메뉴 건너뛰기




Volumn 13, Issue 11, 2017, Pages 2678-2687

Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics

Author keywords

cancer; clinical translation; drug delivery system; extracellular vesicles

Indexed keywords

CD40 LIGAND; CD63 ANTIGEN; CHOLINERGIC RECEPTOR; CURCUMIN; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; GLYCOPROTEIN IIB; INTEGRIN; PHOSPHATIDYLSERINE; SELECTIN; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TETRASPANIN; NANOMATERIAL; PROTEIN;

EID: 85034775164     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2017.1363935     Document Type: Review
Times cited : (28)

References (126)
  • 1
    • 41949100244 scopus 로고    scopus 로고
    • Drug nanoparticles: Formulating poorly water-soluble compounds
    • 18337220
    • Merisko-Liversidge EM, Liversidge GG. Drug nanoparticles: Formulating poorly water-soluble compounds. Toxicol Pathol. 2008;36:43-8. doi:10.1177/0192623307310946. PMID:18337220
    • (2008) Toxicol Pathol , vol.36 , pp. 43-48
    • Merisko-Liversidge, E.M.1    Liversidge, G.G.2
  • 2
    • 75549088044 scopus 로고    scopus 로고
    • Microemulsion system with improved loading of piroxicam: A study of microstructure
    • 19876741
    • Nazar MF, Khan AM, Shah SS. Microemulsion system with improved loading of piroxicam: A study of microstructure. AAPS Pharmscitech. 2009;10:1286-94. doi:10.1208/s12249-009-9328-9. PMID:19876741
    • (2009) AAPS Pharmscitech , vol.10 , pp. 1286-1294
    • Nazar, M.F.1    Khan, A.M.2    Shah, S.S.3
  • 3
    • 84879088542 scopus 로고    scopus 로고
    • Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo
    • 23634882
    • Wei T, Liu J, Ma H, Cheng Q, Huang Y, Zhao J, Huo S, Xue X, Liang Z, Liang XJ. Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo. Nano Lett. 2013;13:2528-34. doi:10.1021/nl400586t. PMID:23634882
    • (2013) Nano Lett , vol.13 , pp. 2528-2534
    • Wei, T.1    Liu, J.2    Ma, H.3    Cheng, Q.4    Huang, Y.5    Zhao, J.6    Huo, S.7    Xue, X.8    Liang, Z.9    Liang, X.J.10
  • 4
    • 84871950662 scopus 로고    scopus 로고
    • Oral bioavailability of cantharidin-loaded solid lipid nanoparticles
    • 23298453
    • Dang YJ, Zhu CY. Oral bioavailability of cantharidin-loaded solid lipid nanoparticles. Chin Med. 2013;8:1. doi:10.1186/1749-8546-8-1. PMID:23298453
    • (2013) Chin Med , vol.8 , pp. 1
    • Dang, Y.J.1    Zhu, C.Y.2
  • 5
    • 84864046050 scopus 로고    scopus 로고
    • Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo
    • 22829966
    • Kiziltepe T, Ashley JD, Stefanick JF, Qi YM, Alves NJ, Handlogten MW, Suckow MA, Navari RM, Bilgicer B. Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo. Blood Cancer J. 2012;2:e64. doi:10.1038/bcj.2012.10. PMID:22829966
    • (2012) Blood Cancer J , vol.2 , pp. e64
    • Kiziltepe, T.1    Ashley, J.D.2    Stefanick, J.F.3    Qi, Y.M.4    Alves, N.J.5    Handlogten, M.W.6    Suckow, M.A.7    Navari, R.M.8    Bilgicer, B.9
  • 7
    • 84982242468 scopus 로고    scopus 로고
    • Development of a microemulsion-based formulation to improve the availability of poorly water-soluble drug
    • 22491208,. PMID
    • Abd-Allah FI, Dawaba HM, Ahmed AM. Development of a microemulsion-based formulation to improve the availability of poorly water-soluble drug. Drug Discov Ther. 2010;4:257-66. PMID:22491208
    • (2010) Drug Discov Ther , vol.4 , pp. 257-266
    • Abd-Allah, F.I.1    Dawaba, H.M.2    Ahmed, A.M.3
  • 8
    • 84895468887 scopus 로고    scopus 로고
    • Carbon dioxide-mediated generation of hybrid nanoparticles for improved bioavailability of protein kinase inhibitors
    • 23990314
    • Jesson G, Brisander M, Andersson P, Demirbuker M, Derand H, Lennernas H, Malmsten M. Carbon dioxide-mediated generation of hybrid nanoparticles for improved bioavailability of protein kinase inhibitors. Pharm Res. 2014;31:694-705. doi:10.1007/s11095-013-1191-4. PMID:23990314
    • (2014) Pharm Res , vol.31 , pp. 694-705
    • Jesson, G.1    Brisander, M.2    Andersson, P.3    Demirbuker, M.4    Derand, H.5    Lennernas, H.6    Malmsten, M.7
  • 9
    • 84897430096 scopus 로고    scopus 로고
    • Pharmacokinetics study of arteether loaded solid lipid nanoparticles: An improved oral bioavailability in rats
    • 24657144
    • Dwivedi P, Khatik R, Khandelwal K, Taneja I, Raju KS, Wahajuddin, Paliwal SK, Dwivedi AK, Mishra PR. Pharmacokinetics study of arteether loaded solid lipid nanoparticles: An improved oral bioavailability in rats. Int J Pharm. 2014;466:321-7. doi:10.1016/j.ijpharm.2014.03.036. PMID:24657144
    • (2014) Int J Pharm , vol.466 , pp. 321-327
    • Dwivedi, P.1    Khatik, R.2    Khandelwal, K.3    Taneja, I.4    Raju, K.S.5    Wahajuddin, S.K.6    Dwivedi, A.K.7    Mishra, P.R.8
  • 10
    • 84899087299 scopus 로고    scopus 로고
    • Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential
    • 24661109
    • Singh G, Pai RS. Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential. Expert Opin Drug Deliv. 2014;11:647-59. doi:10.1517/17425247.2014.890588. PMID:24661109
    • (2014) Expert Opin Drug Deliv , vol.11 , pp. 647-659
    • Singh, G.1    Pai, R.S.2
  • 11
    • 84901944392 scopus 로고    scopus 로고
    • Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery
    • 24810394
    • Joshi G, Kumar A, Sawant K. Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. Eur J Pharm Sci. 2014;60:80-9. doi:10.1016/j.ejps.2014.04.014. PMID:24810394
    • (2014) Eur J Pharm Sci , vol.60 , pp. 80-89
    • Joshi, G.1    Kumar, A.2    Sawant, K.3
  • 12
    • 84870310787 scopus 로고    scopus 로고
    • Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle
    • 23055726
    • Chen JP, Yang PC, Ma YH, Tu SJ, Lu YJ. Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle. Int J Nanomedicine. 2012;7:5137-49. doi:10.2147/IJN.S36197. PMID:23055726
    • (2012) Int J Nanomedicine , vol.7 , pp. 5137-5149
    • Chen, J.P.1    Yang, P.C.2    Ma, Y.H.3    Tu, S.J.4    Lu, Y.J.5
  • 14
    • 84864046050 scopus 로고    scopus 로고
    • Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo
    • 22829966
    • Kiziltepe T, Ashley JD, Stefanick JF, Qi YM, Alves NJ, Handlogten MW, Suckow MA, Navari RM, Bilgicer B. Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo. Blood Cancer J. 2012;2:e64. doi:10.1038/bcj.2012.10. PMID:22829966
    • (2012) Blood Cancer J , vol.2 , pp. e64
    • Kiziltepe, T.1    Ashley, J.D.2    Stefanick, J.F.3    Qi, Y.M.4    Alves, N.J.5    Handlogten, M.W.6    Suckow, M.A.7    Navari, R.M.8    Bilgicer, B.9
  • 15
    • 84920545747 scopus 로고    scopus 로고
    • Poly(L-lactide) nanoparticles reduce amphotericin B cytotoxicity and maintain its in vitro antifungal activity
    • 26328449
    • Casa DM, Carraro TC, de Camargo LE, Dalmolin LF, Khalil NM, Mainardes RM. Poly(L-lactide) nanoparticles reduce amphotericin B cytotoxicity and maintain its in vitro antifungal activity. J Nanosci Nanotechnol. 2015;15:848-54. doi:10.1166/jnn.2015.9177. PMID:26328449
    • (2015) J Nanosci Nanotechnol , vol.15 , pp. 848-854
    • Casa, D.M.1    Carraro, T.C.2    de Camargo, L.E.3    Dalmolin, L.F.4    Khalil, N.M.5    Mainardes, R.M.6
  • 16
  • 17
    • 84946065415 scopus 로고    scopus 로고
    • Self-monitoring and self-delivery of photosensitizer-doped nanoparticles for highly effective combination cancer therapy in Vitro and in Vivo
    • 26390118
    • Zhang J, Liang YC, Lin X, Zhu X, Yan L, Li S, Yang X, Zhu G, Rogach AL, Yu PK, et al. Self-monitoring and self-delivery of photosensitizer-doped nanoparticles for highly effective combination cancer therapy in Vitro and in Vivo. ACS Nano. 2015;9:9741-56. doi:10.1021/acsnano.5b02513. PMID:26390118
    • (2015) ACS Nano , vol.9 , pp. 9741-9756
    • Zhang, J.1    Liang, Y.C.2    Lin, X.3    Zhu, X.4    Yan, L.5    Li, S.6    Yang, X.7    Zhu, G.8    Rogach, A.L.9    Yu, P.K.10
  • 18
    • 84938885074 scopus 로고    scopus 로고
    • Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release
    • 26199064
    • Zhang J, Li S, An FF, Liu J, Jin S, Zhang JC, Wang PC, Zhang X, Lee CS, Liang XJ. Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release. Nanoscale. 2015;7:13503-10. doi:10.1039/C5NR03259H. PMID:26199064
    • (2015) Nanoscale , vol.7 , pp. 13503-13510
    • Zhang, J.1    Li, S.2    An, F.F.3    Liu, J.4    Jin, S.5    Zhang, J.C.6    Wang, P.C.7    Zhang, X.8    Lee, C.S.9    Liang, X.J.10
  • 19
    • 85013223257 scopus 로고    scopus 로고
    • Overview on therapeutic applications of microparticulate drug delivery systems
    • 27910739
    • Bale S, Khurana A, Reddy AS, Singh M, Godugu C. Overview on therapeutic applications of microparticulate drug delivery systems. Crit Rev Ther Drug Carrier Syst. 2016;33:309-61. doi:10.1615/CritRevTherDrugCarrierSyst.2016015798. PMID:27910739
    • (2016) Crit Rev Ther Drug Carrier Syst , vol.33 , pp. 309-361
    • Bale, S.1    Khurana, A.2    Reddy, A.S.3    Singh, M.4    Godugu, C.5
  • 21
    • 60549093400 scopus 로고    scopus 로고
    • Toxicity and environmental risks of nanomaterials: Challenges and future needs
    • 19204862
    • Ray PC, Yu H, Fu PP. Toxicity and environmental risks of nanomaterials: Challenges and future needs. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009;27:1-35. doi:10.1080/10590500802708267. PMID:19204862
    • (2009) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev , vol.27 , pp. 1-35
    • Ray, P.C.1    Yu, H.2    Fu, P.P.3
  • 22
    • 77957860448 scopus 로고    scopus 로고
    • Toxicity assessment of nanomaterials: Methods and challenges
    • 20652549
    • Dhawan A, Sharma V. Toxicity assessment of nanomaterials: Methods and challenges. Anal Bioanal Chem. 2010;398:589-605. doi:10.1007/s00216-010-3996-x. PMID:20652549
    • (2010) Anal Bioanal Chem , vol.398 , pp. 589-605
    • Dhawan, A.1    Sharma, V.2
  • 23
    • 84938346002 scopus 로고    scopus 로고
    • Magnetic removal of Entamoeba cysts from water using chitosan oligosaccharide-coated iron oxide nanoparticles
    • 26261417
    • Shukla S, Arora V, Jadaun A, Kumar J, Singh N, Jain VK. Magnetic removal of Entamoeba cysts from water using chitosan oligosaccharide-coated iron oxide nanoparticles. Int J Nanomedicine. 2015;10:4901-17. doi:10.2147/IJN.S77675. PMID:26261417
    • (2015) Int J Nanomedicine , vol.10 , pp. 4901-4917
    • Shukla, S.1    Arora, V.2    Jadaun, A.3    Kumar, J.4    Singh, N.5    Jain, V.K.6
  • 25
    • 33750633978 scopus 로고    scopus 로고
    • Nanomedicine: An unresolved regulatory issue
    • 17081666
    • Chan VS. Nanomedicine: An unresolved regulatory issue. Regul Toxicol Pharmacol. 2006;46:218-24. doi:10.1016/j.yrtph.2006.04.009. PMID:17081666
    • (2006) Regul Toxicol Pharmacol , vol.46 , pp. 218-224
    • Chan, V.S.1
  • 26
    • 77649141809 scopus 로고    scopus 로고
    • On the toxicity of therapeutically used nanoparticles: An overview
    • 20130771
    • El-Ansary A, Al-Daihan S. On the toxicity of therapeutically used nanoparticles: An overview. J Toxicol. 2009;2009:754810. doi:10.1155/2009/754810. PMID:20130771
    • (2009) J Toxicol , vol.2009 , pp. 754810
    • El-Ansary, A.1    Al-Daihan, S.2
  • 27
    • 84908402319 scopus 로고    scopus 로고
    • Toxicity of nanomaterials; an undermined issue
    • 25123555
    • Mogharabi M, Abdollahi M, Faramarzi MA. Toxicity of nanomaterials; an undermined issue. DARU. 2014;22:59. doi:10.1186/s40199-014-0059-4. PMID:25123555
    • (2014) DARU , vol.22 , pp. 59
    • Mogharabi, M.1    Abdollahi, M.2    Faramarzi, M.A.3
  • 28
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • 23456661
    • Akers JC, Gonda D, Kim R, Carter BS, Chen CC. Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol. 2013;113:1-11. doi:10.1007/s11060-013-1084-8. PMID:23456661
    • (2013) J Neurooncol , vol.113 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3    Carter, B.S.4    Chen, C.C.5
  • 29
    • 85003945007 scopus 로고    scopus 로고
    • Extracellular vesicles in cancer: Cell-to-cell mediators of metastasis
    • 27960084
    • Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D. Extracellular vesicles in cancer: Cell-to-cell mediators of metastasis. Cancer Cell. 2016;30:836-48. doi:10.1016/j.ccell.2016.10.009. PMID:27960084
    • (2016) Cancer Cell , vol.30 , pp. 836-848
    • Becker, A.1    Thakur, B.K.2    Weiss, J.M.3    Kim, H.S.4    Peinado, H.5    Lyden, D.6
  • 31
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: Biology and emerging therapeutic opportunities
    • 23584393
    • El AS, Mager I, Breakefield XO, Wood MJ. Extracellular vesicles: Biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12:347-57. doi:10.1038/nrd3978. PMID:23584393
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 347-357
    • El, A.S.1    Mager, I.2    Breakefield, X.O.3    Wood, M.J.4
  • 32
    • 84962130194 scopus 로고    scopus 로고
    • Cellular engineering with membrane fusogenic liposomes to produce functionalized extracellular vesicles
    • 26954538
    • Lee J, Lee H, Goh U, Kim J, Jeong M, Lee J, Park JH. Cellular engineering with membrane fusogenic liposomes to produce functionalized extracellular vesicles. ACS Appl Mater Interfaces. 2016;8:6790-5. doi:10.1021/acsami.6b01315. PMID:26954538
    • (2016) ACS Appl Mater Interfaces , vol.8 , pp. 6790-6795
    • Lee, J.1    Lee, H.2    Goh, U.3    Kim, J.4    Jeong, M.5    Lee, J.6    Park, J.H.7
  • 33
    • 85018192726 scopus 로고    scopus 로고
    • Re-Engineering extracellular vesicles as smart nanoscale therapeutics
    • 28068069
    • Armstrong JP, Holme MN, Stevens MM. Re-Engineering extracellular vesicles as smart nanoscale therapeutics. ACS Nano. 2017;11:69-83. doi:10.1021/acsnano.6b07607. PMID:28068069
    • (2017) ACS Nano , vol.11 , pp. 69-83
    • Armstrong, J.P.1    Holme, M.N.2    Stevens, M.M.3
  • 34
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • 19498381
    • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581-93. doi:10.1038/nri2567. PMID:19498381
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 35
    • 84957583645 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Introducing the next small big thing
    • 26861301
    • Kalra H, Drummen GP, Mathivanan S. Focus on extracellular vesicles: Introducing the next small big thing. Int J Mol Sci. 2016;17:170. doi:10.3390/ijms17020170. PMID:26861301
    • (2016) Int J Mol Sci , vol.17 , pp. 170
    • Kalra, H.1    Drummen, G.P.2    Mathivanan, S.3
  • 36
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Chapter
    • Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2006;Chapter 3:3-22.
    • (2006) Curr Protoc Cell Biol , vol.3 , pp. 3-22
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 37
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
    • 3597417,. PMID
    • Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987;262:9412-20. PMID:3597417
    • (1987) J Biol Chem , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 39
    • 84886738545 scopus 로고    scopus 로고
    • Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies
    • 24140720
    • Record M, Carayon K, Poirot M, Silvente-Poirot S. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim Biophys Acta. 2014;1841:108-20. doi:10.1016/j.bbalip.2013.10.004. PMID:24140720
    • (2014) Biochim Biophys Acta , vol.1841 , pp. 108-120
    • Record, M.1    Carayon, K.2    Poirot, M.3    Silvente-Poirot, S.4
  • 40
    • 84888026332 scopus 로고    scopus 로고
    • ExoCarta as a resource for exosomal research
    • Simpson RJ, Kalra H, Mathivanan S. ExoCarta as a resource for exosomal research. J Extracell Vesicles. 2012;1:24009883. doi:10.3402/jev.v1i0.18374
    • (2012) J Extracell Vesicles , vol.1 , pp. 24009883
    • Simpson, R.J.1    Kalra, H.2    Mathivanan, S.3
  • 42
    • 84862618600 scopus 로고    scopus 로고
    • Tumor-derived microvesicles: Shedding light on novel microenvironment modulators and prospective cancer biomarkers
    • 22713869
    • D'Souza-Schorey C, Clancy JW. Tumor-derived microvesicles: Shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev. 2012;26:1287-99. doi:10.1101/gad.192351.112. PMID:22713869
    • (2012) Genes Dev , vol.26 , pp. 1287-1299
    • D'Souza-Schorey, C.1    Clancy, J.W.2
  • 44
    • 59249089695 scopus 로고    scopus 로고
    • Shedding microvesicles: Artefacts no more
    • 19144520
    • Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: Artefacts no more. Trends Cell Biol. 2009;19:43-51. doi:10.1016/j.tcb.2008.11.003. PMID:19144520
    • (2009) Trends Cell Biol , vol.19 , pp. 43-51
    • Cocucci, E.1    Racchetti, G.2    Meldolesi, J.3
  • 45
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles
    • 11390481
    • Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S. Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J Immunol. 2001;166:7309-18. doi:10.4049/jimmunol.166.12.7309. PMID:11390481
    • (2001) J Immunol , vol.166 , pp. 7309-7318
    • Thery, C.1    Boussac, M.2    Veron, P.3    Ricciardi-Castagnoli, P.4    Raposo, G.5    Garin, J.6    Amigorena, S.7
  • 46
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • 25288114
    • Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255-89. doi:10.1146/annurev-cellbio-101512-122326. PMID:25288114
    • (2014) Annu Rev Cell Dev Biol , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Thery, C.3
  • 48
    • 84919680929 scopus 로고    scopus 로고
    • Hypoxic exosomes promote angiogenesis
    • 25498451
    • Fan GC. Hypoxic exosomes promote angiogenesis. Blood. 2014;124:3669-70. doi:10.1182/blood-2014-10-607846. PMID:25498451
    • (2014) Blood , vol.124 , pp. 3669-3670
    • Fan, G.C.1
  • 49
    • 84902579112 scopus 로고    scopus 로고
    • Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention
    • 25050215
    • Baragano RA, Suarez-Alvarez B, Lopez-Larrea C. Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention. OncoImmunology. 2014;3:e28497. doi:10.4161/onci.28497. PMID:25050215
    • (2014) OncoImmunology , vol.3 , pp. e28497
    • Baragano, R.A.1    Suarez-Alvarez, B.2    Lopez-Larrea, C.3
  • 50
    • 84919465425 scopus 로고    scopus 로고
    • Exosomes and autophagy: Coordinated mechanisms for the maintenance of cellular fitness
    • 25191326
    • Baixauli F, Lopez-Otin C, Mittelbrunn M. Exosomes and autophagy: Coordinated mechanisms for the maintenance of cellular fitness. Front Immunol. 2014;5:403. doi:10.3389/fimmu.2014.00403. PMID:25191326
    • (2014) Front Immunol , vol.5 , pp. 403
    • Baixauli, F.1    Lopez-Otin, C.2    Mittelbrunn, M.3
  • 51
    • 84900505110 scopus 로고    scopus 로고
    • Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells
    • 24657661
    • Corrado C, Raimondo S, Saieva L, Flugy AM, De Leo G, Alessandro R. Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells. Cancer Lett. 2014;348:71-6. doi:10.1016/j.canlet.2014.03.009. PMID:24657661
    • (2014) Cancer Lett , vol.348 , pp. 71-76
    • Corrado, C.1    Raimondo, S.2    Saieva, L.3    Flugy, A.M.4    De Leo, G.5    Alessandro, R.6
  • 52
    • 84912080852 scopus 로고    scopus 로고
    • Pathologic function and therapeutic potential of exosomes in cardiovascular disease
    • 25463630
    • Ailawadi S, Wang X, Gu H, Fan GC. Pathologic function and therapeutic potential of exosomes in cardiovascular disease. Biochim Biophys Acta. 2015;1852:1-11. doi:10.1016/j.bbadis.2014.10.008. PMID:25463630
    • (2015) Biochim Biophys Acta , vol.1852 , pp. 1-11
    • Ailawadi, S.1    Wang, X.2    Gu, H.3    Fan, G.C.4
  • 55
    • 74749099537 scopus 로고    scopus 로고
    • The early endosome: A busy sorting station for proteins at the crossroads
    • 19924646,. PMID
    • Jovic M, Sharma M, Rahajeng J, Caplan S. The early endosome: A busy sorting station for proteins at the crossroads. Histol Histopathol. 2010;25:99-112. PMID:19924646
    • (2010) Histol Histopathol , vol.25 , pp. 99-112
    • Jovic, M.1    Sharma, M.2    Rahajeng, J.3    Caplan, S.4
  • 56
    • 84919468543 scopus 로고    scopus 로고
    • Tetraspanins in extracellular vesicle formation and function
    • 25278937
    • Andreu Z, Yanez-Mo M. Tetraspanins in extracellular vesicle formation and function. Front Immunol. 2014;5:442. doi:10.3389/fimmu.2014.00442. PMID:25278937
    • (2014) Front Immunol , vol.5 , pp. 442
    • Andreu, Z.1    Yanez-Mo, M.2
  • 58
    • 84890458696 scopus 로고    scopus 로고
    • Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
    • 24105262
    • Colombo M, Moita C, van Niel G, Kowal J, Vigneron J, Benaroch P, Manel N, Moita LF, Thery C, Raposo G. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci. 2013;126:5553-65. doi:10.1242/jcs.128868. PMID:24105262
    • (2013) J Cell Sci , vol.126 , pp. 5553-5565
    • Colombo, M.1    Moita, C.2    van Niel, G.3    Kowal, J.4    Vigneron, J.5    Benaroch, P.6    Manel, N.7    Moita, L.F.8    Thery, C.9    Raposo, G.10
  • 59
    • 67249110996 scopus 로고    scopus 로고
    • Multivesicular endosome biogenesis in the absence of ESCRTs
    • 19490536
    • Stuffers S, Sem WC, Stenmark H, Brech A. Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic. 2009;10:925-37. doi:10.1111/j.1600-0854.2009.00920.x. PMID:19490536
    • (2009) Traffic , vol.10 , pp. 925-937
    • Stuffers, S.1    Sem, W.C.2    Stenmark, H.3    Brech, A.4
  • 60
    • 78649741781 scopus 로고    scopus 로고
    • Ectosomes as modulators of inflammation and immunity
    • 21039423
    • Sadallah S, Eken C, Schifferli JA. Ectosomes as modulators of inflammation and immunity. Clin Exp Immunol. 2011;163:26-32. doi:10.1111/j.1365-2249.2010.04271.x. PMID:21039423
    • (2011) Clin Exp Immunol , vol.163 , pp. 26-32
    • Sadallah, S.1    Eken, C.2    Schifferli, J.A.3
  • 61
    • 84947485402 scopus 로고    scopus 로고
    • Using exosomes, naturally-equipped nanocarriers, for drug delivery
    • 26241750
    • Batrakova EV, Kim MS. Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release. 2015;219:396-405. doi:10.1016/j.jconrel.2015.07.030. PMID:26241750
    • (2015) J Control Release , vol.219 , pp. 396-405
    • Batrakova, E.V.1    Kim, M.S.2
  • 64
    • 84856638259 scopus 로고    scopus 로고
    • Clinical development of liposome-based drugs: Formulation, characterization, and therapeutic efficacy
    • 22275822,. PMID
    • Chang HI, Yeh MK. Clinical development of liposome-based drugs: Formulation, characterization, and therapeutic efficacy. Int J Nanomedicine. 2012;7:49-60. PMID:22275822
    • (2012) Int J Nanomedicine , vol.7 , pp. 49-60
    • Chang, H.I.1    Yeh, M.K.2
  • 66
    • 84874980515 scopus 로고    scopus 로고
    • Exosomes for targeted siRNA delivery across biological barriers
    • 22921840
    • El AS, Lakhal S, Mager I, Wood MJ. Exosomes for targeted siRNA delivery across biological barriers. Adv Drug Deliv Rev. 2013;65:391-7. doi:10.1016/j.addr.2012.08.008. PMID:22921840
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 391-397
    • El, A.S.1    Lakhal, S.2    Mager, I.3    Wood, M.J.4
  • 67
    • 84874967621 scopus 로고    scopus 로고
    • Exosomal tumor-suppressive microRNAs as novel cancer therapy: “exocure” is another choice for cancer treatment
    • 22841506
    • Kosaka N, Takeshita F, Yoshioka Y, Hagiwara K, Katsuda T, Ono M, Ochiya T. Exosomal tumor-suppressive microRNAs as novel cancer therapy: “exocure” is another choice for cancer treatment. Adv Drug Deliv Rev. 2013;65:376-82. doi:10.1016/j.addr.2012.07.011. PMID:22841506
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 376-382
    • Kosaka, N.1    Takeshita, F.2    Yoshioka, Y.3    Hagiwara, K.4    Katsuda, T.5    Ono, M.6    Ochiya, T.7
  • 68
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • 21423189
    • Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341-5. doi:10.1038/nbt.1807. PMID:21423189
    • (2011) Nat Biotechnol , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 69
    • 85013841167 scopus 로고    scopus 로고
    • Exosomes as novel bio-carriers for gene and drug delivery
    • 28216464
    • Jiang XC, Gao JQ. Exosomes as novel bio-carriers for gene and drug delivery. Int J Pharm. 2017;521:167-75. doi:10.1016/j.ijpharm.2017.02.038. PMID:28216464
    • (2017) Int J Pharm , vol.521 , pp. 167-175
    • Jiang, X.C.1    Gao, J.Q.2
  • 70
    • 85013474226 scopus 로고    scopus 로고
    • Exosomes: Therapy delivery tools and biomarkers of diseases
    • 28202367,. 2017;174:63-78.
    • Barile L, Vassalli G. Exosomes: Therapy delivery tools and biomarkers of diseases. Pharmacol Ther. 2017;174:63-78. doi:10.1016/j.pharmthera.2017.02.020. PMID:28202367
    • Pharmacol Ther
    • Barile, L.1    Vassalli, G.2
  • 71
    • 84869496799 scopus 로고    scopus 로고
    • Macromolecular therapeutics in cancer treatment: The EPR effect and beyond
    • 22595146
    • Maeda H. Macromolecular therapeutics in cancer treatment: The EPR effect and beyond. J Control Release. 2012;164:138-44. doi:10.1016/j.jconrel.2012.04.038. PMID:22595146
    • (2012) J Control Release , vol.164 , pp. 138-144
    • Maeda, H.1
  • 74
    • 84896700643 scopus 로고    scopus 로고
    • Microvesicle-mediated delivery of transforming growth factor beta1 siRNA for the suppression of tumor growth in mice
    • 24565517
    • Zhang Y, Li L, Yu J, Zhu D, Zhang Y, Li X, Gu H, Zhang CY, Zen K. Microvesicle-mediated delivery of transforming growth factor beta1 siRNA for the suppression of tumor growth in mice. Biomaterials. 2014;35:4390-400. doi:10.1016/j.biomaterials.2014.02.003. PMID:24565517
    • (2014) Biomaterials , vol.35 , pp. 4390-4400
    • Zhang, Y.1    Li, L.2    Yu, J.3    Zhu, D.4    Zhang, Y.5    Li, X.6    Gu, H.7    Zhang, C.Y.8    Zen, K.9
  • 76
    • 84886625070 scopus 로고    scopus 로고
    • Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity
    • 24084846
    • Munoz JL, Bliss SA, Greco SJ, Ramkissoon SH, Ligon KL, Rameshwar P. Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity. Mol Ther Nucleic Acids. 2013;2:e126. doi:10.1038/mtna.2013.60. PMID:24084846
    • (2013) Mol Ther Nucleic Acids , vol.2 , pp. e126
    • Munoz, J.L.1    Bliss, S.A.2    Greco, S.J.3    Ramkissoon, S.H.4    Ligon, K.L.5    Rameshwar, P.6
  • 78
    • 84894630001 scopus 로고    scopus 로고
    • Bioengineered bacterial outer membrane vesicles as cell-specific drug-delivery vehicles for cancer therapy
    • 24410085
    • Gujrati V, Kim S, Kim SH, Min JJ, Choy HE, Kim SC, Jon S. Bioengineered bacterial outer membrane vesicles as cell-specific drug-delivery vehicles for cancer therapy. ACS Nano. 2014;8:1525-37. doi:10.1021/nn405724x. PMID:24410085
    • (2014) ACS Nano , vol.8 , pp. 1525-1537
    • Gujrati, V.1    Kim, S.2    Kim, S.H.3    Min, J.J.4    Choy, H.E.5    Kim, S.C.6    Jon, S.7
  • 79
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • 24345736
    • Tian Y, Li S, Song J, Ji T, Zhu M, Anderson GJ, Wei J, Nie G. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials. 2014;35:2383-90. doi:10.1016/j.biomaterials.2013.11.083. PMID:24345736
    • (2014) Biomaterials , vol.35 , pp. 2383-2390
    • Tian, Y.1    Li, S.2    Song, J.3    Ji, T.4    Zhu, M.5    Anderson, G.J.6    Wei, J.7    Nie, G.8
  • 80
    • 84884935709 scopus 로고    scopus 로고
    • Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors
    • 24004438
    • Jang SC, Kim OY, Yoon CM, Choi DS, Roh TY, Park J, Nilsson J, Lotvall J, Kim YK, Gho YS. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano. 2013;7:7698-710. doi:10.1021/nn402232g. PMID:24004438
    • (2013) ACS Nano , vol.7 , pp. 7698-7710
    • Jang, S.C.1    Kim, O.Y.2    Yoon, C.M.3    Choi, D.S.4    Roh, T.Y.5    Park, J.6    Nilsson, J.7    Lotvall, J.8    Kim, Y.K.9    Gho, Y.S.10
  • 81
  • 82
    • 84949564767 scopus 로고    scopus 로고
    • Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells
    • 26390807
    • Saari H, Lazaro-Ibanez E, Viitala T, Vuorimaa-Laukkanen E, Siljander P, Yliperttula M. Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells. J Control Release. 2015;220:727-37. doi:10.1016/j.jconrel.2015.09.031. PMID:26390807
    • (2015) J Control Release , vol.220 , pp. 727-737
    • Saari, H.1    Lazaro-Ibanez, E.2    Viitala, T.3    Vuorimaa-Laukkanen, E.4    Siljander, P.5    Yliperttula, M.6
  • 83
    • 59649100584 scopus 로고    scopus 로고
    • Anti-tumour effects of exosomes in combination with cyclophosphamide and polyinosinic-polycytidylic acid
    • 19094445
    • Guo F, Chang CK, Fan HH, Nie XX, Ren YN, Liu YY, Zhao LH. Anti-tumour effects of exosomes in combination with cyclophosphamide and polyinosinic-polycytidylic acid. J Int Med Res. 2008;36:1342-53. doi:10.1177/147323000803600623. PMID:19094445
    • (2008) J Int Med Res , vol.36 , pp. 1342-1353
    • Guo, F.1    Chang, C.K.2    Fan, H.H.3    Nie, X.X.4    Ren, Y.N.5    Liu, Y.Y.6    Zhao, L.H.7
  • 84
    • 84907228576 scopus 로고    scopus 로고
    • Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery
    • 25084218
    • Pascucci L, Cocce V, Bonomi A, Ami D, Ceccarelli P, Ciusani E, Vigano L, Locatelli A, Sisto F, Doglia SM, et al. Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. J Control Release. 2014;192:262-70. doi:10.1016/j.jconrel.2014.07.042. PMID:25084218
    • (2014) J Control Release , vol.192 , pp. 262-270
    • Pascucci, L.1    Cocce, V.2    Bonomi, A.3    Ami, D.4    Ceccarelli, P.5    Ciusani, E.6    Vigano, L.7    Locatelli, A.8    Sisto, F.9    Doglia, S.M.10
  • 87
    • 85014653850 scopus 로고    scopus 로고
    • Enhancement of Gemcitabine sensitivity in pancreatic adenocarcinoma by novel exosome-mediated delivery of the Survivin-T34A mutant
    • Aspe JR, Diaz OC, Jutzy JM, Deshields S, Whang S, Wall NR. Enhancement of Gemcitabine sensitivity in pancreatic adenocarcinoma by novel exosome-mediated delivery of the Survivin-T34A mutant. J Extracell Vesicles. 2014;3:24624263. doi:10.3402/jev.v3.23244
    • (2014) J Extracell Vesicles , vol.3 , pp. 24624263
    • Aspe, J.R.1    Diaz, O.C.2    Jutzy, J.M.3    Deshields, S.4    Whang, S.5    Wall, N.R.6
  • 88
    • 84901947865 scopus 로고    scopus 로고
    • Emerging role of extracellular vesicles in inflammatory diseases
    • 24535546
    • Buzas EI, Gyorgy B, Nagy G, Falus A, Gay S. Emerging role of extracellular vesicles in inflammatory diseases. Nat Rev Rheumatol. 2014;10:356-64. doi:10.1038/nrrheum.2014.19. PMID:24535546
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 356-364
    • Buzas, E.I.1    Gyorgy, B.2    Nagy, G.3    Falus, A.4    Gay, S.5
  • 89
    • 84903531999 scopus 로고    scopus 로고
    • The role of extracellular vesicles in the progression of neurodegenerative disease and cancer
    • 24835084
    • Candelario KM, Steindler DA. The role of extracellular vesicles in the progression of neurodegenerative disease and cancer. Trends Mol Med. 2014;20:368-74. doi:10.1016/j.molmed.2014.04.003. PMID:24835084
    • (2014) Trends Mol Med , vol.20 , pp. 368-374
    • Candelario, K.M.1    Steindler, D.A.2
  • 90
    • 84896707955 scopus 로고    scopus 로고
    • Extracellular vesicles: New players in cardiovascular diseases
    • 24509128
    • Gaceb A, Martinez MC, Andriantsitohaina R. Extracellular vesicles: New players in cardiovascular diseases. Int J Biochem Cell Biol. 2014;50:24-8. doi:10.1016/j.biocel.2014.01.018. PMID:24509128
    • (2014) Int J Biochem Cell Biol , vol.50 , pp. 24-28
    • Gaceb, A.1    Martinez, M.C.2    Andriantsitohaina, R.3
  • 91
    • 84905664114 scopus 로고    scopus 로고
    • Extracellular vesicles as therapeutic tools in cardiovascular diseases
    • 25136343
    • Fleury A, Martinez MC, Le Lay S. Extracellular vesicles as therapeutic tools in cardiovascular diseases. Front Immunol. 2014;5:370. doi:10.3389/fimmu.2014.00370. PMID:25136343
    • (2014) Front Immunol , vol.5 , pp. 370
    • Fleury, A.1    Martinez, M.C.2    Le Lay, S.3
  • 92
    • 85011629207 scopus 로고    scopus 로고
    • Extracellular vesicles in coronary artery disease
    • 28150804
    • Boulanger CM, Loyer X, Rautou PE, Amabile N. Extracellular vesicles in coronary artery disease. Nat Rev Cardiol. 2017;14:259-72. doi:10.1038/nrcardio.2017.7. PMID:28150804
    • (2017) Nat Rev Cardiol , vol.14 , pp. 259-272
    • Boulanger, C.M.1    Loyer, X.2    Rautou, P.E.3    Amabile, N.4
  • 93
    • 84873713781 scopus 로고    scopus 로고
    • Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury
    • 23318173
    • Chen L, Wang Y, Pan Y, Zhang L, Shen C, Qin G, Ashraf M, Weintraub N, Ma G, Tang Y. Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury. Biochem Biophys Res Commun. 2013;431:566-71. doi:10.1016/j.bbrc.2013.01.015. PMID:23318173
    • (2013) Biochem Biophys Res Commun , vol.431 , pp. 566-571
    • Chen, L.1    Wang, Y.2    Pan, Y.3    Zhang, L.4    Shen, C.5    Qin, G.6    Ashraf, M.7    Weintraub, N.8    Ma, G.9    Tang, Y.10
  • 94
    • 77958555989 scopus 로고    scopus 로고
    • Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice
    • 20856928
    • Benameur T, Soleti R, Porro C, Andriantsitohaina R, Martinez MC. Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice. PLoS One. 2010;5:e12688. doi:10.1371/journal.pone.0012688. PMID:20856928
    • (2010) PLoS One , vol.5
    • Benameur, T.1    Soleti, R.2    Porro, C.3    Andriantsitohaina, R.4    Martinez, M.C.5
  • 95
    • 64349092619 scopus 로고    scopus 로고
    • Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors
    • 19168578
    • Soleti R, Benameur T, Porro C, Panaro MA, Andriantsitohaina R, Martinez MC. Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors. Carcinogenesis. 2009;30:580-8. doi:10.1093/carcin/bgp030. PMID:19168578
    • (2009) Carcinogenesis , vol.30 , pp. 580-588
    • Soleti, R.1    Benameur, T.2    Porro, C.3    Panaro, M.A.4    Andriantsitohaina, R.5    Martinez, M.C.6
  • 97
    • 80053574021 scopus 로고    scopus 로고
    • Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
    • 21915101
    • Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, Ju S, Mu J, Zhang L, Steinman L, et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther. 2011;19:1769-79. doi:10.1038/mt.2011.164. PMID:21915101
    • (2011) Mol Ther , vol.19 , pp. 1769-1779
    • Zhuang, X.1    Xiang, X.2    Grizzle, W.3    Sun, D.4    Zhang, S.5    Axtell, R.C.6    Ju, S.7    Mu, J.8    Zhang, L.9    Steinman, L.10
  • 98
    • 84902539393 scopus 로고    scopus 로고
    • Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia
    • 24780320
    • Kalani A, Kamat PK, Chaturvedi P, Tyagi SC, Tyagi N. Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia. Life Sci. 2014;107:1-7. doi:10.1016/j.lfs.2014.04.018. PMID:24780320
    • (2014) Life Sci , vol.107 , pp. 1-7
    • Kalani, A.1    Kamat, P.K.2    Chaturvedi, P.3    Tyagi, S.C.4    Tyagi, N.5
  • 99
    • 77956264919 scopus 로고    scopus 로고
    • A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    • 20571541
    • Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu C, Barnes S, Grizzle W, Miller D, Zhang HG. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther. 2010;18:1606-14. doi:10.1038/mt.2010.105. PMID:20571541
    • (2010) Mol Ther , vol.18 , pp. 1606-1614
    • Sun, D.1    Zhuang, X.2    Xiang, X.3    Liu, Y.4    Zhang, S.5    Liu, C.6    Barnes, S.7    Grizzle, W.8    Miller, D.9    Zhang, H.G.10
  • 100
    • 20844458756 scopus 로고    scopus 로고
    • Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis
    • 15879146
    • Kim SH, Lechman ER, Bianco N, Menon R, Keravala A, Nash J, Mi Z, Watkins SC, Gambotto A, Robbins PD. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol. 2005;174:6440-8. doi:10.4049/jimmunol.174.10.6440. PMID:15879146
    • (2005) J Immunol , vol.174 , pp. 6440-6448
    • Kim, S.H.1    Lechman, E.R.2    Bianco, N.3    Menon, R.4    Keravala, A.5    Nash, J.6    Mi, Z.7    Watkins, S.C.8    Gambotto, A.9    Robbins, P.D.10
  • 101
    • 3042643331 scopus 로고    scopus 로고
    • Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection
    • 15213158
    • Aline F, Bout D, Amigorena S, Roingeard P, Dimier-Poisson I. Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. Infect Immun. 2004;72:4127-37. doi:10.1128/IAI.72.7.4127-4137.2004. PMID:15213158
    • (2004) Infect Immun , vol.72 , pp. 4127-4137
    • Aline, F.1    Bout, D.2    Amigorena, S.3    Roingeard, P.4    Dimier-Poisson, I.5
  • 103
    • 34247243255 scopus 로고    scopus 로고
    • Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies
    • 17258782
    • Kuate S, Cinatl J, Doerr HW, Uberla K. Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies. Virology. 2007;362:26-37. doi:10.1016/j.virol.2006.12.011. PMID:17258782
    • (2007) Virology , vol.362 , pp. 26-37
    • Kuate, S.1    Cinatl, J.2    Doerr, H.W.3    Uberla, K.4
  • 104
    • 84955203483 scopus 로고    scopus 로고
    • A novel platform for cancer therapy using extracellular vesicles
    • 26482189
    • Tominaga N, Yoshioka Y, Ochiya T. A novel platform for cancer therapy using extracellular vesicles. Adv Drug Deliv Rev. 2015;95:50-5. doi:10.1016/j.addr.2015.10.002. PMID:26482189
    • (2015) Adv Drug Deliv Rev , vol.95 , pp. 50-55
    • Tominaga, N.1    Yoshioka, Y.2    Ochiya, T.3
  • 106
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of thefirst phase I clinical trial
    • 15740633
    • Escudier B, Dorval T, Chaput N, Andre F, Caby MP, Novault S, Flament C, Leboulaire C, Borg C, Amigorena S, et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of thefirst phase I clinical trial. J Transl Med. 2005;3:10. doi:10.1186/1479-5876-3-10. PMID:15740633
    • (2005) J Transl Med , vol.3 , pp. 10
    • Escudier, B.1    Dorval, T.2    Chaput, N.3    Andre, F.4    Caby, M.P.5    Novault, S.6    Flament, C.7    Leboulaire, C.8    Borg, C.9    Amigorena, S.10
  • 108
    • 78650672083 scopus 로고    scopus 로고
    • Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: a critical role of interferon-gamma
    • 21150714
    • Viaud S, Ploix S, Lapierre V, Thery C, Commere PH, Tramalloni D, Gorrichon K, Virault-Rocroy P, Tursz T, Lantz O, et al. Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: a critical role of interferon-gamma. J Immunother. 2011;34:65-75. doi:10.1097/CJI.0b013e3181fe535b. PMID:21150714
    • (2011) J Immunother , vol.34 , pp. 65-75
    • Viaud, S.1    Ploix, S.2    Lapierre, V.3    Thery, C.4    Commere, P.H.5    Tramalloni, D.6    Gorrichon, K.7    Virault-Rocroy, P.8    Tursz, T.9    Lantz, O.10
  • 109
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • 18362931
    • Dai S, Wei D, Wu Z, Zhou X, Wei X, Huang H, Li G. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther. 2008;16:782-90. doi:10.1038/mt.2008.1. PMID:18362931
    • (2008) Mol Ther , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4    Wei, X.5    Huang, H.6    Li, G.7
  • 111
    • 84946913090 scopus 로고    scopus 로고
    • Outer membrane vesicles as platform vaccine technology
    • 26912077
    • van der Pol L, Stork M, van der Ley P. Outer membrane vesicles as platform vaccine technology. Biotechnol J. 2015;10:1689-706. doi:10.1002/biot.201400395. PMID:26912077
    • (2015) Biotechnol J , vol.10 , pp. 1689-1706
    • van der Pol, L.1    Stork, M.2    van der Ley, P.3
  • 112
    • 78349257850 scopus 로고    scopus 로고
    • Multicenter, open-label, randomized phase II controlled trial of an investigational recombinant Meningococcal serogroup B vaccine with and without outer membrane vesicles, administered in infancy
    • 20954968
    • Findlow J, Borrow R, Snape MD, Dawson T, Holland A, John TM, Evans A, Telford KL, Ypma E, Toneatto D, et al. Multicenter, open-label, randomized phase II controlled trial of an investigational recombinant Meningococcal serogroup B vaccine with and without outer membrane vesicles, administered in infancy. Clin Infect Dis. 2010;51:1127-37. doi:10.1086/656741. PMID:20954968
    • (2010) Clin Infect Dis , vol.51 , pp. 1127-1137
    • Findlow, J.1    Borrow, R.2    Snape, M.D.3    Dawson, T.4    Holland, A.5    John, T.M.6    Evans, A.7    Telford, K.L.8    Ypma, E.9    Toneatto, D.10
  • 118
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the international society for extracellular vesicles
    • 25536934
    • Lotvall J, Hill AF, Hochberg F, Buzas EI, Di Vizio D, Gardiner C, Gho YS, Kurochkin IV, Mathivanan S, Quesenberry P, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the international society for extracellular vesicles. J Extracell Vesicles. 2014;3:26913. doi:10.3402/jev.v3.26913. PMID:25536934
    • (2014) J Extracell Vesicles , vol.3 , pp. 26913
    • Lotvall, J.1    Hill, A.F.2    Hochberg, F.3    Buzas, E.I.4    Di Vizio, D.5    Gardiner, C.6    Gho, Y.S.7    Kurochkin, I.V.8    Mathivanan, S.9    Quesenberry, P.10
  • 119
    • 0037114287 scopus 로고    scopus 로고
    • Le Pecq JB. Production and characterization of clinical grade exosomes derived from dendritic cells
    • 12379326
    • Lamparski HG, Metha-Damani A, Yao JY, Patel S, Hsu DH, Ruegg C, Le Pecq JB. Production and characterization of clinical grade exosomes derived from dendritic cells. J Immunol Methods. 2002;270:211-26. doi:10.1016/S0022-1759(02)00330-7. PMID:12379326
    • (2002) J Immunol Methods , vol.270 , pp. 211-226
    • Lamparski, H.G.1    Metha-Damani, A.2    Yao, J.Y.3    Patel, S.4    Hsu, D.H.5    Ruegg, C.6
  • 123
    • 84965058098 scopus 로고    scopus 로고
    • Bio-inspired virus-like nanovesicle for effective vaccination
    • 27141919
    • Mi P, Zhang P, Liu G. Bio-inspired virus-like nanovesicle for effective vaccination. Hum Vaccin Immunother. 2016;12:2090-1. doi:10.1080/21645515.2016.1157244. PMID:27141919
    • (2016) Hum Vaccin Immunother , vol.12 , pp. 2090-2091
    • Mi, P.1    Zhang, P.2    Liu, G.3
  • 124
    • 85006817571 scopus 로고    scopus 로고
    • Nanobiotechnology: Cell membrane-based delivery systems
    • 28435439
    • Zhang P, Liu G, Chen X. Nanobiotechnology: Cell membrane-based delivery systems. Nano Today. 2017;13:7-9. doi:10.1016/j.nantod.2016.10.008. PMID:28435439
    • (2017) Nano Today , vol.13 , pp. 7-9
    • Zhang, P.1    Liu, G.2    Chen, X.3
  • 125
    • 85034735699 scopus 로고    scopus 로고
    • Feb, 2017Feb6, ]accessed
    • Thomas Jefferson University Hospita. Pilot immunotherapy trial for recurrent malignant gliomas. 2012 Feb 14 ]accessed 2017Feb6]. https://www.clinicaltrials.gov/ct2/show/study/NCT01294072
    • (2012) Pilot immunotherapy trial for recurrent malignant gliomas


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.