-
1
-
-
77956645419
-
EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity
-
H. Alam, T.W. Williams, K.J. Dumas, C. Guo, S. Yoshina, S. Mitani, and P.J. Hu EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity Cell Metab. 12 2010 30 41
-
(2010)
Cell Metab.
, vol.12
, pp. 30-41
-
-
Alam, H.1
Williams, T.W.2
Dumas, K.J.3
Guo, C.4
Yoshina, S.5
Mitani, S.6
Hu, P.J.7
-
2
-
-
77956627087
-
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
-
G. Asher, H. Reinke, M. Altmeyer, M. Gutierrez-Arcelus, M.O. Hottiger, and U. Schibler Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding Cell 142 2010 943 953
-
(2010)
Cell
, vol.142
, pp. 943-953
-
-
Asher, G.1
Reinke, H.2
Altmeyer, M.3
Gutierrez-Arcelus, M.4
Hottiger, M.O.5
Schibler, U.6
-
3
-
-
79953761260
-
PARP-2 regulates SIRT1 expression and whole-body energy expenditure
-
P. Bai, C. Canto, A. Brunyánszki, A. Huber, M. Szántó, Y. Cen, H. Yamamoto, S.M. Houten, B. Kiss, and H. Oudart PARP-2 regulates SIRT1 expression and whole-body energy expenditure Cell Metab. 13 2011 450 460
-
(2011)
Cell Metab.
, vol.13
, pp. 450-460
-
-
Bai, P.1
Canto, C.2
Brunyánszki, A.3
Huber, A.4
Szántó, M.5
Cen, Y.6
Yamamoto, H.7
Houten, S.M.8
Kiss, B.9
Oudart, H.10
-
4
-
-
79953752384
-
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
-
P. Bai, C. Cantó, H. Oudart, A. Brunyánszki, Y. Cen, C. Thomas, H. Yamamoto, A. Huber, B. Kiss, and R.H. Houtkooper PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation Cell Metab. 13 2011 461 468
-
(2011)
Cell Metab.
, vol.13
, pp. 461-468
-
-
Bai, P.1
Cantó, C.2
Oudart, H.3
Brunyánszki, A.4
Cen, Y.5
Thomas, C.6
Yamamoto, H.7
Huber, A.8
Kiss, B.9
Houtkooper, R.H.10
-
5
-
-
36049038217
-
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
-
M.T. Barbosa, S.M. Soares, C.M. Novak, D. Sinclair, J.A. Levine, P. Aksoy, and E.N. Chini The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity FASEB J. 21 2007 3629 3639
-
(2007)
FASEB J.
, vol.21
, pp. 3629-3639
-
-
Barbosa, M.T.1
Soares, S.M.2
Novak, C.M.3
Sinclair, D.4
Levine, J.A.5
Aksoy, P.6
Chini, E.N.7
-
6
-
-
33744976074
-
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
-
A. Berdichevsky, M. Viswanathan, H.R. Horvitz, and L. Guarente C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span Cell 125 2006 1165 1177
-
(2006)
Cell
, vol.125
, pp. 1165-1177
-
-
Berdichevsky, A.1
Viswanathan, M.2
Horvitz, H.R.3
Guarente, L.4
-
7
-
-
79955591489
-
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats
-
N. Braidy, G.J. Guillemin, H. Mansour, T. Chan-Ling, A. Poljak, and R. Grant Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats PLoS ONE 6 2011 e19194
-
(2011)
PLoS ONE
, vol.6
, pp. 19194
-
-
Braidy, N.1
Guillemin, G.J.2
Mansour, H.3
Chan-Ling, T.4
Poljak, A.5
Grant, R.6
-
8
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
A. Brunet, L.B. Sweeney, J.F. Sturgill, K.F. Chua, P.L. Greer, Y. Lin, H. Tran, S.E. Ross, R. Mostoslavsky, and H.Y. Cohen Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2004 2011 2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
-
9
-
-
80053168829
-
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
-
C. Burnett, S. Valentini, F. Cabreiro, M. Goss, M. Somogyvári, M.D. Piper, M. Hoddinott, G.L. Sutphin, V. Leko, and J.J. McElwee Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila Nature 477 2011 482 485
-
(2011)
Nature
, vol.477
, pp. 482-485
-
-
Burnett, C.1
Valentini, S.2
Cabreiro, F.3
Goss, M.4
Somogyvári, M.5
Piper, M.D.6
Hoddinott, M.7
Sutphin, G.L.8
Leko, V.9
McElwee, J.J.10
-
10
-
-
83455206803
-
Targeting sirtuin 1 to improve metabolism: All you need is NAD(+)?
-
C. Cantó, and J. Auwerx Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol. Rev. 64 2012 166 187
-
(2012)
Pharmacol. Rev.
, vol.64
, pp. 166-187
-
-
Cantó, C.1
Auwerx, J.2
-
11
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
C. Cantó, Z. Gerhart-Hines, J.N. Feige, M. Lagouge, L. Noriega, J.C. Milne, P.J. Elliott, P. Puigserver, and J. Auwerx AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Nature 458 2009 1056 1060
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
12
-
-
84862022077
-
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
-
C. Cantó, R.H. Houtkooper, E. Pirinen, D.Y. Youn, M.H. Oosterveer, Y. Cen, P.J. Fernandez-Marcos, H. Yamamoto, P.A. Andreux, and P. Cettour-Rose The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity Cell Metab. 15 2012 838 847
-
(2012)
Cell Metab.
, vol.15
, pp. 838-847
-
-
Cantó, C.1
Houtkooper, R.H.2
Pirinen, E.3
Youn, D.Y.4
Oosterveer, M.H.5
Cen, Y.6
Fernandez-Marcos, P.J.7
Yamamoto, H.8
Andreux, P.A.9
Cettour-Rose, P.10
-
13
-
-
84859977895
-
Sirtuins mediate mammalian metabolic responses to nutrient availability
-
A. Chalkiadaki, and L. Guarente Sirtuins mediate mammalian metabolic responses to nutrient availability Nat. Rev. Endocrinol. 8 2012 287 296
-
(2012)
Nat. Rev. Endocrinol.
, vol.8
, pp. 287-296
-
-
Chalkiadaki, A.1
Guarente, L.2
-
14
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chain-mediated longevity
-
J. Durieux, S. Wolff, and A. Dillin The cell-non-autonomous nature of electron transport chain-mediated longevity Cell 144 2011 79 91
-
(2011)
Cell
, vol.144
, pp. 79-91
-
-
Durieux, J.1
Wolff, S.2
Dillin, A.3
-
15
-
-
84861775176
-
ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation
-
S. Erener, A. Mirsaidi, M. Hesse, A.N. Tiaden, H. Ellingsgaard, R. Kostadinova, M.Y. Donath, P.J. Richards, and M.O. Hottiger ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation FASEB J. 26 2012 2631 2638
-
(2012)
FASEB J.
, vol.26
, pp. 2631-2638
-
-
Erener, S.1
Mirsaidi, A.2
Hesse, M.3
Tiaden, A.N.4
Ellingsgaard, H.5
Kostadinova, R.6
Donath, M.Y.7
Richards, P.J.8
Hottiger, M.O.9
-
16
-
-
77953764486
-
Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. from concept to clinic
-
D.V. Ferraris Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic J. Med. Chem. 53 2010 4561 4584
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4561-4584
-
-
Ferraris, D.V.1
-
17
-
-
2242471203
-
The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans
-
S.N. Gagnon, M.O. Hengartner, and S. Desnoyers The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans Biochem. J. 368 2002 263 271
-
(2002)
Biochem. J.
, vol.368
, pp. 263-271
-
-
Gagnon, S.N.1
Hengartner, M.O.2
Desnoyers, S.3
-
18
-
-
84862758175
-
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
-
B.A. Gibson, and W.L. Kraus New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs Nat. Rev. Mol. Cell Biol. 13 2012 411 424
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 411-424
-
-
Gibson, B.A.1
Kraus, W.L.2
-
19
-
-
0027081044
-
Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span
-
K. Grube, and A. Bürkle Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span Proc. Natl. Acad. Sci. USA 89 1992 11759 11763
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11759-11763
-
-
Grube, K.1
Bürkle, A.2
-
20
-
-
38649132337
-
Mitochondria - A nexus for aging, calorie restriction, and sirtuins?
-
L. Guarente Mitochondria - a nexus for aging, calorie restriction, and sirtuins? Cell 132 2008 171 176
-
(2008)
Cell
, vol.132
, pp. 171-176
-
-
Guarente, L.1
-
21
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
M.C. Haigis, and D.A. Sinclair Mammalian sirtuins: biological insights and disease relevance Annu. Rev. Pathol. 5 2010 253 295
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
22
-
-
73449114300
-
Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16
-
T. Hashimoto, M. Horikawa, T. Nomura, and K. Sakamoto Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16 Biogerontology 11 2010 31 43
-
(2010)
Biogerontology
, vol.11
, pp. 31-43
-
-
Hashimoto, T.1
Horikawa, M.2
Nomura, T.3
Sakamoto, K.4
-
23
-
-
78649728763
-
The mitochondrial UPR - Protecting organelle protein homeostasis
-
C.M. Haynes, and D. Ron The mitochondrial UPR - protecting organelle protein homeostasis J. Cell Sci. 123 2010 3849 3855
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3849-3855
-
-
Haynes, C.M.1
Ron, D.2
-
24
-
-
70349859881
-
DNA damage, aging, and cancer
-
J.H. Hoeijmakers DNA damage, aging, and cancer N. Engl. J. Med. 361 2009 1475 1485
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
25
-
-
0032782364
-
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
-
Y. Honda, and S. Honda The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans FASEB J. 13 1999 1385 1393
-
(1999)
FASEB J.
, vol.13
, pp. 1385-1393
-
-
Honda, Y.1
Honda, S.2
-
26
-
-
84869121812
-
Exploring the therapeutic space around NAD+
-
R.H. Houtkooper, and J. Auwerx Exploring the therapeutic space around NAD+ J. Cell Biol. 199 2012 205 209
-
(2012)
J. Cell Biol.
, vol.199
, pp. 205-209
-
-
Houtkooper, R.H.1
Auwerx, J.2
-
27
-
-
77953631698
-
The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways
-
R.H. Houtkooper, C. Cantó, R.J. Wanders, and J. Auwerx The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways Endocr. Rev. 31 2010 194 223
-
(2010)
Endocr. Rev.
, vol.31
, pp. 194-223
-
-
Houtkooper, R.H.1
Cantó, C.2
Wanders, R.J.3
Auwerx, J.4
-
29
-
-
84859568041
-
The metabolic footprint of aging in mice
-
R.H. Houtkooper, C. Argmann, S.M. Houten, C. Canto, E.H. Jeninga, P.A. Andreux, C. Thomas, R. Doenlen, K. Schoonjans, and J. Auwerx The metabolic footprint of aging in mice Sci. Rep. 1 2011 134
-
(2011)
Sci. Rep.
, vol.1
, pp. 134
-
-
Houtkooper, R.H.1
Argmann, C.2
Houten, S.M.3
Canto, C.4
Jeninga, E.H.5
Andreux, P.A.6
Thomas, C.7
Doenlen, R.8
Schoonjans, K.9
Auwerx, J.10
-
31
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
R.H. Houtkooper, L. Mouchiroud, D. Ryu, N. Moullan, E. Katsyuba, G. Knott, R.W. Williams, and J. Auwerx Mitonuclear protein imbalance as a conserved longevity mechanism Nature 497 2013 451 457
-
(2013)
Nature
, vol.497
, pp. 451-457
-
-
Houtkooper, R.H.1
Mouchiroud, L.2
Ryu, D.3
Moullan, N.4
Katsyuba, E.5
Knott, G.6
Williams, R.W.7
Auwerx, J.8
-
32
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
S. Imai, C.M. Armstrong, M. Kaeberlein, and L. Guarente Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
33
-
-
77955057498
-
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1
-
A. Mangerich, N. Herbach, B. Hanf, A. Fischbach, O. Popp, M. Moreno-Villanueva, O.T. Bruns, and A. Bürkle Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1 Mech. Ageing Dev. 131 2010 389 404
-
(2010)
Mech. Ageing Dev.
, vol.131
, pp. 389-404
-
-
Mangerich, A.1
Herbach, N.2
Hanf, B.3
Fischbach, A.4
Popp, O.5
Moreno-Villanueva, M.6
Bruns, O.T.7
Bürkle, A.8
-
34
-
-
54549103449
-
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl] -2H-phthalazin-1-one: A novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1
-
K.A. Menear, C. Adcock, R. Boulter, X.L. Cockcroft, L. Copsey, A. Cranston, K.J. Dillon, J. Drzewiecki, S. Garman, and S. Gomez 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl] -2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1 J. Med. Chem. 51 2008 6581 6591
-
(2008)
J. Med. Chem.
, vol.51
, pp. 6581-6591
-
-
Menear, K.A.1
Adcock, C.2
Boulter, R.3
Cockcroft, X.L.4
Copsey, L.5
Cranston, A.6
Dillon, K.J.7
Drzewiecki, J.8
Garman, S.9
Gomez, S.10
-
35
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
M.C. Motta, N. Divecha, M. Lemieux, C. Kamel, D. Chen, W. Gu, Y. Bultsma, M. McBurney, and L. Guarente Mammalian SIRT1 represses forkhead transcription factors Cell 116 2004 551 563
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
36
-
-
78651276219
-
Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans
-
L. Mouchiroud, L. Molin, P. Kasturi, M.N. Triba, M.E. Dumas, M.C. Wilson, A.P. Halestrap, D. Roussel, I. Masse, and N. Dallière Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans Aging Cell 10 2011 39 54
-
(2011)
Aging Cell
, vol.10
, pp. 39-54
-
-
Mouchiroud, L.1
Molin, L.2
Kasturi, P.3
Triba, M.N.4
Dumas, M.E.5
Wilson, M.C.6
Halestrap, A.P.7
Roussel, D.8
Masse, I.9
Dallière, N.10
-
37
-
-
60549117554
-
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer
-
T.D. Penning, G.D. Zhu, V.B. Gandhi, J. Gong, X. Liu, Y. Shi, V. Klinghofer, E.F. Johnson, C.K. Donawho, and D.J. Frost Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H- benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer J. Med. Chem. 52 2009 514 523
-
(2009)
J. Med. Chem.
, vol.52
, pp. 514-523
-
-
Penning, T.D.1
Zhu, G.D.2
Gandhi, V.B.3
Gong, J.4
Liu, X.5
Shi, Y.6
Klinghofer, V.7
Johnson, E.F.8
Donawho, C.K.9
Frost, D.J.10
-
38
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman, and P. Puigserver Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 2005 113 118
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
39
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
B. Rogina, and S.L. Helfand Sir2 mediates longevity in the fly through a pathway related to calorie restriction Proc. Natl. Acad. Sci. USA 101 2004 15998 16003
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
41
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
T.J. Schulz, K. Zarse, A. Voigt, N. Urban, M. Birringer, and M. Ristow Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress Cell Metab. 6 2007 280 293
-
(2007)
Cell Metab.
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
42
-
-
84868007565
-
Physiological roles of mitochondrial reactive oxygen species
-
L.A. Sena, and N.S. Chandel Physiological roles of mitochondrial reactive oxygen species Mol. Cell 48 2012 158 167
-
(2012)
Mol. Cell
, vol.48
, pp. 158-167
-
-
Sena, L.A.1
Chandel, N.S.2
-
43
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
H.A. Tissenbaum, and L. Guarente Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature 410 2001 227 230
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
44
-
-
3142742707
-
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
-
A. van der Horst, L.G. Tertoolen, L.M. de Vries-Smits, R.A. Frye, R.H. Medema, and B.M. Burgering FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) J. Biol. Chem. 279 2004 28873 28879
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 28873-28879
-
-
Van Der Horst, A.1
Tertoolen, L.G.2
De Vries-Smits, L.M.3
Frye, R.A.4
Medema, R.H.5
Burgering, B.M.6
-
45
-
-
80053134340
-
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
-
M. Viswanathan, and L. Guarente Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes Nature 477 2011 E1 E2
-
(2011)
Nature
, vol.477
-
-
Viswanathan, M.1
Guarente, L.2
-
46
-
-
4944234936
-
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
-
T. Yoneda, C. Benedetti, F. Urano, S.G. Clark, H.P. Harding, and D. Ron Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones J. Cell Sci. 117 2004 4055 4066
-
(2004)
J. Cell Sci.
, vol.117
, pp. 4055-4066
-
-
Yoneda, T.1
Benedetti, C.2
Urano, F.3
Clark, S.G.4
Harding, H.P.5
Ron, D.6
-
47
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
-
J. Yoshino, K.F. Mills, M.J. Yoon, and S. Imai Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice Cell Metab. 14 2011 528 536
-
(2011)
Cell Metab.
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
48
-
-
84859475161
-
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
-
K. Zarse, S. Schmeisser, M. Groth, S. Priebe, G. Beuster, D. Kuhlow, R. Guthke, M. Platzer, C.R. Kahn, and M. Ristow Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal Cell Metab. 15 2012 451 465
-
(2012)
Cell Metab.
, vol.15
, pp. 451-465
-
-
Zarse, K.1
Schmeisser, S.2
Groth, M.3
Priebe, S.4
Beuster, G.5
Kuhlow, D.6
Guthke, R.7
Platzer, M.8
Kahn, C.R.9
Ristow, M.10
-
49
-
-
0037009521
-
A mitochondrial specific stress response in mammalian cells
-
Q. Zhao, J. Wang, I.V. Levichkin, S. Stasinopoulos, M.T. Ryan, and N.J. Hoogenraad A mitochondrial specific stress response in mammalian cells EMBO J. 21 2002 4411 4419
-
(2002)
EMBO J.
, vol.21
, pp. 4411-4419
-
-
Zhao, Q.1
Wang, J.2
Levichkin, I.V.3
Stasinopoulos, S.4
Ryan, M.T.5
Hoogenraad, N.J.6
-
50
-
-
77955280004
-
Caenorhabditis elegans as a model system for mtDNA replication defects
-
I. Bratic, J. Hench, and A. Trifunovic Caenorhabditis elegans as a model system for mtDNA replication defects Methods 51 2010 437 443
-
(2010)
Methods
, vol.51
, pp. 437-443
-
-
Bratic, I.1
Hench, J.2
Trifunovic, A.3
-
51
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
D. Chen, J. Bruno, E. Easlon, S.J. Lin, H.L. Cheng, F.W. Alt, and L. Guarente Tissue-specific regulation of SIRT1 by calorie restriction Genes Dev. 22 2008 1753 1757
-
(2008)
Genes Dev.
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
Lin, S.J.4
Cheng, H.L.5
Alt, F.W.6
Guarente, L.7
-
52
-
-
2442489891
-
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression
-
R. Dentin, J.P. Pégorier, F. Benhamed, F. Foufelle, P. Ferré, V. Fauveau, M.A. Magnuson, J. Girard, and C. Postic Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression J. Biol. Chem. 279 2004 20314 20326
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20314-20326
-
-
Dentin, R.1
Pégorier, J.P.2
Benhamed, F.3
Foufelle, F.4
Ferré, P.5
Fauveau, V.6
Magnuson, M.A.7
Girard, J.8
Postic, C.9
-
53
-
-
0035229245
-
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
-
RESEARCH0002
-
R.S. Kamath, M. Martinez-Campos, P. Zipperlen, A.G. Fraser, and J. Ahringer Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans Genome Biol. 2 2001 RESEARCH0002
-
(2001)
Genome Biol.
, vol.2
-
-
Kamath, R.S.1
Martinez-Campos, M.2
Zipperlen, P.3
Fraser, A.G.4
Ahringer, J.5
-
54
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, and P. Elliott Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha Cell 127 2006 1109 1122
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
-
55
-
-
78651276219
-
Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans
-
L. Mouchiroud, L. Molin, P. Kasturi, M.N. Triba, M.E. Dumas, M.C. Wilson, A.P. Halestrap, D. Roussel, I. Masse, and N. Dallière Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans Aging Cell 10 2011 39 54
-
(2011)
Aging Cell
, vol.10
, pp. 39-54
-
-
Mouchiroud, L.1
Molin, L.2
Kasturi, P.3
Triba, M.N.4
Dumas, M.E.5
Wilson, M.C.6
Halestrap, A.P.7
Roussel, D.8
Masse, I.9
Dallière, N.10
-
56
-
-
84864752368
-
LRH-1-dependent glucose sensing determines intermediary metabolism in liver
-
M.H. Oosterveer, C. Mataki, H. Yamamoto, T. Harach, N. Moullan, T.H. van Dijk, E. Ayuso, F. Bosch, C. Postic, and A.K. Groen LRH-1-dependent glucose sensing determines intermediary metabolism in liver J. Clin. Invest. 122 2012 2817 2826
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2817-2826
-
-
Oosterveer, M.H.1
Mataki, C.2
Yamamoto, H.3
Harach, T.4
Moullan, N.5
Van Dijk, T.H.6
Ayuso, E.7
Bosch, F.8
Postic, C.9
Groen, A.K.10
-
57
-
-
0034041160
-
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
-
C.I. Rodríguez, F. Buchholz, J. Galloway, R. Sequerra, J. Kasper, R. Ayala, A.F. Stewart, and S.M. Dymecki High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP Nat. Genet. 25 2000 139 140
-
(2000)
Nat. Genet.
, vol.25
, pp. 139-140
-
-
Rodríguez, C.I.1
Buchholz, F.2
Galloway, J.3
Sequerra, R.4
Kasper, J.5
Ayala, R.6
Stewart, A.F.7
Dymecki, S.M.8
-
58
-
-
81055125669
-
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function
-
H. Yamamoto, E.G. Williams, L. Mouchiroud, C. Cantó, W. Fan, M. Downes, C. Héligon, G.D. Barish, B. Desvergne, and R.M. Evans NCoR1 is a conserved physiological modulator of muscle mass and oxidative function Cell 147 2011 827 839
-
(2011)
Cell
, vol.147
, pp. 827-839
-
-
Yamamoto, H.1
Williams, E.G.2
Mouchiroud, L.3
Cantó, C.4
Fan, W.5
Downes, M.6
Héligon, C.7
Barish, G.D.8
Desvergne, B.9
Evans, R.M.10
-
59
-
-
78650455712
-
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
-
W. Yang, and S. Hekimi A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans PLoS Biol. 8 2010 e1000556
-
(2010)
PLoS Biol.
, vol.8
, pp. 1000556
-
-
Yang, W.1
Hekimi, S.2
|