Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome

FASEB Journal

Volumn 20, Issue 9, 2006, Pages 1361-1368

  Sun, Xiulian ^a,b   Tong, Yigang ^a   Qing, Hong ^a   Chen, Chia Hsiung ^a,b   Song, Weihong ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer's disease pathogenesis; Amyloid

Indexed keywords

BACE1 ENZYME; BETA SECRETASE; GLYCOSYLATED PROTEIN; PROTEINASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; ENZYME INHIBITOR; PEPTIDE FRAGMENT; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOWN SYNDROME; GENE MUTATION; GENETIC TRANSCRIPTION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMAGE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; FEMALE; FETUS; FIBROBLAST; GENETICS; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PREGNANCY; REFERENCE VALUE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELLS, CULTURED; DOWN SYNDROME; ENDOPEPTIDASES; ENZYME INHIBITORS; FEMALE; FETUS; FIBROBLASTS; GOLGI APPARATUS; HUMANS; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PREGNANCY; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33746572249     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-5628com     Document Type: Article

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