.R.4    Morris, A.D.5    Evans, J.M.6
  • 48
    • 80052397117 scopus 로고    scopus 로고
    • Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions
    • B. Liu, Z. Fan, S.M. Edgerton, X. Yang, S.E. Lind, and A.D. Thor Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions Cell Cycle 10 2011 2959 2966
    • (2011) Cell Cycle , vol.10 , pp. 2959-2966
    • Liu, B.1    Fan, Z.2    Edgerton, S.M.3    Yang, X.4    Lind, S.E.5    Thor, A.D.6
  • 50
    • 84924723896 scopus 로고    scopus 로고
    • Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts
    • J. Lu, J. Shi, M. Li, B. Gui, R. Fu, G. Yao, Z. Duan, Z. Lv, Y. Yang, Z. Chen, and et al. Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts Life Sci. 127 2015 59 65
    • (2015) Life Sci. , vol.127 , pp. 59-65
    • Lu, J.1    Shi, J.2    Li, M.3    Gui, B.4    Fu, R.5    Yao, G.6    Duan, Z.7    Lv, Z.8    Yang, Y.9    Chen, Z.10
  • 60
    • 84907495391 scopus 로고    scopus 로고
    • Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: Role of specificity protein (Sp) transcription factors
    • V. Nair, S. Sreevalsan, R. Basha, M. Abdelrahim, A. Abudayyeh, A. Rodrigues Hoffman, and S. Safe Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors J. Biol. Chem. 289 2014 27692 27701
    • (2014) J. Biol. Chem. , vol.289 , pp. 27692-27701
    • Nair, V.1    Sreevalsan, S.2    Basha, R.3    Abdelrahim, M.4    Abudayyeh, A.5    Rodrigues Hoffman, A.6    Safe, S.7
  • 61
    • 84902239478 scopus 로고    scopus 로고
    • Long-term metformin usage and cognitive function among older adults with diabetes
    • T.P. Ng, L. Feng, K.B. Yap, T.S. Lee, C.H. Tan, and B. Winblad Long-term metformin usage and cognitive function among older adults with diabetes J. Alzheimers Dis. 41 2014 61 68
    • (2014) J. Alzheimers Dis. , vol.41 , pp. 61-68
    • Ng, T.P.1    Feng, L.2    Yap, K.B.3    Lee, T.S.4    Tan, C.H.5    Winblad, B.6
  • 62
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. Elegans Healthspan via AMPK, LKB1, and SKN-1
    • B. Onken, and M. Driscoll Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. Elegans Healthspan via AMPK, LKB1, and SKN-1 PLoS ONE 5 2010 e8758
    • (2010) PLoS ONE , vol.5 , pp. e8758
    • Onken, B.1    Driscoll, M.2
  • 66
    • 84942115958 scopus 로고    scopus 로고
    • Metformin and Inflammation: Its Potential beyond Glucose-lowering Effect
    • Y. Saisho Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect Endocr. Metab. Immune Disord. Drug Targets 15 2015 196 205
    • (2015) Endocr. Metab. Immune Disord. Drug Targets , vol.15 , pp. 196-205
    • Saisho, Y.1
  • 68
    • 84867621125 scopus 로고    scopus 로고
    • Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
    • C. Slack, A. Foley, and L. Partridge Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila PLoS ONE 7 2012 e47699
    • (2012) PLoS ONE , vol.7 , pp. e47699
    • Slack, C.1    Foley, A.2    Partridge, L.3
  • 70
    • 84923376645 scopus 로고    scopus 로고
    • Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
    • Y.M. Song, Y.H. Lee, J.W. Kim, D.S. Ham, E.S. Kang, B.S. Cha, H.C. Lee, and B.W. Lee Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway Autophagy 11 2015 46 59
    • (2015) Autophagy , vol.11 , pp. 46-59
    • Song, Y.M.1    Lee, Y.H.2    Kim, J.W.3    Ham, D.S.4    Kang, E.S.5    Cha, B.S.6    Lee, H.C.7    Lee, B.W.8
  • 71
    • 84866138849 scopus 로고    scopus 로고
    • Cancer outcomes and all-cause mortality in adults allocated to metformin: Systematic review and collaborative meta-analysis of randomised clinical trials
    • R.J. Stevens, R. Ali, C.R. Bankhead, M.A. Bethel, B.J. Cairns, R.P. Camisasca, F.L. Crowe, A.J. Farmer, S. Harrison, J.A. Hirst, and et al. Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials Diabetologia 55 2012 2593 2603
    • (2012) Diabetologia , vol.55 , pp. 2593-2603
    • Stevens, R.J.1    Ali, R.2    Bankhead, C.R.3    Bethel, M.A.4    Cairns, B.J.5    Camisasca, R.P.6    Crowe, F.L.7    Farmer, A.J.8    Harrison, S.9    Hirst, J.A.10
  • 73
    • 84947279001 scopus 로고    scopus 로고
    • Association between guideline recommended drugs and death in older adults with multiple chronic conditions: Population based cohort study
    • M.E. Tinetti, G. McAvay, M. Trentalange, A.B. Cohen, and H.G. Allore Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study BMJ 351 2015 h4984
    • (2015) BMJ , vol.351 , pp. h4984
    • Tinetti, M.E.1    McAvay, G.2    Trentalange, M.3    Cohen, A.B.4    Allore, H.G.5
  • 74
    • 75149186480 scopus 로고    scopus 로고
    • Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells
    • L. Tosca, C. Ramé, C. Chabrolle, S. Tesseraud, and J. Dupont Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells Reproduction 139 2010 409 418
    • (2010) Reproduction , vol.139 , pp. 409-418
    • Tosca, L.1    Ramé, C.2    Chabrolle, C.3    Tesseraud, S.4    Dupont, J.5
  • 75
    • 84865717087 scopus 로고    scopus 로고
    • Diabetes, metformin use, and colon cancer: A population-based cohort study in Taiwan
    • C.H. Tseng Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan Eur. J. Endocrinol. 167 2012 409 416
    • (2012) Eur. J. Endocrinol. , vol.167 , pp. 409-416
    • Tseng, C.H.1
  • 76
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) Lancet 352 1998 854 865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 79
    • 79959385996 scopus 로고    scopus 로고
    • Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
    • Z. Xie, K. Lau, B. Eby, P. Lozano, C. He, B. Pennington, H. Li, S. Rathi, Y. Dong, R. Tian, and et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice Diabetes 60 2011 1770 1778
    • (2011) Diabetes , vol.60 , pp. 1770-1778
    • Xie, Z.1    Lau, K.2    Eby, B.3    Lozano, P.4    He, C.5    Pennington, B.6    Li, H.7    Rathi, S.8    Dong, Y.9    Tian, R.10
  • 80
    • 84555188488 scopus 로고    scopus 로고
    • Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin
    • Z. Zheng, H. Chen, J. Li, T. Li, B. Zheng, Y. Zheng, H. Jin, Y. He, Q. Gu, and X. Xu Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin Diabetes 61 2012 217 228
    • (2012) Diabetes , vol.61 , pp. 217-228
    • Zheng, Z.1    Chen, H.2    Li, J.3    Li, T.4    Zheng, B.5    Zheng, Y.6    Jin, H.7    He, Y.8    Gu, Q.9    Xu, X.10


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