Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Nature Medicine

Volumn 22, Issue 1, 2016, Pages 78-83

  Chang, Jianhui ^a,b   Wang, Yingying ^a,b,c   Shao, Lijian ^a,b   Laberge, Remi Martin ^d   Demaria, Marco ^d   Campisi, Judith ^d,e   Janakiraman, Krishnamurthy ^f   Sharpless, Norman E ^f   Ding, Sheng ^g   Feng, Wei ^a,b   Luo, Yi ^a,b   Wang, Xiaoyan ^a   Aykin Burns, Nukhet ^a,b   Krager, Kimberly ^a,b   Ponnappan, Usha ^h   Hauer Jensen, Martin ^a,b   Meng, Aimin ^c   Zhou, Daohong ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^d BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^h UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; NAVITOCLAX; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BCL2 PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GANCICLOVIR; MESSENGER RNA; PROTEIN BCL X; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGING; CELL KILLING; CELLS BY BODY ANATOMY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; MOUSE; MUSCLE STEM CELL; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; RADIATION EXPOSURE; SPECIES; WHOLE BODY RADIATION; ANIMAL; B LYMPHOCYTE; CELL CYCLE; CELL LINE; CELL SURVIVAL; CFU COUNTING; CYTOLOGY; DNA DAMAGE; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; MICROSCOPY; MYOBLAST; PATHOLOGY; REJUVENATION; SKELETAL MUSCLE; WESTERN BLOTTING;

ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; APOPTOSIS; B-LYMPHOCYTES; BCL-X PROTEIN; BLOTTING, WESTERN; CELL AGING; CELL CYCLE; CELL LINE; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; GANCICLOVIR; GENE KNOCKDOWN TECHNIQUES; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MICROSCOPY; MUSCLE, SKELETAL; MYOBLASTS; PROTO-ONCOGENE PROTEINS C-BCL-2; REJUVENATION; RNA, MESSENGER; SULFONAMIDES; WHOLE-BODY IRRADIATION;

EID: 84954218515     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4010     Document Type: Article

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