A Splice Variant of β-Secretase Deficient in the Amyloidogenic Processing of the Amyloid Precursor Protein

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 12019-12023

  Bodendorf, Ursula ^a   Fischer, Frauke ^a   Bodian, Dale ^a   Multhaup, Gerd ^b   Paganetti, Paolo ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYME KINETICS; NUCLEIC ACID SEQUENCES; PROTEINS; RNA;

ENDOPLASMIC RETICULUM;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CELL MARKER; GLUCOSE REGULATED PROTEIN 78; MESSENGER RNA; UNCLASSIFIED DRUG; AMYLOID; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE2 PROTEIN, HUMAN; BETA SITE APP CLEAVING ENZYME 2; BETA-SITE APP CLEAVING ENZYME 2; DNA; PROTEINASE; SECRETASE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BASE PAIRING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME DEFICIENCY; ENZYME RELEASE; EXON; HUMAN; HUMAN CELL; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; RNA TRANSLATION; SENILE PLAQUE; SEQUENCE ALIGNMENT; TISSUE SPECIFICITY; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RNA SPLICING;

ANIMALIA;

AMINO ACID SEQUENCE; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; CELL LINE; DNA; ENDOPEPTIDASES; HUMANS; IMMUNOHISTOCHEMISTRY; MOLECULAR SEQUENCE DATA; RNA SPLICING; RNA, MESSENGER;

EID: 0035853821     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008861200     Document Type: Article

References (22)

1. Glenner, G. G., and Wong. C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
3. Selkoe, D. J. (1998) Trends Cell Biol. 8, 447-453
4. Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J., and Younkin, S. G. (1992) Science 255, 728-730
5. Citron, M., Teplow, D. B., and Selkoe, D. J. (1995) Neuron 14, 661-670
6. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., and Selkoe, D. J. (1992) Nature 360, 672-674
7. Cai, X. D., Golde, T. E., and Younkin, S. G. (1993) Science 259, 514-516
8. Haass, C., Hung, A. Y., Schlossmacher, M. G., Teplow, D. B., and Selkoe, D. J. (1993) J. Biol. Chem. 268, 3021-3024
9. Schrader-Fischer, G., and Paganetti, P. A. (1996) Brain Res. 716, 91-100
10. Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B., and Koo, E. H. (1999) J. Biol. Chem. 274, 18851-18856
11. Cescato, R., Dumermuth, E., Spiess, M., and Paganetti, P. A. (2000) J. Neurochem. 74, 1131-1139
12. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
13. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., Zhao, J., McConlogue, L., and John, V. (1999) Nature 402, 537-540
14. Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashier, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., Carter, D. B., Tomasselli, A. G., Parodi, L. A., Heinrikson, R. L., and Gurney, M. E. (1999) Nature 402, 533-537
15. Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., Smith, T. S., Simmons, D. L., Walsh, F. S., Dingwall, C., and Christie, G. (1999) Mol. Cell. Neurosci. 14, 419-427
16. Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., and Tang, J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1456-1460
17. Saunders, A. J., Kim, T. W., and Tanzi, R. E. (1999) Science 286, 1255
18. Fan, W., Bennett, B. D., Babu-Kahn, S., Luo, Y., Louis, J. C., McCaleb, M. M., Citron, M., Vassar, R., and Richards, W. G. (1999) Science 286, 1255
19. Haniu, M., Denis, P., Young, Y., Mendiaz, E. A., Fuller, J., Hui, J. O., Bennett, B. D., Kahn, S., Ross, S., Burgess, T., Katta, V., Rogers, G., Vassar, R., and Citron, M. (2000) J. Biol. Chem. 275, 21099-21106
20. Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G., and Haass, C. (2000) J. Biol. Chem. 275, 30849-30854
21. Seubert, P., Oltersdorf, T., Lee, M. G., Barbour, R., Blomquist, C., Davis, D. L., Bryant, K., Fritz, L. C., Galasko, D., Thal, L. J., Lieberburg, I., and Schenk, D. (1993) Nature 361, 260-263
22. Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M. Y., and Doms, R. W. (2000) J. Biol. Chem. 275, 33729-33737