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Volumn 154, Issue 2, 2013, Pages 430-

XThe NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN; SIRTUIN 2; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO;

EID: 84880517634     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2013.06.016     Document Type: Article
Times cited : (939)

References (59)
  • 1
    • 77956645419 scopus 로고    scopus 로고
    • EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity
    • H. Alam, T.W. Williams, K.J. Dumas, C. Guo, S. Yoshina, S. Mitani, and P.J. Hu EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity Cell Metab. 12 2010 30 41
    • (2010) Cell Metab. , vol.12 , pp. 30-41
    • Alam, H.1    Williams, T.W.2    Dumas, K.J.3    Guo, C.4    Yoshina, S.5    Mitani, S.6    Hu, P.J.7
  • 2
    • 77956627087 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
    • G. Asher, H. Reinke, M. Altmeyer, M. Gutierrez-Arcelus, M.O. Hottiger, and U. Schibler Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding Cell 142 2010 943 953
    • (2010) Cell , vol.142 , pp. 943-953
    • Asher, G.1    Reinke, H.2    Altmeyer, M.3    Gutierrez-Arcelus, M.4    Hottiger, M.O.5    Schibler, U.6
  • 5
    • 36049038217 scopus 로고    scopus 로고
    • The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
    • M.T. Barbosa, S.M. Soares, C.M. Novak, D. Sinclair, J.A. Levine, P. Aksoy, and E.N. Chini The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity FASEB J. 21 2007 3629 3639
    • (2007) FASEB J. , vol.21 , pp. 3629-3639
    • Barbosa, M.T.1    Soares, S.M.2    Novak, C.M.3    Sinclair, D.4    Levine, J.A.5    Aksoy, P.6    Chini, E.N.7
  • 6
    • 33744976074 scopus 로고    scopus 로고
    • C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
    • A. Berdichevsky, M. Viswanathan, H.R. Horvitz, and L. Guarente C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span Cell 125 2006 1165 1177
    • (2006) Cell , vol.125 , pp. 1165-1177
    • Berdichevsky, A.1    Viswanathan, M.2    Horvitz, H.R.3    Guarente, L.4
  • 7
    • 79955591489 scopus 로고    scopus 로고
    • Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats
    • N. Braidy, G.J. Guillemin, H. Mansour, T. Chan-Ling, A. Poljak, and R. Grant Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats PLoS ONE 6 2011 e19194
    • (2011) PLoS ONE , vol.6 , pp. 19194
    • Braidy, N.1    Guillemin, G.J.2    Mansour, H.3    Chan-Ling, T.4    Poljak, A.5    Grant, R.6
  • 10
    • 83455206803 scopus 로고    scopus 로고
    • Targeting sirtuin 1 to improve metabolism: All you need is NAD(+)?
    • C. Cantó, and J. Auwerx Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol. Rev. 64 2012 166 187
    • (2012) Pharmacol. Rev. , vol.64 , pp. 166-187
    • Cantó, C.1    Auwerx, J.2
  • 13
    • 84859977895 scopus 로고    scopus 로고
    • Sirtuins mediate mammalian metabolic responses to nutrient availability
    • A. Chalkiadaki, and L. Guarente Sirtuins mediate mammalian metabolic responses to nutrient availability Nat. Rev. Endocrinol. 8 2012 287 296
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 287-296
    • Chalkiadaki, A.1    Guarente, L.2
  • 14
    • 78650944949 scopus 로고    scopus 로고
    • The cell-non-autonomous nature of electron transport chain-mediated longevity
    • J. Durieux, S. Wolff, and A. Dillin The cell-non-autonomous nature of electron transport chain-mediated longevity Cell 144 2011 79 91
    • (2011) Cell , vol.144 , pp. 79-91
    • Durieux, J.1    Wolff, S.2    Dillin, A.3
  • 16
    • 77953764486 scopus 로고    scopus 로고
    • Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. from concept to clinic
    • D.V. Ferraris Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic J. Med. Chem. 53 2010 4561 4584
    • (2010) J. Med. Chem. , vol.53 , pp. 4561-4584
    • Ferraris, D.V.1
  • 17
    • 2242471203 scopus 로고    scopus 로고
    • The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans
    • S.N. Gagnon, M.O. Hengartner, and S. Desnoyers The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans Biochem. J. 368 2002 263 271
    • (2002) Biochem. J. , vol.368 , pp. 263-271
    • Gagnon, S.N.1    Hengartner, M.O.2    Desnoyers, S.3
  • 18
    • 84862758175 scopus 로고    scopus 로고
    • New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
    • B.A. Gibson, and W.L. Kraus New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs Nat. Rev. Mol. Cell Biol. 13 2012 411 424
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 411-424
    • Gibson, B.A.1    Kraus, W.L.2
  • 19
    • 0027081044 scopus 로고
    • Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span
    • K. Grube, and A. Bürkle Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span Proc. Natl. Acad. Sci. USA 89 1992 11759 11763
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11759-11763
    • Grube, K.1    Bürkle, A.2
  • 20
    • 38649132337 scopus 로고    scopus 로고
    • Mitochondria - A nexus for aging, calorie restriction, and sirtuins?
    • L. Guarente Mitochondria - a nexus for aging, calorie restriction, and sirtuins? Cell 132 2008 171 176
    • (2008) Cell , vol.132 , pp. 171-176
    • Guarente, L.1
  • 21
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • M.C. Haigis, and D.A. Sinclair Mammalian sirtuins: biological insights and disease relevance Annu. Rev. Pathol. 5 2010 253 295
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 22
    • 73449114300 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16
    • T. Hashimoto, M. Horikawa, T. Nomura, and K. Sakamoto Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16 Biogerontology 11 2010 31 43
    • (2010) Biogerontology , vol.11 , pp. 31-43
    • Hashimoto, T.1    Horikawa, M.2    Nomura, T.3    Sakamoto, K.4
  • 23
    • 78649728763 scopus 로고    scopus 로고
    • The mitochondrial UPR - Protecting organelle protein homeostasis
    • C.M. Haynes, and D. Ron The mitochondrial UPR - protecting organelle protein homeostasis J. Cell Sci. 123 2010 3849 3855
    • (2010) J. Cell Sci. , vol.123 , pp. 3849-3855
    • Haynes, C.M.1    Ron, D.2
  • 24
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • J.H. Hoeijmakers DNA damage, aging, and cancer N. Engl. J. Med. 361 2009 1475 1485
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.1
  • 25
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Y. Honda, and S. Honda The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans FASEB J. 13 1999 1385 1393
    • (1999) FASEB J. , vol.13 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 26
    • 84869121812 scopus 로고    scopus 로고
    • Exploring the therapeutic space around NAD+
    • R.H. Houtkooper, and J. Auwerx Exploring the therapeutic space around NAD+ J. Cell Biol. 199 2012 205 209
    • (2012) J. Cell Biol. , vol.199 , pp. 205-209
    • Houtkooper, R.H.1    Auwerx, J.2
  • 27
    • 77953631698 scopus 로고    scopus 로고
    • The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways
    • R.H. Houtkooper, C. Cantó, R.J. Wanders, and J. Auwerx The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways Endocr. Rev. 31 2010 194 223
    • (2010) Endocr. Rev. , vol.31 , pp. 194-223
    • Houtkooper, R.H.1    Cantó, C.2    Wanders, R.J.3    Auwerx, J.4
  • 32
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • S. Imai, C.M. Armstrong, M. Kaeberlein, and L. Guarente Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 34
    • 54549103449 scopus 로고    scopus 로고
    • 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl] -2H-phthalazin-1-one: A novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1
    • K.A. Menear, C. Adcock, R. Boulter, X.L. Cockcroft, L. Copsey, A. Cranston, K.J. Dillon, J. Drzewiecki, S. Garman, and S. Gomez 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl] -2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1 J. Med. Chem. 51 2008 6581 6591
    • (2008) J. Med. Chem. , vol.51 , pp. 6581-6591
    • Menear, K.A.1    Adcock, C.2    Boulter, R.3    Cockcroft, X.L.4    Copsey, L.5    Cranston, A.6    Dillon, K.J.7    Drzewiecki, J.8    Garman, S.9    Gomez, S.10
  • 37
    • 60549117554 scopus 로고    scopus 로고
    • Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer
    • T.D. Penning, G.D. Zhu, V.B. Gandhi, J. Gong, X. Liu, Y. Shi, V. Klinghofer, E.F. Johnson, C.K. Donawho, and D.J. Frost Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H- benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer J. Med. Chem. 52 2009 514 523
    • (2009) J. Med. Chem. , vol.52 , pp. 514-523
    • Penning, T.D.1    Zhu, G.D.2    Gandhi, V.B.3    Gong, J.4    Liu, X.5    Shi, Y.6    Klinghofer, V.7    Johnson, E.F.8    Donawho, C.K.9    Frost, D.J.10
  • 38
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman, and P. Puigserver Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 2005 113 118
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 39
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • B. Rogina, and S.L. Helfand Sir2 mediates longevity in the fly through a pathway related to calorie restriction Proc. Natl. Acad. Sci. USA 101 2004 15998 16003
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 41
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • T.J. Schulz, K. Zarse, A. Voigt, N. Urban, M. Birringer, and M. Ristow Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress Cell Metab. 6 2007 280 293
    • (2007) Cell Metab. , vol.6 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 42
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • L.A. Sena, and N.S. Chandel Physiological roles of mitochondrial reactive oxygen species Mol. Cell 48 2012 158 167
    • (2012) Mol. Cell , vol.48 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 43
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • H.A. Tissenbaum, and L. Guarente Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature 410 2001 227 230
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 45
    • 80053134340 scopus 로고    scopus 로고
    • Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
    • M. Viswanathan, and L. Guarente Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes Nature 477 2011 E1 E2
    • (2011) Nature , vol.477
    • Viswanathan, M.1    Guarente, L.2
  • 46
    • 4944234936 scopus 로고    scopus 로고
    • Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
    • T. Yoneda, C. Benedetti, F. Urano, S.G. Clark, H.P. Harding, and D. Ron Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones J. Cell Sci. 117 2004 4055 4066
    • (2004) J. Cell Sci. , vol.117 , pp. 4055-4066
    • Yoneda, T.1    Benedetti, C.2    Urano, F.3    Clark, S.G.4    Harding, H.P.5    Ron, D.6
  • 47
    • 80053920774 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
    • J. Yoshino, K.F. Mills, M.J. Yoon, and S. Imai Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice Cell Metab. 14 2011 528 536
    • (2011) Cell Metab. , vol.14 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.4
  • 48
  • 50
    • 77955280004 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a model system for mtDNA replication defects
    • I. Bratic, J. Hench, and A. Trifunovic Caenorhabditis elegans as a model system for mtDNA replication defects Methods 51 2010 437 443
    • (2010) Methods , vol.51 , pp. 437-443
    • Bratic, I.1    Hench, J.2    Trifunovic, A.3
  • 53
    • 0035229245 scopus 로고    scopus 로고
    • Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
    • RESEARCH0002
    • R.S. Kamath, M. Martinez-Campos, P. Zipperlen, A.G. Fraser, and J. Ahringer Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans Genome Biol. 2 2001 RESEARCH0002
    • (2001) Genome Biol. , vol.2
    • Kamath, R.S.1    Martinez-Campos, M.2    Zipperlen, P.3    Fraser, A.G.4    Ahringer, J.5
  • 59
    • 78650455712 scopus 로고    scopus 로고
    • A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    • W. Yang, and S. Hekimi A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans PLoS Biol. 8 2010 e1000556
    • (2010) PLoS Biol. , vol.8 , pp. 1000556
    • Yang, W.1    Hekimi, S.2


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