Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism

Aging Cell

Volumn 16, Issue 3, 2017, Pages 564-574

  Wang, Rong ^a   Yu, Zhen ^a   Sunchu, Bharath ^a,b   Shoaf, James ^b   Dang, Ivana ^b   Zhao, Stephanie ^a   Caples, Kelsey ^b   Bradley, Lynda ^b   Beaver, Laura M ^a,b   Ho, Emily ^a,b   Löhr, Christiane V ^b   Perez, Viviana I ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

cell senescence; Nrf2; rapamycin; SASP; gal

Indexed keywords

BETA ACTIN; BETA GALACTOSIDASE; CYTOKINE; HISTONE H2AX; HYDROGEN PEROXIDE; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; KC PROTEIN; LEPTIN RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 5; PROTEIN P16; PROTEIN P21; RAPAMYCIN; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1ALPHA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MTOR PROTEIN, MOUSE; NFE2L2 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE; AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; PRIMARY CELL CULTURE;

AGING; ANIMALS; AUTOPHAGY; BETA-GALACTOSIDASE; CELL PROLIFERATION; CELLULAR SENESCENCE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOKINES; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; PHENOTYPE; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SIROLIMUS; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES;

EID: 85017096102     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12587     Document Type: Article

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