Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Cell

Volumn 169, Issue 1, 2017, Pages 132-147.e16

  Baar, Marjolein P ^a   Brandt, Renata M C ^a   Putavet, Diana A ^a   Klein, Julian D D ^a   Derks, Kasper W J ^a   Bourgeois, Benjamin R M ^b   Stryeck, Sarah ^b   Rijksen, Yvonne ^a   van Willigenburg, Hester ^a   Feijtel, Danny A ^a   van der Pluijm, Ingrid ^a   Essers, Jeroen ^a   van Cappellen, Wiggert A ^a   van IJcken, Wilfred F ^a   Houtsmuller, Adriaan B ^a   Pothof, Joris ^a   de Bruin, Ron W F ^a   Madl, Tobias ^b   Hoeijmakers, Jan H J ^a   Campisi, Judith ^c,d   de Keizer, Peter L J ^a,c   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

aging; apoptosis; cell penetrating peptide; chemotherapy; FOXO4; IL6; LMNB1; Senescence; tissue homeostasis; TP53

Indexed keywords

DOXORUBICIN; PROTEIN P53; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CELL PENETRATING PEPTIDE; FORKHEAD TRANSCRIPTION FACTOR; FOXO4 PROTEIN, MOUSE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLUMINESCENCE; CELL AGING; CELL VIABILITY; CONTROLLED STUDY; DENSITY; FIBROBLAST; FRAILTY; HOMEOSTASIS; KIDNEY FUNCTION; LIVER FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; TEMPERATURE; ANIMAL; CELL INCLUSION; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; HUMAN; KIDNEY; LIVER; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRICHOTHIODYSTROPHY SYNDROMES;

AGING; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL AGING; CELL LINE; CELL SURVIVAL; CELL-PENETRATING PEPTIDES; DOXORUBICIN; FEMALE; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INCLUSION BODIES; KIDNEY; LIVER; MALE; MICE; TRICHOTHIODYSTROPHY SYNDROMES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85016052515     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.02.031     Document Type: Article

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