Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α-dependent senescence-associated secretory phenotype

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 9, 2015, Pages 1963-1974

  Gardner, Sarah E ^a   Humphry, Melanie ^a   Bennett, Martin R ^a   Clarke, Murray C H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

aging; atherosclerosis; inflammation; interleukin 1; muscle, smooth, vascular

Indexed keywords

BETA GALACTOSIDASE; CARBON TETRACHLORIDE; COLLAGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GELATINASE B; INFLAMMASOME; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; RANTES; TOLL LIKE RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1; DNA BINDING PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RNA; TRANSCRIPTION FACTOR;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CELLULAR SECRETION; CHEMOTAXIS; CHRONIC INFLAMMATION; ENDOTHELIUM CELL; GLUCOSE UTILIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MONONUCLEAR CELL; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN SECRETION; SECRETORY CELL; SENESCENCE; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL AGING; CELL CULTURE; DISEASE MODEL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; MALE; METABOLISM; MOUSE; PATHOLOGY; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL AGING; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-1ALPHA; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION FACTORS;

EID: 84940391650     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.305896     Document Type: Article

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