-
1
-
-
1542346420
-
The new life of a centenarian: signalling functions of NAD(P)
-
Berger F., et al. The new life of a centenarian: signalling functions of NAD(P). Trends Biochem. Sci. 2004, 29:111-118.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 111-118
-
-
Berger, F.1
-
2
-
-
0014399645
-
Joining of DNA strands by DNA ligase of E. coli
-
Gellert M., et al. Joining of DNA strands by DNA ligase of E. coli. Cold Spring Harb. Symp. Quant. Biol. 1968, 33:21-26.
-
(1968)
Cold Spring Harb. Symp. Quant. Biol.
, vol.33
, pp. 21-26
-
-
Gellert, M.1
-
3
-
-
0002160618
-
Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
-
Chambon P., et al. Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem. Biophys. Res. Commun. 1963, 11:39-43.
-
(1963)
Biochem. Biophys. Res. Commun.
, vol.11
, pp. 39-43
-
-
Chambon, P.1
-
4
-
-
14944349319
-
+/cyclic ADP-ribose system
-
+/cyclic ADP-ribose system. Ann. N. Y. Acad. Sci. 2004, 1028:176-191.
-
(2004)
Ann. N. Y. Acad. Sci.
, vol.1028
, pp. 176-191
-
-
De Flora, A.1
-
5
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S., et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000, 403:795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
-
6
-
-
0347128279
-
Calorie restriction extends yeast life span by lowering the level of NADH
-
Lin S-J., et al. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004, 18:12-16.
-
(2004)
Genes Dev.
, vol.18
, pp. 12-16
-
-
Lin, S.-J.1
-
7
-
-
0014636042
-
Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes
-
Krebs H.A., Veech R.L. Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes. Adv. Enzyme Regul. 1969, 7:397-413.
-
(1969)
Adv. Enzyme Regul.
, vol.7
, pp. 397-413
-
-
Krebs, H.A.1
Veech, R.L.2
-
8
-
-
79957557182
-
Dissecting systemic control of metabolism and aging in the NAD world: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis
-
Imai S. Dissecting systemic control of metabolism and aging in the NAD world: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS Lett. 2011, 585:1657-1662.
-
(2011)
FEBS Lett.
, vol.585
, pp. 1657-1662
-
-
Imai, S.1
-
9
-
-
84883491871
-
The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
-
Imai S., Yoshino J. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes Obes. Metab. 2013, 15(Suppl. 3):26-33.
-
(2013)
Diabetes Obes. Metab.
, vol.15
, Issue.SUPPL. 3
, pp. 26-33
-
-
Imai, S.1
Yoshino, J.2
-
10
-
-
84893262127
-
PARP inhibitors for anticancer therapy
-
Curtin N. PARP inhibitors for anticancer therapy. Biochem. Soc. Trans. 2014, 42:82-88.
-
(2014)
Biochem. Soc. Trans.
, vol.42
, pp. 82-88
-
-
Curtin, N.1
-
11
-
-
77949887506
-
Mammalian sirtuins: biological insights and disease relevance
-
Haigis M.C., Sinclair D.A. Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 2010, 5:253-295.
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
12
-
-
78650889400
-
Chromatin regulation and genome maintenance by mammalian SIRT6
-
Tennen R.I., Chua K.F. Chromatin regulation and genome maintenance by mammalian SIRT6. Trends Biochem. Sci. 2011, 36:39-46.
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 39-46
-
-
Tennen, R.I.1
Chua, K.F.2
-
13
-
-
84885355365
-
Calorie restriction and sirtuins revisited
-
Guarente L. Calorie restriction and sirtuins revisited. Genes Dev. 2013, 27:2072-2085.
-
(2013)
Genes Dev.
, vol.27
, pp. 2072-2085
-
-
Guarente, L.1
-
14
-
-
80054771657
-
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity
-
Satoh A., et al. The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb. Exp. Pharmacol. 2011, 206:125-162.
-
(2011)
Handb. Exp. Pharmacol.
, vol.206
, pp. 125-162
-
-
Satoh, A.1
-
15
-
-
80053168829
-
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
-
Burnett C., et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011, 477:482-485.
-
(2011)
Nature
, vol.477
, pp. 482-485
-
-
Burnett, C.1
-
16
-
-
84871695502
-
DSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner
-
Banerjee K.K., et al. dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner. Cell Rep. 2012, 2:1485-1491.
-
(2012)
Cell Rep.
, vol.2
, pp. 1485-1491
-
-
Banerjee, K.K.1
-
17
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
Kanfi Y., et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012, 483:218-221.
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
-
18
-
-
84880517634
-
+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
-
+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 2013, 154:430-441.
-
(2013)
Cell
, vol.154
, pp. 430-441
-
-
Mouchiroud, L.1
-
19
-
-
80053460544
-
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
-
Rizki G., et al. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet. 2011, 7:e1002235.
-
(2011)
PLoS Genet.
, vol.7
-
-
Rizki, G.1
-
20
-
-
84883476818
-
Sirt1 Extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
-
Satoh A., et al. Sirt1 Extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 2013, 18:416-430.
-
(2013)
Cell Metab.
, vol.18
, pp. 416-430
-
-
Satoh, A.1
-
21
-
-
84886476382
-
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
-
Schmeisser K., et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat. Chem. Biol. 2013, 9:693-700.
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 693-700
-
-
Schmeisser, K.1
-
22
-
-
84867190452
-
Natural genetic variation in yeast longevity
-
Stumpferl S.W., et al. Natural genetic variation in yeast longevity. Genome Res. 2012, 22:1963-1973.
-
(2012)
Genome Res.
, vol.22
, pp. 1963-1973
-
-
Stumpferl, S.W.1
-
23
-
-
80053134340
-
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
-
Viswanathan M., Guarente L. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 2011, 477:E1-E2.
-
(2011)
Nature
, vol.477
-
-
Viswanathan, M.1
Guarente, L.2
-
24
-
-
47749140333
-
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
-
Asher G., et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 2008, 134:317-328.
-
(2008)
Cell
, vol.134
, pp. 317-328
-
-
Asher, G.1
-
25
-
-
47549088250
-
+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
-
+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 2008, 134:329-340.
-
(2008)
Cell
, vol.134
, pp. 329-340
-
-
Nakahata, Y.1
-
26
-
-
84879391795
-
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
-
Chang H.C., Guarente L. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 2013, 153:1448-1460.
-
(2013)
Cell
, vol.153
, pp. 1448-1460
-
-
Chang, H.C.1
Guarente, L.2
-
27
-
-
84908510371
-
Circadian disruption in the pathogenesis of metabolic syndrome
-
Maury E., et al. Circadian disruption in the pathogenesis of metabolic syndrome. Diabetes Metab. 2014, 10.1016/j.diabet.2013.12.005.
-
(2014)
Diabetes Metab.
-
-
Maury, E.1
-
28
-
-
77953290430
-
"Clocks" in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging
-
Imai S. "Clocks" in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim. Biophys. Acta 2010, 1804:1584-1590.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1584-1590
-
-
Imai, S.1
-
29
-
-
65549118773
-
+ salvage pathway by CLOCK-SIRT1
-
+ salvage pathway by CLOCK-SIRT1. Science 2009, 324:654-657.
-
(2009)
Science
, vol.324
, pp. 654-657
-
-
Nakahata, Y.1
-
30
-
-
65549103855
-
+ biosynthesis
-
+ biosynthesis. Science 2009, 324:651-654.
-
(2009)
Science
, vol.324
, pp. 651-654
-
-
Ramsey, K.M.1
-
31
-
-
84884248040
-
+ cycle drives mitochondrial oxidative metabolism in mice
-
+ cycle drives mitochondrial oxidative metabolism in mice. Science 2013, 10.1126/science.1243417.
-
(2013)
Science
-
-
Peek, C.B.1
-
32
-
-
33744509311
-
Regulation of intracellular levels of NAD: a novel role for CD38
-
Aksoy P., et al. Regulation of intracellular levels of NAD: a novel role for CD38. Biochem. Biophys. Res. Commun. 2006, 345:1386-1392.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.345
, pp. 1386-1392
-
-
Aksoy, P.1
-
34
-
-
84866361328
-
Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization
-
Lee H.C. Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization. J. Biol. Chem. 2012, 287:31633-31640.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 31633-31640
-
-
Lee, H.C.1
-
35
-
-
84893442805
-
+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013, 155:1624-1638.
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
-
36
-
-
38349112898
-
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in β cell-specific Sirt1-overexpressing (BESTO) mice
-
Ramsey K.M., et al. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in β cell-specific Sirt1-overexpressing (BESTO) mice. Aging Cell 2008, 7:78-88.
-
(2008)
Aging Cell
, vol.7
, pp. 78-88
-
-
Ramsey, K.M.1
-
37
-
-
80053920774
-
+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
-
+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011, 14:528-536.
-
(2011)
Cell Metab.
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
-
38
-
-
34247502715
-
+
-
+. Cell 2007, 129:473-484.
-
(2007)
Cell
, vol.129
, pp. 473-484
-
-
Belenky, P.1
-
40
-
-
84862022077
-
+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
-
+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012, 15:838-847.
-
(2012)
Cell Metab.
, vol.15
, pp. 838-847
-
-
Canto, C.1
-
41
-
-
84881348520
-
Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure
-
Karamanlidis G., et al. Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure. Cell Metab. 2013, 18:239-250.
-
(2013)
Cell Metab.
, vol.18
, pp. 239-250
-
-
Karamanlidis, G.1
-
42
-
-
73649133942
-
Skeletal muscle NAMPT is induced by exercise in humans
-
Costford S.R., et al. Skeletal muscle NAMPT is induced by exercise in humans. Am. J. Physiol. Endocrinol. Metab. 2010, 298:E117-E126.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Costford, S.R.1
-
43
-
-
34547873915
-
TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription
-
Cavadini G., et al. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:12843-12848.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 12843-12848
-
-
Cavadini, G.1
-
44
-
-
79955973916
-
Inflammatory markers in population studies of aging
-
Singh T., Newman A.B. Inflammatory markers in population studies of aging. Ageing Res. Rev. 2011, 10:319-329.
-
(2011)
Ageing Res. Rev.
, vol.10
, pp. 319-329
-
-
Singh, T.1
Newman, A.B.2
-
45
-
-
79953752384
-
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
-
Bai P., et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 2011, 13:461-468.
-
(2011)
Cell Metab.
, vol.13
, pp. 461-468
-
-
Bai, P.1
-
46
-
-
36049038217
-
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
-
Barbosa M.T., et al. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 2007, 21:3629-3639.
-
(2007)
FASEB J.
, vol.21
, pp. 3629-3639
-
-
Barbosa, M.T.1
-
47
-
-
84875431269
-
+ metabolism, protein acetylation, and treatment of metabolic syndrome
-
+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes 2013, 62:1084-1093.
-
(2013)
Diabetes
, vol.62
, pp. 1084-1093
-
-
Escande, C.1
-
48
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
-
Rodgers J.T., et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 2005, 434:113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
49
-
-
33744976074
-
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
-
Berdichevsky A., et al. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 2006, 125:1165-1177.
-
(2006)
Cell
, vol.125
, pp. 1165-1177
-
-
Berdichevsky, A.1
-
50
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015.
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
-
51
-
-
84892989225
-
SirT3 regulates the mitochondrial unfolded protein response
-
Papa L., Germain D. SirT3 regulates the mitochondrial unfolded protein response. Mol. Cell. Biol. 2014, 34:699-710.
-
(2014)
Mol. Cell. Biol.
, vol.34
, pp. 699-710
-
-
Papa, L.1
Germain, D.2
-
52
-
-
84867417361
-
Bioenergetic origins of complexity and disease
-
Wallace D.C. Bioenergetic origins of complexity and disease. Cold Spring Harb. Symp. Quant. Biol. 2011, 76:1-16.
-
(2011)
Cold Spring Harb. Symp. Quant. Biol.
, vol.76
, pp. 1-16
-
-
Wallace, D.C.1
-
53
-
-
77955046461
-
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
-
Donmez G., et al. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010, 142:320-332.
-
(2010)
Cell
, vol.142
, pp. 320-332
-
-
Donmez, G.1
-
54
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
-
Kim D., et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007, 26:3169-3179.
-
(2007)
EMBO J.
, vol.26
, pp. 3169-3179
-
-
Kim, D.1
-
55
-
-
84855929223
-
SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones
-
Donmez G., et al. SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones. J. Neurosci. 2012, 32:124-132.
-
(2012)
J. Neurosci.
, vol.32
, pp. 124-132
-
-
Donmez, G.1
-
56
-
-
84855563516
-
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
-
Jeong H., et al. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat. Med. 2011, 18:159-165.
-
(2011)
Nat. Med.
, vol.18
, pp. 159-165
-
-
Jeong, H.1
-
57
-
-
84855544817
-
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
-
Jiang M., et al. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat. Med. 2011, 18:153-158.
-
(2011)
Nat. Med.
, vol.18
, pp. 153-158
-
-
Jiang, M.1
-
58
-
-
0035195636
-
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene
-
Mack T.G., et al. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat. Neurosci. 2001, 4:1199-1206.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 1199-1206
-
-
Mack, T.G.1
-
59
-
-
61449113031
-
Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice
-
Conforti L., et al. Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice. J. Cell Biol. 2009, 184:491-500.
-
(2009)
J. Cell Biol.
, vol.184
, pp. 491-500
-
-
Conforti, L.1
-
60
-
-
65649126738
-
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide
-
Sasaki Y., et al. Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. J. Neurosci. 2009, 29:5525-5535.
-
(2009)
J. Neurosci.
, vol.29
, pp. 5525-5535
-
-
Sasaki, Y.1
-
61
-
-
34548614799
-
Defective DNA repair and neurodegenerative disease
-
Rass U., et al. Defective DNA repair and neurodegenerative disease. Cell 2007, 130:991-1004.
-
(2007)
Cell
, vol.130
, pp. 991-1004
-
-
Rass, U.1
-
62
-
-
84884902129
-
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons
-
Wang W.Y., et al. Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nat. Neurosci. 2013, 16:1383-1391.
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 1383-1391
-
-
Wang, W.Y.1
-
63
-
-
84875245617
-
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
-
Gong B., et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiol. Aging 2013, 34:1581-1588.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 1581-1588
-
-
Gong, B.1
-
64
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M., et al. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 1999, 13:2570-2580.
-
(1999)
Genes Dev.
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
-
65
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B., Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15998-16003.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
66
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001, 410:227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
67
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson R.M., et al. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 2003, 423:181-185.
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
-
68
-
-
0034703217
-
Life span extension by calorie restriction in S. cerevisiae requires NAD and SIR2
-
Lin S-J., et al. Life span extension by calorie restriction in S. cerevisiae requires NAD and SIR2. Science 2000, 289:2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.-J.1
-
69
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin S-J., et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002, 418:344-348.
-
(2002)
Nature
, vol.418
, pp. 344-348
-
-
Lin, S.-J.1
-
70
-
-
28244475950
-
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
-
Wang Y., Tissenbaum H.A. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech. Ageing Dev. 2006, 127:48-56.
-
(2006)
Mech. Ageing Dev.
, vol.127
, pp. 48-56
-
-
Wang, Y.1
Tissenbaum, H.A.2
-
71
-
-
78650758398
-
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
-
Herranz D., et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat. Commun. 2010, 1:3.
-
(2010)
Nat. Commun.
, vol.1
, pp. 3
-
-
Herranz, D.1
|