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Volumn 530, Issue 7589, 2016, Pages 184-189

Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; POTASSIUM CHANNEL;

EID: 84958093401     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16932     Document Type: Article
Times cited : (2098)

References (50)
  • 1
    • 84873638532 scopus 로고    scopus 로고
    • Aging cellular senescence, and cancer
    • Campisi, J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 75, 685-705 (2013).
    • (2013) Annu. Rev. Physiol , vol.75 , pp. 685-705
    • Campisi, J.1
  • 2
    • 84933050555 scopus 로고    scopus 로고
    • Forging a signature of in vivo senescence
    • Sharpless, N. E., Sherr, C. J. Forging a signature of in vivo senescence. Nature Rev. Cancer 15, 397-408 (2015).
    • (2015) Nature Rev. Cancer , vol.15 , pp. 397-408
    • Sharpless, N.E.1    Sherr, C.J.2
  • 3
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • van Deursen, J. M. The role of senescent cells in ageing. Nature 509, 439-446 (2014).
    • (2014) Nature , vol.509 , pp. 439-446
    • Van Deursen, J.M.1
  • 4
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    • Baker, D. J. et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232-236 (2011).
    • (2011) Nature , vol.479 , pp. 232-236
    • Baker, D.J.1
  • 5
    • 46449083569 scopus 로고    scopus 로고
    • Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
    • Baker, D. J. et al. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nature Cell Biol. 10, 825-836 (2008).
    • (2008) Nature Cell Biol , vol.10 , pp. 825-836
    • Baker, D.J.1
  • 6
    • 77954243065 scopus 로고    scopus 로고
    • The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
    • Jun, J. I., Lau, L. F. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nature Cell Biol. 12, 676-685 (2010).
    • (2010) Nature Cell Biol , vol.12 , pp. 676-685
    • Jun, J.I.1    Lau, L.F.2
  • 7
    • 49749145668 scopus 로고    scopus 로고
    • Senescence of activated stellate cells limits liver fibrosis
    • Krizhanovsky, V. et al. Senescence of activated stellate cells limits liver fibrosis. Cell 134, 657-667 (2008).
    • (2008) Cell , vol.134 , pp. 657-667
    • Krizhanovsky, V.1
  • 8
    • 84919480323 scopus 로고    scopus 로고
    • An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
    • Demaria, M. et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev. Cell 31, 722-733 (2014).
    • (2014) Dev. Cell , vol.31 , pp. 722-733
    • Demaria, M.1
  • 9
    • 84889600900 scopus 로고    scopus 로고
    • Programmed cell senescence during mammalian embryonic development
    • Munõz-Espin, D. et al. Programmed cell senescence during mammalian embryonic development. Cell 155, 1104-1118 (2013).
    • (2013) Cell , vol.155 , pp. 1104-1118
    • Munõz-Espin, D.1
  • 10
    • 84889565689 scopus 로고    scopus 로고
    • Senescence is a developmental mechanism that contributes to embryonic growth and patterning
    • Storer, M. et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 155, 1119-1130 (2013).
    • (2013) Cell , vol.155 , pp. 1119-1130
    • Storer, M.1
  • 11
    • 0035966101 scopus 로고    scopus 로고
    • Characterization of regulatory elements on the promoter region of p16INK4a that contribute to overexpression of p16 in senescent fibroblasts
    • Wang, W., Wu, J., Zhang, Z., Tong, T. Characterization of regulatory elements on the promoter region of p16INK4a that contribute to overexpression of p16 in senescent fibroblasts. J. Biol. Chem. 276, 48655-48661 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 48655-48661
    • Wang, W.1    Wu, J.2    Zhang, Z.3    Tong, T.4
  • 12
    • 78349299099 scopus 로고    scopus 로고
    • Fat tissue, aging, and cellular senescence
    • Tchkonia, T. et al. Fat tissue, aging, and cellular senescence. Aging Cell 9, 667-684 (2010).
    • (2010) Aging Cell , vol.9 , pp. 667-684
    • Tchkonia, T.1
  • 13
    • 67651180787 scopus 로고    scopus 로고
    • Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging
    • Liu, Y. et al. Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging. Aging Cell 8, 439-448 (2009).
    • (2009) Aging Cell , vol.8 , pp. 439-448
    • Liu, Y.1
  • 14
  • 15
    • 0025354670 scopus 로고
    • Effects of intermittent feeding upon body weight and lifespan in inbred mice: Interaction of genotype and age
    • Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., Cider, N. Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age. Mech. Ageing Dev. 55, 69-87 (1990).
    • (1990) Mech. Ageing Dev , vol.55 , pp. 69-87
    • Goodrick, C.L.1    Ingram, D.K.2    Reynolds, M.A.3    Freeman, J.R.4    Cider, N.5
  • 16
    • 0028787256 scopus 로고
    • Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet
    • Blackwell, B. N., Bucci, T. J., Hart, R. W., Turturro, A. Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet. Toxicol. Pathol. 23, 570-582 (1995).
    • (1995) Toxicol. Pathol , vol.23 , pp. 570-582
    • Blackwell, B.N.1    Bucci, T.J.2    Hart, R.W.3    Turturro, A.4
  • 17
    • 0025841730 scopus 로고
    • Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice
    • Bronson, R. T., Lipman, R. D. Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. Growth Dev. Aging 55, 169-184 (1991).
    • (1991) Growth Dev. Aging , vol.55 , pp. 169-184
    • Bronson, R.T.1    Lipman, R.D.2
  • 18
    • 33750681712 scopus 로고    scopus 로고
    • Transgenic mice with a reduced core body temperature have an increased life span
    • Conti, B. et al. Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828 (2006).
    • (2006) Science , vol.314 , pp. 825-828
    • Conti, B.1
  • 19
    • 0041419437 scopus 로고    scopus 로고
    • Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor i levels and increased life span
    • Coschigano, K. T. et al. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144, 3799-3810 (2003).
    • (2003) Endocrinology , vol.144 , pp. 3799-3810
    • Coschigano, K.T.1
  • 20
    • 0037387682 scopus 로고    scopus 로고
    • Genotype and age influence the effect of caloric intake on mortality in mice
    • Forster, M. J., Morris, P., Sohal, R. S. Genotype and age influence the effect of caloric intake on mortality in mice. FASEB J. 17, 690-692 (2003).
    • (2003) FASEB J , vol.17 , pp. 690-692
    • Forster, M.J.1    Morris, P.2    Sohal, R.S.3
  • 21
    • 31344478502 scopus 로고    scopus 로고
    • Housing density does not influence the longevity effect of calorie restriction
    • Ikeno, Y. et al. Housing density does not influence the longevity effect of calorie restriction. J. Gerontol. A Biol. Sci. Med. Sci. 60, 1510-1517 (2005).
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci , vol.60 , pp. 1510-1517
    • Ikeno, Y.1
  • 22
    • 0016680125 scopus 로고
    • Gerontological data of C57BL/6J mice I. Sex differences in survival curves
    • Kunstyr, I., Leuenberger, H. G. Gerontological data of C57BL/6J mice. I. Sex differences in survival curves. J. Gerontol. 30, 157-162 (1975).
    • (1975) J. Gerontol , vol.30 , pp. 157-162
    • Kunstyr, I.1    Leuenberger, H.G.2
  • 23
    • 40449142493 scopus 로고    scopus 로고
    • Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
    • Selman, C. et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 22, 807-818 (2008).
    • (2008) FASEB J , vol.22 , pp. 807-818
    • Selman, C.1
  • 24
    • 0028342438 scopus 로고
    • Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
    • Sohal, R. S., Ku, H. H., Agarwal, S., Forster, M. J., Lal, H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Dev. 74, 121-133 (1994).
    • (1994) Mech. Ageing Dev , vol.74 , pp. 121-133
    • Sohal, R.S.1    Ku, H.H.2    Agarwal, S.3    Forster, M.J.4    Lal, H.5
  • 25
    • 0025991730 scopus 로고
    • Effect of dietary restriction on the fidelity of DNA polymerases in aging mice
    • Srivastava, V. K., Tilley, R. D., Hart, R. W., Busbee, D. L. Effect of dietary restriction on the fidelity of DNA polymerases in aging mice. Exp. Gerontol. 26, 453-466 (1991).
    • (1991) Exp. Gerontol , vol.26 , pp. 453-466
    • Srivastava, V.K.1    Tilley, R.D.2    Hart, R.W.3    Busbee, D.L.4
  • 26
    • 0033398548 scopus 로고    scopus 로고
    • Growth curves and survival characteristics of the animals used in the biomarkers of aging program
    • Turturro, A. et al. Growth curves and survival characteristics of the animals used in the biomarkers of aging program. J. Gerontol. A Biol. Sci. Med. Sci. 54, B492-B501 (1999).
    • (1999) J. Gerontol A Biol. Sci. Med. Sci , vol.54 , pp. B492-B501
    • Turturro, A.1
  • 27
    • 84861448087 scopus 로고    scopus 로고
    • Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains
    • Yuan, R. et al. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc. Natl Acad. Sci. USA 109, 8224-8229 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 8224-8229
    • Yuan, R.1
  • 28
    • 84881508008 scopus 로고    scopus 로고
    • The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    • Zhang, Y. et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife 1, e00065 (2012).
    • (2012) Elife , vol.1 , pp. e00065
    • Zhang, Y.1
  • 29
    • 84964890856 scopus 로고    scopus 로고
    • Measures of healthspan as indices of aging in mice - A recommendation
    • Richardson, A. et al. Measures of healthspan as indices of aging in mice-a recommendation. J. Gerontol. A Biol. Sci. Med. Sci. http:://dx.doi.org/10.1093/gerona/glv080 (2015).
    • (2015) J. Gerontol. A Biol. Sci. Med. Sci.
    • Richardson, A.1
  • 30
    • 34548666429 scopus 로고    scopus 로고
    • Does renal ageing affect survival
    • Razzaque, M. S. Does renal ageing affect survival? Ageing Res. Rev. 6, 211-222 (2007).
    • (2007) Ageing Res Rev , vol.6 , pp. 211-222
    • Razzaque, M.S.1
  • 31
    • 0037361003 scopus 로고    scopus 로고
    • Effects of renin-angiotensin system blockade in the aging kidney
    • Ferder, L. F., Inserra, F., Basso, N. Effects of renin-angiotensin system blockade in the aging kidney. Exp. Gerontol. 38, 237-244 (2003).
    • (2003) Exp. Gerontol , vol.38 , pp. 237-244
    • Ferder, L.F.1    Inserra, F.2    Basso, N.3
  • 32
    • 33745845825 scopus 로고    scopus 로고
    • Physiology of local renin-angiotensin systems
    • Paul, M., Poyan Mehr, A., Kreutz, R. Physiology of local renin-angiotensin systems. Physiol. Rev. 86, 747-803 (2006).
    • (2006) Physiol. Rev , vol.86 , pp. 747-803
    • Paul, M.1    Poyan Mehr, A.2    Kreutz, R.3
  • 33
    • 43249122323 scopus 로고    scopus 로고
    • The aging cardiomyocyte: A mini-review
    • Bernhard, D., Laufer, G. The aging cardiomyocyte: a mini-review. Gerontology 54, 24-31 (2008).
    • (2008) Gerontology , vol.54 , pp. 24-31
    • Bernhard, D.1    Laufer, G.2
  • 34
    • 79958119946 scopus 로고    scopus 로고
    • Ageing-induced decline in physical endurance in mice is associated with decrease in cardiac SUR2A and increase in cardiac susceptibility to metabolic stress: Therapeutic prospects for up-regulation of SUR2A
    • Sudhir, R., Sukhodub, A., Du, Q., Jovanovic, S., Jovanovic, A. Ageing-induced decline in physical endurance in mice is associated with decrease in cardiac SUR2A and increase in cardiac susceptibility to metabolic stress: therapeutic prospects for up-regulation of SUR2A. Biogerontology 12, 147-155 (2011).
    • (2011) Biogerontology , vol.12 , pp. 147-155
    • Sudhir, R.1    Sukhodub, A.2    Du, Q.3    Jovanovic, S.4    Jovanovic, A.5
  • 35
    • 84871717211 scopus 로고    scopus 로고
    • Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
    • Baker, D. J. et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nature Cell Biol. 15, 96-102 (2012).
    • (2012) Nature Cell Biol , vol.15 , pp. 96-102
    • Baker, D.J.1
  • 36
    • 84949555897 scopus 로고    scopus 로고
    • Cellular senescence in aging and age-related disease: From mechanisms to therapy
    • Childs, B. G., Durik, M., Baker, D. J., van Deursen, J. M. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nature Med. 21, 1424-1435 (2015).
    • (2015) Nature Med , vol.21 , pp. 1424-1435
    • Childs, B.G.1    Durik, M.2    Baker, D.J.3    Van Deursen, J.M.4
  • 37
    • 84876998223 scopus 로고    scopus 로고
    • P21 both attenuates and drives senescence and aging in BubR1 progeroid mice
    • Baker, D. J., Weaver, R. L., van Deursen, J. M. p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep. 3, 1164-1174 (2013).
    • (2013) Cell Rep , vol.3 , pp. 1164-1174
    • Baker, D.J.1    Weaver, R.L.2    Van Deursen, J.M.3
  • 38
    • 84871717211 scopus 로고    scopus 로고
    • Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
    • Baker, D. J. et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nature Cell Biol. 15, 96-102 (2013).
    • (2013) Nature Cell Biol , vol.15 , pp. 96-102
    • Baker, D.J.1
  • 39
    • 0036789964 scopus 로고    scopus 로고
    • Kir6.2 is required for adaptation to stress
    • Zingman, L. V. et al. Kir6.2 is required for adaptation to stress. Proc. Natl Acad. Sci. USA 99, 13278-13283 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13278-13283
    • Zingman, L.V.1
  • 40
    • 84872018271 scopus 로고    scopus 로고
    • Reduced life-and healthspan in mice carrying a mono-allelic BubR1 MVA mutation
    • Wijshake, T. et al. Reduced life-and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet. 8, e1003138 (2012).
    • (2012) PLoS Genet , vol.8 , pp. e1003138
    • Wijshake, T.1
  • 41
    • 68449105075 scopus 로고    scopus 로고
    • Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection
    • Buenz, E. J. et al. Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection. Am. J. Pathol. 175, 668-684 (2009).
    • (2009) Am. J. Pathol , vol.175 , pp. 668-684
    • Buenz, E.J.1
  • 42
    • 84923385382 scopus 로고    scopus 로고
    • Spartan deficiency causes genomic instability and progeroid phenotypes
    • Maskey, R. S. et al. Spartan deficiency causes genomic instability and progeroid phenotypes. Nature Commun. 5, 5744 (2014).
    • (2014) Nature Commun , vol.5 , pp. 5744
    • Maskey, R.S.1
  • 43
    • 84879401216 scopus 로고    scopus 로고
    • Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer
    • Blatner, N. R. et al. Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer. Sci. Transl. Med. 4, 164-159 (2012).
    • (2012) Sci. Transl. Med , vol.4 , pp. 164-169
    • Blatner, N.R.1
  • 44
    • 3042761646 scopus 로고    scopus 로고
    • BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
    • Baker, D. J. et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genet. 36, 744-749 (2004).
    • (2004) Nature Genet , vol.36 , pp. 744-749
    • Baker, D.J.1
  • 45
    • 0029859856 scopus 로고    scopus 로고
    • Electron microscopic analysis of Drosophila midline glia during embryogenesis and larval development using ?-galactosidase expression as endogenous cell marker
    • Stollewerk, A., Klambt, C., Cantera, R. Electron microscopic analysis of Drosophila midline glia during embryogenesis and larval development using ?-galactosidase expression as endogenous cell marker. Microsc. Res. Tech. 35, 294-306 (1996).
    • (1996) Microsc. Res. Tech , vol.35 , pp. 294-306
    • Stollewerk, A.1    Klambt, C.2    Cantera, R.3
  • 46
    • 84881483132 scopus 로고    scopus 로고
    • Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo
    • Garelick, M. G. et al. Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo. Cell Cycle 12, 2493-2504 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 2493-2504
    • Garelick, M.G.1
  • 47
    • 84924241303 scopus 로고    scopus 로고
    • Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins
    • Schreiber, K. H. et al. Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins. Aging Cell 14, 265-273 (2015).
    • (2015) Aging Cell , vol.14 , pp. 265-273
    • Schreiber, K.H.1
  • 48
    • 3042761646 scopus 로고    scopus 로고
    • BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
    • Baker, D. J. et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genet. 36, 744-749 (2004).
    • (2004) Nature Genet , vol.36 , pp. 744-749
    • Baker, D.J.1
  • 49
    • 84872569990 scopus 로고    scopus 로고
    • Monitoring tumorigenesis and senescence in vivo with a p16INK4a-luciferase model
    • Burd, C. E. et al. Monitoring tumorigenesis and senescence in vivo with a p16INK4a-luciferase model. Cell 152, 340-351 (2013).
    • (2013) Cell , vol.152 , pp. 340-351
    • Burd, C.E.1
  • 50
    • 84872043569 scopus 로고    scopus 로고
    • Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
    • Ricke, R. M., Jeganathan, K. B., Malureanu, L., Harrison, A. M., van Deursen, J. M. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J. Cell Biol. 199, 931-949 (2012).
    • (2012) J. Cell Biol , vol.199 , pp. 931-949
    • Ricke, R.M.1    Jeganathan, K.B.2    Malureanu, L.3    Harrison, A.M.4    Van Deursen, J.M.5


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