Cellular senescence in ageing, age-related disease and longevity

Current Vascular Pharmacology

Volumn 12, Issue 5, 2014, Pages 698-706

  Sikora, Ewa ^a   Bielak Zmijewska, Anna ^a   Mosieniak, Grazyna ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Age related disease; Biomarkers; DNA damage; Low grade inflammation; Secretory phenotype; Senescence; Telomeres

Indexed keywords

BETA GALACTOSIDASE; CURCUMIN; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOKINE; HISTONE H2AX; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P16; PROTEIN P21; PROTEIN P53; SENESCENCE ASSOCIATED BETA GALACTOSIDASE; UNCLASSIFIED DRUG; AUTACOID;

ADIPOCYTE; AGING; ARTICLE; ATHEROSCLEROSIS; CALCIFICATION; CARCINOGENESIS; CELL AGING; CELL CYCLE ARREST; CELL STRUCTURE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOMAL INSTABILITY; CLINICAL TRIAL (TOPIC); DIABETES MELLITUS; DNA DAMAGE; ENDOTHELIUM CELL; ENZYME ACTIVITY; EPIGENETICS; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LONGEVITY; NONHUMAN; NUCLEAR REPROGRAMMING; OBESITY; PHENOTYPE; PROADIPOCYTE; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; SMOOTH MUSCLE FIBER; TELOMERE; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL PROLIFERATION; GENETICS; METABOLISM; PHYSIOLOGY;

AGING; ANIMALS; CELL AGING; CELL PROLIFERATION; HUMANS; INFLAMMATION MEDIATORS; LONGEVITY;

EID: 84924140282     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/1570161111666131219094045     Document Type: Article

References (98)

1. Kirkwood TB. A systematic look at an old problem. Nature 2008; 451: 644-7.
2. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 2005; 120: 449-60.
3. Burton DG. Cellular senescence, ageing and disease. Age (Dordr) 2009; 31: 1-9.
4. Willcox BJ, He Q, Chen R, et al. Midlife risk factors and healthy survival in men. JAMA 2006; 296: 2343-50.
5. Niccoli T, Partridge L. Ageing as a risk factor for disease. Curr Biol 2012; 22: R741-52.
6. Stein GH, Drullinger LF, Robetorye RS, et al. Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc Natl Acad Sci USA 1991; 88: 11012-6.
7. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
8. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-60.
9. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-52.
10. d'Adda di Fagagna F. Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer 2008; 8: 512-22.
11. Prieur A, Peeper DS. Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 2008; 20: 150-5.
12. Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001; 11: S27-31.
13. Bandyopadhyay D, Timchenko N, Suwa T, et al. The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells. Exp Gerontol 2001; 36: 1265-75.
14. Effros RB, Dagarag M, Valenzuela HF. In vitro senescence of immune cells. Exp Gerontol 2003; 38: 1243-9.
15. Romanov SR, Kozakiewicz BK, Holst CR, et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001; 409: 633-7.
16. Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 2009; 106: 326-32.
17. Gorenne I, Kavurma M, Scott S, et al. Vascular smooth muscle cell senescence in atherosclerosis. Cardiovasc Res 2006; 72: 9-17.
18. Shibata KR, Aoyama T, Shima Y, et al. Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion. Stem Cells 2007; 25: 2371-82.
19. Brack C, Lithgow G, Osiewacz H, et al. EMBO WORKSHOP REPORT: Molecular and cellular gerontology Serpiano, Switzerland, September 18-22, 1999. Embo J 2000; 19: 1929-34.
20. Toussaint O, Medrano EE, von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of hu man diploid fibroblasts and melanocytes. Exp Gerontol 2000; 35: 927-45.
21. Blazkova H, Krejcikova K, Moudry P, et al. Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling. J Cell Mol Med 2010; 14: 357-67.
22. Toussaint O, Dumont P, Remacle J, et al. Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two possible definitions? ScientificWorldJournal 2002; 2: 230-47.
23. Kuilman T, Michaloglou C, Mooi WJ, et al. The essence of senescence. Genes Dev 2011; 24: 2463-79.
24. von Zglinicki T, Petrie J, Kirkwood TB. Telomere-driven replicative senescence is a stress response. Nat Biotechnol 2003; 21: 229-30.
25. Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004; 23: 2919-33.
26. Sikora E, Arendt T, Bennett M, et al. Impact of cellular senescence signature on ageing research. Ageing Res Rev 2011; 10: 146-52.
27. Brzezinska A, Magalska A, Szybinska A, et al. Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging. Exp Gerontol 2004; 39: 539-44.
28. Brzezinska A, Magalska A, Sikora E. Proliferation of CD8+ in culture of human T cells derived from peripheral blood of adult donors and cord blood of newborns. Mech Ageing Dev 2003; 124: 379-87.
29. Ksiazek K. A comprehensive review on mesenchymal stem cell growth and senescence. Rejuvenation Res 2009; 12: 105-16.
30. Ksiazek K, Passos JF, Olijslagers S, et al. Premature senescence of mesothelial cells is associated with non-telomeric DNA damage. Biochem Biophys Res Commun 2007; 362: 707-11.
31. Ksiazek K, Piwocka K, Brzezinska A, et al. Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16INK4a-mediated premature senescence. J Appl Physiol 2006; 100: 988-95.
32. Burton DG, Matsubara H, Ikeda K. Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells. Exp Gerontol 2010; 45: 819-24.
33. Jeyapalan JC, Sedivy JM. Cellular senescence and organismal aging. Mech Ageing Dev 2008; 129: 467-74.
34. Kreiling JA, Tamamori-Adachi M, Sexton AN, et al. Ageassociated increase in heterochromatic marks in murine and primate tissues. Aging Cell 2011; 10: 292-304.
35. Jurk D, Wang C, Miwa S, et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012.
36. Sedelnikova OA, Horikawa I, Zimonjic DB, et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol 2004; 6: 168-70.
37. Krishnamurthy J, Torrice C, Ramsey MR, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004; 114: 1299-307.
38. Wang C, Jurk D, Maddick M, et al. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009; 8: 311-23.
39. Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4apositive senescent cells delays ageing-associated disorders. Nature 2011; 479: 232-6.
40. Liu L, Rando TA. Manifestations and mechanisms of stem cell aging. J Cell Biol 2012; 193: 257-66.
41. Ratajczak MZ, Shin DM, Liu R, et al. Very small embryonic/epiblast-like stem cells (VSELs) and their potential role in aging and organ rejuvenation-an update and comparison to other primitive small stem cells isolated from adult tissues. Aging (Albany NY) 2012; 4: 235-46.
42. Butler RN, Miller RA, Perry D, et al. New model of health promotion and disease prevention for the 21st century. BMJ 2008; 337: a399.
43. Vijg J, Campisi J. Puzzles, promises and a cure for ageing. Nature 2008; 454: 1065-71.
44. Tacutu R, Budovsky A, Yanai H, et al. Molecular links between cellular senescence, longevity and age-related diseases-a systems biology perspective. Aging (Albany NY) 2011; 3: 1178-91.
45. Franceschi C, Bonafe M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000; 908: 244-54.
46. Candore G, Caruso C, Jirillo E, et al. Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievement. Curr Pharm Des 2010; 16: 584-96.
47. Davalos AR, Coppe JP, Campisi J, et al. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev 2010; 29: 273-83.
48. Kuilman T, Peeper DS. Senescence-messaging secretome: SMSing cellular stress. Nat Rev Cancer 2009; 9: 81-94.
49. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192: 547-56.
50. Sansoni P, Vescovini R, Fagnoni F, et al. The immune system in extreme longevity. Exp Gerontol 2008; 43: 61-5.
51. Mantovani A. Cancer: Inflaming metastasis. Nature 2009; 457: 36-7.
52. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
53. Vasto S, Candore G, Duro G, et al. Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics 2007; 8: 1735-45.
54. Chung HY, Cesari M, Anton S, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009; 8: 18-30.
55. Finch CE, Morgan TE. Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr Alzheimer Res 2007; 4: 185-9.
56. Gupta A, Pansari K. Inflammation and Alzheimer's disease. Int J Clin Pract 2003; 57: 36-9.
57. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444: 860-7.
58. Serrano M, Lin AW, McCurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88: 593-602.
59. Evan GI, d'Adda di Fagagna F. Cellular senescence: hot or what? Curr Opin Genet Dev 2009; 19: 25-31.
60. Kuilman T, Michaloglou C, Vredeveld LC, et al. Oncogeneinduced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008; 133: 1019-31.
61. Bonafe M, Storci G, Franceschi C. Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people. Bioessays 2012; 34: 40-9.
62. Anisimov VN, Sikora E, Pawelec G. Relationships between cancer and aging: a multilevel approach. Biogerontology 2009; 10: 323-38.
63. Mosieniak G, Sikora E. Polyploidy: the link between senescence and cancer. Curr Pharm Des 2010; 16: 734-40.
64. Storchova Z, Kuffer C. The consequences of tetraploidy and aneuploidy. J Cell Sci 2008; 121: 3859-66.
65. Gupta S. Hepatic polyploidy and liver growth control. Semin Cancer Biol 2000; 10: 161-71.
66. Yang D, McCrann DJ, Nguyen H, et al. Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell 2007; 6: 257-60.
67. Wojda A, Zietkiewicz E, Mossakowska M, et al. Correlation between the level of cytogenetic aberrations in cultured human lymphocytes and the age and gender of donors. J Gerontol A Biol Sci Med Sci 2006; 61: 763-72.
68. Wagner M, Hampel B, Bernhard D, et al. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis. Exp Gerontol 2001; 36: 1327-47.
69. Walen KH. Human diploid fibroblast cells in senescence; cycling through polyploidy to mitotic cells. In vitro Cell Dev Biol Anim 2006; 42: 216-24.
70. Kaji K, Matsuo M. Aging of chick embryo fibroblasts in vitro. V. Time course studies on polyploid nucleus accumulation. Exp Cell Res 1981; 131: 410-2.
71. Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005; 26: 867-74.
72. Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res 2003; 63: 2705-15.
73. Nardella C, Clohessy JG, Alimonti A, et al. Pro-senescence therapy for cancer treatment. Nat Rev Cancer 2011; 11: 503-11.
74. Sliwinska MA, Mosieniak G, Wolanin K, et al. Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells. Mech Ageing Dev 2009; 130: 24-32.
75. Puig PE, Guilly MN, Bouchot A, et al. Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy. Cell Biol Int 2008; 32(9): 1031-43.
76. Erusalimsky JD, Skene C. Mechanisms of endothelial senescence. Exp Physiol 2009; 94: 299-304.
77. Minamino T, Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ Res 2007; 100: 15-26.
78. Mahmoudi M, Gorenne I, Mercer J, et al. Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circ Res 2008; 103: 717-25.
79. Matthews C, Gorenne I, Scott S, et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. Circ Res 2006; 99: 156-64.
80. Minamino T. Role of cellular senescence in lifestyle-related disease. Circ J 2010; 74: 2527-33.
81. Stegbauer J, Coffman TM. New insights into angiotensin receptor actions: from blood pressure to aging. Curr Opin Nephrol Hypertens 2011; 20: 84-8.
82. Minamino T, Orimo M, Shimizu I, et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009; 15: 1082-7.
83. Tchkonia T, Morbeck DE, Von Zglinicki T, et al. Fat tissue, aging, and cellular senescence. Aging Cell 2010; 9: 667-84.
84. Tzanetakou IP, Katsilambros NL, Benetos A, et al. "Is obesity linked to aging?" adipose tissue and the role of telomeres. Ageing Res Rev 2012; 11: 220-9.
85. Rando TA, Chang HY. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 2012; 148: 46-57.
86. Sikora E, Bielak-Zmijewska A, Mosieniak G, et al. The promise of slow down ageing may come from curcumin. Curr Pharm Des 2010; 16: 884-92.
87. Ali RE, Rattan SI. Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes. Ann N Y Acad Sci 2006; 1067: 394-9.
88. Mosieniak G, Adamowicz M, Alster O, et al. Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy. Mech Ageing Dev 2012; 133: 444-55.
89. Blagosklonny MV. Progeria, rapamycin and normal aging: recent breakthrough. Aging (Albany NY) 2011; 3: 685-91.
90. Menendez JA, Vellon L, Oliveras-Ferraros C, et al. mTORregulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle 2011; 10: 3658-77.
91. Cao K, Graziotto JJ, Blair CD, et al. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci Transl Med 2011; 3: 89ra58.
92. Olivieri F, Mazzanti I, Abbatecola AM, et al. Telomere/Telomerase system: a new target of statins pleiotropic effect? Curr Vasc Pharmacol 2012; 10: 216-24.
93. Saliques S, Teyssier JR, Vergely C, et al. Circulating leukocyte telomere length and oxidative stress: a new target for statin therapy. Atherosclerosis 2011; 219: 753-60.
94. Tomaszewski M, Stepien KM, Tomaszewska J, et al. Statininduced myopathies. Pharmacol Rep 2011; 63: 859-66.
95. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005; 120: 513-22.
96. Krizhanovsky V, Yon M, Dickins RA, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008; 134: 657-67.
97. Jun JI, Lau LF. Cellular senescence controls fibrosis in wound healing. Aging (Albany NY) 2010; 2: 627-31.
98. Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007; 445: 656-60.