Prion protein expression in senile plaques in Alzheimer's disease

Acta Neuropathologica

Volumn 101, Issue 1, 2001, Pages 49-56

  Ferrer, I ^a   Blanco, R ^b   Carmona, M ^b   Puig, B ^b   Ribera, R ^c   Rey, M J ^c   Ribalta, T ^c  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b Unitat de Neuropatologia   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Alzheimer's disease; Nuclear factor B, N Myc; Prion protein; Synaptophysin; A4 amyloid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CELL MEMBRANE PROTEIN; GLYCOLIPID; PRION PROTEIN; PROTEINASE K; SIALOGLYCOPROTEIN; SYNAPTOPHYSIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD VESSEL WALL; CELL COMPARTMENTALIZATION; CLINICAL ARTICLE; CROSS REACTION; ELECTROPHORESIS; ENDOCYTOSIS; ENDOSOME; EXTRACELLULAR SPACE; FEMALE; HUMAN; HUMAN TISSUE; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; INCUBATION TIME; MALE; PRESERVATION; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SENILE PLAQUE; SYNAPSE; SYNAPSE VESICLE; TISSUE DISTRIBUTION; TISSUE SECTION; VASCULAR AMYLOIDOSIS; WESTERN BLOTTING;

EID: 0035141524     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010000271     Document Type: Article

References (57)

1. Rapid anterograde transport of the cellular prion glycoprotein in the peripheral and central nervous system
2. Neuropathological staging of Alzheimer-related changes
3. Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease
4. Normal development and behaviour of mice lacking the neuronal surface PrP protein
5. Alzheimer patients and Down patients: Abnormal presynaptic terminals are related to cerebral preamyloid deposits
6. Prion protein is necessary for normal synaptic function
7. Prion diseases
8. Synaptobrevin binding to synaptophysin: A potential mechanism for controlling the exocytotic machine
9. Ageing and dementia
10. N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease
11. NF-κB immunoreactivity is observed in association with βA4 diffuse plaques in patients with Alzheimer's disease
12. Dystrophic neurites of senile plaques are defective in proteins involved in exocytosis and neurotransmission
13. Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt-Jakob disease
14. C) in synaptic boutons of normal hamster hippocampus
15. Synaptic activation of NF-κB by glutamate in cerebellar granule neurons in vitro
16. Synaptic loss in Alzheimer's disease and other dementias
17. Asparagine-linked glycosylation of the scrapie and cellular prion proteins
18. α-Synuclein in Lewy body disease and Alzheimer's disease
19. Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease
20. Patchclamp analysis of synaptic transmission to cerebellar Purkinje cells of prion protein knockout mice
21. Evidence of presynaptic location and function of the prion protein
22. Synaptic vesicles and exocytosis
23. Brain synapses contain inducible forms of the transcription factor NF-κB
24. Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
25. Abnormal isoform of prion protein accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob disease
26. Synaptic pathology in Alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles
27. Synaptic pathology of Alzheimer's disease
28. Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus
29. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
30. Diffuse plaques do not accentuate synapse loss in Alzheimer's disease
31. Synaptophysin, a major synaptic protein, is not essential for neurotrasmitter release
32. Gene expression of the transcription factor NF-κB in hippocampus: Regulation by synaptic activity
33. Behavioural and anatomical deficits in mice homozygous for a modified β-amyloid precursor protein
34. Chromogranin A-like immunoreactive neurons are major constituents of senile plaques
35. NF-κB: A crucial transcription factor for glial and neuronal cell functions
36. Neuropathology of Alzheimer's disease
37. Deposition of βA4 protein along neuronal plasma membranes in diffuse senile plaques
38. Alzheimer disease: A description of the structural lesions
39. Cell biology and transgenic models of prion diseases
40. Biology of Prions
41. Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse
42. Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein
43. Cellular and molecular biology of β-amyloid precursor and Alzheimer's disease
44. Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease
45. Neurotransmission: Harnessing fusion machinery at the synapse
46. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
47. Hypersensitivity to seizures in β-amyloid precursor protein deficient mice
48. The amyloid precursor protein of Alzheimer's disease and the Aβ peptide
49. The synaptic vesicle cycle: A cascade of protein-protein interactions
50. Loss of presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
51. Altered circadian activity rhythms and sleep in mice devoid of prion protein
52. Brain parenchymal and microvascular amyloid in Alzheimer's disease
53. Regulation of the neural crest cell fate by N-myc: Promotion of ventral migration and neuronal differentiation
54. Intracellular APP processing and Aβ production in Alzheimer disease
55. Electron micrograph of diffuse plaques: Initial stage of senile plaque formation in the Alzheimer brain
56. Expression of chromogranin A in lesions in the central nervous system from patients with neurological diseases
57. Processing of the Alzheimer's disease βA4 amyloid protein precursor