β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis

Journal of Neuroscience

Volumn 27, Issue 14, 2007, Pages 3639-3649

  Zhao, Jie ^a,c   Fu, Yifan ^a   Yasvoina, Marina ^a   Shao, Peizhen ^a   Hitt, Brian ^a   O'Connor, Tracy ^a   Logan, Sreemathi ^a   Maus, Erika ^a   Citron, Martin ^b   Berry, Robert ^a   Binder, Lester ^a   Vassar, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b AMGEN INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

secretase; 5XFAD; APP transgenic; BACE Cat1; Neurodegeneration; Tg2576

Indexed keywords

BETA SECRETASE; BETA SECRETASE INHIBITOR; MONOCLONAL ANTIBODY;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CELL LOSS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; SENILE PLAQUES;

EID: 34147120073     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4396-06.2007     Document Type: Article

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