메뉴 건너뛰기




Volumn 8, Issue 9, 2007, Pages 729-740

Cellular senescence: When bad things happen to good cells

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; PROTEIN P53;

EID: 34548186667     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm2233     Document Type: Review
Times cited : (3361)

References (157)
  • 1
    • 50549218525 scopus 로고    scopus 로고
    • Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636 (1965). A classic paper that describes the limited replicative lifespan of normal human cells.
    • Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636 (1965). A classic paper that describes the limited replicative lifespan of normal human cells.
  • 2
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 0029028701 scopus 로고    scopus 로고
    • Bishop, J. M. Cancer: the rise of the genetic paradigm. Genes Dev. 9, 1309-1315 (1995). References 2 and 3 describe the characteristics of cancer cells and the importance of mutations in cancer development.
    • Bishop, J. M. Cancer: the rise of the genetic paradigm. Genes Dev. 9, 1309-1315 (1995). References 2 and 3 describe the characteristics of cancer cells and the importance of mutations in cancer development.
  • 4
    • 29244432159 scopus 로고    scopus 로고
    • Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice
    • Busuttil, R. A., Rubio, M., Dolle, M. E., Campisi, J. & Vijg, J. Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair 5, 52-60 (2006).
    • (2006) DNA Repair , vol.5 , pp. 52-60
    • Busuttil, R.A.1    Rubio, M.2    Dolle, M.E.3    Campisi, J.4    Vijg, J.5
  • 5
    • 0026006294 scopus 로고
    • Senescence as a mode of tumor suppression
    • Sager, R. Senescence as a mode of tumor suppression. Environ. Health Perspect. 93, 59-62 (1991).
    • (1991) Environ. Health Perspect , vol.93 , pp. 59-62
    • Sager, R.1
  • 6
    • 0035500487 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-suppressor mechanism
    • Campisi, J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11, 27-31 (2001).
    • (2001) Trends Cell Biol , vol.11 , pp. 27-31
    • Campisi, J.1
  • 7
    • 33645526114 scopus 로고    scopus 로고
    • Oncogene-induced senescence: Putting the brakes on tumor development
    • Braig, M. & Schmitt, C. A. Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res. 66, 2881-2884 (2006).
    • (2006) Cancer Res , vol.66 , pp. 2881-2884
    • Braig, M.1    Schmitt, C.A.2
  • 8
    • 0038049143 scopus 로고    scopus 로고
    • Cancer and ageing: Rival demons?
    • Campisi, J. Cancer and ageing: rival demons? Nature Rev. Cancer 3, 339-349 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 339-349
    • Campisi, J.1
  • 9
    • 0034626774 scopus 로고    scopus 로고
    • Why do we age?
    • Kirkwood, T. B. & Austad, S. N. Why do we age? Nature 408, 233-238 (2000).
    • (2000) Nature , vol.408 , pp. 233-238
    • Kirkwood, T.B.1    Austad, S.N.2
  • 10
    • 20444370974 scopus 로고    scopus 로고
    • What has senescence got to do with cancer?
    • Dimri, G. P. What has senescence got to do with cancer? Cancer Cell 7, 505-512 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 505-512
    • Dimri, G.P.1
  • 11
    • 0035253719 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-protection mechanism: The essential role of counting
    • Wright, W. E. & Shay, J. W. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr. Opin. Genet. Dev. 11, 98-103 (2001).
    • (2001) Curr. Opin. Genet. Dev , vol.11 , pp. 98-103
    • Wright, W.E.1    Shay, J.W.2
  • 12
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression and organismal aging: Good citizens, bad neighbors
    • Campisi, J. Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors. Cell 120, 513-522 (2005).
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 13
    • 0036303126 scopus 로고    scopus 로고
    • Hornsby, P. J. Cellular senescence and tissue aging in vivo. J. Gerontol. 57, 251-256 (2002). References 5-13 describe the historic and current evidence that cellular senescence suppresses the development of cancer. In addition, references 8 and 9 explain the concept of antagonistic pleiotropy.
    • Hornsby, P. J. Cellular senescence and tissue aging in vivo. J. Gerontol. 57, 251-256 (2002). References 5-13 describe the historic and current evidence that cellular senescence suppresses the development of cancer. In addition, references 8 and 9 explain the concept of antagonistic pleiotropy.
  • 14
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • Kim, W. Y. & Sharpless, N. E. The regulation of INK4/ARF in cancer and aging. Cell 127, 265-275 (2006).
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 15
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • DiLeonardo, A., Linke, S. P., Clarkin, K. & Wahl, G. M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540-2551 (1994).
    • (1994) Genes Dev , vol.8 , pp. 2540-2551
    • DiLeonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 16
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    • Herbig, U., Jobling, W. A., Chen, B. P., Chen, D. J. & Sedivy, J. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14, 501-513 (2004).
    • (2004) Mol. Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.5
  • 17
    • 0029778901 scopus 로고    scopus 로고
    • Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
    • Ogryzko, V. V., Hirai, T. H., Russanova, V. R., Barbie, D. A. & Howard, B. H. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. Mol. Cell. Biol. 16, 5210-5218 (1996).
    • (1996) Mol. Cell. Biol , vol.16 , pp. 5210-5218
    • Ogryzko, V.V.1    Hirai, T.H.2    Russanova, V.R.3    Barbie, D.A.4    Howard, B.H.5
  • 18
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (1997).
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 19
    • 12144290513 scopus 로고    scopus 로고
    • MKK7 couples stress signaling to G2/M cell-cycle progression and cellular senescence
    • Wada, T. et al. MKK7 couples stress signaling to G2/M cell-cycle progression and cellular senescence. Nature Cell Biol. 6, 215-226 (2004).
    • (2004) Nature Cell Biol , vol.6 , pp. 215-226
    • Wada, T.1
  • 20
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyperreplication
    • Di Micco, R. et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyperreplication. Nature 444, 638-642 (2006).
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1
  • 21
    • 0037068753 scopus 로고    scopus 로고
    • Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
    • Olsen, C. L., Gardie, B., Yaswen, P. & Stampfer, M. R. Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 21, 6328-6339 (2002).
    • (2002) Oncogene , vol.21 , pp. 6328-6339
    • Olsen, C.L.1    Gardie, B.2    Yaswen, P.3    Stampfer, M.R.4
  • 22
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic raf
    • Zhu, J., Woods, D., McMahon, M. & Bishop, J. M. Senescence of human fibroblasts induced by oncogenic raf. Genes Dev. 12, 2997-3007 (1998).
    • (1998) Genes Dev , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 23
    • 2342570379 scopus 로고    scopus 로고
    • Shay, J. W. & Roninson, I. B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23, 2919-2933 (2004). References 15-23 show that many potentially oncogenic stimuli can induce a senescence response.
    • Shay, J. W. & Roninson, I. B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23, 2919-2933 (2004). References 15-23 show that many potentially oncogenic stimuli can induce a senescence response.
  • 24
    • 1842789989 scopus 로고    scopus 로고
    • Mechanisms of cellular senescence in human and mouse cells
    • Itahana, K., Campisi, J. & Dimri, G. P. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 5, 1-10 (2004).
    • (2004) Biogerontology , vol.5 , pp. 1-10
    • Itahana, K.1    Campisi, J.2    Dimri, G.P.3
  • 26
    • 0036463405 scopus 로고    scopus 로고
    • A matter of life and death
    • Green, D. R. & Evan, G. I. A matter of life and death. Cancer Cell 1, 19-30 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 19-30
    • Green, D.R.1    Evan, G.I.2
  • 27
    • 9644310524 scopus 로고    scopus 로고
    • Differential regulation of apoptotic cell death in senescent human cells
    • Hampel, B., Malisan, F., Niederegger, H., Testi, R. & Jansen-Durr, P. Differential regulation of apoptotic cell death in senescent human cells. Exp. Gerontol. 39, 1713-1721 (2004).
    • (2004) Exp. Gerontol , vol.39 , pp. 1713-1721
    • Hampel, B.1    Malisan, F.2    Niederegger, H.3    Testi, R.4    Jansen-Durr, P.5
  • 28
    • 0034655373 scopus 로고    scopus 로고
    • Apoptosis or senescence-like growth arrest: Influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
    • Chen, Q. M., Liu, J. & Merrett, J. B. Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem. J. 347, 543-551 (2000).
    • (2000) Biochem. J , vol.347 , pp. 543-551
    • Chen, Q.M.1    Liu, J.2    Merrett, J.B.3
  • 29
    • 0034633958 scopus 로고    scopus 로고
    • Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts
    • Tepper, C. G., Seldin, M. F. & Mudryj, M. Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts. Exp. Cell Res. 260, 9-19 (2000).
    • (2000) Exp. Cell Res , vol.260 , pp. 9-19
    • Tepper, C.G.1    Seldin, M.F.2    Mudryj, M.3
  • 30
    • 0038292179 scopus 로고    scopus 로고
    • Caspase inhibition switches doxorubicin-induced apoptosis to senescence
    • Rebbaa, A., Zheng, X., Chou, P. M. & Mirkin, B. L. Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene 22, 2805-2811 (2003).
    • (2003) Oncogene , vol.22 , pp. 2805-2811
    • Rebbaa, A.1    Zheng, X.2    Chou, P.M.3    Mirkin, B.L.4
  • 31
    • 0035131153 scopus 로고    scopus 로고
    • Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
    • Seluanov, A. et al. Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol. Cell. Biol. 21, 1552-1564 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 1552-1564
    • Seluanov, A.1
  • 32
    • 0142231578 scopus 로고    scopus 로고
    • Bcl-2 activates a programme of premature senescence in human carcinoma cells
    • Crescenzi, E., Palumbo, G. & Brady, H. J. Bcl-2 activates a programme of premature senescence in human carcinoma cells. Biochem. J. 375, 263-274 (2003).
    • (2003) Biochem. J , vol.375 , pp. 263-274
    • Crescenzi, E.1    Palumbo, G.2    Brady, H.J.3
  • 33
    • 8344230643 scopus 로고    scopus 로고
    • Senescent fibroblasts resist apoptosis by downregulating caspase-3
    • Marcotte, R., Lacelle, C. & Wang, E. Senescent fibroblasts resist apoptosis by downregulating caspase-3. Mech. Ageing Dev. 125, 777-783 (2004).
    • (2004) Mech. Ageing Dev , vol.125 , pp. 777-783
    • Marcotte, R.1    Lacelle, C.2    Wang, E.3
  • 34
    • 33750523876 scopus 로고    scopus 로고
    • Death-associated protein 3 regulates cellular senescence through oxidative stress response
    • Murata, Y. et al. Death-associated protein 3 regulates cellular senescence through oxidative stress response. FEBS Lett. 580, 6093-6099 (2006).
    • (2006) FEBS Lett , vol.580 , pp. 6093-6099
    • Murata, Y.1
  • 35
    • 33749020871 scopus 로고    scopus 로고
    • p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts
    • Jackson, J. G. & Pereira-Smith, O. M. p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res. 66, 8356-8360 (2006).
    • (2006) Cancer Res , vol.66 , pp. 8356-8360
    • Jackson, J.G.1    Pereira-Smith, O.M.2
  • 36
    • 0037039381 scopus 로고    scopus 로고
    • Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent
    • Chang, B. D. et al. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl Acad. Sci. USA 99, 389-394 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 389-394
    • Chang, B.D.1
  • 37
    • 11244334166 scopus 로고    scopus 로고
    • Molecular signature of oncogenic ras-induced senescence
    • Mason, D. X., Jackson, T. J. & Lin, A. W. Molecular signature of oncogenic ras-induced senescence. Oncogene 23, 9238-9246 (2004).
    • (2004) Oncogene , vol.23 , pp. 9238-9246
    • Mason, D.X.1    Jackson, T.J.2    Lin, A.W.3
  • 39
    • 28244499304 scopus 로고    scopus 로고
    • Identification of differentially expressed proteins in senescent human embryonic fibroblasts
    • Trougakos, I. P., Saridaki, A., Panayotou, G. & Gonos, E. S. Identification of differentially expressed proteins in senescent human embryonic fibroblasts. Mech. Ageing Dev. 127, 88-92 (2006).
    • (2006) Mech. Ageing Dev , vol.127 , pp. 88-92
    • Trougakos, I.P.1    Saridaki, A.2    Panayotou, G.3    Gonos, E.S.4
  • 40
    • 5444253109 scopus 로고    scopus 로고
    • Exploration of replicative senescence- associated genes in human dermal fibroblasts by cDNA microarray technology
    • Yoon, I. K. et al. Exploration of replicative senescence- associated genes in human dermal fibroblasts by cDNA microarray technology. Exp. Gerontol. 39, 1369-1378 (2004).
    • (2004) Exp. Gerontol , vol.39 , pp. 1369-1378
    • Yoon, I.K.1
  • 41
    • 0037452888 scopus 로고    scopus 로고
    • Zhang, H., Pan, K. H. & Cohen, S. N. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc. Natl Acad. Sci. USA 100, 3251-3256 (2003). References 36-41 describe the many changes in gene expression that are linked to the senescence response.
    • Zhang, H., Pan, K. H. & Cohen, S. N. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc. Natl Acad. Sci. USA 100, 3251-3256 (2003). References 36-41 describe the many changes in gene expression that are linked to the senescence response.
  • 42
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr, C. J. & McCormick, F. The RB and p53 pathways in cancer. Cancer Cell 2, 103-112 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 43
    • 0242329884 scopus 로고    scopus 로고
    • p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
    • Espinosa, J. M., Verdun, R. E. & Emerson, B. M. p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol. Cell 12, 1015-1027 (2003).
    • (2003) Mol. Cell , vol.12 , pp. 1015-1027
    • Espinosa, J.M.1    Verdun, R.E.2    Emerson, B.M.3
  • 44
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • Gil, J. & Peters, G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nature Rev. Mol. Cell Biol. 7, 667-677 (2006).
    • (2006) Nature Rev. Mol. Cell Biol , vol.7 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 45
    • 0037667702 scopus 로고    scopus 로고
    • Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716 (2003). The first description of senescence-associated heterochromatin foci.
    • Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716 (2003). The first description of senescence-associated heterochromatin foci.
  • 46
    • 0028146852 scopus 로고
    • Global change of gene expression at late G1/S boundary may occur in human IMR-90 diploid fibroblasts during senescence
    • Pang, J. H. & Chen, K. Y. Global change of gene expression at late G1/S boundary may occur in human IMR-90 diploid fibroblasts during senescence. J. Cell Physiol. 160, 531-538 (1994).
    • (1994) J. Cell Physiol , vol.160 , pp. 531-538
    • Pang, J.H.1    Chen, K.Y.2
  • 47
    • 0025052004 scopus 로고
    • Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
    • Seshadri, T. & Campisi, J. Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 247, 205-209 (1990).
    • (1990) Science , vol.247 , pp. 205-209
    • Seshadri, T.1    Campisi, J.2
  • 49
    • 85177159661 scopus 로고    scopus 로고
    • Dimri, G. P. et al. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995). First description of a senescence-associated marker that allowed the identification of senescent cells in vivo.
    • Dimri, G. P. et al. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995). First description of a senescence-associated marker that allowed the identification of senescent cells in vivo.
  • 50
    • 33646946746 scopus 로고    scopus 로고
    • Senescence-associated β-galactosidase is lysosomal β-galactosidase
    • Lee, B. Y. et al. Senescence-associated β-galactosidase is lysosomal β-galactosidase. Aging Cell 5, 187-195 (2006).
    • (2006) Aging Cell , vol.5 , pp. 187-195
    • Lee, B.Y.1
  • 51
    • 84900969225 scopus 로고    scopus 로고
    • Ink4a/Arf expression is a biomarker of aging
    • Krishnamurthy, J. et al. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114, 1299-1307 (2004).
    • (2004) J. Clin. Invest , vol.114 , pp. 1299-1307
    • Krishnamurthy, J.1
  • 52
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: Roles of the p53 and p16 pathways
    • Beausejour, C. M. et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22, 4212-4222 (2003).
    • (2003) EMBO J , vol.22 , pp. 4212-4222
    • Beausejour, C.M.1
  • 53
    • 0037214382 scopus 로고    scopus 로고
    • Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1
    • Itahana, K. et al. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell. Biol. 23, 389-401 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 389-401
    • Itahana, K.1
  • 54
    • 33745712849 scopus 로고    scopus 로고
    • The power and the promise of oncogene-induced senescence markers
    • Collado, M. & Serrano, M. The power and the promise of oncogene-induced senescence markers. Nature Rev. Cancer 6, 472-476 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 472-476
    • Collado, M.1    Serrano, M.2
  • 55
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
    • (2003) Nature , vol.426 , pp. 194-198
    • d'Adda di Fagagna, F.1
  • 56
    • 0042420304 scopus 로고    scopus 로고
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003). References 55 and 56, along with reference 16, provide the first direct evidence that dysfunctional telomeres trigger a DNA-damage response.
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003). References 55 and 56, along with reference 16, provide the first direct evidence that dysfunctional telomeres trigger a DNA-damage response.
  • 57
    • 0025829808 scopus 로고
    • Nuclear distribution of centromeres during the cell cycle of human diploid fibroblasts
    • Bartholdi, M. F. Nuclear distribution of centromeres during the cell cycle of human diploid fibroblasts. J. Cell Sci. 99, 255-263 (1991).
    • (1991) J. Cell Sci , vol.99 , pp. 255-263
    • Bartholdi, M.F.1
  • 59
    • 3543056880 scopus 로고    scopus 로고
    • Functional links between telomeres and proteins of the DNA-damage response
    • d'Adda di Fagagna, F., Teo, S. H. & Jackson, S. P. Functional links between telomeres and proteins of the DNA-damage response. Genes Dev. 18, 1781-1799 (2004).
    • (2004) Genes Dev , vol.18 , pp. 1781-1799
    • d'Adda di Fagagna, F.1    Teo, S.H.2    Jackson, S.P.3
  • 60
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith, J. D. et al. Mammalian telomeres end in a large duplex loop. Cell 97, 503-514 (1999).
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1
  • 61
    • 0025279931 scopus 로고    scopus 로고
    • Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during aging of human fibroblasts. Nature 345, 458-460 (1990). First evidence linking telomere shortening to replicative senescence.
    • Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during aging of human fibroblasts. Nature 345, 458-460 (1990). First evidence linking telomere shortening to replicative senescence.
  • 62
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann, M. T., Strong, M.A., Hao, L. Y. & Greider, C. W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77 (2001).
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 63
    • 0034630432 scopus 로고    scopus 로고
    • Accumulation of short telomeres in human fibroblasts prior to replicative senescence
    • Martens, U. M., Chavez, E. A., Poon, S. S., Schmoor, C. & Lansdorp, P. M. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp. Cell Res. 256, 291-299 (2000).
    • (2000) Exp. Cell Res , vol.256 , pp. 291-299
    • Martens, U.M.1    Chavez, E.A.2    Poon, S.S.3    Schmoor, C.4    Lansdorp, P.M.5
  • 64
    • 3342929538 scopus 로고    scopus 로고
    • DNA damage checkpoint kinase Chk2 triggers replicative senescence
    • Gire, V., Roux, P., Wynford-Thomas, D., Brondello, J. M. & Dulic, V. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J. 23, 2554-2563 (2004).
    • (2004) EMBO J , vol.23 , pp. 2554-2563
    • Gire, V.1    Roux, P.2    Wynford-Thomas, D.3    Brondello, J.M.4    Dulic, V.5
  • 65
    • 0037148271 scopus 로고    scopus 로고
    • Telomerase in the human organism
    • Collins, K. & Mitchell, J. R. Telomerase in the human organism. Oncogene 21, 564-579 (2002).
    • (2002) Oncogene , vol.21 , pp. 564-579
    • Collins, K.1    Mitchell, J.R.2
  • 67
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi, K. et al. Telomerase maintains telomere structure in normal human cells. Cell 114, 241-253 (2003).
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1
  • 68
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life span by introduction of telomerase into normal human cells
    • Bodnar, A. G. et al. Extension of life span by introduction of telomerase into normal human cells. Science 279, 349-352 (1998).
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 69
    • 0035325264 scopus 로고    scopus 로고
    • Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts
    • Chen, Q. M., Prowse, K. R., Tu, V. C., Purdom, S. & Linskens, M. H. Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp. Cell Res. 265, 294-303 (2001).
    • (2001) Exp. Cell Res , vol.265 , pp. 294-303
    • Chen, Q.M.1    Prowse, K.R.2    Tu, V.C.3    Purdom, S.4    Linskens, M.H.5
  • 70
    • 0042195820 scopus 로고    scopus 로고
    • Oxygen sensitivity severely limits the replicative life span of murine cells
    • Parrinello, S. et al. Oxygen sensitivity severely limits the replicative life span of murine cells. Nature Cell Biol. 5, 741-747 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 741-747
    • Parrinello, S.1
  • 71
    • 11144268164 scopus 로고    scopus 로고
    • Significant role for p16(INK4a) in p53-independent telomere-directed senescence
    • Jacobs, J. J. & de Lange, T. Significant role for p16(INK4a) in p53-independent telomere-directed senescence. Curr. Biol. 14, 2302-2308 (2004).
    • (2004) Curr. Biol , vol.14 , pp. 2302-2308
    • Jacobs, J.J.1    de Lange, T.2
  • 72
    • 0033013980 scopus 로고    scopus 로고
    • Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
    • Stein, G. H., Drullinger, L. F., Soulard, A. & Dulic, V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 19, 2109-2117 (1999).
    • (1999) Mol. Cell. Biol , vol.19 , pp. 2109-2117
    • Stein, G.H.1    Drullinger, L.F.2    Soulard, A.3    Dulic, V.4
  • 73
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • Roninson, I. B. Tumor cell senescence in cancer treatment. Cancer Res. 63, 2705-2715 (2003).
    • (2003) Cancer Res , vol.63 , pp. 2705-2715
    • Roninson, I.B.1
  • 74
    • 16844373387 scopus 로고    scopus 로고
    • Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers
    • Roberson, R. S., Kussick, S. J., Vallieres, E., Chen, S. Y. & Wu, D. Y. Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res. 65, 2795-2803 (2005).
    • (2005) Cancer Res , vol.65 , pp. 2795-2803
    • Roberson, R.S.1    Kussick, S.J.2    Vallieres, E.3    Chen, S.Y.4    Wu, D.Y.5
  • 75
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    • Schmitt, C. A. et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109, 335-346 (2002).
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1
  • 77
    • 1842861744 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock
    • Munro, J., Barr, N. I., Ireland, H., Morrison, V. & Parkinson, E. K. Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. Exp. Cell Res. 295, 525-538 (2004).
    • (2004) Exp. Cell Res , vol.295 , pp. 525-538
    • Munro, J.1    Barr, N.I.2    Ireland, H.3    Morrison, V.4    Parkinson, E.K.5
  • 78
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003).
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 79
    • 0036829085 scopus 로고    scopus 로고
    • Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes
    • Bandyopadhyay, D. et al. Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. Cancer Res. 62, 6231-6239 (2002).
    • (2002) Cancer Res , vol.62 , pp. 6231-6239
    • Bandyopadhyay, D.1
  • 80
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci, S. & Pelicci, P. G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nature Rev. Cancer 6, 38-51 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 81
    • 0033989829 scopus 로고    scopus 로고
    • Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14/ARF tumor suppressor
    • Dimri, G. P., Itahana, K., Acosta, M. & Campisi, J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14/ARF tumor suppressor. Mol. Cell. Biol. 20, 273-285 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 273-285
    • Dimri, G.P.1    Itahana, K.2    Acosta, M.3    Campisi, J.4
  • 82
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin, A. W. et al. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12, 3008-3019 (1998).
    • (1998) Genes Dev , vol.12 , pp. 3008-3019
    • Lin, A.W.1
  • 83
    • 23244447037 scopus 로고    scopus 로고
    • E600-associated senescence-like cell cycle arrest of human nevi
    • E600-associated senescence-like cell cycle arrest of human nevi. Nature 436, 720-724 (2005).
    • (2005) Nature , vol.436 , pp. 720-724
    • Michaloglou, C.1
  • 84
    • 2642527955 scopus 로고    scopus 로고
    • Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
    • Woo, R. A. & Poon, R. Y. Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev. 18 (2004).
    • (2004) Genes Dev , vol.18
    • Woo, R.A.1    Poon, R.Y.2
  • 86
    • 0035793380 scopus 로고    scopus 로고
    • Tang, D. G., Tokumoto, Y. M., Apperly, J. A., Lloyd, A. C. & Raff, M. C. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science 291, 868-871 (2001).
    • Tang, D. G., Tokumoto, Y. M., Apperly, J. A., Lloyd, A. C. & Raff, M. C. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science 291, 868-871 (2001).
  • 87
    • 0035931859 scopus 로고    scopus 로고
    • Opposing effects of Ets and Id proteins on p16/INK4a expression during cellular senescence
    • Ohtani, N. et al. Opposing effects of Ets and Id proteins on p16/INK4a expression during cellular senescence. Nature 409, 1067-1070 (2001).
    • (2001) Nature , vol.409 , pp. 1067-1070
    • Ohtani, N.1
  • 88
    • 19944427674 scopus 로고    scopus 로고
    • Formation of macroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
    • Zhang, R. et al. Formation of macroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev. Cell 8, 19-31 (2005).
    • (2005) Dev. Cell , vol.8 , pp. 19-31
    • Zhang, R.1
  • 89
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova, J. et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637 (2006).
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1
  • 90
    • 1642355129 scopus 로고    scopus 로고
    • Normal human fibroblasts are resistant to RAS-induced senescence
    • Benanti, J. A. & Galloway, D. A. Normal human fibroblasts are resistant to RAS-induced senescence. Mol. Cell. Biol. 24, 2842-2852 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , pp. 2842-2852
    • Benanti, J.A.1    Galloway, D.A.2
  • 91
    • 4043063729 scopus 로고    scopus 로고
    • Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: Implications for models of human tumorigenesis
    • Skinner, J. et al. Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis. Oncogene 23, 5994-5999 (2004).
    • (2004) Oncogene , vol.23 , pp. 5994-5999
    • Skinner, J.1
  • 92
    • 23244461708 scopus 로고    scopus 로고
    • Oncogene-induced senescence as an initial barrier in lymphoma development
    • Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005).
    • (2005) Nature , vol.436 , pp. 660-665
    • Braig, M.1
  • 93
    • 23244460597 scopus 로고    scopus 로고
    • Critical role of p53-dependent cellular senescence in suppression of PTEN-deficient tumorigenesis
    • Chen, Z. et al. Critical role of p53-dependent cellular senescence in suppression of PTEN-deficient tumorigenesis. Nature 436, 725-730 (2005).
    • (2005) Nature , vol.436 , pp. 725-730
    • Chen, Z.1
  • 94
    • 23244447893 scopus 로고    scopus 로고
    • Identification of senescent cells in premalignant tumours
    • Collado, M. et al. Identification of senescent cells in premalignant tumours. Nature 436, 642 (2005).
    • (2005) Nature , vol.436 , pp. 642
    • Collado, M.1
  • 95
    • 15044351968 scopus 로고    scopus 로고
    • Lazzerini Denchi, E., Attwooll, C., Pasini, D. & Helin, K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol. Cell. Biol. 25, 2660-2672 (2005). Together with references 83 and 89, references 92-95 provide evidence that cellular senescence suppresses tumorigenesis in vivo.
    • Lazzerini Denchi, E., Attwooll, C., Pasini, D. & Helin, K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol. Cell. Biol. 25, 2660-2672 (2005). Together with references 83 and 89, references 92-95 provide evidence that cellular senescence suppresses tumorigenesis in vivo.
  • 96
    • 33745363911 scopus 로고    scopus 로고
    • DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
    • Moiseeva, O., Mallette, F. A., Mukhopadhyay, U. K., Moores, A. & Ferbeyre, G. DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation. Mol. Biol. Cell 17, 1583-1592 (2006).
    • (2006) Mol. Biol. Cell , vol.17 , pp. 1583-1592
    • Moiseeva, O.1    Mallette, F.A.2    Mukhopadhyay, U.K.3    Moores, A.4    Ferbeyre, G.5
  • 97
    • 0037742433 scopus 로고    scopus 로고
    • Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model
    • Vijayachandra, K., Lee, J. & Glick, A. B. Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model. Cancer Res. 63, 3447-3452 (2003).
    • (2003) Cancer Res , vol.63 , pp. 3447-3452
    • Vijayachandra, K.1    Lee, J.2    Glick, A.B.3
  • 98
    • 10644263286 scopus 로고    scopus 로고
    • Smurf2 up-regulation activates telomere-dependent senescence
    • Zhang, H. & Cohen, S. N. Smurf2 up-regulation activates telomere-dependent senescence. Genes Dev. 18, 3028-3040 (2004).
    • (2004) Genes Dev , vol.18 , pp. 3028-3040
    • Zhang, H.1    Cohen, S.N.2
  • 99
    • 0035114576 scopus 로고    scopus 로고
    • Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    • Ramirez, R. D. et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15, 398-403 (2001).
    • (2001) Genes Dev , vol.15 , pp. 398-403
    • Ramirez, R.D.1
  • 100
    • 0032537762 scopus 로고    scopus 로고
    • Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
    • Brenner, A. J., Stampfer, M. R. & Aldaz, C. M. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene 17, 199-205 (1998).
    • (1998) Oncogene , vol.17 , pp. 199-205
    • Brenner, A.J.1    Stampfer, M.R.2    Aldaz, C.M.3
  • 101
    • 0032528623 scopus 로고    scopus 로고
    • Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells
    • Huschtscha, L. I. et al. Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res. 58, 3508-3512 (1998).
    • (1998) Cancer Res , vol.58 , pp. 3508-3512
    • Huschtscha, L.I.1
  • 102
    • 2142666372 scopus 로고    scopus 로고
    • Developmental differences in the immortalization of lung fibroblasts by telomerase
    • Forsyth, N. R., Evans, A. P., Shay, J. W. & Wright, W. E. Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell 2, 235-243 (2003).
    • (2003) Aging Cell , vol.2 , pp. 235-243
    • Forsyth, N.R.1    Evans, A.P.2    Shay, J.W.3    Wright, W.E.4
  • 103
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene BMI-1 regulates cell proliferation and senescence through the INK4a locus
    • Jacobs, J. J., Kieboom, K., Marino, S., DePinho, R. A. & van Lohuizen, M. The oncogene and Polycomb-group gene BMI-1 regulates cell proliferation and senescence through the INK4a locus. Nature 397, 164-168 (1999).
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    van Lohuizen, M.5
  • 104
    • 0030612349 scopus 로고    scopus 로고
    • Zindy, F., Quelle, D. E., Roussel, M. F. & Sherr, C. J. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15, 203-211 (1997). First report that p16 expression increases during ageing.
    • Zindy, F., Quelle, D. E., Roussel, M. F. & Sherr, C. J. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15, 203-211 (1997). First report that p16 expression increases during ageing.
  • 105
    • 33749172559 scopus 로고    scopus 로고
    • INK4a
    • INK4a. Nature 443, 421-426 (2006).
    • (2006) Nature , vol.443 , pp. 421-426
    • Janzen, V.1
  • 106
    • 33749187810 scopus 로고    scopus 로고
    • INK4a induces an age-dependent decline in islet regenerative potential
    • INK4a induces an age-dependent decline in islet regenerative potential. Nature 443, 453-457 (2006).
    • (2006) Nature , vol.443 , pp. 453-457
    • Krishnamurthy, J.1
  • 107
    • 33749171885 scopus 로고    scopus 로고
    • Molofsky, A. V. et al. Declines in forebrain progenitor function and neurogenesis during aging are partially caused by increasing Ink4a expression. Nature 443, 448-452 (2006). References 105-107 describe evidence that p16 limits stem-cell or progenitor-cell proliferation, which drives ageing phenotypes.
    • Molofsky, A. V. et al. Declines in forebrain progenitor function and neurogenesis during aging are partially caused by increasing Ink4a expression. Nature 443, 448-452 (2006). References 105-107 describe evidence that p16 limits stem-cell or progenitor-cell proliferation, which drives ageing phenotypes.
  • 108
    • 0037380886 scopus 로고    scopus 로고
    • Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia
    • Holst, C. R. et al. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res. 63, 1596-1601 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1596-1601
    • Holst, C.R.1
  • 109
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
    • Brown, J. P., Wei, W. & Sedivy, J. M. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277, 831-834 (1997).
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 110
    • 33745310473 scopus 로고    scopus 로고
    • Small molecule-based reversible reprogramming of cellular lifespan
    • Won, J. et al. Small molecule-based reversible reprogramming of cellular lifespan. Nature Chem. Biol. 2, 369-374 (2006).
    • (2006) Nature Chem. Biol , vol.2 , pp. 369-374
    • Won, J.1
  • 111
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: Role of telomeres and telomerase
    • Shay, J. W. & Wright, W. E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26, 867-874 (2005).
    • (2005) Carcinogenesis , vol.26 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 112
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864-870 (2005).
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1
  • 113
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (2005).
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1
  • 114
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska, A. & de Lange, T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21, 4338-4348 (2002).
    • (2002) EMBO J , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    de Lange, T.2
  • 115
    • 0027976669 scopus 로고
    • Id related genes encoding helix loop helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
    • Hara, E. et al. Id related genes encoding helix loop helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269, 2139-2145 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 2139-2145
    • Hara, E.1
  • 116
    • 33947134834 scopus 로고    scopus 로고
    • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • Bracken, A. P. et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 21, 525-530 (2007).
    • (2007) Genes Dev , vol.21 , pp. 525-530
    • Bracken, A.P.1
  • 117
    • 1342332096 scopus 로고    scopus 로고
    • Polycomb CBX7 has a unifying role in cellular lifespan
    • Gil, J., Bernard, D., Martinez, D. & Beach, D. Polycomb CBX7 has a unifying role in cellular lifespan. Nature Cell Biol. 6, 62-67 (2004).
    • (2004) Nature Cell Biol , vol.6 , pp. 62-67
    • Gil, J.1    Bernard, D.2    Martinez, D.3    Beach, D.4
  • 118
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr, C. J. & Roberts, J. M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512 (1999).
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 119
    • 0032504783 scopus 로고    scopus 로고
    • p14ARF links the tumor suppressors RB and p53
    • Bates, S. et al. p14ARF links the tumor suppressors RB and p53. Nature 395, 125-125 (1998).
    • (1998) Nature , vol.395 , pp. 125-125
    • Bates, S.1
  • 120
    • 33751299336 scopus 로고    scopus 로고
    • p16INK4a modulates p53 in primary human mammary epithelial cells
    • Zhang, J., Pickering, C. R., Holst, C. R., Gauthier, M. L. & Tlsty, T. D. p16INK4a modulates p53 in primary human mammary epithelial cells. Cancer Res. 66, 10325-10331 (2006).
    • (2006) Cancer Res , vol.66 , pp. 10325-10331
    • Zhang, J.1    Pickering, C.R.2    Holst, C.R.3    Gauthier, M.L.4    Tlsty, T.D.5
  • 121
    • 33845687060 scopus 로고    scopus 로고
    • Loss of linker histone H1 in cellular senescence
    • Funayama, R., Saito, M., Tanobe, H. & Ishikawa, F. Loss of linker histone H1 in cellular senescence. J. Cell Biol. 175, 869-880 (2006).
    • (2006) J. Cell Biol , vol.175 , pp. 869-880
    • Funayama, R.1    Saito, M.2    Tanobe, H.3    Ishikawa, F.4
  • 122
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • Zhang, R., Chen, W. & Adams, P. D. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 27, 2343-2358 (2007).
    • (2007) Mol. Cell. Biol , vol.27 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 123
    • 33748084700 scopus 로고    scopus 로고
    • Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes
    • Macaluso, M., Montanari, M. & Giordano, A. Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes. Oncogene 25, 5263-5267 (2006).
    • (2006) Oncogene , vol.25 , pp. 5263-5267
    • Macaluso, M.1    Montanari, M.2    Giordano, A.3
  • 124
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • Jeyapalan, J. C., Ferreira, M., Sedivy, J. M. & Herbig, U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 128, 36-44 (2007).
    • (2007) Mech. Ageing Dev , vol.128 , pp. 36-44
    • Jeyapalan, J.C.1    Ferreira, M.2    Sedivy, J.M.3    Herbig, U.4
  • 125
    • 0028856794 scopus 로고
    • Telomere length and replicative aging in human vascular tissues
    • Chang, E. & Harley, C. B. Telomere length and replicative aging in human vascular tissues. Proc. Natl Acad. Sci. USA 92, 11190-11194 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 11190-11194
    • Chang, E.1    Harley, C.B.2
  • 126
    • 0042734423 scopus 로고    scopus 로고
    • The role of chondrocyte senescence in osteoarthritis
    • Price, J. S. et al. The role of chondrocyte senescence in osteoarthritis. Aging Cell 1, 57-65 (2002).
    • (2002) Aging Cell , vol.1 , pp. 57-65
    • Price, J.S.1
  • 127
    • 0035130153 scopus 로고    scopus 로고
    • Differential expression of thymosin β-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: Evidence for senescent endothelial cells in vivo at sites of atherosclerosis
    • Vasile, E., Tomita, Y., Brown, L. F., Kocher, O. & Dvorak, H. F. Differential expression of thymosin β-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: Evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 15, 458-466 (2001).
    • (2001) FASEB J , vol.15 , pp. 458-466
    • Vasile, E.1    Tomita, Y.2    Brown, L.F.3    Kocher, O.4    Dvorak, H.F.5
  • 128
    • 0037382970 scopus 로고    scopus 로고
    • Cellular senescence in the pathogenesis of benign prostatic hyperplasia
    • Castro, P., Giri, D., Lamb, D. & Ittmann, M. Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate 55, 30-38 (2003).
    • (2003) Prostate , vol.55 , pp. 30-38
    • Castro, P.1    Giri, D.2    Lamb, D.3    Ittmann, M.4
  • 129
    • 33846899456 scopus 로고    scopus 로고
    • Restoration of p53 function leads to tumour regression in vivo
    • Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo. Nature 445, 661-665 (2007).
    • (2007) Nature , vol.445 , pp. 661-665
    • Ventura, A.1
  • 130
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-650 (2007).
    • (2007) Nature , vol.445 , pp. 656-650
    • Xue, W.1
  • 131
    • 34247860915 scopus 로고    scopus 로고
    • Cosme-Blanco, W. et al. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 8, 497-503 (2007).
    • Cosme-Blanco, W. et al. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 8, 497-503 (2007).
  • 132
    • 33748670457 scopus 로고    scopus 로고
    • The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    • Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B. & Evan, G. I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443, 214-217 (2006).
    • (2006) Nature , vol.443 , pp. 214-217
    • Christophorou, M.A.1    Ringshausen, I.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5
  • 133
    • 34247581288 scopus 로고    scopus 로고
    • Short telomeres limit tumor progression in vivo by inducing senescence
    • Feldser, D. M. & Greider, C. W. Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11, 461-469 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 461-469
    • Feldser, D.M.1    Greider, C.W.2
  • 134
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
    • Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356, 215-221 (1992).
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 135
    • 25444475263 scopus 로고    scopus 로고
    • Li-Fraumeni syndrome: A p53 family affair
    • Iwakuma, T., Lozano, G. & Flores, E. R. Li-Fraumeni syndrome: a p53 family affair. Cell Cycle 4, 865-867 (2005).
    • (2005) Cell Cycle , vol.4 , pp. 865-867
    • Iwakuma, T.1    Lozano, G.2    Flores, E.R.3
  • 136
    • 0035890407 scopus 로고    scopus 로고
    • Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni syndrome
    • Lee, S. B. et al. Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni syndrome. Cancer Res. 61, 8062-8067 (2001).
    • (2001) Cancer Res , vol.61 , pp. 8062-8067
    • Lee, S.B.1
  • 137
    • 0028936194 scopus 로고
    • Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome
    • Shay, J. W., Tomlinson, G., Piatyszek, M. A. & Gollahon, L. S. Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome. Mol. Cell Biol. 15, 425-432 (1995).
    • (1995) Mol. Cell Biol , vol.15 , pp. 425-432
    • Shay, J.W.1    Tomlinson, G.2    Piatyszek, M.A.3    Gollahon, L.S.4
  • 138
    • 0032924343 scopus 로고    scopus 로고
    • Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
    • Morales, C. P. et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genet. 21, 115-118 (1999).
    • (1999) Nature Genet , vol.21 , pp. 115-118
    • Morales, C.P.1
  • 139
    • 0027496456 scopus 로고
    • The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen
    • Shay, J. W., Van Der Haegen, B. A., Ying, Y. & Wright, W. E. The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp. Cell Res. 209, 45-52 (1993).
    • (1993) Exp. Cell Res , vol.209 , pp. 45-52
    • Shay, J.W.1    Van Der Haegen, B.A.2    Ying, Y.3    Wright, W.E.4
  • 140
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumor cells with defined genetic elements
    • Hahn, W. C. et al. Creation of human tumor cells with defined genetic elements. Nature 400, 464-468 (1999).
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1
  • 141
    • 0037011958 scopus 로고    scopus 로고
    • p53 mutant mice that display early aging-associated phenotypes
    • Tyner, S. D. et al. p53 mutant mice that display early aging-associated phenotypes. Nature 415, 45-53 (2002).
    • (2002) Nature , vol.415 , pp. 45-53
    • Tyner, S.D.1
  • 142
    • 1042266548 scopus 로고    scopus 로고
    • Maier, B. et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18, 306-319 (2004). References 141 and 142 show that constitutive p53 activity can suppress the development of cancer at the cost of accelerating ageing phenotypes.
    • Maier, B. et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18, 306-319 (2004). References 141 and 142 show that constitutive p53 activity can suppress the development of cancer at the cost of accelerating ageing phenotypes.
  • 143
    • 0034255633 scopus 로고    scopus 로고
    • Telomerase expression restores dermal integrity to in vitro aged fibroblasts in a reconstituted skin model
    • Funk, W. D. et al. Telomerase expression restores dermal integrity to in vitro aged fibroblasts in a reconstituted skin model. Exp. Cell Res. 258, 270-278 (2000).
    • (2000) Exp. Cell Res , vol.258 , pp. 270-278
    • Funk, W.D.1
  • 144
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
    • Parrinello, S., Coppe, J. P., Krtolica, A. & Campisi, J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci. 118, 485-496 (2005).
    • (2005) J. Cell Sci , vol.118 , pp. 485-496
    • Parrinello, S.1    Coppe, J.P.2    Krtolica, A.3    Campisi, J.4
  • 145
    • 31544479046 scopus 로고    scopus 로고
    • The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
    • Bavik, C. et al. The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res. 66, 794-802 (2006).
    • (2006) Cancer Res , vol.66 , pp. 794-802
    • Bavik, C.1
  • 146
    • 33749549246 scopus 로고    scopus 로고
    • Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
    • Coppe, J. P., Kauser, K., Campisi, J. & Beausejour, C. M. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J. Biol. Chem. 281, 29568-29574 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 29568-29574
    • Coppe, J.P.1    Kauser, K.2    Campisi, J.3    Beausejour, C.M.4
  • 147
    • 0141792500 scopus 로고    scopus 로고
    • Novel mechanisms of sublethal oxidant toxicity: Induction of premature senescence in human fibroblasts confers tumor promoter activity
    • Dilley, T. K., Bowden, G. T. & Chen, Q. M. Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity. Exp. Cell Res. 290, 38-48 (2003).
    • (2003) Exp. Cell Res , vol.290 , pp. 38-48
    • Dilley, T.K.1    Bowden, G.T.2    Chen, Q.M.3
  • 148
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. & Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl Acad. Sci. USA 98, 12072-12077 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.4    Campisi, J.5
  • 149
    • 0037329040 scopus 로고    scopus 로고
    • Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression
    • Martens, J. W. et al. Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression. Thromb. Haemost. 89, 393-404 (2003).
    • (2003) Thromb. Haemost , vol.89 , pp. 393-404
    • Martens, J.W.1
  • 150
    • 0037112844 scopus 로고    scopus 로고
    • Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
    • Garcia-Cao, I. et al. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21, 6225-6235 (2002).
    • (2002) EMBO J , vol.21 , pp. 6225-6235
    • Garcia-Cao, I.1
  • 151
    • 8644284936 scopus 로고    scopus 로고
    • Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
    • Matheu, A. et al. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev. 18, 2736-2746 (2004).
    • (2004) Genes Dev , vol.18 , pp. 2736-2746
    • Matheu, A.1
  • 152
    • 29944447632 scopus 로고    scopus 로고
    • Mendrysa, S. M. et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev. 20, 16-21 (2006). References 150-152 show that resistance to cancer need not accelerate ageing.
    • Mendrysa, S. M. et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev. 20, 16-21 (2006). References 150-152 show that resistance to cancer need not accelerate ageing.
  • 154
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • Romanov, S. R. et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 409, 633-637 (2001).
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1
  • 155
    • 19544362405 scopus 로고    scopus 로고
    • Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells
    • Emsley, J. G., Mitchell, B. D., Kempermann, G. & Macklis, J. D. Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells. Prog. Neurobiol. 75, 321-341 (2005).
    • (2005) Prog. Neurobiol , vol.75 , pp. 321-341
    • Emsley, J.G.1    Mitchell, B.D.2    Kempermann, G.3    Macklis, J.D.4
  • 156
    • 33745625628 scopus 로고    scopus 로고
    • Muscle stem cells in development, regeneration, and disease
    • Shi, X. & Garry, D. J. Muscle stem cells in development, regeneration, and disease. Genes Dev. 20, 1692-1708 (2006).
    • (2006) Genes Dev , vol.20 , pp. 1692-1708
    • Shi, X.1    Garry, D.J.2
  • 157
    • 33745628337 scopus 로고    scopus 로고
    • Potential of stem-cell-based therapies for heart disease
    • Srivastava, D. & Ivey, K. N. Potential of stem-cell-based therapies for heart disease. Nature 441, 1097-1099 (2006).
    • (2006) Nature , vol.441 , pp. 1097-1099
    • Srivastava, D.1    Ivey, K.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.