Human β-secretase (BACE) and BACE inhibitors: Progress report

Current Topics in Medicinal Chemistry

Volumn 6, Issue 6, 2006, Pages 569-578

  John, Varghese ^a  

^a Apollon Therapeutics   (United States)

Author keywords

Alzheimer's disease; Amyloidogenic pathway; APP processing; Hydroxyethylene inhibitors; Hydroxymethylcarbonyl (HMC)

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE INHIBITOR; ETHANOLAMINE DERIVATIVE; GAMMA SECRETASE; NAPHTHALENE DERIVATIVE; OM 99 2; PROTEINASE INHIBITOR; STATINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BRAIN REGION; CARBOXY TERMINAL SEQUENCE; CLINICAL FEATURE; CRYSTAL STRUCTURE; DISEASE COURSE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HYPOTHESIS; NEUROTOXICITY; PATHOGENESIS; PHARMACOPHORE; PROTEIN DEGRADATION; REVIEW; SENILE PLAQUE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; ENDOPEPTIDASES; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; RECEPTORS, CELL SURFACE; SENILE PLAQUES;

EID: 33646189389     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802606776743084     Document Type: Review

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