Structure-based design of potent and selective cell-permeable inhibitors of human β-secretase (BACE-1)

Journal of Medicinal Chemistry

Volumn 47, Issue 26, 2004, Pages 6447-6450

  Stachel, Shawn J ^a   Coburn, Craig A ^a   Steele, Thomas G ^a   Jones, Kristen G ^a   Loutzenhiser, Elizabeth F ^a   Gregro, Alison R ^a   Rajapakse, Hemaka A ^a   Lai, Ming Tain ^a   Crouthamel, Ming Chih ^a   Xu, Min ^a   Tugusheva, Katherine ^a   Lineberger, Janet E ^a   Pietrak, Beth L ^a   Espeseth, Amy S ^a   Shi, Xiao Ping ^a   Chen Dodson, Elizabeth ^a   Holloway, M Katharine ^a   Munshi, Sanjeev ^a   Simon, Adam J ^a   Kuo, Lawrence ^a   Vacca, Joseph P ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE INHIBITOR; HYDROXYETHYLAMINE; HYDROXYETHYLENE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CELL LINE; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ETHYLAMINES; HUMANS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 10644249886     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049379g     Document Type: Article

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25. All compounds reported in Table 1 were noncytotoxic at 10 μM in cells.
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30. 1′ region.