Biochemical and kinetic characterization of BACE1: Investigation into the putative species-specificity for β- and β′-cleavage sites by human and murine BACE1

Journal of Neurochemistry

Volumn 91, Issue 6, 2004, Pages 1249-1259

  Yang, Hsiu Chiung ^a   Chai, Xiyun ^a   Mosior, Marian ^a   Kohn, Wayne ^a   Boggs, Leonard N ^a   Erickson, Jon A ^a   McClure, Don B ^a   Yeh, Wu Kuang ^a   Zhang, Lianshen ^a   Gonzalez DeWhitt, Patricia ^a   Mayer, John P ^a   Martin, Jose Alfredo ^b   Hu, Jingdan ^a   Chen, Shu Hui ^a   Bueno, Ana Belen ^b   Little, Sheila P ^a   McCarthy, James R ^a   May, Patrick C ^a  

^a ELI LILLY AND COMPANY   (United States)

^b ELI LILLY AND COMPANY   (Spain)

Author keywords

cleavage; amyloid precursor protein cleaving enzyme; cleavage; Amyloid precursor protein; Species specificity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; GAMMA SECRETASE; LY 2039911; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; GUINEA PIG; HUMAN; HUMAN CELL; HYPOTHESIS; MAMMAL; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; WILD TYPE;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOPEPTIDASES; GUINEA PIGS; HUMANS; KINETICS; MICE; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SPECIES SPECIFICITY;

ANIMALIA; CAVIA PORCELLUS; MAMMALIA; MURINAE; MUS MUSCULUS; SUS SCROFA;

EID: 10644265978     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02764.x     Document Type: Article

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