Nutritional factors affecting adult neurogenesis and cognitive function

Advances in Nutrition

Volumn 8, Issue 6, 2017, Pages 804-811

  Poulose, Shibu M ^a   Miller, Marshall G ^a   Scott, Tammy ^a   Shukitt Hale, Barbara ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Aging brain; Cognition; Hippocampal neurogenesis; Neurodegeneration; Polyphenols; Stem cells

Indexed keywords

ADULT; AGED; AGING; BRAIN; COGNITION; COGNITIVE DEFECT; DEGENERATIVE DISEASE; FEMALE; HIPPOCAMPUS; HUMAN; MALE; MIDDLE AGED; NERVOUS SYSTEM DEVELOPMENT; NUTRITION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; AGED; AGING; BRAIN; COGNITION; COGNITIVE DYSFUNCTION; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES; NEUROGENESIS; NUTRITIONAL PHYSIOLOGICAL PHENOMENA;

EID: 85034054536     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.117.016261     Document Type: Review

References (115)

1. Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 1965;124: 319-35.
2. Temple S. Division and differentiation of isolated CNS blast cells in microculture. Nature 1989;340:471-3.
3. Bayer SA. Development of the hippocampal region in the rat. I. Neurogenesis examined with 3H-thymidine autoradiography. J Comp Neurol 1980;190:87-114.
4. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707-10.
5. Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP, Greenberg DA. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA 2001;98:4710-5.
6. Overall RW, Paszkowski-Rogacz M, Kempermann G. The mammalian adult neurogenesis gene ontology (MANGO) provides a structural framework for published information on genes regulating adult hippocampal neurogenesis. PLoS One 2012;7:e48527.
7. Lois C, Garcia-Verdugo JM, Alvarez-Buylla A. Chain migration of neuronal precursors. Science 1996;271:978-81.
8. Luskin MB. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 1993;11:173-89.
9. Ming GL, Song H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 2011;70:687-702.
10. Balu DT, Lucki I. Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology. Neurosci Biobehav Rev 2009;33:232-52.
11. Cameron HA, McKay RD. Restoring production of hippocampal neurons in old age. Nat Neurosci 1999;2:894-7.
12. Tanapat P, Hastings NB, Reeves AJ, Gould E. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci 1999;19:5792-801.
13. O'Kusky JR, Ye P, D'Ercole AJ. Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development. J Neurosci 2000;20:8435-42.
14. Cameron HA, Tanapat P, Gould E. Adrenal steroids and N-methyl-Daspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience 1998; 82:349-54.
15. Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 1999; 2:260-5.
16. Yau SY, Lau BW, So KF. Adult hippocampal neurogenesis: a possible way how physical exercise counteracts stress. Cell Transplant 2011;20: 99-111.
17. Veena J, Rao BS, Srikumar BN. Regulation of adult neurogenesis in the hippocampus by stress, acetylcholine and dopamine. J Nat Sci Biol Med 2011;2:26-37.
18. Stangl D, Thuret S. Impact of diet on adult hippocampal neurogenesis. Genes Nutr 2009;4:271-82.
19. Foster TC. Biological markers of age-related memory deficits: treatment of senescent physiology. CNS Drugs 2006;20:153-66.
20. Winner B, Winkler J. Adult neurogenesis in neurodegenerative diseases. Cold Spring Harb Perspect Biol 2015;7:a021287.
21. Bekinschtein P, Katche C, Slipczuk L, Gonzalez C, Dorman G, Cammarota M, Izquierdo I, Medina JH. Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures. Neurotox Res 2010;18:377-85.
22. Armstrong RA, Cairns NJ. Comparative quantitative study of 'signature' pathological lesions in the hippocampus and adjacent gyri of 12 neurodegenerative disorders. J Neural Transm (Vienna) 2015;122: 1355-67.
23. Dokter M, von Bohlen und Halbach O. Neurogenesis within the adult hippocampus under physiological conditions and in depression. Neural Regen Res 2012;7:552-9.
24. Deng W, Aimone JB, Gage FH. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 2010;11:339-50.
25. Fabel K, Kempermann G. Physical activity and the regulation of neurogenesis in the adult and aging brain. Neuromolecular Med 2008;10:59-66.
26. Huang FL, Huang KP, Wu J, Boucheron C. Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice. J Neurosci 2006;26:6230-7.
27. Levenson CW, Rich NJ. Eat less, live longer? New insights into the role of caloric restriction in the brain. Nutr Rev 2007;65:412-5.
28. Valente T, Hidalgo J, Bolea I, Ramirez B, Angles N, Reguant J, Morello JR, Gutierrez C, Boada M, Unzeta M. A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain. J Alzheimers Dis 2009;18:849-65.
29. Beltz BS, Tlusty MF, Benton JL, Sandeman DC. Omega-3 fatty acids upregulate adult neurogenesis. Neurosci Lett 2007;415:154-8.
30. Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol Chem 2008;283:14497-505.
31. Shukitt-Hale B, Bielinski DF, Lau FC, Willis LM, Carey AN, Joseph JA. The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. Br J Nutr 2015;114:1542-9.
32. Torres-Pérez M, Tellez-Ballesteros RI, Ortiz-López L, Ichwan M, Vega-Rivera NM, Castro-García M, Gómez-Sánchez A, Kempermann G, Ramirez-Rodriguez GB. Resveratrol enhances neuroplastic changes, including hippocampal neurogenesis, and memory in Balb/C mice at six months of age. PLoS One 2015;10:e0145687.
33. Sawamoto A, Okuyama S, Yamamoto K, Amakura Y, Yoshimura M, Nakajima M, Furukawa Y. 3, 5, 6, 7, 8, 39, 49-Heptamethoxyflavone, a citrus flavonoid, ameliorates corticosterone-induced depression-like behavior and restores brain-derived neurotrophic factor expression, neurogenesis, and neuroplasticity in the hippocampus. Molecules 2016;21:541.
34. Poulose SM, Carey AN, Shukitt-Hale B. Improving brain signaling in aging: could berries be the answer? Expert Rev Neurother 2012;12: 887-9.
35. Migaud M, Batailler M, Segura S, Duittoz A, Franceschini I, Pillon D. Emerging new sites for adult neurogenesis in the mammalian brain: a comparative study between the hypothalamus and the classical neurogenic zones. Eur J Neurosci 2010;32:2042-52.
36. Seib DR, Martin-Villalba A. Neurogenesis in the normal ageing hippocampus: a mini-review. Gerontology 2015;61:327-35.
37. Galvan V, Jin K. Neurogenesis in the aging brain. Clin Interv Aging 2007;2:605-10.
38. Lazarov O, Mattson MP, Peterson DA, Pimplikar SW, van Praag H. When neurogenesis encounters aging and disease. Trends Neurosci 2010;33:569-79.
39. Varela-Nallar L, Aranguiz FC, Abbott AC, Slater PG, Inestrosa NC. Adult hippocampal neurogenesis in aging and Alzheimer's disease. Birth Defects Res C Embryo Today 2010;90:284-96.
40. Marín-Burgin A, Schinder AF. Requirement of adult-born neurons for hippocampus-dependent learning. Behav Brain Res 2012;227: 391-9.
41. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011; 477:90-4.
42. Drapeau E, Mayo W, Aurousseau C, Le Moal M, Piazza PV, Abrous DN. Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc Natl Acad Sci USA 2003;100:14385-90.
43. Clelland CD, Choi M, Romberg C, Clemenson GD Jr., Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 2009;325:210-3.
44. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 2014;69:S4-9.
45. Simen AA, Bordner KA, Martin MP, Moy LA, Barry LC. Cognitive dysfunction with aging and the role of inflammation. Ther Adv Chronic Dis 2011;2:175-95.
46. Sartori AC, Vance DE, Slater LZ, Crowe M. The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research. J Neurosci Nurs 2012;44:206-17.
47. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000;21:383-421.
48. Wyss-Coray T, Rogers J. Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2012;2:a006346.
49. Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003;302:1760-5.
50. Ekdahl CT, Claasen JH, Bonde S, Kokaia Z, Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA 2003;100:13632-7.
51. Gemma C, Bachstetter AD, Bickford PC. Neuron-microglia dialogue and hippocampal neurogenesis in the aged brain. Aging Dis 2010;1: 232-44.
52. Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol Aging 2009;30:337-52.
53. Weiss N, Miller F, Cazaubon S, Couraud PO. The blood-brain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta 2009;1788:842-57.
54. Ekdahl CT, Kokaia Z, Lindvall O. Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience 2009;158:1021-9.
55. Fuster-Matanzo A, Llorens-Martin M, Hernandez F, Avila J. Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches. Mediators Inflamm 2013;2013:260925.
56. Moon M, Kim S, Hwang L, Park S. Ghrelin regulates hippocampal neurogenesis in adult mice. Endocr J 2009;56:525-31.
57. Kent BA, Beynon AL, Hornsby AK, Bekinschtein P, Bussey TJ, Davies JS, Saksida LM. The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation. Psychoneuroendocrinology 2015;51:431-9.
58. Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann N Y Acad Sci 2007;1119:147-64.
59. Li E, Chung H, Kim Y, Kim DH, Ryu JH, Sato T, Kojima M, Park S. Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocr J 2013;60:781-9.
60. Lee SW, Clemenson GD, Gage FH. New neurons in an aged brain. Behav Brain Res 2012;227:497-507.
61. Knopman D, Boland LL, Mosley T, Howard G, Liao D, Szklo M, McGovern P, Folsom AR; Atherosclerosis Risk in Communities (ARIC) Study Investigators. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology 2001;56:42-8.
62. Kalmijn S, White L, Ross GW, Petrovitch H, Foley D, Curb JD, Havlik RJ, Launer LJ. The metabolic cardiovascular syndrome and the risk of dementia in elderly men: the Honolulu-Asia aging study. Neurology 2000;54:A76.
63. Kalmijn S, Launer LJ, Ott A, Witteman JCM, Hofman A, Breteler MMB. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 1997;42:776-82.
64. Lindqvist A, Mohapel P, Bouter B, Frielingsdorf H, Pizzo D, Brundin P, Erlanson-Albertsson C. High-fat diet impairs hippocampal neurogenesis in male rats. Eur J Neurol 2006;13:1385-8.
65. Molteni R, Barnard RJ, Ying Z, Roberts CK, Gomez-Pinilla F. A highfat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002; 112:803-14.
66. Stranahan AM, Norman ED, Lee K, Cutler RG, Telljohann RS, Egan JM, Mattson MP. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008;18:1085-8.
67. Park HR, Park M, Choi J, Park KY, Chung HY, Lee J. A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brainderived neurotrophic factor. Neurosci Lett 2010;482:235-9.
68. van der Borght K, Kohnke R, Goransson N, Deierborg T, Brundin P, Erlanson-Albertsson C, Lindqvist A. Reduced neurogenesis in the rat hippocampus following high fructose consumption. Regul Pept 2011; 167:26-30.
69. Ross AP, Bartness TJ, Mielke JG, Parent MB. A high fructose diet impairs spatial memory in male rats. Neurobiol Learn Mem 2009;92:410-6.
70. Lee J, Duan WZ, Long JM, Ingram DK, Mattson MP. Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J Mol Neurosci 2000;15:99-108.
71. Lee J, Seroogy KB, Mattson MP. Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem 2002;80:539-47.
72. Hornsby AKE, Redhead YT, Rees DJ, Ratcliff MSG, Reichenbach A, Wells T, Francis L, Amstalden K, Andrews ZB, Davies JS. Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner. Psychoneuroendocrinology 2016;63:198-207.
73. Kim Y, Kim S, Kim C, Sato T, Kojima M, Park S. Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: lessons from ghrelin knockout mice. Endocr J 2015;62:269-75.
74. Yuan TF, Gu S, Shan C, Marchado S, Arias-Carrion O. Oxidative stress and adult neurogenesis. Stem Cell Rev 2015;11:706-9.
75. Santos R, Ruiz de Almodovar C, Bulteau AL, Gomes CM. Neurodegeneration, neurogenesis, and oxidative stress. Oxid Med Cell Longev 2013;2013:730581.
76. Simon M, Czeh B, Fuchs E. Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress. Brain Res 2005;1049:244-8.
77. Taylor JM, Main BS, Crack PJ. Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson's disease. Neurochem Int 2013;62:803-19.
78. Miller MG, Thangthaeng N, Poulose SM, Shukitt-Hale B. Role of fruits, nuts, and vegetables in maintaining cognitive health. Exp Gerontol 2017;94:24-8.
79. Kado DM, Karlamangla AS, Huang M-H, Troen A, Rowe JW, Selhub J, Seeman TE. Homocysteine versus the vitamins folate, B 6, and B 12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 2005;118:161-7.
80. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2012;27:592-600.
81. Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208-16.
82. Kronenberg G, Harms C, Sobol RW, Cardozo-Pelaez F, Linhart H, Winter B, Balkaya M, Gertz K, Gay SB, Cox D, et al. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. J Neurosci 2008;28:7219-30.
83. Smith AD. Hippocampus as a mediator of the role of vitamin B-12 in memory. Am J Clin Nutr 2016;103:959-60.
84. Zhang X, Huang G, Liu H, Chang H, Wilson JX. Folic acid enhances notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. Nutr Neurosci 2012;15:55-61.
85. Oyarce K, Bongarzone ER, Nualart F. Unconventional neurogenic niches and neurogenesis modulation by vitamins. J Stem Cell Res Ther 2014;4:184.
86. Ciaroni S, Cuppini R, Cecchini T, Ferri P, Ambrogini P, Cuppini C, Del Grande P. Neurogenesis in the adult rat dentate gyrus is enhanced by vitamin E deficiency. J Comp Neurol 1999;411:495-502.
87. Ciaroni S, Cecchini T, Ferri P, Cuppini R, Ambrogini P, Santi S, Benedetti S, Del Grande P, Papa S. Neural precursor proliferation and newborn cell survival in the adult rat dentate gyrus are affected by vitamin E deficiency. Neurosci Res 2002;44:369-77.
88. Cuppini R, Ciaroni S, Cecchini T, Ambrogini P, Ferri P, Del Grande P, Papa S. a-Tocopherol controls cell proliferation in the adult rat dentate gyrus. Neurosci Lett 2001;303:198-200.
89. USDA and US Department of Health and Human Services. Scientific report of the 2015 dietary guidelines advisory committee. Washington (DC): USDA and US Department of Health and Human Services; 2015.
90. Burckhardt M, Herke M, Wustmann T, Watzke S, Langer G, Fink A. Omega-3 fatty acids for the treatment of dementia. Cochrane Database Syst Rev 2016 4:CD009002.
91. Jackson PA, Forster JS, Bell JG, Dick JR, Younger I, Kennedy DO. DHA supplementation alone or in combination with other nutrients does not modulate cerebral hemodynamics or cognitive function in healthy older adults. Nutrients 2016;8:86.
92. Phillips MA, Childs CE, Calder PC, Rogers PJ. No effect of omega-3 fatty acid supplementation on cognition and mood in individuals with cognitive impairment and probable Alzheimer's disease: a randomised controlled trial. Int J Mol Sci 2015;16:24600-13.
93. Lee LK, Shahar S, Chin A-V, Yusoff NAM. Docosahexaenoic acidconcentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebocontrolled trial. Psychopharmacology (Berl) 2013;225:605-12.
94. Karr JE, Grindstaff TR, Alexander JE. Omega-3 polyunsaturated fatty acids and cognition in a college-aged population. Exp Clin Psychopharmacol 2012;20:236-42.
95. Jackson PA, Deary ME, Reay JL, Scholey AB, Kennedy DO. No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years. Br J Nutr 2012;107:1232-43.
96. Stough C, Downey L, Silber B, Lloyd J, Kure C, Wesnes K, Camfield D. The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. Neurobiol Aging 2012;33:824.e1-e3.
97. Mazereeuw G, Lanctôt KL, Chau SA, Swardfager W, Herrmann N. Effects of omega-3 fatty acids on cognitive performance: a meta-analysis. Neurobiol Aging 2012;33:1482.e17-e29.
98. Stonehouse W, Conlon CA, Podd J, Hill SR, Minihane AM, Haskell C, Kennedy D. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. Am J Clin Nutr 2013;97:1134-43.
99. Kawakita E, Hashimoto M, Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 2006;139:991-7.
100. Dyall SC, Michael GJ, Michael-Titus AT. Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res 2010;88:2091-102.
101. Yurko-Mauro K, Alexander DD, Van Elswyk ME. Docosahexaenoic acid and adult memory: a systematic review and meta-analysis. PLoS One 2015;10:e0120391.
102. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 1999;19:8114-21.
103. Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. Blueberry supplementation improves memory in older adultsy. J Agric Food Chem 2010;58:3996-4000.
104. Miller MG, Hamilton DA, Joseph JA, Shukitt-Hale B. Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. Eur J Nutr 2017 Mar 10 (Epub ahead of print; DOI: 10.1007/s00394-017-1400-8).
105. Whyte AR, Williams CM. Effects of a single dose of a flavonoid-rich blueberry drink on memory in 8 to 10 y old children. Nutrition 2015;31:531-4.
106. Whyte AR, Schafer G, Williams CM. Cognitive effects following acute wild blueberry supplementation in 7-to 10-year-old children. Eur J Nutr 2016;55:2151-62.
107. Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee H-G, Smith MA, Joseph JA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci 2004;7:309-16.
108. Reyes-Izquierdo T, Nemzer B, Shu C, Huynh L, Argumedo R, Keller R, Pietrzkowski Z. Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. Br J Nutr 2013;110:420-5.
109. Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Ramirez-Tortosa M. Curcumin and health. Molecules 2016;21:264.
110. Dong S, Zeng Q, Mitchell ES, Xiu J, Duan Y, Li C, Tiwari JK, Hu Y, Cao X, Zhao Z. Curcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity. PLoS One 2012;7:e31211.
111. Xu Y, Ku B, Cui L, Li X, Barish PA, Foster TC, Ogle WO. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 2007;1162:9-18.
112. Poulose SM, Thangthaeng N, Miller MG, Shukitt-Hale B. Effects of pterostilbene and resveratrol on brain and behavior. Neurochem Int 2015;89:227-33.
113. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-42.
114. Moriya J, Chen R, Yamakawa J-i, Sasaki K, Ishigaki Y, Takahashi T. Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells. Biol Pharm Bull 2011;34:354-9.
115. Fernández-Fernández L, Comes G, Bolea I, Valente T, Ruiz J, Murtra P, Ramirez B, Anglés N, Reguant J, Morelló JR. LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease. Behav Brain Res 2012;228:261-71.