Cellular senescence: A link between cancer and age-related degenerative disease?

Seminars in Cancer Biology

Volumn 21, Issue 6, 2011, Pages 354-359

  Campisi, Judith ^a,b   Andersen, Julie K ^a   Kapahi, Pankaj ^a   Melov, Simon ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Aging; Cancer; Damage; Inflammation; Senescence

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; MATRIX METALLOPROTEINASE; MESSENGER RNA;

CANCER CELL; CANCER RISK; CAUSAL ATTRIBUTION; CELL AGING; CELL DAMAGE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CYTOKINE RELEASE; DEGENERATIVE DISEASE; DNA DAMAGE; NEOPLASM; OXIDATIVE STRESS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; REVIEW; SOMATIC MUTATION; TUMOR GROWTH;

AGING; CELL AGING; HUMANS; NEOPLASMS; PHENOTYPE;

EID: 80855128461     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2011.09.001     Document Type: Review

References (89)

1. The silver book. Chronic disease and medical innovation in an aging nation. Available from: 2009 [updated 24.05.11]. http://www.silverbook.org/.
2. Vijg J., Campisi J. Puzzles, promises and a cure for ageing. Nature 2008, 454:1065-1071.
3. Balducci L., Ershler W.B. Cancer and ageing: a nexus at several levels. Nat Rev Cancer 2005, 5:655-662.
4. Campisi J. Cancer and ageing: rival demons?. Nat Rev Cancer 2003, 3:339-349.
5. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277-300.
6. Knudson A.G. Chasing the cancer demon. Annu Rev Genet 2000, 34:1-19.
7. Gray J.W., Collins C. Genome changes and gene expression in human solid tumors. Carcinogenesis 2000, 21:443-452.
8. Loeb L.A. Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer 2011, 11:450-457.
9. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
10. Bissell M.J., Radisky D. Putting tumours in context. Nat Rev Cancer 2001, 1:46-54.
11. Joyce J.A. Therapeutic targeting of the tumor microenvironment. Cancer Cell 2005, 7:513-520.
12. McAllister S.S., Weinberg R.A. Tumor-host interactions: a far-reaching relationship. J Clin Oncol 2010, 28:4022-4028.
13. Liotta L.A., Kohn E.C. The microenvironment of the tumour-host interface. Nature 2001, 411:375-379.
14. Park C.C., Bissell M.J., Barcellos-Hoff M.H. The influence of the microenvironment on the malignant phenotype. Mol Med Today 2000, 6:324-329.
15. McCullough D., Coleman W.B., Smith G.J., Grisham J.W. Age-dependent induction of hepatic tumor regression by the tissue microenvironment after transplantation of neoplastically transformed rat liver epithelial cells into the liver. Cancer Res 1997, 57:1807-1813.
16. DePinho R.A. The age of cancer. Nature 2000, 408:248-254.
17. Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001, 11:27-31.
18. Dimri G.P. What has senescence got to do with cancer?. Cancer Cell 2005, 7:505-512.
19. Itahana K., Dimri G., Campisi J. Regulation of cellular senescence by p53. Eur J Biochem 2001, 268:2784-2791.
20. Ohtani N., Yamakoshi K., Takahashi A., Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest 2004, 51:146-153.
21. Ben-Porath I., Weinberg R.A. When cells get stressed: an integrative view of cellular senescence. J Clin Invest 2004, 113:8-13.
22. Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007, 8:729-740.
23. Passos J.F., Von Zglinicki T. Oxygen free radicals in cell senescence: are they signal transducers?. Free Radic Res 2006, 40:1277-1283.
24. Serrano M., Blasco M.A. Putting the stress on senescence. Curr Opin Cell Biol 2001, 13:748-753.
25. Colavitti R., Finkel T. Reactive oxygen species as mediators of cellular senescence. IUBMB Life 2005, 57:277-281.
26. Blagosklonny M.V. Cell cycle arrest is not senescence. Aging 2011, 3:94-101.
27. Acosta J.C., O'Loghlen A., Banito A., Guijarro M.V., Augert A., Raguz S., et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008, 133:1006-1018.
28. Bavik C., Coleman I., Dean J.P., Knudsen B., Plymate S., Nelson P.S. The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res 2006, 66:794-802.
29. Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D., Goldstein J., et al. Senescence-associated secretory phenotypes reveal cell non-automous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008, 6:2853-2868.
30. Kortlever R.M., Higgins P.J., Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 2006, 8:877-884.
31. Kuilman T., Michaloglou C., Vredeveld L.C.W., Douma S., van Doorn R., Desmet C.J., et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008, 133:1019-1031.
32. Wajapeyee N., Serra R.W., Zhu X., Mahalingam M., Green M.R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 2008, 132:363-374.
33. Coppe J.P., Patil C.K., Rodier F., Krtolica A., Beausejour C., Parrinello S., et al. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One 2010, 5:e9188.
34. Salminen A., Ojala J., Kaarniranta K., Haapasalo A., Hiltunen M., Soininen H. Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. Eur J Neurosci 2011, 34:3-11.
35. Erusalimsky J.D., Kurz D.J. Cellular senescence in vivo: its relevance in ageing and cardiovascular disease. Exp Gerontol 2005, 40:634-642.
36. Orjalo A., Bhaumik D., Gengler B., Scott G.K., Campisi J. Cell surface IL-1α is an upstream regulator of the senescence-associated IL6/IL-8 cytokine network. Proc Natl Acad Sci USA 2009, 106:17031-17036.
37. Freund A., Patil P.K., Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011, 30:1536-1548.
38. Bhaumik D., Scott G.K., Schokrpur S., Patil C.K., Orjalo A., Rodier F., et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging 2009, 1:402-411.
39. Freund A., Orjalo A., Desprez P.Y., Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010, 16:238-248.
40. Rodier F., Coppé J.P., Patil C.K., Hoeijmakers W.A., Muñoz D.P., Raza S.R., et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009, 11:973-979.
41. Rodier F., Munoz D.P., Teachenor R., Chu V., Le O., Bhaumik D., et al. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci 2011, 124:68-81.
42. Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev 2011, 21:107-112.
43. Rodier F., Campisi J. Four faces of cellular senescence. J Cell Biol 2011, 192:547-556.
44. Krizhanovsky V., Yon M., Dickins R.A., Hearn S., Simon J., Miething C., et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008, 134:657-667.
45. Jun J.I., Lau L.F. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 2010, 12:676-685.
46. Xue W., Zender L., Miething C., Dickins R.A., Hernando E., Krizhanovsky V., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660.
47. Kirkwood T.B., Austad S.N. Why do we age?. Nature 2000, 408:233-238.
48. Longo V.D., Finch C.E. Evolutionary medicine: from dwarf model systems to healthy centenarians?. Science 2003, 299:1342-1346.
49. Adams P.D. Healing and hurting: molecular mechanisms, functions and pathologies of cellular senescence. Mol Cell 2009, 36:2-14.
50. Campisi J. Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors. Cell 2005, 120:513-522.
51. Tchkonia T., Morbeck D.E., Von Zglinicki T., Van Deursen J., Lustgarten J., Scrable H., et al. Fat tissue, aging, and cellular senescence. Aging Cell 2010, 9:667-684.
52. McElhaney J.E., Effros R.B. Immunosenescence: what does it mean to health outcomes in older adults?. Curr Opin Immunol 2009, 21:242-418.
53. Rosenstiel P., Derer S., Till A., Häsler R., Eberstein H., Bewig B., et al. Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes. Genes Immun 2008, 9:103-114.
54. Melov S., Shoffner J.M., Kaufman A., Wallace D.C. Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res 1995, 23:4122-4126.
55. Parrinello S., Coppe J.P., Krtolica A., Campisi J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 2005, 118:485-496.
56. Tsai K.K., Chuang E.Y., Little J.B., Yuan Z.M. Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Res 2005, 65:6734-6744.
57. Burton D.G., Matsubara H., Ikeda K. Pathophysiology of vascular calcification: pivotal role of cellular senescence in vascular smooth muscle cells. Exp Gerontol 2010, 45:819-824.
58. Gorenne I., Kavurma M., Scott S., Bennett M. Vascular smooth muscle cell senescence in atherosclerosis. Cardiovasc Res 2006, 72:9-17.
59. Manolagas S.C. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 2010, 31:266-300.
60. Kassem M., Marie P.J. Senescence-associated intrinsic mechanisms of osteoblast dysfunctions. Aging Cell 2011, 10:191-197.
61. Bitto A., Sell C., Crowe E., Lorenzini A., Malaguti M., Hrelia S., et al. Stress-induced senescence in human and rodent astrocytes. Exp Cell Res 2010, 316:2961-2968.
62. Gil J., Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006, 7:667-677.
63. Krishnamurthy J., Torrice C., Ramsey M.R., Kovalev G.I., Al-Regaiey K., Su L., et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004, 114:1299-1307.
64. Liu Y., Sanoff H.K., Cho H., Burd C.E., Torrice C., Ibrahim J.G., et al. Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 2009, 8:439-448.
65. Ressler S., Bartkova J., Niederegger H., Bartek J., Scharffetter-Kochanek K., Jansen-Durr P., et al. p16 is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 2006, 5:379-389.
66. INK4a. Nature 2006, 443:421-426.
67. INK4a induces an age-dependent decline in islet regenerative potential. Nature 2006, 443:453-457.
68. Molofsky A.V., Slutsky S.G., Joseph N.M., He S., Pardal R., Krishnamurthy J., et al. Increasing Ink4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 2006, 443:448-452.
69. Coppe J.P., Kauser K., Campisi J., Beausejour C.M. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 2006, 281:29568-29574.
70. Dilley T.K., Bowden G.T., Chen Q.M. Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity. Exp Cell Res 2003, 290:38-48.
71. Liu D., Hornsby P.J. Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res 2007, 67:3117-3126.
72. Roninson I.B. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett 2002, 179:1-14.
73. Krtolica A., Parrinello S., Lockett S., Desprez P., Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 2001, 98:12072-12077.
74. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 2003, 299:1355-1359.
75. Bartkova J., Horejsi Z., Koed K., Kramer A., Tort F., Zieger K., et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434:864-870.
76. Halazonetis T.D., Gorgoulis V.G., Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355.
77. Beausejour C.M., Krtolica A., Galimi F., Narita M., Lowe S.W., Yaswen P., et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003, 22:4212-4222.
78. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., et al. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995, 92:9363-9367.
79. Jeyapalan J.C., Ferreira M., Sedivy J.M., Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 2007, 128:36-44.
80. Kiecolt-Glaser J.K., Preacher K.J., MacCallum R.C., Atkinson C., Malarkey W.B., Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 2003, 100:9090-9095.
81. Maggio M., Guralnik J.M., Longo D.L., Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci 2006, 61:575-584.
82. Naugler W.E., Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 2008, 14:109-119.
83. Conboy I.M., Conboy M.J., Wagers A.J., Girma E.R., Weissman I.L., Rando T.A. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005, 433:760-764.
84. Brack A.S., Conboy M.J., Roy S., Lee M., Kuo C.J., Keller C., et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007, 317:807-810.
85. Carlson M.E., Conboy M.J., Hsu M., Barchas L., Jeong J., Agrawal A., et al. Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell 2009, 8:676-689.
86. Buford T.W., Anton S.D., Judge A.R., Marzetti E., Wohlgemuth S.E., Carter C.S., et al. Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Res Rev 2010, 9:369-383.
87. Didelot A., Honnorat J. Update on paraneoplastic neurological syndromes. Curr Opin Oncol 2009, 21:566-572.
88. Ilieva H., Polymenidou M., Cleveland D.W. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 2009, 187:761-772.
89. Redon C.E., Dickey J.S., Nakamura A.J., Kareva I.G., Naf D., Nowsheen S., et al. Tumors induce complex DNA damage in distant proliferative tissues in vivo. Proc Natl Acad Sci USA 2010, 107:17992-17997.