Asp1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site

Molecular and Cellular Neuroscience

Volumn 16, Issue 5, 2000, Pages 609-619

  Hussain, I ^a   Powell, D J ^a   Howlett, D R ^a   Chapman, G A ^a   Gilmour, L ^a   Murdock, P R ^a   Tew, D G ^a   Meek, T D ^a   Chapman, C ^a   Schneider, K ^a   Ratcliffe, S J ^a   Tattersall, D ^a   Testa, T T ^a   Southan, C ^a   Ryan, D M ^a   Simmons, D L ^a   Walsh, F S ^a   Dingwall, C ^a   Christie, G ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE 1; BETA SECRETASE; HYBRID PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; BRAIN LEVEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FEMALE; GOLGI COMPLEX; HUMAN; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SENILE PLAQUE;

EID: 0034533808     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2000.0884     Document Type: Article

References (34)

1. The gene encoding DRAP (BACE 2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region
2. Expression analysis of BACE2 in brain and peripheral tissues
3. Release of excess amyloid β protein from a mutant amyloid β protein precursor
4. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
5. Cleavage of amyloid β peptide during constitutive processing of its precursor
6. Selective neurotoxicity of COOH-terminal fragments of the β-amyloid precursor protein
7. Alzheimer's disease: Initial report of the purification and characterisation of a novel cerebrovascular amyloid protein
8. Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
9. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
10. Identification of a novel aspartic protease (Asp2) as β-secretase
11. Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid by a newly developed sensitive Western blot assay
12. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
13. Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
14. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease
15. Intracellular accumulation of β-amyloid in cells expressing the Swedish mutant amyloid precursor protein
16. Amyloid plaque core protein in Alzheimer disease and Downs syndrome
17. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
18. Antigenic profile of plaques and neurofibrillary tangles in the amygdala in Down's syndrome: A comparison with Alzheimer's disease
19. Transgenic mice expressing APP-C100 in the brain
20. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor
21. BACE maps to chromosome 11 and BACE homolog, BACE 2, reside in the obligate Down Syndrome region of chromosome 21
22. Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues
23. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease
24. Purification and cloning of amyloid precursor protein β-secretase from human brain
25. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing
26. Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the β-amyloid precursor protein
27. Metabolism of the 'Swedish' amyloid precursor protein variant in Neuro2a (N2a) cells
28. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
29. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
30. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
31. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
32. Membrane-anchored aspartic protease with Alzheimer's disease β-secretase activity
33. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease