Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition

Cancer Science

Volumn 106, Issue 1, 2015, Pages 94-101

  Kim, Rae Kwon ^a   Suh, Yongjoon ^a   Yoo, Ki Chun ^a   Cui, Yan Hong ^a   Hwang, Eunji ^a   Kim, Hyun Jin ^a   Kang, Ju Seop ^a   Kim, Min Jung ^b   Lee, Young Yiul ^a   Lee, Su Jae ^a  

^a Hanyang University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Basal type breast cancer cells; Cancer metastasis; Epithelial mesenchymal transition; Phloroglucinol; SLUG

Indexed keywords

ANTIMETASTATIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PHLOROGLUCINOL; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR SLUG; ANTINEOPLASTIC AGENT; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; BROWN ALGA; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL TIME; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; FEMALE; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; SECONDARY; TUMOR INVASION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; PHLOROGLUCINOL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84923229083     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12562     Document Type: Article

References (24)

1. Polyak K. Breast cancer: origins and evolution. J Clin Invest 2007; 117: 3155-63.
2. Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011; 331: 1559-64.
3. Liang X. EMT: new signals from the invasive front. Oral Oncol 2011; 47: 686-7.
4. Christofori G. New signals from the invasive front. Nature 2006; 441: 444-50.
5. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54.
6. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147: 275-92.
7. Micalizzi DS, Farabaugh SM, Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 2010; 15: 117-34.
8. Singh IP, Sidana J, Bharate SB, Foley WJ. Phloroglucinol compounds of natural origin: synthetic aspects. Nat Prod Rep 2010; 27: 393-416.
9. Kang KA, Lee KH, Chae S et al. Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation. J Cell Biochem 2006; 97: 609-20.
10. Kang KA, Zhang R, Chae S et al. Phloroglucinol (1, 3, 5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo. Chem Biol Interact 2010; 185: 215-26.
11. Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 2005; 24: 7443-54.
12. Yao KYe PP, Tan J, Tang XJ, Shen Tu XC. Involvement of PI3K/Akt pathway in TGF-beta2-mediated epithelial mesenchymal transition in human lens epithelial cells. Ophthalmic Res 2008; 40: 69-76.
13. Grille SJ, Bellacosa A, Upson J et al. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 2003; 63: 2172-8.
14. Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9: 274-84.
15. Piao MJ, Zhang R, Lee NH, Hyun JW. Phloroglucinol attenuates ultraviolet B radiation-induced matrix metalloproteinase-1 production in human keratinocytes via inhibitory actions against mitogen-activated protein kinases and activator protein-1. Photochem Photobiol 2012; 88: 381-8.
16. Turner NC, Jones AL. Management of breast cancer-Part II. BMJ 2008; 337: a540.
17. Haffty BG, Yang Q, Reiss M et al. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 2006; 24: 5652-7.
18. Carey LA, Dees EC, Sawyer L et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 2007; 13: 2329-34.
19. Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 2000; 406: 747-52.
20. Sarrio D, Rodriguez-Pinilla SM, Hardisson D, Cano A, Moreno-Bueno G, Palacios J. Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res 2008; 68: 989-97.
21. Choi Y, Lee HJ, Jang MH et al. Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer. Hum Pathol 2013; 44: 2581-9.
22. Storci G, Sansone P, Trere D et al. The basal-like breast carcinoma phenotype is regulated by SLUG gene expression. J Pathol 2008; 214: 25-37.
23. Kang MH, Kim IH, Nam TJ. Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells. Int J Oncol 2014; 45: 1036-42.
24. Sun Y, Gao C, Luo M et al. Aspidin PB, a phloroglucinol derivative, induces apoptosis in human hepatocarcinoma HepG2 cells by modulating PI3K/Akt/GSK3beta pathway. Chem Biol Interact 2013; 201: 1-8.