Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human β-secretase

Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2003, Pages 1799-1802

  Hom, Roy K ^a   Fang, Larry Y ^a   Mamo, Shumeye ^a   Tung, Jay S ^a   Guinn, Ashley C ^a   Walker, Don E ^a   Davis, David L ^a   Gailunas, Andrea F ^a   Thorsett, Eugene D ^a   Sinha, Sukanto ^a   Knops, Jeroen E ^a   Jewett, Nancy E ^a   Anderson, John P ^a   Varghese, John ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 3,5 DIMETHYL CYCLOHEXANEDICARBOXYLATE; 3,5 DIFLUOROPHENYLSTATINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CARBOXYLIC ACID DERIVATIVE; PEPTIDOMIMETIC INHIBITOR OF HUMAN BETA SECRETASE; STATIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; DIASTEREOISOMER; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; KIDNEY CELL; PROTEIN MODIFICATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; MOLECULAR MIMICRY; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037740743     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm025619l     Document Type: Article

References (16)

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12. + (CI) 216.1.
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