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Volumn 493, Issue 7432, 2013, Pages 338-345

MTOR is a key modulator of ageing and age-related disease

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CANCER ANTIBODY; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOSUPPRESSIVE AGENT; INFLUENZA VACCINE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; SOMATOMEDIN C; VACCINIA VACCINE; VASCULOTROPIN ANTIBODY;

EID: 84872527628     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11861     Document Type: Review
Times cited : (1317)

References (100)
  • 1
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante, M. & Sabatini, D. M. mTOR signaling in growth control and disease. Cell 149, 274-293 (2012).
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 3
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • Lamming, D. W. et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 1638-1643 (2012).
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1
  • 4
    • 0035853552 scopus 로고    scopus 로고
    • Regulation of longevity and stress resistance by Sch9 in yeast
    • Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M. & Longo, V. D. Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-290 (2001).
    • (2001) Science , vol.292 , pp. 288-290
    • Fabrizio, P.1    Pozza, F.2    Pletcher, S.D.3    Gendron, C.M.4    Longo, V.D.5
  • 5
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia, K., Chen, D. & Riddle, D. L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131, 3897-3906 (2004).
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 6
    • 0642367846 scopus 로고    scopus 로고
    • Influence of TOR kinase on lifespan in C. elegans
    • Vellai, T. et al. Influence of TOR kinase on lifespan in C. elegans. Nature 426, 620 (2003).
    • (2003) Nature , vol.426 , pp. 620
    • Vellai, T.1
  • 7
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi, P. et al. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885-890 (2004).
    • (2004) Curr. Biol , vol.14 , pp. 885-890
    • Kapahi, P.1
  • 8
    • 27744511769 scopus 로고    scopus 로고
    • Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
    • Kaeberlein, M. et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196 (2005).
    • (2005) Science , vol.310 , pp. 1193-1196
    • Kaeberlein, M.1
  • 9
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers, R. W. III, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K. & Fields, S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20, 174-184 (2006).
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers Iii., R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 10
    • 35648995939 scopus 로고    scopus 로고
    • MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae
    • Medvedik, O., Lamming, D. W., Kim, K. D. & Sinclair, D. A. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 5, e261 (2007).
    • (2007) PLoS Biol , vol.5
    • Medvedik, O.1    Lamming, D.W.2    Kim, K.D.3    Sinclair, D.A.4
  • 11
    • 84860461929 scopus 로고    scopus 로고
    • TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
    • Robida-Stubbs, S. et al. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15, 713-724 (2012).
    • (2012) Cell Metab , vol.15 , pp. 713-724
    • Robida-Stubbs, S.1
  • 12
    • 72649091698 scopus 로고    scopus 로고
    • Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
    • Bjedov, I. et al. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11, 35-46 (2010).
    • (2010) Cell Metab , vol.11 , pp. 35-46
    • Bjedov, I.1
  • 13
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395 (2009).
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1
  • 14
    • 79951794971 scopus 로고    scopus 로고
    • Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    • Miller, R. A. et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 66, 191-201 (2011).
    • (2011) J. Gerontol. A Biol. Sci. Med. Sci , vol.66 , pp. 191-201
    • Miller, R.A.1
  • 15
    • 83755165458 scopus 로고    scopus 로고
    • Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    • Anisimov, V. N. et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 10, 4230-4236 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 4230-4236
    • Anisimov, V.N.1
  • 16
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy lifespan-from yeast to humans
    • Fontana, L., Partridge, L. & Longo, V. D. Extending healthy lifespan-from yeast to humans. Science 328, 321-326 (2010).
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 17
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen, M. et al. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6, 95-110 (2007).
    • (2007) Aging Cell , vol.6 , pp. 95-110
    • Hansen, M.1
  • 18
    • 70349438679 scopus 로고    scopus 로고
    • 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
    • Zid, B. M. et al. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139, 149-160 (2009).
    • (2009) Cell , vol.139 , pp. 149-160
    • Zid, B.M.1
  • 19
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon, C. J. The genetics of ageing. Nature 464, 504-512 (2010).
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 20
    • 0034947869 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
    • Takano, A. et al. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol. Cell. Biol. 21, 5050-5062 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 5050-5062
    • Takano, A.1
  • 21
    • 77952373274 scopus 로고    scopus 로고
    • FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1
    • Khatri, S., Yepiskoposyan, H., Gallo, C. A., Tandon, P. & Plas, D. R. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J. Biol. Chem. 285, 15960-15965 (2010).
    • (2010) J. Biol. Chem , vol.285 , pp. 15960-15965
    • Khatri, S.1    Yepiskoposyan, H.2    Gallo, C.A.3    Tandon, P.4    Plas, D.R.5
  • 22
    • 23944507152 scopus 로고    scopus 로고
    • Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein d4E-BP
    • Tettweiler, G., Miron, M., Jenkins, M., Sonenberg, N. & Lasko, P. F. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev. 19, 1840-1843 (2005).
    • (2005) Genes Dev , vol.19 , pp. 1840-1843
    • Tettweiler, G.1    Miron, M.2    Jenkins, M.3    Sonenberg, N.4    Lasko, P.F.5
  • 23
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1
    • Guertin, D. A. et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1. Dev. Cell 11, 859-871 (2006).
    • (2006) Dev. Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1
  • 24
    • 33846418352 scopus 로고    scopus 로고
    • Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
    • Pan, K. Z. et al. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6, 111-119 (2007).
    • (2007) Aging Cell , vol.6 , pp. 111-119
    • Pan, K.Z.1
  • 25
    • 10644282295 scopus 로고    scopus 로고
    • The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
    • Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S. & Curtis, R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 18, 3004-3009 (2004).
    • (2004) Genes Dev , vol.18 , pp. 3004-3009
    • Apfeld, J.1    O'Connor, G.2    McDonagh, T.3    Distefano, P.S.4    Curtis, R.5
  • 26
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK LKB1, and SKN-1
    • Onken, B. & Driscoll, M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1. PLoS ONE 5, e8758 (2010).
    • (2010) PLoS ONE , vol.5
    • Onken, B.1    Driscoll, M.2
  • 27
    • 78650316639 scopus 로고    scopus 로고
    • Metformin for aging and cancer prevention
    • Albany NY
    • Anisimov, V. N. Metformin for aging and cancer prevention. Aging (Albany NY) 2, 760-774 (2010).
    • (2010) Aging , vol.2 , pp. 760-774
    • Anisimov, V.N.1
  • 28
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki, K., Zhu, T. & Guan, K. L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590 (2003).
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 29
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn, D. M. et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1
  • 30
    • 79951787452 scopus 로고    scopus 로고
    • Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
    • Mair, W. et al. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470, 404-408 (2011).
    • (2011) Nature , vol.470 , pp. 404-408
    • Mair, W.1
  • 31
    • 78049380218 scopus 로고    scopus 로고
    • The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging
    • Leiser, S. F. & Kaeberlein, M. The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol. Chem. 391, 1131-1137 (2010).
    • (2010) Biol. Chem , vol.391 , pp. 1131-1137
    • Leiser, S.F.1    Kaeberlein, M.2
  • 32
    • 0036789574 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
    • Hudson, C. C. et al. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 22, 7004-7014 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , pp. 7004-7014
    • Hudson, C.C.1
  • 33
    • 66349098677 scopus 로고    scopus 로고
    • Proteasomal regulation of the hypoxic response modulates aging in C. elegans
    • Mehta, R. et al. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324, 1196-1198 (2009).
    • (2009) Science , vol.324 , pp. 1196-1198
    • Mehta, R.1
  • 34
    • 68149149835 scopus 로고    scopus 로고
    • The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans
    • Zhang, Y., Shao, Z., Zhai, Z., Shen, C. & Powell-Coffman, J. A. The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS ONE 4, e6348 (2009).
    • (2009) PLoS ONE , vol.4
    • Zhang, Y.1    Shao, Z.2    Zhai, Z.3    Shen, C.4    Powell-Coffman, J.A.5
  • 35
    • 79952582588 scopus 로고    scopus 로고
    • HIF-1 modulates longevity and healthspan in a temperature-dependent manner
    • Leiser, S. F., Begun, A. & Kaeberlein, M. HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell 10, 318-326 (2011).
    • (2011) Aging Cell , vol.10 , pp. 318-326
    • Leiser, S.F.1    Begun, A.2    Kaeberlein, M.3
  • 36
    • 67149107430 scopus 로고    scopus 로고
    • HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    • Chen, D., Thomas, E. L. & Kapahi, P. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet. 5, e1000486 (2009).
    • (2009) PLoS Genet , vol.5
    • Chen, D.1    Thomas, E.L.2    Kapahi, P.3
  • 37
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan
    • Selman, C. et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan. Science 326, 140-144 (2009).
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1
  • 38
    • 67650439330 scopus 로고    scopus 로고
    • Caloric restriction delays disease onset and mortality in rhesus monkeys
    • Colman, R. J. et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325, 201-204 (2009).
    • (2009) Science , vol.325 , pp. 201-204
    • Colman, R.J.1
  • 39
    • 0018876664 scopus 로고
    • Aging natural death, and the compression of morbidity
    • Fries, J. F. Aging, natural death, and the compression of morbidity. N. Engl. J. Med. 303, 130-135 (1980).
    • (1980) N. Engl. J. Med , vol.303 , pp. 130-135
    • Fries, J.F.1
  • 40
    • 84864021710 scopus 로고    scopus 로고
    • Rapamycin slows aging in mice
    • Wilkinson, J. E. et al. Rapamycin slows aging in mice. Aging Cell 11, 675-682 (2012).
    • (2012) Aging Cell , vol.11 , pp. 675-682
    • Wilkinson, J.E.1
  • 41
    • 84865525400 scopus 로고    scopus 로고
    • Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
    • Halloran, J. et al. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience 223, 102-113 (2012).
    • (2012) Neuroscience , vol.223 , pp. 102-113
    • Halloran, J.1
  • 42
    • 84858342119 scopus 로고    scopus 로고
    • Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
    • Majumder, S. et al. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell 11, 326-335 (2012).
    • (2012) Aging Cell , vol.11 , pp. 326-335
    • Majumder, S.1
  • 43
    • 79952622353 scopus 로고    scopus 로고
    • Hot topics in aging research: Protein translation and TOR signaling
    • Kaeberlein, M. & Kennedy, B. K. Hot topics in aging research: protein translation and TOR signaling. Aging Cell 10, 185-190 (2011).
    • (2011) Aging Cell , vol.10 , pp. 185-190
    • Kaeberlein, M.1    Kennedy, B.K.2
  • 44
    • 41649094265 scopus 로고    scopus 로고
    • Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
    • Smith, E. D. et al. Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res. 18, 564-570 (2008).
    • (2008) Genome Res , vol.18 , pp. 564-570
    • Smith, E.D.1
  • 46
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny, M. V. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 5, 2087-2102 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 47
    • 41949089130 scopus 로고    scopus 로고
    • Yeast lifespan extension by depletion of 60S ribosomal subunits is mediated by Gcn4
    • Steffen, K. K. et al. Yeast lifespan extension by depletion of 60S ribosomal subunits is mediated by Gcn4. Cell 133, 292-302 (2008).
    • (2008) Cell , vol.133 , pp. 292-302
    • Steffen, K.K.1
  • 48
    • 79959981053 scopus 로고    scopus 로고
    • Lifespan extension via eIF4G inhibition is mediated by post-transcriptional remodeling of stress response gene expression in C. elegans
    • Rogers, A. N. et al. Lifespan extension via eIF4G inhibition is mediated by post-transcriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 14, 55-66 (2011).
    • (2011) Cell Metab , vol.14 , pp. 55-66
    • Rogers, A.N.1
  • 49
    • 84860527756 scopus 로고    scopus 로고
    • A unifying model for mTORC1-mediated regulation of mRNA translation
    • Thoreen, C. C. et al. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485, 109-113 (2012).
    • (2012) Nature , vol.485 , pp. 109-113
    • Thoreen, C.C.1
  • 50
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075 (2008).
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 51
    • 56349168452 scopus 로고    scopus 로고
    • Autophagy and aging: Keeping that old broom working
    • Cuervo, A. M. Autophagy and aging: keeping that old broom working. Trends Genet. 24, 604-612 (2008).
    • (2008) Trends Genet , vol.24 , pp. 604-612
    • Cuervo, A.M.1
  • 52
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • Hansen, M. et al. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 4, e24 (2008).
    • (2008) PLoS Genet , vol.4
    • Hansen, M.1
  • 53
    • 69449106873 scopus 로고    scopus 로고
    • Autophagy is required for extension of yeast chronological life span by rapamycin
    • Alvers, A. L. et al. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 5, 847-849 (2009).
    • (2009) Autophagy , vol.5 , pp. 847-849
    • Alvers, A.L.1
  • 54
    • 38949137849 scopus 로고    scopus 로고
    • Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA Tor, and Sch9
    • Wei, M. et al. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 4, e13 (2008).
    • (2008) PLoS Genet , vol.4
    • Wei, M.1
  • 55
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • Bishop, N. A. & Guarente, L. Two neurons mediate diet-restriction- induced longevity in C. elegans. Nature 447, 545-549 (2007).
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 56
    • 84865108931 scopus 로고    scopus 로고
    • Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan
    • Steinbaugh, M. J., Sun, L. Y., Bartke, A. & Miller, R. A. Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am. J. Physiol. Endocrinol. Metab. 303, E488-E495 (2012).
    • (2012) Am. J. Physiol. Endocrinol. Metab , vol.303
    • Steinbaugh, M.J.1    Sun, L.Y.2    Bartke, A.3    Miller, R.A.4
  • 57
    • 36749081539 scopus 로고    scopus 로고
    • MTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
    • Cunningham, J. T. et al. mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex. Nature 450, 736-740 (2007).
    • (2007) Nature , vol.450 , pp. 736-740
    • Cunningham, J.T.1
  • 58
    • 33947574775 scopus 로고    scopus 로고
    • Reduced TOR signaling extends chronological lifespan via increased respiration and upregulation of mitochondrial gene expression
    • Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y. & Shadel, G. S. Reduced TOR signaling extends chronological lifespan via increased respiration and upregulation of mitochondrial gene expression. Cell Metab. 5, 265-277 (2007).
    • (2007) Cell Metab , vol.5 , pp. 265-277
    • Bonawitz, N.D.1    Chatenay-Lapointe, M.2    Pan, Y.3    Shadel, G.S.4
  • 59
    • 79958068191 scopus 로고    scopus 로고
    • Regulation of yeast chronological lifespan by TORC1 via adaptive mitochondrial ROS signaling
    • Pan, Y., Schroeder, E. A., Ocampo, A., Barrientos, A. & Shadel, G. S. Regulation of yeast chronological lifespan by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab. 13, 668-678 (2011).
    • (2011) Cell Metab , vol.13 , pp. 668-678
    • Pan, Y.1    Schroeder, E.A.2    Ocampo, A.3    Barrientos, A.4    Shadel, G.S.5
  • 60
    • 54849431380 scopus 로고    scopus 로고
    • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
    • Polak, P. et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 8, 399-410 (2008).
    • (2008) Cell Metab , vol.8 , pp. 399-410
    • Polak, P.1
  • 61
    • 57949087452 scopus 로고    scopus 로고
    • Molecular inflammation: Underpinnings of aging and age-related diseases
    • Chung, H. Y. et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 8, 18-30 (2009).
    • (2009) Ageing Res. Rev , vol.8 , pp. 18-30
    • Chung, H.Y.1
  • 62
    • 33847772417 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms of dietary restriction in slowing aging processes
    • Morgan, T. E., Wong, A. M. & Finch, C. E. Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. Interdiscip. Top. Gerontol. 35, 83-97 (2007).
    • (2007) Interdiscip. Top. Gerontol , vol.35 , pp. 83-97
    • Morgan, T.E.1    Wong, A.M.2    Finch, C.E.3
  • 63
    • 33745237651 scopus 로고    scopus 로고
    • Rapamycin and chronic kidney disease: Beyond the inhibition of inflammation
    • Liu, Y. Rapamycin and chronic kidney disease: beyond the inhibition of inflammation. Kidney Int. 69, 1925-1927 (2006).
    • (2006) Kidney Int , vol.69 , pp. 1925-1927
    • Liu, Y.1
  • 64
    • 19944432650 scopus 로고    scopus 로고
    • Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty
    • Nuhrenberg, T. G. et al. Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty. FASEB J. 19, 246-248 (2005).
    • (2005) FASEB J , vol.19 , pp. 246-248
    • Nuhrenberg, T.G.1
  • 65
    • 67650602355 scopus 로고    scopus 로고
    • Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
    • Chen, W. Q. et al. Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels. Br. J. Pharmacol. 156, 941-951 (2009).
    • (2009) Br. J. Pharmacol , vol.156 , pp. 941-951
    • Chen, W.Q.1
  • 66
    • 80655134731 scopus 로고    scopus 로고
    • Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
    • Abdulrahman, B. A. et al. Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy 7, 1359-1370 (2011).
    • (2011) Autophagy , vol.7 , pp. 1359-1370
    • Abdulrahman, B.A.1
  • 67
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless, N. E. & DePinho, R. A. How stem cells age and why this makes us grow old. Nature Rev. Mol. Cell Biol. 8, 703-713 (2007).
    • (2007) Nature Rev. Mol. Cell Biol , vol.8 , pp. 703-713
    • Sharpless, N.E.1    Depinho, R.A.2
  • 68
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen, C., Liu, Y. & Zheng, P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2, ra75 (2009).
    • (2009) Sci. Signal , vol.2
    • Chen, C.1    Liu, Y.2    Zheng, P.3
  • 69
    • 84862994618 scopus 로고    scopus 로고
    • MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
    • Yilmaz, O. H. et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 486, 490-495 (2012).
    • (2012) Nature , vol.486 , pp. 490-495
    • Yilmaz, O.H.1
  • 70
    • 84860614281 scopus 로고    scopus 로고
    • Short-term calorie restriction enhances skeletal muscle stem cell function
    • Cerletti, M., Jang, Y. C., Finley, L. W., Haigis, M. C. & Wagers, A. J. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell 10, 515-519 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 515-519
    • Cerletti, M.1    Jang, Y.C.2    Finley, L.W.3    Haigis, M.C.4    Wagers, A.J.5
  • 71
    • 84862991985 scopus 로고    scopus 로고
    • A healthy diet for stem cells
    • Ramos, F. J. & Kaeberlein, M. A healthy diet for stem cells. Nature 486, 477-478 (2012).
    • (2012) Nature , vol.486 , pp. 477-478
    • Ramos, F.J.1    Kaeberlein, M.2
  • 72
    • 84859005924 scopus 로고    scopus 로고
    • Timing of onset of cognitive decline: Results from Whitehall II prospective cohort study
    • Singh-Manoux, A. et al. Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. Br. Med. J. 344, d7622 (2012).
    • (2012) Br. Med. J , vol.344
    • Singh-Manoux, A.1
  • 73
    • 80155142474 scopus 로고    scopus 로고
    • Rapamycin passes the torch: A new generation of mTOR inhibitors
    • Benjamin, D., Colombi, M., Moroni, C. & Hall, M. N. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nature Rev. Drug Discov. 10, 868-880 (2011).
    • (2011) Nature Rev. Drug Discov , vol.10 , pp. 868-880
    • Benjamin, D.1    Colombi, M.2    Moroni, C.3    Hall, M.N.4
  • 74
    • 33847199335 scopus 로고    scopus 로고
    • EIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
    • Syntichaki, P., Troulinaki, K. & Tavernarakis, N. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445, 922-926 (2007).
    • (2007) Nature , vol.445 , pp. 922-926
    • Syntichaki, P.1    Troulinaki, K.2    Tavernarakis, N.3
  • 75
    • 34247569105 scopus 로고    scopus 로고
    • Lifespan regulation by evolutionarily conserved genes essential for viability
    • Curran, S. P. & Ruvkun, G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 3, e56 (2007).
    • (2007) PLoS Genet , vol.3
    • Curran, S.P.1    Ruvkun, G.2
  • 76
    • 33847680031 scopus 로고    scopus 로고
    • Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span
    • Chiocchetti, A. et al. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Exp. Gerontol. 42, 275-286 (2007).
    • (2007) Exp. Gerontol , vol.42 , pp. 275-286
    • Chiocchetti, A.1
  • 77
    • 75749127850 scopus 로고    scopus 로고
    • Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease
    • Malagelada, C., Jin, Z. H., Jackson-Lewis, V., Przedborski, S. & Greene, L. A. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J. Neurosci. 30, 1166-1175 (2010).
    • (2010) J. Neurosci , vol.30 , pp. 1166-1175
    • Malagelada, C.1    Jin, Z.H.2    Jackson-Lewis, V.3    Przedborski, S.4    Greene, L.A.5
  • 78
    • 69449084089 scopus 로고    scopus 로고
    • Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
    • Tain, L. S. et al. Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nature Neurosci. 12, 1129-1135 (2009).
    • (2009) Nature Neurosci , vol.12 , pp. 1129-1135
    • Tain, L.S.1
  • 79
    • 80053243942 scopus 로고    scopus 로고
    • Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
    • Majumder, S., Richardson, A., Strong, R. & Oddo, S. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS ONE 6, e25416 (2011).
    • (2011) PLoS ONE , vol.6
    • Majumder, S.1    Richardson, A.2    Strong, R.3    Oddo, S.4
  • 80
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer's disease
    • Spilman, P. et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer's disease. PLoS ONE 5, e9979 (2010).
    • (2010) PLoS ONE , vol.5
    • Spilman, P.1
  • 81
    • 84866289381 scopus 로고    scopus 로고
    • Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
    • Wang, I. F. et al. Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Proc. Natl Acad. Sci. USA 109, 15024-15029 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 15024-15029
    • Wang, I.F.1
  • 82
    • 62449132606 scopus 로고    scopus 로고
    • Targeting mTOR: Something old, something new
    • Garber, K. Targeting mTOR: something old, something new. J. Natl Cancer Inst. 101, 288-290 (2009).
    • (2009) J. Natl Cancer Inst , vol.101 , pp. 288-290
    • Garber, K.1
  • 83
    • 0037382861 scopus 로고    scopus 로고
    • Rapamycin attenuates load-induced cardiac hypertrophy in mice
    • Shioi, T. et al. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 107, 1664-1670 (2003).
    • (2003) Circulation , vol.107 , pp. 1664-1670
    • Shioi, T.1
  • 84
    • 3042608187 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
    • McMullen, J. R. et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 109, 3050-3055 (2004).
    • (2004) Circulation , vol.109 , pp. 3050-3055
    • McMullen, J.R.1
  • 85
    • 80052581224 scopus 로고    scopus 로고
    • Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish
    • Ding, Y. et al. Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish. Circ. Res. 109, 658-669 (2011).
    • (2011) Circ. Res , vol.109 , pp. 658-669
    • Ding, Y.1
  • 86
    • 84864523531 scopus 로고    scopus 로고
    • Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival
    • Ramos, F. J. et al. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci. Transl. Med. 4, 144ra103 (2012).
    • (2012) Sci. Transl. Med , vol.4
    • Ramos, F.J.1
  • 87
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity
    • Um, S. H. et al. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 431, 200-205 (2004).
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1
  • 88
    • 84864927001 scopus 로고    scopus 로고
    • Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
    • Yang, S. B. et al. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron 75, 425-436 (2012).
    • (2012) Neuron , vol.75 , pp. 425-436
    • Yang, S.B.1
  • 89
    • 84555178660 scopus 로고    scopus 로고
    • Rapamycin-induced enhancement of vaccine efficacy in mice
    • Jagannath, C. & Bakhru, P. Rapamycin-induced enhancement of vaccine efficacy in mice. Methods Mol. Biol. 821, 295-303 (2012).
    • (2012) Methods Mol. Biol , vol.821 , pp. 295-303
    • Jagannath, C.1    Bakhru, P.2
  • 90
    • 84865435212 scopus 로고    scopus 로고
    • Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice
    • Amiel, E. et al. Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. J. Immunol. 189, 2151-2158 (2012).
    • (2012) J. Immunol , vol.189 , pp. 2151-2158
    • Amiel, E.1
  • 91
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T-cell differentiation
    • Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112 (2009).
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1
  • 92
    • 84863937859 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications
    • Lieberthal, W. & Levine, J. S. Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications. Am. J. Physiol. Renal Physiol. 303, F180-F191 (2012).
    • (2012) Am. J. Physiol. Renal Physiol , vol.303
    • Lieberthal, W.1    Levine, J.S.2
  • 93
    • 84864128574 scopus 로고    scopus 로고
    • Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats
    • Kolosova, N. G. et al. Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats. Am. J. Pathol. 181, 472-477 (2012).
    • (2012) Am. J. Pathol , vol.181 , pp. 472-477
    • Kolosova, N.G.1
  • 94
    • 84869764786 scopus 로고    scopus 로고
    • Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice
    • Yin, L., Ye, S., Chen, Z. & Zeng, Y. Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice. Int. J. Neurosci. 122, 748-756 (2012).
    • (2012) Int. J. Neurosci , vol.122 , pp. 748-756
    • Yin, L.1    Ye, S.2    Chen, Z.3    Zeng, Y.4
  • 95
    • 84865508373 scopus 로고    scopus 로고
    • Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
    • Tsai, P. T. et al. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 488, 647-651(2012).
    • (2012) Nature , vol.488 , pp. 647-651
    • Tsai, P.T.1
  • 96
    • 84865630995 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition: Potential for antiseizure, antiepileptogenic, and epileptostatic therapy
    • Ryther, R. C. & Wong, M. Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy. Curr. Neurol. Neurosci. Rep. 12, 410-418 (2012).
    • (2012) Curr. Neurol. Neurosci. Rep , vol.12 , pp. 410-418
    • Ryther, R.C.1    Wong, M.2
  • 97
    • 84866469838 scopus 로고    scopus 로고
    • Preventive and therapeutic effects of rapamycin, a mammalian target of rapamycin inhibitor, on food allergy in mice
    • Yamaki, K. & Yoshino, S. Preventive and therapeutic effects of rapamycin, a mammalian target of rapamycin inhibitor, on food allergy in mice. Allergy 67, 1259-1270 (2012).
    • (2012) Allergy , vol.67 , pp. 1259-1270
    • Yamaki, K.1    Yoshino, S.2
  • 98
    • 83455238260 scopus 로고    scopus 로고
    • MTOR signaling and metabolic regulation of T cells: New potential therapeutic targets in autoimmune diseases
    • Pierdominici, M., Vacirca, D., Delunardo, F. & Ortona, E. mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases. Curr. Pharm. Des. 17, 3888-3897 (2011).
    • (2011) Curr. Pharm. des , vol.17 , pp. 3888-3897
    • Pierdominici, M.1    Vacirca, D.2    Delunardo, F.3    Ortona, E.4
  • 99
    • 78650799667 scopus 로고    scopus 로고
    • A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization
    • Nussenblatt, R. B. et al. A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization. Retina 30, 1579-1587 (2010).
    • (2010) Retina , vol.30 , pp. 1579-1587
    • Nussenblatt, R.B.1
  • 100
    • 79959776029 scopus 로고    scopus 로고
    • Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
    • Cao, K. et al. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci. Transl. Med. 3, 89ra58 (2011).
    • (2011) Sci. Transl. Med , vol.3
    • Cao, K.1


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