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Volumn 219, Issue 1, 2017, Pages 138-151

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium

Author keywords

AMPK; cancer; diabetes; EDV; metformin; SIRT1

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; MICRORNA; PROTECTIVE AGENT; SIRTUIN 1; ANTIDIABETIC AGENT;

EID: 84954287264     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12644     Document Type: Review
Times cited : (86)

References (126)
  • 2
    • 77249158771 scopus 로고    scopus 로고
    • SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol
    • Arunachalam, G., Yao, H., Sundar, I.K., Caito, S. & Rahman, I. 2010. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol. Biochem Biophys Res Commun 393, 66–72.
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 66-72
    • Arunachalam, G.1    Yao, H.2    Sundar, I.K.3    Caito, S.4    Rahman, I.5
  • 3
    • 84891275812 scopus 로고    scopus 로고
    • Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1
    • Arunachalam, G., Samuel, S.M., Marei, I., Ding, H. & Triggle, C.R. 2014a. Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br J Pharmacol 171, 523–535.
    • (2014) Br J Pharmacol , vol.171 , pp. 523-535
    • Arunachalam, G.1    Samuel, S.M.2    Marei, I.3    Ding, H.4    Triggle, C.R.5
  • 4
    • 84930271758 scopus 로고    scopus 로고
    • Micro RNA-34a mediates impaired angiogenesis in diabetes: Role of SIRT1 and metformin
    • &, (abstract)
    • Arunachalam, G., Samuel, S.M., Marei, I., Ding, H. & Triggle, C.R. 2014b. Micro RNA-34a mediates impaired angiogenesis in diabetes: Role of SIRT1 and metformin. FASEB J 28, 1051.2 (abstract).
    • (2014) FASEB J , vol.28 , pp. 1051.2
    • Arunachalam, G.1    Samuel, S.M.2    Marei, I.3    Ding, H.4    Triggle, C.R.5
  • 6
    • 84959420544 scopus 로고    scopus 로고
    • Molecular interplay between microRNA-34a and sirtuin1 in hyperglycaemia-mediated impaired angiogenesis in endothelial cells: Effects of metformin
    • &, [Epub ahead of print
    • Arunachalam, G., Lakshmanan, A.P., Samuel, S.M., Triggle, C.R. & Ding, H. 2015b. Molecular interplay between microRNA-34a and sirtuin1 in hyperglycaemia-mediated impaired angiogenesis in endothelial cells: Effects of metformin. J Pharmacol Exp Ther. [Epub ahead of print]
    • (2015) J Pharmacol Exp Ther
    • Arunachalam, G.1    Lakshmanan, A.P.2    Samuel, S.M.3    Triggle, C.R.4    Ding, H.5
  • 7
    • 84904036821 scopus 로고    scopus 로고
    • Diabetes and cancer: 5 years into the recent controversy
    • Badrick, E. & Renehan, A.G. 2014. Diabetes and cancer: 5 years into the recent controversy. Eur J Cancer 50, 2119–2125.
    • (2014) Eur J Cancer , vol.50 , pp. 2119-2125
    • Badrick, E.1    Renehan, A.G.2
  • 8
    • 2342424434 scopus 로고    scopus 로고
    • Metformin: its botanical background
    • Bailey, C.J. & Day, C. 2004. Metformin: its botanical background. Pract Diabetes Int 21, 115–117.
    • (2004) Pract Diabetes Int , vol.21 , pp. 115-117
    • Bailey, C.J.1    Day, C.2
  • 10
    • 77955458963 scopus 로고    scopus 로고
    • The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
    • Ben Sahra, I., Tanti, J.F. & Bost, F. 2010. The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells. Autophagy 6, 670–671.
    • (2010) Autophagy , vol.6 , pp. 670-671
    • Ben Sahra, I.1    Tanti, J.F.2    Bost, F.3
  • 13
    • 0030175581 scopus 로고    scopus 로고
    • Vascular effects of metformin
    • Bhalla, R.C. & Sharma, R.V. 1996. Vascular effects of metformin. Am J Hypertens 9, 570–576.
    • (1996) Am J Hypertens , vol.9 , pp. 570-576
    • Bhalla, R.C.1    Sharma, R.V.2
  • 16
    • 17144429302 scopus 로고    scopus 로고
    • Calorie restriction, SIRT1 and metabolism: understanding longevity
    • Bordone, L. & Guarente, L. 2005. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 6, 298–305.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 298-305
    • Bordone, L.1    Guarente, L.2
  • 17
    • 0035856980 scopus 로고    scopus 로고
    • Biochemisty and molecular cell biology of diabetic complications
    • Brownlee, M. 2001. Biochemisty and molecular cell biology of diabetic complications. Nature 414, 813–820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 19
    • 0036599352 scopus 로고    scopus 로고
    • Regulation of lifespan by histone deacetylase
    • Chang, K.T. & Min, K.T. 2002. Regulation of lifespan by histone deacetylase. Ageing Res Rev 1, 313–326.
    • (2002) Ageing Res Rev , vol.1 , pp. 313-326
    • Chang, K.T.1    Min, K.T.2
  • 20
    • 84897398609 scopus 로고    scopus 로고
    • Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway
    • Cheang, W.S., Tian, X.Y., Wong, W.T., Lau, C.W., Lee, S.S., Chen, Z.Y., Yao, X., Wang, N. & Huang, Y. 2014. Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arterioscler Thromb Vasc Biol 34, 830–836.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 830-836
    • Cheang, W.S.1    Tian, X.Y.2    Wong, W.T.3    Lau, C.W.4    Lee, S.S.5    Chen, Z.Y.6    Yao, X.7    Wang, N.8    Huang, Y.9
  • 24
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • Davis, B.J., Xie, Z., Viollet, B. & Zou, M.H. 2006. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 55, 496–505.
    • (2006) Diabetes , vol.55 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.H.4
  • 25
    • 0022486738 scopus 로고
    • What is there that is not poison? A study of the Third Defense by Paracelsus
    • Deichmann, W.B., Henschler, D., Holmsted, B. & Keil, G. 1986. What is there that is not poison? A study of the Third Defense by Paracelsus. Arch Toxicol 58, 207–213.
    • (1986) Arch Toxicol , vol.58 , pp. 207-213
    • Deichmann, W.B.1    Henschler, D.2    Holmsted, B.3    Keil, G.4
  • 26
    • 21344462345 scopus 로고    scopus 로고
    • Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process
    • Detaille, D., Guigas, B., Chauvin, C., Batandier, C., Fontaine, E., Wiernsperger, N. & Leverve, X. 2005. Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes 54, 2179–2187.
    • (2005) Diabetes , vol.54 , pp. 2179-2187
    • Detaille, D.1    Guigas, B.2    Chauvin, C.3    Batandier, C.4    Fontaine, E.5    Wiernsperger, N.6    Leverve, X.7
  • 27
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Diabetes Control and Complications Trial Research Group 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329, 977–998.
    • (1993) N Engl J Med , vol.329 , pp. 977-998
  • 28
    • 77955290312 scopus 로고    scopus 로고
    • Endothelial dysfunction in diabetes: multiple targets for treatment
    • Ding, H. & Triggle, C.R. 2010. Endothelial dysfunction in diabetes: multiple targets for treatment. Pflugers Arch 459, 977–994.
    • (2010) Pflugers Arch , vol.459 , pp. 977-994
    • Ding, H.1    Triggle, C.R.2
  • 29
    • 0020563692 scopus 로고
    • Metabolic properties of freshly isolated bovine endothelial cells
    • Dobrina, A. & Rossi, F. 1983. Metabolic properties of freshly isolated bovine endothelial cells. Biochim Biophys Acta 762, 295–301.
    • (1983) Biochim Biophys Acta , vol.762 , pp. 295-301
    • Dobrina, A.1    Rossi, F.2
  • 30
    • 80053456372 scopus 로고    scopus 로고
    • Calorie restriction and resveratrol in cardiovascular health and disease
    • Dolinsky, V.W. & Dyck, J.R. 2011. Calorie restriction and resveratrol in cardiovascular health and disease. Biochim Biophys Acta 1812, 1477–1489.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 1477-1489
    • Dolinsky, V.W.1    Dyck, J.R.2
  • 31
    • 84883488437 scopus 로고    scopus 로고
    • MicroRNAs and metabolism crosstalk in energy homeostasis
    • Dumortier, O., Hinault, C. & Van Obberghen, E. 2013. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab 18, 312–324.
    • (2013) Cell Metab , vol.18 , pp. 312-324
    • Dumortier, O.1    Hinault, C.2    Van Obberghen, E.3
  • 32
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • El-Mir, M.Y., Nogueira, V., Fontaine, E., Averet, N., Rigoulet, M. & Leverve, X. 2000. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 275, 223–228.
    • (2000) J Biol Chem , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 33
    • 84903190232 scopus 로고    scopus 로고
    • Endothelial AMP-activated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice
    • Enkhjargal, B., Godo, S., Sawada, A., Suvd, N., Saito, H., Noda, K., Satoh, K. & Shimokawa, H. 2014. Endothelial AMP-activated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice. Arterioscler Thromb Vasc Biol 34, 1505–1513.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1505-1513
    • Enkhjargal, B.1    Godo, S.2    Sawada, A.3    Suvd, N.4    Saito, H.5    Noda, K.6    Satoh, K.7    Shimokawa, H.8
  • 36
    • 0033008628 scopus 로고    scopus 로고
    • An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats
    • Faure, P., Rossini, E., Wiernsperger, N., Richard, M.J., Favier, A. & Halimi, S. 1999. An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats. Diabetes 48, 353–357.
    • (1999) Diabetes , vol.48 , pp. 353-357
    • Faure, P.1    Rossini, E.2    Wiernsperger, N.3    Richard, M.J.4    Favier, A.5    Halimi, S.6
  • 37
    • 68049103917 scopus 로고    scopus 로고
    • Activation and signaling by the AMP-activated protein kinase in endothelial cells
    • Fisslthaler, B. & Fleming, I. 2009. Activation and signaling by the AMP-activated protein kinase in endothelial cells. Circ Res 105, 114–127.
    • (2009) Circ Res , vol.105 , pp. 114-127
    • Fisslthaler, B.1    Fleming, I.2
  • 38
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F. & Viollet, B. 2010. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 120, 2355–2369.
    • (2010) J Clin Invest , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hébrard, S.2    Leclerc, J.3    Zarrinpashneh, E.4    Soty, M.5    Mithieux, G.6    Sakamoto, K.7    Andreelli, F.8    Viollet, B.9
  • 41
    • 84946559701 scopus 로고    scopus 로고
    • Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions
    • Ghosh, S., Lakshmanan, A.P., Hwang, M.J., Kubba, H., Mushannen, A., Triggle, C.R. & Ding, H. 2015. Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions. Biochem Pharmacol 98, 412–421.
    • (2015) Biochem Pharmacol , vol.98 , pp. 412-421
    • Ghosh, S.1    Lakshmanan, A.P.2    Hwang, M.J.3    Kubba, H.4    Mushannen, A.5    Triggle, C.R.6    Ding, H.7
  • 43
    • 0037035456 scopus 로고    scopus 로고
    • Prevention conference VI: diabetes and cardiovascular disease: executive summary: conference proceeding for healthcare professionals from a special writing group of the American Heart Association
    • Grundy, S.M., Howard, B., Smith, S. Jr, Eckel, R., Redberg, R. & Bonow, R.O. 2003. Prevention conference VI: diabetes and cardiovascular disease: executive summary: conference proceeding for healthcare professionals from a special writing group of the American Heart Association. Circulation 105, 2231–2239.
    • (2003) Circulation , vol.105 , pp. 2231-2239
    • Grundy, S.M.1    Howard, B.2    Smith, S.3    Eckel, R.4    Redberg, R.5    Bonow, R.O.6
  • 44
    • 35848961647 scopus 로고    scopus 로고
    • Goat's rue – French lilac – Italian fitch –Spanish sainfoin: gallega officinalis and metformin: The Edinburgh connection
    • Hadden, D.R. 2005. Goat's rue – French lilac – Italian fitch –Spanish sainfoin: gallega officinalis and metformin: The Edinburgh connection. J R Coll Physicians Edinb 35, 258–260.
    • (2005) J R Coll Physicians Edinb , vol.35 , pp. 258-260
    • Hadden, D.R.1
  • 45
    • 84859977229 scopus 로고    scopus 로고
    • Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses
    • Hemmingsen, B., Christensen, L.L., Wetterslev, J., Vaag, A., Gluud, C., Lund, S.S. & Almdal, T. 2012. Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses. BMJ 344, e1771.
    • (2012) BMJ , vol.344
    • Hemmingsen, B.1    Christensen, L.L.2    Wetterslev, J.3    Vaag, A.4    Gluud, C.5    Lund, S.S.6    Almdal, T.7
  • 47
    • 77952741468 scopus 로고    scopus 로고
    • Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway
    • Hou, X., Song, J., Li, X.N., Zhang, L., Wang, X., Chen, L. & Shen, Y.H. 2010. Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway. Biochem Biophys Res Commun 396, 199–205.
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 199-205
    • Hou, X.1    Song, J.2    Li, X.N.3    Zhang, L.4    Wang, X.5    Chen, L.6    Shen, Y.H.7
  • 50
    • 77955417245 scopus 로고    scopus 로고
    • MicroRNA-34a regulation of endothelial senescence
    • Ito, T., Yagi, S. & Yamakuchi, M. 2010. MicroRNA-34a regulation of endothelial senescence. Biochem Biophys Res Commun 398, 735–740.
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 735-740
    • Ito, T.1    Yagi, S.2    Yamakuchi, M.3
  • 51
    • 0030031512 scopus 로고    scopus 로고
    • The effect of metformin on adipose tissue metabolism and peripheral blood flow in subjects with NIDDM
    • Jansson, P.A., Gudbjörnsdóttir, H.S., Andersson, O.K. & Lönnroth, P.N. 1996. The effect of metformin on adipose tissue metabolism and peripheral blood flow in subjects with NIDDM. Diabetes Care 19, 160–164.
    • (1996) Diabetes Care , vol.19 , pp. 160-164
    • Jansson, P.A.1    Gudbjörnsdóttir, H.S.2    Andersson, O.K.3    Lönnroth, P.N.4
  • 53
    • 0038279359 scopus 로고    scopus 로고
    • Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes
    • Johnson, J.A., Majumdar, S.R., Simpson, S.H. & Toth, E.L. 2002. Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes. Diabetes Care 25, 2244–2248.
    • (2002) Diabetes Care , vol.25 , pp. 2244-2248
    • Johnson, J.A.1    Majumdar, S.R.2    Simpson, S.H.3    Toth, E.L.4
  • 54
    • 0033958239 scopus 로고    scopus 로고
    • Metformin improves vascular function in insulin-resistant rats
    • Katakam, P.V., Ujhelyi, M.R., Hoenig, M. & Miller, A.W. 2000. Metformin improves vascular function in insulin-resistant rats. Hypertension 35, 108–112.
    • (2000) Hypertension , vol.35 , pp. 108-112
    • Katakam, P.V.1    Ujhelyi, M.R.2    Hoenig, M.3    Miller, A.W.4
  • 55
    • 84937511483 scopus 로고    scopus 로고
    • Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor
    • Kato, H., Sekine, Y., Furuya, Y., Miyazawa, Y., Koike, H. & Suzuki, K. 2015. Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor. Biochem Biophys Res Commun 461, 115–121.
    • (2015) Biochem Biophys Res Commun , vol.461 , pp. 115-121
    • Kato, H.1    Sekine, Y.2    Furuya, Y.3    Miyazawa, Y.4    Koike, H.5    Suzuki, K.6
  • 57
    • 56649085322 scopus 로고    scopus 로고
    • SIRT1: roles in ageing and cancer
    • Kim, E.J. & Um, S.J. 2008. SIRT1: roles in ageing and cancer. BMB Rep 41, 751–756.
    • (2008) BMB Rep , vol.41 , pp. 751-756
    • Kim, E.J.1    Um, S.J.2
  • 58
    • 84937976768 scopus 로고    scopus 로고
    • Metformin: an old drug for the treatment of diabetes but a new drug for the protection of the endothelium
    • Kinaan, M., Ding, H. & Triggle, C.R. 2015. Metformin: an old drug for the treatment of diabetes but a new drug for the protection of the endothelium. Med Princ Pract 24, 401–415.
    • (2015) Med Princ Pract , vol.24 , pp. 401-415
    • Kinaan, M.1    Ding, H.2    Triggle, C.R.3
  • 59
    • 55549096745 scopus 로고    scopus 로고
    • SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated kinase activation
    • Lan, F., Cacicedo, J.M., Ruderman, N. & Ido, Y. 2008. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated kinase activation. J Biol Chem 283, 27628–27635.
    • (2008) J Biol Chem , vol.283 , pp. 27628-27635
    • Lan, F.1    Cacicedo, J.M.2    Ruderman, N.3    Ido, Y.4
  • 60
    • 33747266771 scopus 로고    scopus 로고
    • Toxicology: then and now
    • Langman, L.J. & Kapur, B.M. 2006. Toxicology: then and now. Clin Biochem 39, 498–510.
    • (2006) Clin Biochem , vol.39 , pp. 498-510
    • Langman, L.J.1    Kapur, B.M.2
  • 61
    • 84856743909 scopus 로고    scopus 로고
    • Metformin-treated patients with type 2 diabetes have normal mitochondrial complex 1 respiration
    • Larsen, S., Rabøl, R., Hansen, C.N., Madsbad, S., Helge, J.W. & Dela, F. 2012. Metformin-treated patients with type 2 diabetes have normal mitochondrial complex 1 respiration. Diabetologia 55, 443–449.
    • (2012) Diabetologia , vol.55 , pp. 443-449
    • Larsen, S.1    Rabøl, R.2    Hansen, C.N.3    Madsbad, S.4    Helge, J.W.5    Dela, F.6
  • 63
    • 84906908221 scopus 로고    scopus 로고
    • Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake
    • Lin, L., Nuotio-Antar, A.M., Ma, X., Liu, F., Fiorotto, M.L. & Sun, Y. 2014. Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. J Nutr 144, 1349–1355.
    • (2014) J Nutr , vol.144 , pp. 1349-1355
    • Lin, L.1    Nuotio-Antar, A.M.2    Ma, X.3    Liu, F.4    Fiorotto, M.L.5    Sun, Y.6
  • 64
    • 80051978747 scopus 로고    scopus 로고
    • Use of metformin in the setting of mild-to-moderate renal insufficiency
    • Lipska, K.J., Bailey, C.J. & Inzucchi, S.E. 2011. Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 34, 1431–1437.
    • (2011) Diabetes Care , vol.34 , pp. 1431-1437
    • Lipska, K.J.1    Bailey, C.J.2    Inzucchi, S.E.3
  • 66
    • 84896300923 scopus 로고    scopus 로고
    • The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent
    • Liu, X., Chhipa, R.R., Nakano, I. & Dasgupta, B. 2014b. The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent. Mol Cancer Ther 13, 596–605.
    • (2014) Mol Cancer Ther , vol.13 , pp. 596-605
    • Liu, X.1    Chhipa, R.R.2    Nakano, I.3    Dasgupta, B.4
  • 67
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: systematic review and meta-analysis
    • Lord, J.M., Flight, I.H.K. & Norman, R.J. 2003. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327, 951–953.
    • (2003) BMJ , vol.327 , pp. 951-953
    • Lord, J.M.1    Flight, I.H.K.2    Norman, R.J.3
  • 68
    • 84890749286 scopus 로고    scopus 로고
    • The latest pharmacotherapy options for type 1 diabetes
    • Ludvigsson, J. 2014. The latest pharmacotherapy options for type 1 diabetes. Expert Opin Pharmacother 15, 37–49.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 37-49
    • Ludvigsson, J.1
  • 73
    • 0035312620 scopus 로고    scopus 로고
    • Improved endothelial function with metformin in type 2
    • Mather, K.J., Verma, S. & Anderson, T.J. 2001. Improved endothelial function with metformin in type 2. J Am Coll Cardiol 37, 1344–1350.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1344-1350
    • Mather, K.J.1    Verma, S.2    Anderson, T.J.3
  • 78
    • 35349011597 scopus 로고    scopus 로고
    • Sirt1 modulates premature senescence-like phenotype in human endothelial cells
    • Ota, H., Akishita, M., Eto, M., Iijima, K., Kaneki, M. & Ouchi, Y. 2007. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol 43, 571–579.
    • (2007) J Mol Cell Cardiol , vol.43 , pp. 571-579
    • Ota, H.1    Akishita, M.2    Eto, M.3    Iijima, K.4    Kaneki, M.5    Ouchi, Y.6
  • 79
    • 51649106480 scopus 로고    scopus 로고
    • Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells
    • Ota, H., Eto, M., Kano, M.R., Ogawa, S., Iijima, K., Akishita, M. & Ouchi, Y. 2008. Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol 28, 1634–1639.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1634-1639
    • Ota, H.1    Eto, M.2    Kano, M.R.3    Ogawa, S.4    Iijima, K.5    Akishita, M.6    Ouchi, Y.7
  • 80
    • 18044393806 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle
    • Ouchi, N., Shibata, R. & Walsh, K. 2005. AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res 96, 838–846.
    • (2005) Circ Res , vol.96 , pp. 838-846
    • Ouchi, N.1    Shibata, R.2    Walsh, K.3
  • 81
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen, M.R., Doran, E. & Halestrap, A.P. 2000. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348(Pt 3), 607–614.
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 82
    • 84905757105 scopus 로고    scopus 로고
    • Metformin–mode of action and clinical implications for diabetes and cancer
    • Pernicova, I. & Korbonits, M. 2014. Metformin–mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 10, 143–156.
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 83
    • 51649087472 scopus 로고    scopus 로고
    • NO targets SIRT1: a novel signaling network in endothelial senescence
    • Potente, M. & Dimmeler, S. 2008. NO targets SIRT1: a novel signaling network in endothelial senescence. Arterioscler Thromb Vasc Biol 28, 1577–1579.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1577-1579
    • Potente, M.1    Dimmeler, S.2
  • 84
    • 84863093927 scopus 로고    scopus 로고
    • Role of microRNAs in endothelial inflammation and senescence
    • Qin, B., Yang, H. & Xiao, B. 2012. Role of microRNAs in endothelial inflammation and senescence. Mol Biol Rep 39, 4509–4518.
    • (2012) Mol Biol Rep , vol.39 , pp. 4509-4518
    • Qin, B.1    Yang, H.2    Xiao, B.3
  • 85
    • 84881614717 scopus 로고    scopus 로고
    • Molecular mechanism of action of metformin: old or new insights?
    • Rena, G., Peaeson, E.R. & Sakamoto, K. 2013. Molecular mechanism of action of metformin: old or new insights? Diabetologia 56, 1898–1906.
    • (2013) Diabetologia , vol.56 , pp. 1898-1906
    • Rena, G.1    Peaeson, E.R.2    Sakamoto, K.3
  • 87
    • 84873733300 scopus 로고    scopus 로고
    • Metformin: an old but still the best treatment for type 2 diabetes
    • Rojas, L.B. & Gomes, M.B. 2013. Metformin: an old but still the best treatment for type 2 diabetes. Diabetol Metab Syndr 15, 6.
    • (2013) Diabetol Metab Syndr , vol.15 , pp. 6
    • Rojas, L.B.1    Gomes, M.B.2
  • 90
    • 84990931057 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
    • Salpeter, S., Greyber, E., Pasternak, G. & Salpeter, E. 2003. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2, CD002967.
    • (2003) Cochrane Database Syst Rev , vol.2 , pp. CD002967
    • Salpeter, S.1    Greyber, E.2    Pasternak, G.3    Salpeter, E.4
  • 91
    • 0030443768 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus
    • Sambol, N.C., Chiang, J., O'Conner, M., Liu, C.Y., Lin, E.T., Goodman, A.M., Benet, L.Z. & Karam, J.H. 1996. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. J Clin Pharmacol 36, 1012–1021.
    • (1996) J Clin Pharmacol , vol.36 , pp. 1012-1021
    • Sambol, N.C.1    Chiang, J.2    O'Conner, M.3    Liu, C.Y.4    Lin, E.T.5    Goodman, A.M.6    Benet, L.Z.7    Karam, J.H.8
  • 92
    • 0018819017 scopus 로고
    • Guanidines and biguanides
    • Schäfer, G. 1980. Guanidines and biguanides. Pharmacol Ther 8, 275–295.
    • (1980) Pharmacol Ther , vol.8 , pp. 275-295
    • Schäfer, G.1
  • 93
    • 0029933886 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of metformin
    • Scheen, A.J. 1996. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 30, 359–371.
    • (1996) Clin Pharmacokinet , vol.30 , pp. 359-371
    • Scheen, A.J.1
  • 96
    • 0018218638 scopus 로고
    • Dispositin of metformin (NN-dimethylbiguanide) in man
    • Sirtoli, C.R. 1978. Dispositin of metformin (NN-dimethylbiguanide) in man. Clin Pharmacol Ther 24, 683–693.
    • (1978) Clin Pharmacol Ther , vol.24 , pp. 683-693
    • Sirtoli, C.R.1
  • 98
    • 0009540553 scopus 로고
    • Du nouveau dans les antidiabetiques. La NN dimethylamine guanyl guanide (N.N.D.G.)
    • Sterne, J. 1957. Du nouveau dans les antidiabetiques. La NN dimethylamine guanyl guanide (N.N.D.G.). Maroc Med 36, 1295–1296.
    • (1957) Maroc Med , vol.36 , pp. 1295-1296
    • Sterne, J.1
  • 99
    • 61949361268 scopus 로고    scopus 로고
    • MicroRNAs as novel regulators of angiogenesis
    • Suarez, Y. & Sessa, W.C. 2009. MicroRNAs as novel regulators of angiogenesis. Circ Res 104, 442–454.
    • (2009) Circ Res , vol.104 , pp. 442-454
    • Suarez, Y.1    Sessa, W.C.2
  • 100
    • 84869788946 scopus 로고    scopus 로고
    • Metformin and the risk of cancer: time-related biases in observational studies
    • Suissa, S. & Azoulay, L. 2012. Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care 35, 2665–2673.
    • (2012) Diabetes Care , vol.35 , pp. 2665-2673
    • Suissa, S.1    Azoulay, L.2
  • 101
    • 84861567114 scopus 로고    scopus 로고
    • MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
    • Tabuchi, T., Satoh, M., Itoh, T. & Nakamura, M. 2012. MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression. Clin Sci (Lond) 123, 161–171.
    • (2012) Clin Sci (Lond) , vol.123 , pp. 161-171
    • Tabuchi, T.1    Satoh, M.2    Itoh, T.3    Nakamura, M.4
  • 103
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler, M.C. & Hardie, D.G. 2007. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100, 328–341.
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 104
    • 77954724449 scopus 로고    scopus 로고
    • A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS
    • Triggle, C.R. & Ding, H. 2010. A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS. J Am Soc Hypertens 4, 102–115.
    • (2010) J Am Soc Hypertens , vol.4 , pp. 102-115
    • Triggle, C.R.1    Ding, H.2
  • 105
    • 84910055228 scopus 로고    scopus 로고
    • Cardiovascular impact of drugs used in the treatment of diabetes
    • Triggle, C.R. & Ding, H. 2014. Cardiovascular impact of drugs used in the treatment of diabetes. Ther Adv Chronic Dis 5, 245–268.
    • (2014) Ther Adv Chronic Dis , vol.5 , pp. 245-268
    • Triggle, C.R.1    Ding, H.2
  • 106
    • 84930273946 scopus 로고    scopus 로고
    • Metformin: Targets SIRT1 and microRNAs in microvascular endothelial cells
    • &, (abstract)
    • Triggle, C.R., Arunachalam, G., Upadhyay, R., Ding, H. & Triggle, C.R. 2014. Metformin: Targets SIRT1 and microRNAs in microvascular endothelial cells. J Vasc Res 51(Suppl 1), 37 (abstract).
    • (2014) J Vasc Res , vol.51 , pp. 37
    • Triggle, C.R.1    Arunachalam, G.2    Upadhyay, R.3    Ding, H.4    Triggle, C.R.5
  • 108
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes (UKPDS 38)
    • UK Prospective Diabetes Study Group 1998. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes (UKPDS 38). Br Med J 317, 703–713.
    • (1998) Br Med J , vol.317 , pp. 703-713
  • 110
  • 111
    • 0036070666 scopus 로고    scopus 로고
    • Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin
    • Wang, D.S., Jonker, J.W., Kato, Y., Kusuhara, H., Schinkel, A.H. & Sugiyama, Y. 2003. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 302, 510–515.
    • (2003) J Pharmacol Exp Ther , vol.302 , pp. 510-515
    • Wang, D.S.1    Jonker, J.W.2    Kato, Y.3    Kusuhara, H.4    Schinkel, A.H.5    Sugiyama, Y.6
  • 112
    • 37049142934 scopus 로고
    • The preparation of methylguanidine, and of ββ-dimethylguanidine by the interaction of dicyanodiamide, and methylammonium and dimethylammonium chlorides respectively
    • Werner, E. & Bell, J. 1921. The preparation of methylguanidine, and of ββ-dimethylguanidine by the interaction of dicyanodiamide, and methylammonium and dimethylammonium chlorides respectively. J Chem Soc Trans 121, 1790–1795.
    • (1921) J Chem Soc Trans , vol.121 , pp. 1790-1795
    • Werner, E.1    Bell, J.2
  • 113
    • 85006642695 scopus 로고    scopus 로고
    • WHO. 2015. Essential medicines. http://www.who.int/selection_medicines/committees/expert/20/EML_2015_FINAL_amended_JUN2015.pdf?ua=1.
    • (2015) Essential medicines
  • 114
    • 0028158709 scopus 로고
    • Accumulation of metformin by tissues of the normal and diabetic mouse
    • Wilcock, C. & Bailey, C.J. 1994. Accumulation of metformin by tissues of the normal and diabetic mouse. Xenobiotica 24, 49–57.
    • (1994) Xenobiotica , vol.24 , pp. 49-57
    • Wilcock, C.1    Bailey, C.J.2
  • 115
    • 0025904170 scopus 로고
    • Subcellular distribution of metformin in rat liver
    • Wilcock, C., Wyre, N.D. & Bailey, C.J. 1991. Subcellular distribution of metformin in rat liver. J Pharm Pharmacol 43, 442–444.
    • (1991) J Pharm Pharmacol , vol.43 , pp. 442-444
    • Wilcock, C.1    Wyre, N.D.2    Bailey, C.J.3
  • 116
    • 84859881281 scopus 로고    scopus 로고
    • Activation of the AMP-activated protein kinase by eicosapentaenoic acid (EPA, 20:5 n-3) improves endothelial function in vivo
    • Wu, Y., Zhang, C., Dong, Y., Wang, S., Song, P., Viollet, B. & Zou, M.H. 2012. Activation of the AMP-activated protein kinase by eicosapentaenoic acid (EPA, 20:5 n-3) improves endothelial function in vivo. PLoS One 7, e35508.
    • (2012) PLoS One , vol.7
    • Wu, Y.1    Zhang, C.2    Dong, Y.3    Wang, S.4    Song, P.5    Viollet, B.6    Zou, M.H.7
  • 117
    • 26844519964 scopus 로고    scopus 로고
    • Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex
    • Xu, Y., Osborne, B.W. & Stanton, R.C. 2005. Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex. Am J Physiol 289, F1040–F1047.
    • (2005) Am J Physiol , vol.289 , pp. F1040-F1047
    • Xu, Y.1    Osborne, B.W.2    Stanton, R.C.3
  • 119
    • 85006574203 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter
    • Yue, L., Burchard, E.G., Brett, C.M. & Giacomini, K.M. 2008. Effect of genetic variation in the organic cation transporter. Clin Pharmacol Ther 83, 273–280.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 273-280
    • Yue, L.1    Burchard, E.G.2    Brett, C.M.3    Giacomini, K.M.4
  • 120
    • 15444362131 scopus 로고    scopus 로고
    • Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma
    • Yun, H., Lee, M., Kim, S.S. & Ha, J. 2005. Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. J Biol Chem 280, 9963–9972.
    • (2005) J Biol Chem , vol.280 , pp. 9963-9972
    • Yun, H.1    Lee, M.2    Kim, S.S.3    Ha, J.4
  • 121
    • 84856694355 scopus 로고    scopus 로고
    • MicroRNAs in vascular and metabolic disease
    • Zampetaki, A. & Mayr, M. 2012. MicroRNAs in vascular and metabolic disease. Circ Res 110, 508–522.
    • (2012) Circ Res , vol.110 , pp. 508-522
    • Zampetaki, A.1    Mayr, M.2
  • 122
    • 0034704167 scopus 로고    scopus 로고
    • High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells
    • Zhang, Z., Apse, K., Pang, J. & Stanton, R.C. 2000. High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells. J Biol Chem 275, 40042–400047.
    • (2000) J Biol Chem , vol.275 , pp. 40042-400047
    • Zhang, Z.1    Apse, K.2    Pang, J.3    Stanton, R.C.4
  • 123
    • 84875160216 scopus 로고    scopus 로고
    • Metformin reduces vascular endothelial dysfunction caused by an acute glucose load in patients with hypertension
    • Zhang, T.X., Xu, J.X., Peng, F., Chai, D.J. & Lin, J.X. 2013. Metformin reduces vascular endothelial dysfunction caused by an acute glucose load in patients with hypertension. Blood Press 22, 106–113.
    • (2013) Blood Press , vol.22 , pp. 106-113
    • Zhang, T.X.1    Xu, J.X.2    Peng, F.3    Chai, D.J.4    Lin, J.X.5
  • 125
    • 84934777883 scopus 로고    scopus 로고
    • Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies
    • Zhu, H. & Leung, S.W. 2015. Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies. Diabetologia 58, 900–911.
    • (2015) Diabetologia , vol.58 , pp. 900-911
    • Zhu, H.1    Leung, S.W.2
  • 126
    • 77952496696 scopus 로고    scopus 로고
    • SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
    • Zu, Y., Liu, L., Lee, M.Y., Xu, C., Liang, Y., Man, R.Y., Vanhoutte, P.M. & Wang, Y. 2010. SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ Res 106, 1384–1393.
    • (2010) Circ Res , vol.106 , pp. 1384-1393
    • Zu, Y.1    Liu, L.2    Lee, M.Y.3    Xu, C.4    Liang, Y.5    Man, R.Y.6    Vanhoutte, P.M.7    Wang, Y.8


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