Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Nature Medicine

Volumn 22, Issue 8, 2016, Pages 879-888

  Ryu, Dongryeol ^a   Mouchiroud, Laurent ^a   Andreux, Pénélope A ^a   Katsyuba, Elena ^a   Moullan, Norman ^a   Nicolet Dit Félix, Amandine A ^a   Williams, Evan G ^a   Jha, Pooja ^a   Lo Sasso, Giuseppe ^a   Huzard, Damien ^a   Aebischer, Patrick ^a   Sandi, Carmen ^a   Rinsch, Chris ^a   Auwerx, Johan ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

NATURAL PRODUCT; UNCLASSIFIED DRUG; UROLITHIN A; 3,8-DIHYDROXY-6H-DIBENZO(B,D)PYRAN-6-ONE; COUMARIN DERIVATIVE; MESSENGER RNA; MITOCHONDRIAL DNA;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BACTERIAL GROWTH; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ESCHERICHIA COLI; EXERCISE; IN VITRO STUDY; IN VIVO STUDY; LIFE EXTENSION; LIFESPAN; MALE; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MITOPHAGY; MOUSE; MUSCLE FUNCTION; NONHUMAN; PHARYNGEAL MUSCLE; PRIORITY JOURNAL; RAT; RNAI THERAPEUTICS; RODENT; ANIMAL; CONFOCAL MICROSCOPY; DRUG EFFECTS; FERTILITY; LONGEVITY; METABOLISM; MYOBLAST; OXYGEN CONSUMPTION; PHARYNX; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE;

ANIMALS; CAENORHABDITIS ELEGANS; COUMARINS; DNA, MITOCHONDRIAL; FERTILITY; LONGEVITY; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MUSCLE, SKELETAL; MYOBLASTS; OXYGEN CONSUMPTION; PHARYNX; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84978136448     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4132     Document Type: Article

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