-
1
-
-
0035923750
-
Interaction with telencephalon and the amyloid precursor protein predicts a ring structure for presenilins
-
Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B. 2001. Interaction with telencephalon and the amyloid precursor protein predicts a ring structure for presenilins. Neuron 32:579-589.
-
(2001)
Neuron
, vol.32
, pp. 579-589
-
-
Annaert, W.G.1
Esselens, C.2
Baert, V.3
Boeve, C.4
Snellings, G.5
Cupers, P.6
Craessaerts, K.7
De Strooper, B.8
-
2
-
-
0035736326
-
Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts
-
Armogida M, Petit A, Vincent B, Scarzello S, da Costa CA, Checler F. 2001. Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts. Nat Cell Biol 3:1030-1033.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1030-1033
-
-
Armogida, M.1
Petit, A.2
Vincent, B.3
Scarzello, S.4
da Costa, C.A.5
Checler, F.6
-
3
-
-
0035853821
-
A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein
-
Bodendorf U, Fischer F, Bodian D, Multhaup G, Paganetti P. 2001. A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein. J Biol Chem 276:12019-12023.
-
(2001)
J Biol Chem
, vol.276
, pp. 12019-12023
-
-
Bodendorf, U.1
Fischer, F.2
Bodian, D.3
Multhaup, G.4
Paganetti, P.5
-
4
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS. 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17:1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
5
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
6
-
-
0037474287
-
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein
-
Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. 2003. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem 278:3446-3454.
-
(2003)
J Biol Chem
, vol.278
, pp. 3446-3454
-
-
Cai, D.1
Leem, J.Y.2
Greenfield, J.P.3
Wang, P.4
Kim, B.S.5
Wang, R.6
Lopes, K.O.7
Kim, S.H.8
Zheng, H.9
Greengard, P.10
Sisodia, S.S.11
Thinakaran, G.12
Xu, H.13
-
7
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. 1998. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 273:3205-3211.
-
(1998)
J Biol Chem
, vol.273
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
Nixon, R.6
Beyreuther, K.7
Selkoe, D.J.8
Haass, C.9
-
8
-
-
0034613345
-
Maturation and pro-peptide cleavage of beta-secretase
-
Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C. 2000. Maturation and pro-peptide cleavage of beta-secretase. J Biol Chem 275:30849-30854.
-
(2000)
J Biol Chem
, vol.275
, pp. 30849-30854
-
-
Capell, A.1
Steiner, H.2
Willem, M.3
Kaiser, H.4
Meyer, C.5
Walter, J.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
9
-
-
0141482022
-
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition upregulates beta-site processing of the amyloid precursor protein
-
Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ. 2003. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition upregulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 100:11735-11740.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11735-11740
-
-
Cordy, J.M.1
Hussain, I.2
Dingwall, C.3
Hooper, N.M.4
Turner, A.J.5
-
10
-
-
0035830897
-
Processing of beta-secretase by furin and other members of the proprotein convertase family
-
Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B. 2001. Processing of beta-secretase by furin and other members of the proprotein convertase family. J Biol Chem 276:4211-4217.
-
(2001)
J Biol Chem
, vol.276
, pp. 4211-4217
-
-
Creemers, J.W.1
Ines Dominguez, D.2
Plets, E.3
Serneels, L.4
Taylor, N.A.5
Multhaup, G.6
Craessaerts, K.7
Annaert, W.8
De Strooper, B.9
-
11
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S. 1996. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383:710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
12
-
-
0037173115
-
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation
-
Edbauer D, Winkler E, Haass C, Steiner H. 2002. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc Natl Acad Sci U S A 99:8666-8671.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8666-8671
-
-
Edbauer, D.1
Winkler, E.2
Haass, C.3
Steiner, H.4
-
13
-
-
18444417998
-
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. 2002. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3:85-97.
-
(2002)
Dev Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
14
-
-
0036718272
-
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
-
Fukumoto H, Cheung BS, Hyman BT, Irizarry MC. 2002. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol 59:1381-1389.
-
(2002)
Arch Neurol
, vol.59
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
15
-
-
0033208953
-
Role and regulation of the ER chaperone BiP
-
Gething MJ. 1999. Role and regulation of the ER chaperone BiP. Semin Cell Dev Biol 10:465-72.
-
(1999)
Semin Cell Dev Biol
, vol.10
, pp. 465-472
-
-
Gething, M.J.1
-
16
-
-
0027438297
-
Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease
-
Golde TE, Cai XD, Shoji M, Younkin SG. 1993. Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. Ann N Y Acad Sci 695:103-108.
-
(1993)
Ann N Y Acad Sci
, vol.695
, pp. 103-108
-
-
Golde, T.E.1
Cai, X.D.2
Shoji, M.3
Younkin, S.G.4
-
17
-
-
0037470037
-
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin:nicastrin complexes
-
Gu Y, Chen F, Sanjo N, Kawarai T, Hasegawa H, Duthie M, Li W, Ruan X, Luthra A, Mount HT, Tandon A, Fraser PE, St George-Hyslop P. 2003. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin:nicastrin complexes. J Biol Chem 278:7374-7380.
-
(2003)
J Biol Chem
, vol.278
, pp. 7374-7380
-
-
Gu, Y.1
Chen, F.2
Sanjo, N.3
Kawarai, T.4
Hasegawa, H.5
Duthie, M.6
Li, W.7
Ruan, X.8
Luthra, A.9
Mount, H.T.10
Tandon, A.11
Fraser, P.E.12
St George-Hyslop, P.13
-
18
-
-
0027374493
-
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules
-
Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. 1993. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Ann N Y Acad Sci 695:109-116.
-
(1993)
Ann N Y Acad Sci
, vol.695
, pp. 109-116
-
-
Haass, C.1
Hung, A.Y.2
Schlossmacher, M.G.3
Oltersdorf, T.4
Teplow, D.B.5
Selkoe, D.J.6
-
19
-
-
0034647752
-
Characterization of Alzheimer's beta-secretase protein BACE. A pepsin family member with unusual properties
-
Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M. 2000. Characterization of Alzheimer's beta-secretase protein BACE. A pepsin family member with unusual properties. J Biol Chem 275:21099-21106.
-
(2000)
J Biol Chem
, vol.275
, pp. 21099-21106
-
-
Haniu, M.1
Denis, P.2
Young, Y.3
Mendiaz, E.A.4
Fuller, J.5
Hui, J.O.6
Bennett, B.D.7
Kahn, S.8
Ross, S.9
Burgess, T.10
Katta, V.11
Rogers, G.12
Vassar, R.13
Citron, M.14
-
20
-
-
0031003233
-
The Alzheimer family of diseases: Many etiologies, one pathogenesis?
-
Hardy J. 1997a. The Alzheimer family of diseases: many etiologies, one pathogenesis? Proc Natl Acad Sci U S A 94:2095-2097.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 2095-2097
-
-
Hardy, J.1
-
21
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer's disease
-
Hardy J. 1997b. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20:154-159.
-
(1997)
Trends Neurosci
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
22
-
-
0036073112
-
BACE1 interacts with nicastrin
-
Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura S. 2002. BACE1 interacts with nicastrin. Biochem Biophys Res Commun 293:1228-1232.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 1228-1232
-
-
Hattori, C.1
Asai, M.2
Oma, Y.3
Kino, Y.4
Sasagawa, N.5
Saido, T.C.6
Maruyama, K.7
Ishiura, S.8
-
23
-
-
0043203000
-
Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1)
-
Hebert SS, Bourdages V, Godin C, Ferland M, Carreau M, Levesque G. 2003. Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1). Neurobiol Dis 13:238-245.
-
(2003)
Neurobiol Dis
, vol.13
, pp. 238-245
-
-
Hebert, S.S.1
Bourdages, V.2
Godin, C.3
Ferland, M.4
Carreau, M.5
Levesque, G.6
-
24
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B. 1999. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A 96:11872-11877.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
Serneels, L.6
Umans, L.7
Schrijvers, V.8
Checler, F.9
Vanderstichele, H.10
Baekelandt, V.11
Dressel, R.12
Cupers, P.13
Huylebroeck, D.14
Zwijsen, A.15
Van Leuven, F.16
De Strooper, B.17
-
25
-
-
0037444574
-
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
-
Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B. 2003. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. J Cell Sci 116:1127-1136.
-
(2003)
J Cell Sci
, vol.116
, pp. 1127-1136
-
-
Herreman, A.1
Van Gassen, G.2
Bentahir, M.3
Nyabi, O.4
Craessaerts, K.5
Mueller, U.6
Annaert, W.7
De Strooper, B.8
-
26
-
-
0036260892
-
Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
-
Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G. 2002. Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann Neurol 51:783-786.
-
(2002)
Ann Neurol
, vol.51
, pp. 783-786
-
-
Holsinger, R.M.1
McLean, C.A.2
Beyreuther, K.3
Masters, C.L.4
Evin, G.5
-
27
-
-
0034721842
-
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase
-
Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW. 2000. Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J Biol Chem 275:33729-33737.
-
(2000)
J Biol Chem
, vol.275
, pp. 33729-33737
-
-
Huse, J.T.1
Pijak, D.S.2
Leslie, G.J.3
Lee, V.M.4
Doms, R.W.5
-
28
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G. 1999. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14:419-427.
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
29
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
-
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. 2001. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414:643-648.
-
(2001)
Nature
, vol.414
, pp. 643-648
-
-
Kamal, A.1
Almenar-Queralt, A.2
LeBlanc, J.F.3
Roberts, E.A.4
Goldstein, L.S.5
-
30
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
31
-
-
0030756236
-
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
-
Kihara T, Shimohama S, Sawada H, Kimura J, Kume T, Kochiyama H, Maeda T, Akaike A. 1997. Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. Ann Neurol 42:159-163.
-
(1997)
Ann Neurol
, vol.42
, pp. 159-163
-
-
Kihara, T.1
Shimohama, S.2
Sawada, H.3
Kimura, J.4
Kume, T.5
Kochiyama, H.6
Maeda, T.7
Akaike, A.8
-
32
-
-
0035900686
-
Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein
-
Kim SH, Leem JY, Lah JJ, Slunt HH, Levey AI, Thinakaran G, Sisodia SS. 2001. Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein. J Biol Chem 276:43343-43350.
-
(2001)
J Biol Chem
, vol.276
, pp. 43343-43350
-
-
Kim, S.H.1
Leem, J.Y.2
Lah, J.J.3
Slunt, H.H.4
Levey, A.I.5
Thinakaran, G.6
Sisodia, S.S.7
-
33
-
-
0026688633
-
Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions
-
L'Hernault SW, Arduengo PM. 1992. Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions. J Cell Biol 119:55-68.
-
(1992)
J Cell Biol
, vol.119
, pp. 55-68
-
-
L'Hernault, S.W.1
Arduengo, P.M.2
-
34
-
-
0037160063
-
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
-
Lee SF, Shah S, Li H, Yu C, Han W, Yu G. 2002. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem 277:45013-45019.
-
(2002)
J Biol Chem
, vol.277
, pp. 45013-45019
-
-
Lee, S.F.1
Shah, S.2
Li, H.3
Yu, C.4
Han, W.5
Yu, G.6
-
35
-
-
0036453087
-
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface
-
Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. 2002a. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis 11:64-82.
-
(2002)
Neurobiol Dis
, vol.11
, pp. 64-82
-
-
Leem, J.Y.1
Saura, C.A.2
Pietrzik, C.3
Christianson, J.4
Wanamaker, C.5
King, L.T.6
Veselits, M.L.7
Tomita, T.8
Gasparini, L.9
Iwatsubo, T.10
Xu, H.11
Green, W.N.12
Koo, E.H.13
Thinakaran, G.14
-
36
-
-
0037166349
-
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin
-
Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, Veselits ML, Xu H, Thinakaran G. 2002b. Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J Biol Chem 277:19236-19240.
-
(2002)
J Biol Chem
, vol.277
, pp. 19236-19240
-
-
Leem, J.Y.1
Vijayan, S.2
Han, P.3
Cai, D.4
Machura, M.5
Lopes, K.O.6
Veselits, M.L.7
Xu, H.8
Thinakaran, G.9
-
37
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. 1998. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21:1213-1221.
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.J.3
Kusiak, J.W.4
Tomita, T.5
Iwatsubo, T.6
Qian, X.7
Ginty, D.D.8
Price, D.L.9
Borchelt, D.R.10
Wong, P.C.11
Sisodia, S.S.12
-
38
-
-
0035432322
-
-
Pinnix I, Council JE, Roseberry B, Onstead L, Mallender W, Sucic J, Sambamurti K. 2001. Convertases other than furin cleave beta-secretase to its mature form. FASEB J 15:18101812.
-
Pinnix I, Council JE, Roseberry B, Onstead L, Mallender W, Sucic J, Sambamurti K. 2001. Convertases other than furin cleave beta-secretase to its mature form. FASEB J 15:18101812.
-
-
-
-
39
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, et al. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
-
40
-
-
18744435477
-
Presenilin-1 mutations in Alzheimer's disease
-
Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK. 2000. Presenilin-1 mutations in Alzheimer's disease. Nature 405:531-532.
-
(2000)
Nature
, vol.405
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
41
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
42
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V. 1999. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402:537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
Zhao, J.25
McConlogue, L.26
John, V.27
more..
-
43
-
-
0037131218
-
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin
-
Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C. 2002. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem 277:39062-39065.
-
(2002)
J Biol Chem
, vol.277
, pp. 39062-39065
-
-
Steiner, H.1
Winkler, E.2
Edbauer, D.3
Prokop, S.4
Basset, G.5
Yamasaki, A.6
Kostka, M.7
Haass, C.8
-
44
-
-
0032720123
-
The role of presenilins in Alzheimer's disease
-
Thinakaran G. 1999. The role of presenilins in Alzheimer's disease. J Clin Invest 104:1321-1327.
-
(1999)
J Clin Invest
, vol.104
, pp. 1321-1327
-
-
Thinakaran, G.1
-
45
-
-
33744899335
-
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1
-
Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S. 2006. Characterization of sequential N-cadherin cleavage by ADAM10 and PS1. Neurosci Lett 402:278-283.
-
(2006)
Neurosci Lett
, vol.402
, pp. 278-283
-
-
Uemura, K.1
Kihara, T.2
Kuzuya, A.3
Okawa, K.4
Nishimoto, T.5
Ninomiya, H.6
Sugimoto, H.7
Kinoshita, A.8
Shimohama, S.9
-
46
-
-
0141816599
-
Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane
-
Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H, Shimohama S. 2003a. Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane. J Neurosci Res 74:184-191.
-
(2003)
J Neurosci Res
, vol.74
, pp. 184-191
-
-
Uemura, K.1
Kitagawa, N.2
Kohno, R.3
Kuzuya, A.4
Kageyama, T.5
Chonabayashi, K.6
Shibasaki, H.7
Shimohama, S.8
-
47
-
-
0038167076
-
Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling
-
Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Shibasaki H, Shimohama S. 2003b. Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling. J Neurosci Res 73:166-175.
-
(2003)
J Neurosci Res
, vol.73
, pp. 166-175
-
-
Uemura, K.1
Kitagawa, N.2
Kohno, R.3
Kuzuya, A.4
Kageyama, T.5
Shibasaki, H.6
Shimohama, S.7
-
48
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. 1999. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
49
-
-
0035805592
-
Phosphorylation regulates intracellular trafficking of beta-secretase
-
Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C. 2001. Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem 276:14634-14641.
-
(2001)
J Biol Chem
, vol.276
, pp. 14634-14641
-
-
Walter, J.1
Fluhrer, R.2
Hartung, B.3
Willem, M.4
Kaether, C.5
Capell, A.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
50
-
-
0036727463
-
Presenilins are not required for A beta 42 production in the early secretory pathway
-
Wilson CA, Doms RW, Zheng H, Lee VM. 2002. Presenilins are not required for A beta 42 production in the early secretory pathway. Nat Neurosci 5:849-855.
-
(2002)
Nat Neurosci
, vol.5
, pp. 849-855
-
-
Wilson, C.A.1
Doms, R.W.2
Zheng, H.3
Lee, V.M.4
-
51
-
-
0033621152
-
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
-
Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. 1999a. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry 38:11223-11230.
-
(1999)
Biochemistry
, vol.38
, pp. 11223-11230
-
-
Wolfe, M.S.1
De Los Angeles, J.2
Miller, D.D.3
Xia, W.4
Selkoe, D.J.5
-
52
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. 1999b. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398:513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
53
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME. 1999. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402:533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashier, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
Carter, D.B.11
Tomasselli, A.G.12
Parodi, L.A.13
Heinrikson, R.L.14
Gurney, M.E.15
-
54
-
-
0037236622
-
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
-
Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y. 2003. Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med 9:3-4.
-
(2003)
Nat Med
, vol.9
, pp. 3-4
-
-
Yang, L.B.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.L.6
Beach, T.7
Sue, L.8
Wong, P.9
Price, D.10
Li, R.11
Shen, Y.12
-
55
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. 2000. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407:48-54.
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St George-Hyslop, P.30
more..
|