Understanding BACE1: Essential protease for amyloid-β production in Alzheimer's disease

Cellular and Molecular Life Sciences

Volumn 65, Issue 20, 2008, Pages 3265-3289

  Stockley, J H ^a   O'Neill, C ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Alzheimer's disease; Amyloid beta; Aspartic protease; BACE1; Neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; ENZYME INHIBITOR; MESSENGER RNA; PROTEINASE;

ALZHEIMER DISEASE; CATALYSIS; CELL MATURATION; CELL MIGRATION; COGNITIVE DEFECT; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE DELETION; GENE OVEREXPRESSION; HISTORY OF MEDICINE; HUMAN; IN VIVO STUDY; MOLECULAR EVOLUTION; NERVE DEGENERATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROCESSING; REVIEW;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; EVOLUTION, MOLECULAR; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY;

EID: 53849123621     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-8271-3     Document Type: Review

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