Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts

Clinica Terapeutica

Volumn 166, Issue 6, 2015, Pages 365-373

  Durani, L W ^a   Jaafar, F ^a   Tan, J K ^a   Tajul Arifin, K ^a   Mohd Yusof, Y A ^a   Wan Ngah, W Z ^a   Makpol, Suzana ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

Author keywords

Cellular senescence; Genes expression; Senescence associated signalling pathways; Tocotrienol rich fractiontocopherols

Indexed keywords

ALPHA TOCOTRIENOL; ANTIOXIDANT; CHLORAMPHENICOL ACETYLTRANSFERASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLUTATHIONE PEROXIDASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; OXIDOREDUCTASE; P21 ACTIVATED KINASE 2; PEROXIREDOXIN 6; PROTEIN P53; TRANSCRIPTION FACTOR FKHRL1; GENETIC MARKER; INSULIN DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; FIBROBLAST; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION; CELL AGING; CELL CULTURE; DIPLOIDY; DRUG EFFECTS; GENETIC MARKER; GENETICS; METABOLISM; PHYSIOLOGY;

ANTIOXIDANTS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DIPLOIDY; DNA DAMAGE; DOWN-REGULATION; FIBROBLASTS; GENETIC MARKERS; HUMANS; INSULINS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOCOTRIENOLS; UP-REGULATION;

EID: 84991694195     PISSN: 00099074     EISSN: 19726007     Source Type: Journal    
DOI: 10.7417/T.2015.1902     Document Type: Article

References (62)

1. Butterfield DA, Koppal T, Subramaniam R, et al. Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. Rev Neurosci 1999; 10:141-9.
2. Howard AC, McNeil AK, McNeil PL. Promotion of plasma membrane repair by vitamin E. Nat Commun 2011; 2:597.
3. Niki E, Traber MG. A history of vitamin E. Ann Nutr Metab 2012; 61:207-12.
4. Serbinova E, Kagan V, Han D, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med 1991; 10:263-75.
5. Moretti E, Castellini C, Mourvaki E, et al. Distribution of α-and δ-tocopherols in seminal plasma and sperm fractions of men with normal and abnormal sememn parameters. J Androl 2011; 32:232-9.
6. Yoshida Y, Saito Y, Jones LS, et al. Chemical reactivities and physical effects in comparison between tocopherols and tocotrienol: physiological significance and prospects as antioxidants. J Biosci Bioeng 2007; 104:439-45.
7. Makpol S, Durani LW, Chua KH, et al. Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts. J Biomed Biotechnol 2011; doi:10.1155/2011/506171.
8. Yap WN, Chang PN, Han HY. γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. Br J Cancer 2008; 99:1832-41.
9. Chin S-F, Ibrahim J, Makpol S, et al. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study. Nutr Metab 2011; 8:42-55.
10. Wu S, Liu P, Ng L. Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Mol Nutr Food Res 2008; 52:921-9.
11. Then S-M, Wan Ngah WZ, Mazlan M, et al. Comparison of the effects of α-tocopherol and γ-tocotrienol against oxidative stress in two different neuronal cultures. Sains Malaysiana 2010; 39:145-56.
12. Makpol S, Zainuddin A, Chua KH, et al. Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fribroblasts as Revealed by Microrray Analysis. Oxid Med Cell Longev 2013; 2013:454328.
13. Ali SF, Woodman OL. Tocotrienol rich palm oil extract is more effective than pure tocotrienols at improving endothelium-dependent relaxation in the presence of oxidative stress. Oxid Med Cell Longev 2015; 2015:10.
14. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11:298-300.
15. Harman D. Free radical theory of aging. Mutat Res 1992; 275:257-66.
16. Hayflick L, Moorehead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25:585-621.
17. Gambino V, De Michele G, Venezia O, et al. Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging. Aging cell 2013; 12:435-45.
18. Tollet-Egnell P, Flores-Morales A, Stahlberg N, et al. Gene expression profile of the ageing process in rat liver: normalizing effects of growth hormone replacement. Mol Endocrin 2001; 15:308-18.
19. Lee CK, Klopp RG, Weindruch R, et al. Gene expression profile of aging and its retardation by caloric restriction. Science 1999; 285:1390-3.
20. Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005; 24:7410-25.
21. Kuilman T, Michaloglou C, Mooi WJ, et al. The essence of senescence. Genes Dev 2010; 24:2463-79.
22. Spallarossa P, Altieri P, Barisione C, et al. p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells. PLoS One 2010; 5: e15583.
23. Furumoto K, Inoue E, Nagao N, et al. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 1998; 63:935-48.
24. Chen Q, Fischer A, Reagan JD, et al. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci U S A 1995; 92:4337-41.
25. Rozen S, Skaletsky H Primer3 on the WWW for General Users and for Biologist Programmers. In: Misener, S.; Krawetz, S., eds. Bioinformatics Methods and Protocols: Humana Press 1999:365-86.
26. Zainuddin A, Chua KH, Rahim NA, et al. Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts. BMC Mol Biol 2010; 11: 59.
27. Sies H. Strategies of antioxidant defense. Eur J Biochem 1993; 215:213-9.
28. Hazane F, Valenti K, Sauvaigo S, et al. Ageing effects on the expression of cell defence genes after UVA irradiation in human male cutaneous fibroblasts using cDNA arrays. J Photochem Photobiol B: Biol 2005; 79:171-90.
29. Sinha S. Anti-oxidant gene expression imbalance, aging and Down syndrome. Life Sci 2005; 76:1407-26.
30. Jervis KM, Robaire B. Changes in gene expression during aging in the Brown Norway rat epididymis. Exp Gerontol 2002; 37:897-906.
31. Harvey LJ, McArdle HJ. Biomarkers of copper status: a brief update. Br J Nutr 2008; 99: S10-3.
32. Makpol S, Yeoh TW, Ruslam FAC, et al. Comparative effect of Piper betle, Chlorella vulgaris and tocotrienol-rich fraction on antioxidant enzymes activity in cellular ageing of human diploid fibroblasts. BMC Complement Altern Med 2013; 13: 1-10.
33. Lee SP, Mar GY, Ng LT. Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats. Eur J Appl Physiol 2009; 107:587-95.
34. Newaz MA, Nawal NN. Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). Clin Exp Hypertens 1999; 21:1297-313.
35. Azzi A, Stocker A. Vitamin E: non-antioxidant roles. Prog Lipid Res 2000; 39:231-55.
36. De Pascale MC, Bassi AM, Patrone V, et al. Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes. Arch Biochem Biophys 2006; 447:97-106.
37. Liu G, Feinstein SI, Wang Y, et al. Comparison of glutathione peroxidase 1 and peroxiredoxin 6 in protection against oxidative stress in the mouse lung. Free Radical Biol Med 2010; 49:1172-81.
38. Willcox BJ, Donlon TA, He Q, et al. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A 2008; 105:13987-92.
39. Flachsbart F, Caliebe A, Kleindrop R, et al. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A 2009; 106: 2700-5.
40. Kim HK, Kim YK, Song I-H, et al. Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Biol Sci Med Sci 2005; 60:4-9.
41. Adachi H, Ishii N. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 2000; 55:B280-5.
42. Kops JG, Dansen TB, Polderman PE, et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002; 419:316-21.
43. Hoeijmakers JHJ. DNA damage, aging, and cancer. N Engl J Med 2009; 361:1475-85.
44. Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001; 11: S27-31.
45. Roig J, Traugh JA Cytostatic p21 G protein-activated protein kinase γ-PAK. Vitam Horm: Academic Press; 2001: 167-98.
46. Burd CE, Sorrentino JA, Clark KS, et al. Monitoring tumorigenesis and senescence in vivo with a p16INK4a-luciferase model. Cell 2013; 152:340-51.
47. Khor SC, Mohd Yusof YA, Wan Ngah WZ, et al. Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation signaling pathways. Clin Ter 2015; 166: e81-90.
48. MacLaren A, Black EJ, Clark W, et al. c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation. Mol Cell Biol 2004; 24:9006-18.
49. Park H, Kim M, Li Y, et al. Britanin suppresses LPS-induced nitric oxide, PGE(2) and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells. Int Immunopharmacol 2012; 15:296-302.
50. Faust D, Dolado I, Cuadrado A, et al. p38alpha MAPK is required for contact inhibition. Oncogene 2005; 24:7941-5.
51. Casareno RLB, Waggoner D, Gitlin JD. The copper chaperone CCS directy interacts with copper/zinc superoxide dismutase. J Biol Chem 1998; 273:23625-8.
52. Unlu ES, Koc A. Effects of deleting mitochondrial antioxidant genes on life span. Ann N Y Acad Sci 2007; 1100:505-9.
53. Leitch JM, Jensen LT, Bouldin SD, et al. Activation of Cu, Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS. J Biol Chem 2009; 284:21863-71.
54. Scheckhuber CQ, Grief J, Boilan E, et al. Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts. PLoS One 2009; 4:e4919.
55. Tolle A, Schlame M, Charlier N, et al. Vitamin E differentially regulates the expression of peroxiredoxin-1 and-6 in alveolar type II cells. Free Radical Biol Med 2005; 38:1401-8.
56. Makpol S, Zainuddin A, Chua KH, et al. Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts. Clinics 2012; 67:135-43.
57. Makpol S, Abdul Rahim N, Kien Hui C, et al. Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts. Oxid Med Cell Longev 2012; 2012: Article ID 785743.
58. Pinkston-Gosse J, Kenyon C. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet 2007; 39:1403-9.
59. Numakawa Y, Numakawa T, Matsumoto T, et al. Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J Neurochem 2006; 97:1191-202.
60. Zhao Y, Wu K, Yu Y, et al. Roles of ERK1/2 MAPK in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. Journal of Hygiene Research 2003; 32:573-5.
61. Gomez-Lazaro M, Galindo MF, Melero-Fernandez de Mera RM, et al. Reactive oxygen species and p38 mitogen-activated protein kinase activate bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. Mol Pharmacol 2007; 71:736-43.
62. Peus D, Meves A, Pott M, et al. Vitamin E analog modulates UVB-induced signalinh pathway activation and enhances cell survival. Free Radical Biol Med 2001; 30:425-32.